CN105451778B - Rna-导向的转录调控 - Google Patents
Rna-导向的转录调控 Download PDFInfo
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- CN105451778B CN105451778B CN201480043971.2A CN201480043971A CN105451778B CN 105451778 B CN105451778 B CN 105451778B CN 201480043971 A CN201480043971 A CN 201480043971A CN 105451778 B CN105451778 B CN 105451778B
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Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202110830978.0A CN113846096B (zh) | 2013-06-04 | 2014-06-04 | Rna-导向的转录调控 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361830787P | 2013-06-04 | 2013-06-04 | |
| US61/830,787 | 2013-06-04 | ||
| PCT/US2014/040868 WO2014197568A2 (en) | 2013-06-04 | 2014-06-04 | Rna-guideded transcriptional regulation |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202110830978.0A Division CN113846096B (zh) | 2013-06-04 | 2014-06-04 | Rna-导向的转录调控 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN105451778A CN105451778A (zh) | 2016-03-30 |
| CN105451778B true CN105451778B (zh) | 2021-08-03 |
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Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202110830978.0A Active CN113846096B (zh) | 2013-06-04 | 2014-06-04 | Rna-导向的转录调控 |
| CN201480043971.2A Active CN105451778B (zh) | 2013-06-04 | 2014-06-04 | Rna-导向的转录调控 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202110830978.0A Active CN113846096B (zh) | 2013-06-04 | 2014-06-04 | Rna-导向的转录调控 |
Country Status (15)
| Country | Link |
|---|---|
| US (2) | US11981917B2 (enExample) |
| EP (4) | EP3003392B1 (enExample) |
| JP (5) | JP6621738B2 (enExample) |
| KR (3) | KR102884236B1 (enExample) |
| CN (2) | CN113846096B (enExample) |
| AU (4) | AU2014274939B2 (enExample) |
| CA (2) | CA2914638A1 (enExample) |
| ES (1) | ES2930537T3 (enExample) |
| IL (3) | IL302205B2 (enExample) |
| MX (2) | MX385330B (enExample) |
| MY (3) | MY177814A (enExample) |
| RU (2) | RU2756865C2 (enExample) |
| SG (3) | SG10201710030QA (enExample) |
| WO (1) | WO2014197568A2 (enExample) |
| ZA (1) | ZA201509025B (enExample) |
Families Citing this family (121)
| Publication number | Priority date | Publication date | Assignee | Title |
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| JP6261500B2 (ja) | 2011-07-22 | 2018-01-17 | プレジデント アンド フェローズ オブ ハーバード カレッジ | ヌクレアーゼ切断特異性の評価および改善 |
| US10501791B2 (en) | 2011-10-14 | 2019-12-10 | President And Fellows Of Harvard College | Sequencing by structure assembly |
| ES2991004T3 (es) | 2011-12-22 | 2024-12-02 | Harvard College | Métodos para la detección de analitos |
| WO2014163886A1 (en) | 2013-03-12 | 2014-10-09 | President And Fellows Of Harvard College | Method of generating a three-dimensional nucleic acid containing matrix |
| US9637739B2 (en) * | 2012-03-20 | 2017-05-02 | Vilnius University | RNA-directed DNA cleavage by the Cas9-crRNA complex |
| WO2014065596A1 (en) * | 2012-10-23 | 2014-05-01 | Toolgen Incorporated | Composition for cleaving a target dna comprising a guide rna specific for the target dna and cas protein-encoding nucleic acid or cas protein, and use thereof |
| WO2014093709A1 (en) | 2012-12-12 | 2014-06-19 | The Broad Institute, Inc. | Methods, models, systems, and apparatus for identifying target sequences for cas enzymes or crispr-cas systems for target sequences and conveying results thereof |
| EP4299741A3 (en) | 2012-12-12 | 2024-02-28 | The Broad Institute, Inc. | Delivery, engineering and optimization of systems, methods and compositions for sequence manipulation and therapeutic applications |
| WO2014093701A1 (en) | 2012-12-12 | 2014-06-19 | The Broad Institute, Inc. | Functional genomics using crispr-cas systems, compositions, methods, knock out libraries and applications thereof |
| EP4481048A3 (en) * | 2012-12-17 | 2025-02-26 | President and Fellows of Harvard College | Rna-guided human genome engineering |
| US9234213B2 (en) | 2013-03-15 | 2016-01-12 | System Biosciences, Llc | Compositions and methods directed to CRISPR/Cas genomic engineering systems |
| US9828582B2 (en) | 2013-03-19 | 2017-11-28 | Duke University | Compositions and methods for the induction and tuning of gene expression |
| MY177814A (en) | 2013-06-04 | 2020-09-23 | Harvard College | Rna-guided transcriptional regulation |
| US9267135B2 (en) | 2013-06-04 | 2016-02-23 | President And Fellows Of Harvard College | RNA-guided transcriptional regulation |
| KR102733409B1 (ko) * | 2013-06-05 | 2024-11-21 | 듀크 유니버시티 | Rna-가이드 유전자 편집 및 유전자 조절 |
| KR20160056869A (ko) | 2013-06-17 | 2016-05-20 | 더 브로드 인스티튜트, 인코퍼레이티드 | 바이러스 구성성분을 사용하여 장애 및 질환을 표적화하기 위한 crispr-cas 시스템 및 조성물의 전달, 용도 및 치료 적용 |
| DK3011029T3 (da) | 2013-06-17 | 2020-03-16 | Broad Inst Inc | Administration, modificering og optimering af tandem-guidesystemer, fremgangsmåder og sammensætninger til sekvensmanipulering |
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| CN105492611A (zh) * | 2013-06-17 | 2016-04-13 | 布罗德研究所有限公司 | 用于序列操纵的优化的crispr-cas双切口酶系统、方法以及组合物 |
| US20150044192A1 (en) | 2013-08-09 | 2015-02-12 | President And Fellows Of Harvard College | Methods for identifying a target site of a cas9 nuclease |
| US9359599B2 (en) | 2013-08-22 | 2016-06-07 | President And Fellows Of Harvard College | Engineered transcription activator-like effector (TALE) domains and uses thereof |
| US9228207B2 (en) | 2013-09-06 | 2016-01-05 | President And Fellows Of Harvard College | Switchable gRNAs comprising aptamers |
| US9322037B2 (en) | 2013-09-06 | 2016-04-26 | President And Fellows Of Harvard College | Cas9-FokI fusion proteins and uses thereof |
| US9737604B2 (en) | 2013-09-06 | 2017-08-22 | President And Fellows Of Harvard College | Use of cationic lipids to deliver CAS9 |
| WO2015040402A1 (en) * | 2013-09-18 | 2015-03-26 | Kymab Limited | Methods. cells & organisms |
| PT3066201T (pt) | 2013-11-07 | 2018-06-04 | Massachusetts Inst Technology | Métodos e composições relacionadas com crispr com arng reguladores |
| KR20250068794A (ko) | 2013-12-12 | 2025-05-16 | 더 브로드 인스티튜트, 인코퍼레이티드 | 게놈 편집을 위한 crispr-cas 시스템 및 조성물의 전달, 용도 및 치료적 응용 |
| CA2932479A1 (en) | 2013-12-12 | 2015-06-18 | The Rockefeller University | Delivery, use and therapeutic applications of the crispr-cas systems and compositions for hbv and viral diseases and disorders |
| WO2015089364A1 (en) | 2013-12-12 | 2015-06-18 | The Broad Institute Inc. | Crystal structure of a crispr-cas system, and uses thereof |
| CN106103705A (zh) | 2013-12-12 | 2016-11-09 | 布罗德研究所有限公司 | 核苷酸重复障碍中crispr‑cas系统的组合物和使用方法 |
| US9068179B1 (en) | 2013-12-12 | 2015-06-30 | President And Fellows Of Harvard College | Methods for correcting presenilin point mutations |
| WO2015089473A1 (en) | 2013-12-12 | 2015-06-18 | The Broad Institute Inc. | Engineering of systems, methods and optimized guide compositions with new architectures for sequence manipulation |
| WO2015089486A2 (en) | 2013-12-12 | 2015-06-18 | The Broad Institute Inc. | Systems, methods and compositions for sequence manipulation with optimized functional crispr-cas systems |
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