CN105296447A - 具有增强的稳定性和增强的保留催化活性的变体重组β-葡萄糖脑苷脂酶蛋白 - Google Patents
具有增强的稳定性和增强的保留催化活性的变体重组β-葡萄糖脑苷脂酶蛋白 Download PDFInfo
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- CN105296447A CN105296447A CN201510671991.0A CN201510671991A CN105296447A CN 105296447 A CN105296447 A CN 105296447A CN 201510671991 A CN201510671991 A CN 201510671991A CN 105296447 A CN105296447 A CN 105296447A
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- glucocerebrosidase
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- g1ccerase
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| CA3127162A1 (en) * | 2019-02-01 | 2020-08-06 | Oxyrane Uk Ltd | Glucocerebrosidase polypeptides |
| CA3128875A1 (en) | 2019-02-04 | 2020-08-13 | Freeline Therapeutics Limited | Polynucleotides |
| JP2023519934A (ja) * | 2020-03-29 | 2023-05-15 | イエダ・リサーチ・アンド・デベロツプメント・カンパニー・リミテツド | ゴーシェ病の処置において使用するためのベータ－グルコセレブロシダーゼのバリアント |
| BR112023001583A2 (pt) * | 2020-07-29 | 2023-02-14 | Freeline Therapeutics Ltd | Polipeptídeos de ss-glucocerebrosidase (gcase) modificado, polinucleotídeo, partícula viral e composição |
| WO2023145812A1 (ja) * | 2022-01-31 | 2023-08-03 | 株式会社日本触媒 | グルコセレブロシダーゼ活性を有する糖鎖付加タンパク質 |
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| JP2025514645A (ja) | 2022-04-12 | 2025-05-09 | エフ． ホフマン－ラ ロシュ アーゲー | 中枢神経系に対して標的化された融合タンパク質 |
| WO2024074142A1 (en) * | 2022-10-08 | 2024-04-11 | Lingyi Biotech Co., Ltd. | Polynucleotides for the treatment of disease associated with gcase deficiency |
| TW202532096A (zh) * | 2023-12-08 | 2025-08-16 | 美商戴納立製藥公司 | 經修飾之葡萄糖腦苷脂酶多肽及其使用方法 |
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| US20020127219A1 (en) * | 1999-12-30 | 2002-09-12 | Okkels Jens Sigurd | Lysosomal enzymes and lysosomal enzyme activators |
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| AU734290B2 (en) * | 1997-10-29 | 2001-06-07 | Genzyme Corporation | Compositions and methods for treating lysosomal storage disease |
| WO2000012740A2 (en) | 1998-08-28 | 2000-03-09 | Duke University | ADENOVIRUSES DELETED IN THE IVa2, 100K AND/OR PRETERMINAL PROTEIN SEQUENCES |
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| WO2005089047A2 (en) * | 2004-03-18 | 2005-09-29 | Glycofi, Inc. | Glycosylated glucocerebrosidase expression in fungal hosts |
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