ES2743825T3 - Proteínas beta-glucocerebrosidasa recombinantes, variantes con estabilidad aumentada y actividad catalítica retenida aumentada - Google Patents
Proteínas beta-glucocerebrosidasa recombinantes, variantes con estabilidad aumentada y actividad catalítica retenida aumentada Download PDFInfo
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- ES2743825T3 ES2743825T3 ES16178095T ES16178095T ES2743825T3 ES 2743825 T3 ES2743825 T3 ES 2743825T3 ES 16178095 T ES16178095 T ES 16178095T ES 16178095 T ES16178095 T ES 16178095T ES 2743825 T3 ES2743825 T3 ES 2743825T3
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- C12Y302/00—Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
- C12Y302/01—Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
- C12Y302/01045—Glucosylceramidase (3.2.1.45), i.e. beta-glucocerebrosidase
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
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Applications Claiming Priority (2)
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| US41133110P | 2010-11-08 | 2010-11-08 | |
| US41218010P | 2010-11-10 | 2010-11-10 |
Publications (1)
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| ES2743825T3 true ES2743825T3 (es) | 2020-02-20 |
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| ES11839428.7T Active ES2604490T3 (es) | 2010-11-08 | 2011-11-08 | Proteínas beta-glucocerebrosidasa recombinantes, variantes con estabilidad aumentada y actividad catalítica retenida aumentada |
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| ES11839428.7T Active ES2604490T3 (es) | 2010-11-08 | 2011-11-08 | Proteínas beta-glucocerebrosidasa recombinantes, variantes con estabilidad aumentada y actividad catalítica retenida aumentada |
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| JP (2) | JP6073796B2 (enExample) |
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| SM (1) | SMT201600431B (enExample) |
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Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
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| US20220125892A1 (en) * | 2019-02-01 | 2022-04-28 | OXYRANE UK Ltd. | Glucocerebrosidase polypeptides |
| FI3850089T3 (fi) | 2019-02-04 | 2024-02-14 | Freeline Therapeutics Ltd | Polynukleotidejä |
| JP2022547297A (ja) | 2019-09-09 | 2022-11-11 | エフ．ホフマン－ラ ロシュ アーゲー | グルコセレブロシダーゼ変異体 |
| US20230132790A1 (en) * | 2020-03-29 | 2023-05-04 | Yeda Research And Development Co. Ltd. | Variants of beta-glucocerebrosidase for use in treating gaucher disease |
| CA3189801A1 (en) * | 2020-07-29 | 2022-02-03 | Freeline Therapeutics Limited | Polypeptide |
| WO2023145814A1 (ja) * | 2022-01-31 | 2023-08-03 | 株式会社日本触媒 | 向上した酵素活性または向上した安定性を有する組換えグルコセレブロシダーゼタンパク質 |
| JPWO2023145813A1 (enExample) * | 2022-01-31 | 2023-08-03 | ||
| US20250145978A1 (en) * | 2022-01-31 | 2025-05-08 | Nippon Shokubai Co., Ltd. | Glycosylated protein having glucocerebrosidase activity |
| EP4508206A1 (en) | 2022-04-12 | 2025-02-19 | F. Hoffmann-La Roche AG | Fusion proteins targeted to the central nervous system |
| CN118715316B (zh) * | 2022-10-08 | 2025-09-19 | 凌意(杭州)生物科技有限公司 | 用于治疗GCase缺乏相关疾病的多核苷酸 |
| WO2025122912A1 (en) * | 2023-12-08 | 2025-06-12 | Denali Therapeutics Inc. | Modified glucocerebrosidase polypeptides and methods of use thereof |
Family Cites Families (16)
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| JPH03503721A (ja) * | 1988-12-23 | 1991-08-22 | ジェンザイム コーポレイション | 酵素的に活性な組換えグルコセレブロシダーゼ |
| DE68926569T2 (de) | 1988-12-23 | 1996-09-26 | Genzyme Corp | Cho-zellen befähigt enzymatisch aktive rekombinante-glukocerebrosidase zu produzieren |
| EP0979311A1 (en) | 1997-04-30 | 2000-02-16 | Of The University Of Minnesota Regents | $i(IN VIVO) USE OF RECOMBINAGENIC OLIGONUCLEOBASES TO CORRECT GENETIC LESIONS IN HEPATOCYTES |
| US6524613B1 (en) | 1997-04-30 | 2003-02-25 | Regents Of The University Of Minnesota | Hepatocellular chimeraplasty |
| EP1027069B1 (en) * | 1997-10-29 | 2006-07-26 | Genzyme Corporation | Gene therapy for gaucher disease |
| IL141403A0 (en) * | 1998-08-28 | 2002-03-10 | Univ Duke | Deleted adenoviruses and methods of making and administering the same |
| US20020127219A1 (en) * | 1999-12-30 | 2002-09-12 | Okkels Jens Sigurd | Lysosomal enzymes and lysosomal enzyme activators |
| IL150314A0 (en) * | 1999-12-30 | 2002-12-01 | Maxygen Aps | Improved lysosomal enzymes and lysosomal enzyme activators |
| AU2001253181A1 (en) * | 2000-04-06 | 2001-10-23 | Exegenics, Inc. | Expression system for efficiently producing clinically effective lysosomal enzymes (glucocerebrosidase) |
| WO2002002597A2 (en) | 2000-06-30 | 2002-01-10 | Maxygen Aps | Peptide extended glycosylated polypeptides |
| EP1613264A4 (en) * | 2003-04-16 | 2007-08-15 | Yeda Res & Dev | MEDICAMENT FOR THE TREATMENT OF GAUCHER DISEASE AND METHOD FOR IDENTIFYING IT |
| US20050265988A1 (en) | 2004-03-18 | 2005-12-01 | Byung-Kwon Choi | Glycosylated glucocerebrosidase expression in fungal hosts |
| WO2008134628A2 (en) * | 2007-04-26 | 2008-11-06 | Amicus Therapeutics, Inc. | Dosing regimens for the treatment of lysosomal storage diseases using pharmacological chaperones |
| KR20100017879A (ko) * | 2007-05-22 | 2010-02-16 | 아미쿠스 세라퓨틱스, 인코포레이티드 | 이소파고민과 이의 유도체를 제조하는 새로운 방법 |
| US20090148887A1 (en) | 2007-11-02 | 2009-06-11 | The Scripps Research Institute | Genetically encoded boronate amino acid |
| BRPI0819092A2 (pt) | 2007-11-02 | 2014-10-14 | Scripps Research Inst | Evolução direcionada usando proteínas que compreendem aminoácidos não naturais. |
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2011
- 2011-11-08 DK DK11839428.7T patent/DK2638152T3/en active
- 2011-11-08 PT PT118394287T patent/PT2638152T/pt unknown
- 2011-11-08 JP JP2013538823A patent/JP6073796B2/ja active Active
- 2011-11-08 ES ES16178095T patent/ES2743825T3/es active Active
- 2011-11-08 RS RS20161010A patent/RS55405B1/sr unknown
- 2011-11-08 ES ES11839428.7T patent/ES2604490T3/es active Active
- 2011-11-08 KR KR1020137014671A patent/KR101901467B1/ko active Active
- 2011-11-08 LT LTEP11839428.7T patent/LT2638152T/lt unknown
- 2011-11-08 US US13/884,126 patent/US8962564B2/en active Active
- 2011-11-08 BR BR112013011152A patent/BR112013011152A2/pt not_active Application Discontinuation
- 2011-11-08 EP EP11839428.7A patent/EP2638152B1/en active Active
- 2011-11-08 CN CN201180064243.6A patent/CN103314105B/zh active Active
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- 2011-11-08 CA CA2817011A patent/CA2817011C/en active Active
- 2011-11-08 EP EP16178095.2A patent/EP3144386B1/en active Active
- 2011-11-08 WO PCT/US2011/059731 patent/WO2012064709A2/en not_active Ceased
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2015
- 2015-02-02 US US14/611,495 patent/US9254313B2/en active Active
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- 2016-01-04 US US14/987,204 patent/US9566316B2/en active Active
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2017
- 2017-01-05 JP JP2017000301A patent/JP6457559B2/ja active Active
- 2017-02-13 US US15/430,682 patent/US9821038B2/en active Active
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