CN105228626A - 用于诱导软骨形成的化合物和方法 - Google Patents

用于诱导软骨形成的化合物和方法 Download PDF

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CN105228626A
CN105228626A CN201480028421.3A CN201480028421A CN105228626A CN 105228626 A CN105228626 A CN 105228626A CN 201480028421 A CN201480028421 A CN 201480028421A CN 105228626 A CN105228626 A CN 105228626A
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optionally substituted
compound
substituted alkyl
alkyl
pharmaceutically acceptable
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Chinese (zh)
Inventor
彼得·G·舒尔茨
阿纳布·K·查特吉
守天·朱
乔舒亚·帕耶特
洪哲·尹
百元·杨
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Scripps Research Institute
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Scripps Research Institute
California Institute for Biomedical Research
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Priority to CN202211717279.6A priority Critical patent/CN116059196A/zh
Priority to CN201710295821.6A priority patent/CN107007587A/zh
Publication of CN105228626A publication Critical patent/CN105228626A/zh
Pending legal-status Critical Current

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CN110719913A (zh) * 2017-06-09 2020-01-21 诺华股份有限公司 诱导软骨发生的化合物和组合物
CN110809468A (zh) * 2017-04-24 2020-02-18 斯克利普斯研究所 诱导软骨发生的方法
CN110937987A (zh) * 2018-09-25 2020-03-31 深圳市灵兰生物医药科技有限公司 一种化合物的合成路线及在抗糖尿病药物制备领域的应用
WO2020142865A1 (zh) * 2019-01-07 2020-07-16 江苏凯迪恩医药科技有限公司 一种苯甲酰胺类化合物、中间体、制备方法及应用
CN111936466A (zh) * 2018-03-29 2020-11-13 埃利克斯生物技术公司 用于治疗心律失常和心力衰竭的化合物
CN114763346A (zh) * 2021-01-15 2022-07-19 华东师范大学 一类用于诱导软骨形成的化合物及其应用
CN114763347A (zh) * 2021-01-15 2022-07-19 华东师范大学 一类用于诱导间充质干细胞向软骨分化的化合物及其应用
CN116113413A (zh) * 2020-08-05 2023-05-12 株式会社Lg化学 胱天蛋白酶抑制剂用于缓解或治疗骨关节炎的用途

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CN105228626A (zh) 2013-03-15 2016-01-06 加州生物医学研究所 用于诱导软骨形成的化合物和方法
CN105294533A (zh) * 2015-12-02 2016-02-03 宋彤云 一种治疗骨病的药物组合物
EA202191050A1 (ru) * 2018-10-15 2022-03-17 Общество С Ограниченной Ответственностью "Геро Дискавери" Ингибиторы pfkfb3 и их использование
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CN109963579A (zh) * 2016-11-14 2019-07-02 诺华股份有限公司 用于治疗软骨损伤和关节炎的方法和组合物
CN110809468A (zh) * 2017-04-24 2020-02-18 斯克利普斯研究所 诱导软骨发生的方法
CN110719913A (zh) * 2017-06-09 2020-01-21 诺华股份有限公司 诱导软骨发生的化合物和组合物
CN107056677A (zh) * 2017-06-19 2017-08-18 常州大学 一种3‑烷基2,3‑二氢异吲哚啉酮衍生物的合成方法
CN111936466A (zh) * 2018-03-29 2020-11-13 埃利克斯生物技术公司 用于治疗心律失常和心力衰竭的化合物
CN110937987B (zh) * 2018-09-25 2022-09-06 深圳市灵兰生物医药科技有限公司 一种化合物的合成路线及在抗糖尿病药物制备领域的应用
CN110937987A (zh) * 2018-09-25 2020-03-31 深圳市灵兰生物医药科技有限公司 一种化合物的合成路线及在抗糖尿病药物制备领域的应用
CN109730999A (zh) * 2018-12-28 2019-05-10 中山大学 噻唑苯甲酰胺衍生在制备抗骨质疏松、抗骨关节炎药物中的应用
CN114105902B (zh) * 2018-12-28 2023-11-03 中山大学 噻唑苯甲酰胺衍生物及其在制备抗骨质疏松药物中的应用
CN109730999B (zh) * 2018-12-28 2021-12-24 中山大学 噻唑苯甲酰胺衍生在制备抗骨质疏松、抗骨关节炎药物中的应用
CN114105902A (zh) * 2018-12-28 2022-03-01 中山大学 噻唑苯甲酰胺衍生物及其在制备抗骨质疏松药物中的应用
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WO2020142865A1 (zh) * 2019-01-07 2020-07-16 江苏凯迪恩医药科技有限公司 一种苯甲酰胺类化合物、中间体、制备方法及应用
CN116113413A (zh) * 2020-08-05 2023-05-12 株式会社Lg化学 胱天蛋白酶抑制剂用于缓解或治疗骨关节炎的用途
CN114763347A (zh) * 2021-01-15 2022-07-19 华东师范大学 一类用于诱导间充质干细胞向软骨分化的化合物及其应用
CN114763346A (zh) * 2021-01-15 2022-07-19 华东师范大学 一类用于诱导软骨形成的化合物及其应用
CN114763347B (zh) * 2021-01-15 2024-06-21 华东师范大学 一类用于诱导间充质干细胞向软骨分化的化合物及其应用
CN114763346B (zh) * 2021-01-15 2025-06-10 华东师范大学 一类用于诱导软骨形成的化合物及其应用

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