CN105198944B - 制备大环内酯和酮内酯及其中间体的方法 - Google Patents

制备大环内酯和酮内酯及其中间体的方法 Download PDF

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Publication number
CN105198944B
CN105198944B CN201510604701.0A CN201510604701A CN105198944B CN 105198944 B CN105198944 B CN 105198944B CN 201510604701 A CN201510604701 A CN 201510604701A CN 105198944 B CN105198944 B CN 105198944B
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formula
compound
another embodiment
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macrolide
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CN105198944A (zh
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D·E·佩雷拉
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Cempra Pharmaceuticals Inc
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Cempra Pharmaceuticals Inc
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CN201510604701.0A 2010-05-20 2011-05-20 制备大环内酯和酮内酯及其中间体的方法 Expired - Fee Related CN105198944B (zh)

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Application Number Priority Date Filing Date Title
US34666410P 2010-05-20 2010-05-20
US61/346,664 2010-05-20
CN201180026739.4A CN102917708B (zh) 2010-05-20 2011-05-20 制备大环内酯和酮内酯及其中间体的方法

Related Parent Applications (1)

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CN201180026739.4A Division CN102917708B (zh) 2010-05-20 2011-05-20 制备大环内酯和酮内酯及其中间体的方法

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CN105198944A CN105198944A (zh) 2015-12-30
CN105198944B true CN105198944B (zh) 2018-06-01

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CN201510604701.0A Expired - Fee Related CN105198944B (zh) 2010-05-20 2011-05-20 制备大环内酯和酮内酯及其中间体的方法
CN201180026739.4A Expired - Fee Related CN102917708B (zh) 2010-05-20 2011-05-20 制备大环内酯和酮内酯及其中间体的方法

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US (4) US9051346B2 (enExample)
EP (1) EP2571506B1 (enExample)
JP (1) JP6184319B2 (enExample)
KR (1) KR101945324B1 (enExample)
CN (2) CN105198944B (enExample)
AU (1) AU2011255464C1 (enExample)
BR (1) BR112012029586A2 (enExample)
CA (1) CA2799937A1 (enExample)
DK (1) DK2571506T3 (enExample)
ES (1) ES2636948T3 (enExample)
IL (1) IL223161A0 (enExample)
PL (1) PL2571506T3 (enExample)
RU (1) RU2608390C2 (enExample)
SI (1) SI2571506T1 (enExample)
WO (1) WO2011146829A1 (enExample)

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US20150232500A1 (en) 2015-08-20
DK2571506T3 (en) 2017-08-28
EP2571506B1 (en) 2017-05-10
JP2013527187A (ja) 2013-06-27
US20130066056A1 (en) 2013-03-14
EP2571506A4 (en) 2014-04-02
SI2571506T1 (sl) 2017-12-29
KR20130120374A (ko) 2013-11-04
ES2636948T3 (es) 2017-10-10
CN102917708A (zh) 2013-02-06
HK1218919A1 (zh) 2017-03-17
BR112012029586A2 (pt) 2016-08-02
CN105198944A (zh) 2015-12-30
WO2011146829A1 (en) 2011-11-24
KR101945324B1 (ko) 2019-02-07
US20190048035A1 (en) 2019-02-14
EP2571506A1 (en) 2013-03-27
CA2799937A1 (en) 2011-11-24
JP6184319B2 (ja) 2017-08-23
AU2011255464B2 (en) 2016-06-16
PL2571506T3 (pl) 2017-10-31
IL223161A0 (en) 2013-02-03
RU2012150753A (ru) 2014-06-27
HK1181672A1 (zh) 2013-11-15
AU2011255464C1 (en) 2017-02-23
CN102917708B (zh) 2015-11-25
AU2011255464A1 (en) 2012-12-13
US9051346B2 (en) 2015-06-09
RU2608390C2 (ru) 2017-01-18
US20200087335A1 (en) 2020-03-19

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