CA2799937A1 - Processes for preparing macrolides and ketolides and intermediates therefor - Google Patents

Processes for preparing macrolides and ketolides and intermediates therefor Download PDF

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Publication number
CA2799937A1
CA2799937A1 CA 2799937 CA2799937A CA2799937A1 CA 2799937 A1 CA2799937 A1 CA 2799937A1 CA 2799937 CA2799937 CA 2799937 CA 2799937 A CA2799937 A CA 2799937A CA 2799937 A1 CA2799937 A1 CA 2799937A1
Authority
CA
Canada
Prior art keywords
compound
formula
acid addition
addition salt
acyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA 2799937
Other languages
English (en)
French (fr)
Inventor
David E. Pereira
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cempra Pharmaceuticals Inc
Original Assignee
Cempra Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cempra Pharmaceuticals Inc filed Critical Cempra Pharmaceuticals Inc
Publication of CA2799937A1 publication Critical patent/CA2799937A1/en
Abandoned legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CA 2799937 2010-05-20 2011-05-20 Processes for preparing macrolides and ketolides and intermediates therefor Abandoned CA2799937A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US34666410P 2010-05-20 2010-05-20
US61/346,664 2010-05-20
PCT/US2011/037330 WO2011146829A1 (en) 2010-05-20 2011-05-20 Processes for preparing macrolides and ketolides and intermediates therefor

Publications (1)

Publication Number Publication Date
CA2799937A1 true CA2799937A1 (en) 2011-11-24

Family

ID=44992076

Family Applications (1)

Application Number Title Priority Date Filing Date
CA 2799937 Abandoned CA2799937A1 (en) 2010-05-20 2011-05-20 Processes for preparing macrolides and ketolides and intermediates therefor

Country Status (15)

Country Link
US (4) US9051346B2 (enExample)
EP (1) EP2571506B1 (enExample)
JP (1) JP6184319B2 (enExample)
KR (1) KR101945324B1 (enExample)
CN (2) CN105198944B (enExample)
AU (1) AU2011255464C1 (enExample)
BR (1) BR112012029586A2 (enExample)
CA (1) CA2799937A1 (enExample)
DK (1) DK2571506T3 (enExample)
ES (1) ES2636948T3 (enExample)
IL (1) IL223161A0 (enExample)
PL (1) PL2571506T3 (enExample)
RU (1) RU2608390C2 (enExample)
SI (1) SI2571506T1 (enExample)
WO (1) WO2011146829A1 (enExample)

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RU2569678C2 (ru) 2010-04-22 2015-11-27 Вертекс Фармасьютикалз Инкорпорейтед Способ получения циклоалкилкарбоксамидо-индольных соединений
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EP2968801B1 (en) 2013-03-14 2018-09-26 Cempra Pharmaceuticals, Inc. Methods for treating respiratory diseases and formulations therefor
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CN105246334A (zh) 2013-04-04 2016-01-13 哈佛大学的校长及成员们 大环内酯及其制备和使用方法
PT3131582T (pt) 2014-04-15 2018-10-08 Vertex Pharma Composições farmacêuticas para o tratamento de doenças mediadas pelo regulador de condutância transmembranar da fibrose quística
CN104151382B (zh) * 2014-08-08 2016-09-14 广东东阳光药业有限公司 一种固态大环内酯的晶型
CN104311611B (zh) * 2014-08-13 2017-01-18 广东东阳光药业有限公司 一种制备固态大环内酯的方法
HK1242920A1 (zh) 2014-10-08 2018-07-06 哈佛大学的校长及成员们 14-元酮内酯及其制备和使用方法
WO2016154591A1 (en) 2015-03-25 2016-09-29 President And Fellows Of Harvard College Macrolides with modified desosamine sugars and uses thereof
CN106554381A (zh) * 2015-09-25 2017-04-05 苏州鹏旭医药科技有限公司 酮内酯类抗生素中间体及其制备方法和应用
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Also Published As

Publication number Publication date
US20150232500A1 (en) 2015-08-20
DK2571506T3 (en) 2017-08-28
EP2571506B1 (en) 2017-05-10
JP2013527187A (ja) 2013-06-27
US20130066056A1 (en) 2013-03-14
EP2571506A4 (en) 2014-04-02
SI2571506T1 (sl) 2017-12-29
KR20130120374A (ko) 2013-11-04
ES2636948T3 (es) 2017-10-10
CN102917708A (zh) 2013-02-06
HK1218919A1 (zh) 2017-03-17
BR112012029586A2 (pt) 2016-08-02
CN105198944A (zh) 2015-12-30
WO2011146829A1 (en) 2011-11-24
KR101945324B1 (ko) 2019-02-07
US20190048035A1 (en) 2019-02-14
EP2571506A1 (en) 2013-03-27
JP6184319B2 (ja) 2017-08-23
AU2011255464B2 (en) 2016-06-16
PL2571506T3 (pl) 2017-10-31
IL223161A0 (en) 2013-02-03
RU2012150753A (ru) 2014-06-27
HK1181672A1 (zh) 2013-11-15
CN105198944B (zh) 2018-06-01
AU2011255464C1 (en) 2017-02-23
CN102917708B (zh) 2015-11-25
AU2011255464A1 (en) 2012-12-13
US9051346B2 (en) 2015-06-09
RU2608390C2 (ru) 2017-01-18
US20200087335A1 (en) 2020-03-19

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Legal Events

Date Code Title Description
EEER Examination request

Effective date: 20160520

FZDE Discontinued

Effective date: 20200831