BR112012029586A2 - processos para preparar macrolídeos e cetolídeos e intermediários dos mesmos - Google Patents

processos para preparar macrolídeos e cetolídeos e intermediários dos mesmos

Info

Publication number
BR112012029586A2
BR112012029586A2 BR112012029586A BR112012029586A BR112012029586A2 BR 112012029586 A2 BR112012029586 A2 BR 112012029586A2 BR 112012029586 A BR112012029586 A BR 112012029586A BR 112012029586 A BR112012029586 A BR 112012029586A BR 112012029586 A2 BR112012029586 A2 BR 112012029586A2
Authority
BR
Brazil
Prior art keywords
processes
ketolides
intermediates
macrolides
preparing
Prior art date
Application number
BR112012029586A
Other languages
English (en)
Portuguese (pt)
Inventor
David E Pereira
Original Assignee
Cempra Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cempra Pharmaceuticals Inc filed Critical Cempra Pharmaceuticals Inc
Publication of BR112012029586A2 publication Critical patent/BR112012029586A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Communicable Diseases (AREA)
  • General Chemical & Material Sciences (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
BR112012029586A 2010-05-20 2011-05-20 processos para preparar macrolídeos e cetolídeos e intermediários dos mesmos BR112012029586A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US34666410P 2010-05-20 2010-05-20
PCT/US2011/037330 WO2011146829A1 (en) 2010-05-20 2011-05-20 Processes for preparing macrolides and ketolides and intermediates therefor

Publications (1)

Publication Number Publication Date
BR112012029586A2 true BR112012029586A2 (pt) 2016-08-02

Family

ID=44992076

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112012029586A BR112012029586A2 (pt) 2010-05-20 2011-05-20 processos para preparar macrolídeos e cetolídeos e intermediários dos mesmos

Country Status (15)

Country Link
US (4) US9051346B2 (enExample)
EP (1) EP2571506B1 (enExample)
JP (1) JP6184319B2 (enExample)
KR (1) KR101945324B1 (enExample)
CN (2) CN102917708B (enExample)
AU (1) AU2011255464C1 (enExample)
BR (1) BR112012029586A2 (enExample)
CA (1) CA2799937A1 (enExample)
DK (1) DK2571506T3 (enExample)
ES (1) ES2636948T3 (enExample)
IL (1) IL223161A0 (enExample)
PL (1) PL2571506T3 (enExample)
RU (1) RU2608390C2 (enExample)
SI (1) SI2571506T1 (enExample)
WO (1) WO2011146829A1 (enExample)

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US9937194B1 (en) 2009-06-12 2018-04-10 Cempra Pharmaceuticals, Inc. Compounds and methods for treating inflammatory diseases
EP2475253B1 (en) 2009-09-10 2016-10-26 Cempra Pharmaceuticals, Inc. Methods for treating malaria, tuberculosis and mac diseases
US8802868B2 (en) 2010-03-25 2014-08-12 Vertex Pharmaceuticals Incorporated Solid forms of (R)-1(2,2-difluorobenzo[D][1,3]dioxo1-5-yl)-N-(1-(2,3-dihydroxypropyl-6-fluoro-2-(1-hydroxy-2-methylpropan2-yl)-1H-Indol-5-yl)-Cyclopropanecarboxamide
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IN2014DN08939A (enExample) 2012-03-27 2015-05-22 Cempra Pharmaceuticals Inc
CN103897002A (zh) * 2012-12-31 2014-07-02 菏泽市方明制药有限公司 一种粗品硫氰酸红霉素制备红霉素a9-肟的方法
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CN104311611B (zh) * 2014-08-13 2017-01-18 广东东阳光药业有限公司 一种制备固态大环内酯的方法
WO2016057798A1 (en) * 2014-10-08 2016-04-14 President And Fellows Of Harvard College 14-membered ketolides and methods of their preparation and use
WO2016154591A1 (en) 2015-03-25 2016-09-29 President And Fellows Of Harvard College Macrolides with modified desosamine sugars and uses thereof
CN106554381A (zh) * 2015-09-25 2017-04-05 苏州鹏旭医药科技有限公司 酮内酯类抗生素中间体及其制备方法和应用
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Also Published As

Publication number Publication date
AU2011255464C1 (en) 2017-02-23
CN102917708B (zh) 2015-11-25
CN102917708A (zh) 2013-02-06
SI2571506T1 (sl) 2017-12-29
ES2636948T3 (es) 2017-10-10
EP2571506A4 (en) 2014-04-02
CN105198944B (zh) 2018-06-01
WO2011146829A1 (en) 2011-11-24
CN105198944A (zh) 2015-12-30
EP2571506B1 (en) 2017-05-10
JP6184319B2 (ja) 2017-08-23
AU2011255464B2 (en) 2016-06-16
AU2011255464A1 (en) 2012-12-13
CA2799937A1 (en) 2011-11-24
IL223161A0 (en) 2013-02-03
RU2608390C2 (ru) 2017-01-18
US20130066056A1 (en) 2013-03-14
KR20130120374A (ko) 2013-11-04
RU2012150753A (ru) 2014-06-27
US20150232500A1 (en) 2015-08-20
KR101945324B1 (ko) 2019-02-07
DK2571506T3 (en) 2017-08-28
HK1181672A1 (zh) 2013-11-15
EP2571506A1 (en) 2013-03-27
HK1218919A1 (zh) 2017-03-17
US20200087335A1 (en) 2020-03-19
US9051346B2 (en) 2015-06-09
PL2571506T3 (pl) 2017-10-31
JP2013527187A (ja) 2013-06-27
US20190048035A1 (en) 2019-02-14

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