CN105188849B - 包含左乙拉西坦的快速分散剂型 - Google Patents

包含左乙拉西坦的快速分散剂型 Download PDF

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Publication number
CN105188849B
CN105188849B CN201480014761.0A CN201480014761A CN105188849B CN 105188849 B CN105188849 B CN 105188849B CN 201480014761 A CN201480014761 A CN 201480014761A CN 105188849 B CN105188849 B CN 105188849B
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CN
China
Prior art keywords
dosage form
matrix
weight
printing
rapidly dispersing
Prior art date
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Active
Application number
CN201480014761.0A
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English (en)
Chinese (zh)
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CN105188849A (zh
Inventor
J·雅各布斯
N·夸勒
T·G·韦斯特
D·C·蒙克豪斯
H·L·苏尔普勒南
N·B·雅音
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pharmaceuticals Pharmaceutical Co Ltd
Original Assignee
Aprecia Pharmaceuticals Co
Aprecia Pharmaceuticals LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
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Priority to CN201811611453.2A priority Critical patent/CN109908355B/zh
Publication of CN105188849A publication Critical patent/CN105188849A/zh
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/4015—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil having oxo groups directly attached to the heterocyclic ring, e.g. piracetam, ethosuximide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2095—Tabletting processes; Dosage units made by direct compression of powders or specially processed granules, by eliminating solvents, by melt-extrusion, by injection molding, by 3D printing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7007—Drug-containing films, membranes or sheets
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

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  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Physiology (AREA)
  • Nutrition Science (AREA)
  • Zoology (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CN201480014761.0A 2013-03-15 2014-03-14 包含左乙拉西坦的快速分散剂型 Active CN105188849B (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201811611453.2A CN109908355B (zh) 2013-03-15 2014-03-14 包含左乙拉西坦的快速分散剂型

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361791444P 2013-03-15 2013-03-15
US61/791,444 2013-03-15
PCT/US2014/028954 WO2014144512A1 (en) 2013-03-15 2014-03-14 Rapid disperse dosage form containing levetiracetam

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CN201811611453.2A Division CN109908355B (zh) 2013-03-15 2014-03-14 包含左乙拉西坦的快速分散剂型

Publications (2)

Publication Number Publication Date
CN105188849A CN105188849A (zh) 2015-12-23
CN105188849B true CN105188849B (zh) 2019-01-15

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CN201480014761.0A Active CN105188849B (zh) 2013-03-15 2014-03-14 包含左乙拉西坦的快速分散剂型
CN201811611453.2A Active CN109908355B (zh) 2013-03-15 2014-03-14 包含左乙拉西坦的快速分散剂型

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Country Status (10)

Country Link
US (2) US20220211668A1 (enExample)
EP (2) EP2968994B1 (enExample)
JP (3) JP6170234B2 (enExample)
CN (2) CN105188849B (enExample)
AU (2) AU2014228990B2 (enExample)
CA (1) CA2906029C (enExample)
ES (2) ES2908292T3 (enExample)
HK (1) HK1216513A1 (enExample)
MX (1) MX365513B (enExample)
WO (1) WO2014144512A1 (enExample)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI734309B (zh) 2019-12-19 2021-07-21 水星生醫股份有限公司 滲透性噴塗製作藥錠裝置
WO2022021524A1 (zh) * 2020-07-30 2022-02-03 中国人民解放军军事科学院军事医学研究院 一种左乙拉西坦3d打印制剂及其制备方法

Families Citing this family (14)

* Cited by examiner, † Cited by third party
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US9339489B2 (en) 2013-03-15 2016-05-17 Aprecia Pharmaceuticals Company Rapid disperse dosage form containing levetiracetam
AU2014228990B2 (en) 2013-03-15 2017-02-02 Aprecia Pharmaceuticals LLC Rapid disperse dosage form containing levetiracetam
US10653622B1 (en) 2015-04-13 2020-05-19 Pharmacoustics Technologies LLC Individualized solid dosage products and a system and method for the globally integrated pharmaceutical manufacturing and its monitoring thereof
CA3254279A1 (en) 2015-06-03 2025-03-18 Triastek, Inc. PHARMACEUTICAL FORMS AND RELATED USES
WO2018046642A1 (en) 2016-09-09 2018-03-15 Merck Patent Gmbh Process for the manufacture of a solid pharmaceutical adminstration form
WO2018137686A1 (en) 2017-01-26 2018-08-02 Triastek, Inc. Dosage forms of controlled release at specific gastrointestinal sites
US11602502B2 (en) 2017-02-24 2023-03-14 Hewlett-Packard Development Company, L.P. Three-dimensional (3D) printing a pharmaceutical tablet
WO2018165404A1 (en) 2017-03-08 2018-09-13 Cinrx Pharma, Llc Pharmaceutical formualtions of phloroglucinol and trimethylphloroglucinol
WO2018182045A1 (ja) 2017-03-31 2018-10-04 新日鐵住金株式会社 固体高分子形燃料電池の触媒担体用炭素材料及びその製造方法
JP6653931B2 (ja) * 2017-06-16 2020-02-26 丸石製薬株式会社 レベチラセタム含有ゲル経口医薬組成物
CN111698983B (zh) 2018-01-09 2022-10-18 南京三迭纪医药科技有限公司 一种包含固定剂量adhd非兴奋剂和adhd兴奋剂的复方口服药物剂型
JP7264711B2 (ja) * 2019-04-26 2023-04-25 東和薬品株式会社 レベチラセタム含有医薬組成物の製造方法
JP2022535390A (ja) 2019-05-31 2022-08-08 ディヘシス デジタル ヘルス システムズ ゲーエムベーハー 医薬品剤形およびその製造方法
CN113599362A (zh) * 2021-01-15 2021-11-05 中国人民解放军军事科学院军事医学研究院 一种3d打印制剂及其制备方法和其应用

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