CN104379131A - 具有改善的干燥保护和保留的眼用组合物 - Google Patents

具有改善的干燥保护和保留的眼用组合物 Download PDF

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Publication number
CN104379131A
CN104379131A CN201380031008.8A CN201380031008A CN104379131A CN 104379131 A CN104379131 A CN 104379131A CN 201380031008 A CN201380031008 A CN 201380031008A CN 104379131 A CN104379131 A CN 104379131A
Authority
CN
China
Prior art keywords
composition
compositions
guar gum
hyaluronic acid
present
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201380031008.8A
Other languages
English (en)
Chinese (zh)
Inventor
J·W·达维斯
H·A·凯特尔森
E·E·卡姆贝尔
D·L·梅多斯
R·兰加拉詹
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Alcon Research LLC
Original Assignee
Alcon Research LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alcon Research LLC filed Critical Alcon Research LLC
Priority to CN201811311427.8A priority Critical patent/CN109157539A/zh
Publication of CN104379131A publication Critical patent/CN104379131A/zh
Pending legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/736—Glucomannans or galactomannans, e.g. locust bean gum, guar gum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/047—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates having two or more hydroxy groups, e.g. sorbitol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
    • A61K31/728—Hyaluronic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/04—Artificial tears; Irrigation solutions

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Inorganic Chemistry (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Ophthalmology & Optometry (AREA)
  • Dermatology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
CN201380031008.8A 2012-05-04 2013-05-03 具有改善的干燥保护和保留的眼用组合物 Pending CN104379131A (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201811311427.8A CN109157539A (zh) 2012-05-04 2013-05-03 具有改善的干燥保护和保留的眼用组合物

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261642901P 2012-05-04 2012-05-04
US61/642,901 2012-05-04
PCT/US2013/039487 WO2013166399A1 (en) 2012-05-04 2013-05-03 Ophthalmic compositions with improved dessication protection and retention

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CN201811311427.8A Division CN109157539A (zh) 2012-05-04 2013-05-03 具有改善的干燥保护和保留的眼用组合物

Publications (1)

Publication Number Publication Date
CN104379131A true CN104379131A (zh) 2015-02-25

Family

ID=48464107

Family Applications (2)

Application Number Title Priority Date Filing Date
CN201380031008.8A Pending CN104379131A (zh) 2012-05-04 2013-05-03 具有改善的干燥保护和保留的眼用组合物
CN201811311427.8A Pending CN109157539A (zh) 2012-05-04 2013-05-03 具有改善的干燥保护和保留的眼用组合物

Family Applications After (1)

Application Number Title Priority Date Filing Date
CN201811311427.8A Pending CN109157539A (zh) 2012-05-04 2013-05-03 具有改善的干燥保护和保留的眼用组合物

Country Status (19)

Country Link
US (6) US20130296264A1 (enExample)
EP (1) EP2844226B1 (enExample)
KR (1) KR102076033B1 (enExample)
CN (2) CN104379131A (enExample)
AR (1) AR090930A1 (enExample)
AU (1) AU2013256144B2 (enExample)
BR (1) BR112014027582B1 (enExample)
CA (1) CA2872622C (enExample)
DK (1) DK2844226T3 (enExample)
ES (1) ES2761373T3 (enExample)
IN (1) IN2014MN02248A (enExample)
MX (1) MX362266B (enExample)
PH (1) PH12014502571B1 (enExample)
PL (1) PL2844226T3 (enExample)
PT (1) PT2844226T (enExample)
RU (1) RU2659207C2 (enExample)
UA (1) UA113434C2 (enExample)
WO (1) WO2013166399A1 (enExample)
ZA (1) ZA201408490B (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105311042A (zh) * 2015-09-07 2016-02-10 广州国宇医药科技有限公司 一种糖醇组合物在治疗干眼症的应用

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT3613423T (pt) 2013-07-10 2022-12-07 Matrix Biology Inst Composições de hialuronano de elevada elasticidade e suas utilizações
US10245324B2 (en) * 2014-10-31 2019-04-02 Johnson & Johnson Consumer Inc. Ophthalmic composition
PT3352766T (pt) 2015-09-24 2022-03-22 Matrix Biology Inst Composições de hialuronano de elevada elasticidade e processos para o seu uso
US10632202B2 (en) 2016-03-04 2020-04-28 Johnson & Johnson Consumer Inc. Preservative containing compositions
TWI913170B (zh) * 2018-02-21 2026-01-21 瑞士商愛爾康公司 基於脂質的眼用乳劑
TWI826685B (zh) 2019-05-02 2023-12-21 瑞士商愛爾康公司 可溶解聚合物眼睛插入物及其使用方法
TWI757773B (zh) * 2019-06-28 2022-03-11 瑞士商愛爾康公司 眼用組成物
CN114191378A (zh) * 2021-11-23 2022-03-18 温州医科大学附属眼视光医院 一种地夸磷索缓释凝胶及其制备方法与应用
AU2025233965A1 (en) 2024-03-04 2026-07-16 Alcon Inc. Carbamoylphenylboronic acid-containing acrylic monomers and uses thereof
WO2026115440A1 (en) 2024-11-27 2026-06-04 Alcon Inc. Stable ophthalmic emulsion
US20260144812A1 (en) 2024-11-27 2026-05-28 Alcon Inc. Antioxidant ophthalmic emulsion

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20090270345A1 (en) * 2008-04-26 2009-10-29 Alcon Research, Ltd. Polymeric artificial tear system
US20100087550A1 (en) * 2008-10-06 2010-04-08 Zora Marlowe Formulations with a Tertiary Amine Oxide

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH09227385A (ja) * 1996-02-29 1997-09-02 Ofutekusu:Kk 眼手術用補助剤
DE69818675T2 (de) 1997-07-29 2004-07-29 Alcon Laboratories, Inc., Fort Worth Galaktomannanpolymere und borat enthaltende augenarzneimittel
US7947295B2 (en) * 2003-06-13 2011-05-24 Alcon, Inc. Ophthalmic compositions containing a synergistic combination of two polymers
CA2839849C (en) * 2003-06-13 2017-03-07 Alcon, Inc. Ophthalmic compositions containing a synergistic combination of two polymers
KR101555291B1 (ko) * 2007-02-09 2015-09-30 알콘, 인코퍼레이티드 세가지 폴리머의 상승성 배합물을 함유하는 안과 조성물
US20090036554A1 (en) 2007-08-01 2009-02-05 Burke Susan E Ophthalmic compositions comprising a terpene compound
US9096819B2 (en) * 2008-01-31 2015-08-04 Bausch & Lomb Incorporated Ophthalmic compositions with an amphoteric surfactant and an anionic biopolymer
NZ603345A (en) * 2010-05-05 2014-12-24 Alcon Res Ltd Stabilized ophthalmic galactomannan formulations

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20090270345A1 (en) * 2008-04-26 2009-10-29 Alcon Research, Ltd. Polymeric artificial tear system
US20100087550A1 (en) * 2008-10-06 2010-04-08 Zora Marlowe Formulations with a Tertiary Amine Oxide

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105311042A (zh) * 2015-09-07 2016-02-10 广州国宇医药科技有限公司 一种糖醇组合物在治疗干眼症的应用

Also Published As

Publication number Publication date
US20230285443A1 (en) 2023-09-14
PL2844226T3 (pl) 2020-04-30
CN109157539A (zh) 2019-01-08
US11376275B2 (en) 2022-07-05
KR102076033B1 (ko) 2020-02-11
AU2013256144B2 (en) 2018-01-18
IN2014MN02248A (enExample) 2015-07-24
PH12014502571A1 (en) 2015-01-21
US11672820B2 (en) 2023-06-13
PH12014502571B1 (en) 2022-04-29
AR090930A1 (es) 2014-12-17
ES2761373T3 (es) 2020-05-19
US20200138853A1 (en) 2020-05-07
MX362266B (es) 2019-01-10
BR112014027582A2 (pt) 2017-06-27
US20220273699A1 (en) 2022-09-01
EP2844226B1 (en) 2019-11-13
EP2844226A1 (en) 2015-03-11
AU2013256144A1 (en) 2014-12-04
CA2872622A1 (en) 2013-11-07
KR20150003868A (ko) 2015-01-09
US20170136057A1 (en) 2017-05-18
RU2014148758A (ru) 2016-06-27
US20210060056A1 (en) 2021-03-04
WO2013166399A1 (en) 2013-11-07
MX2014013444A (es) 2015-05-11
DK2844226T3 (da) 2020-01-02
PT2844226T (pt) 2019-12-16
CA2872622C (en) 2020-07-28
BR112014027582B1 (pt) 2022-05-10
UA113434C2 (uk) 2017-01-25
BR112014027582A8 (pt) 2021-06-15
RU2659207C2 (ru) 2018-06-28
US10828320B2 (en) 2020-11-10
US20130296264A1 (en) 2013-11-07
ZA201408490B (en) 2016-08-31

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SE01 Entry into force of request for substantive examination
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Application publication date: 20150225