ES2761373T3 - Composiciones oftálmicas con protección contra la desecación y retención mejoradas - Google Patents
Composiciones oftálmicas con protección contra la desecación y retención mejoradas Download PDFInfo
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- ES2761373T3 ES2761373T3 ES13723623T ES13723623T ES2761373T3 ES 2761373 T3 ES2761373 T3 ES 2761373T3 ES 13723623 T ES13723623 T ES 13723623T ES 13723623 T ES13723623 T ES 13723623T ES 2761373 T3 ES2761373 T3 ES 2761373T3
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- hyaluronic acid
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- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 description 1
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 description 1
- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 description 1
- 235000013828 hydroxypropyl starch Nutrition 0.000 description 1
- 238000011534 incubation Methods 0.000 description 1
- 239000002563 ionic surfactant Substances 0.000 description 1
- 235000010494 karaya gum Nutrition 0.000 description 1
- 239000000231 karaya gum Substances 0.000 description 1
- 229940039371 karaya gum Drugs 0.000 description 1
- OZWKMVRBQXNZKK-UHFFFAOYSA-N ketorolac Chemical compound OC(=O)C1CCN2C1=CC=C2C(=O)C1=CC=CC=C1 OZWKMVRBQXNZKK-UHFFFAOYSA-N 0.000 description 1
- 229960004752 ketorolac Drugs 0.000 description 1
- 235000010420 locust bean gum Nutrition 0.000 description 1
- 239000000711 locust bean gum Substances 0.000 description 1
- 208000002780 macular degeneration Diseases 0.000 description 1
- 239000000594 mannitol Substances 0.000 description 1
- 235000010355 mannitol Nutrition 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 239000002480 mineral oil Substances 0.000 description 1
- 235000019426 modified starch Nutrition 0.000 description 1
- 239000003068 molecular probe Substances 0.000 description 1
- FABPRXSRWADJSP-MEDUHNTESA-N moxifloxacin Chemical compound COC1=C(N2C[C@H]3NCCC[C@H]3C2)C(F)=CC(C(C(C(O)=O)=C2)=O)=C1N2C1CC1 FABPRXSRWADJSP-MEDUHNTESA-N 0.000 description 1
- 229960003702 moxifloxacin Drugs 0.000 description 1
- 229950006780 n-acetylglucosamine Drugs 0.000 description 1
- 229960002009 naproxen Drugs 0.000 description 1
- CMWTZPSULFXXJA-VIFPVBQESA-N naproxen Chemical compound C1=C([C@H](C)C(O)=O)C=CC2=CC(OC)=CC=C21 CMWTZPSULFXXJA-VIFPVBQESA-N 0.000 description 1
- 229920001206 natural gum Polymers 0.000 description 1
- 229920005615 natural polymer Polymers 0.000 description 1
- 229930014626 natural product Natural products 0.000 description 1
- QEFAQIPZVLVERP-UHFFFAOYSA-N nepafenac Chemical compound NC(=O)CC1=CC=CC(C(=O)C=2C=CC=CC=2)=C1N QEFAQIPZVLVERP-UHFFFAOYSA-N 0.000 description 1
- 229960001002 nepafenac Drugs 0.000 description 1
- 229940021182 non-steroidal anti-inflammatory drug Drugs 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 229960004114 olopatadine Drugs 0.000 description 1
- JBIMVDZLSHOPLA-LSCVHKIXSA-N olopatadine Chemical compound C1OC2=CC=C(CC(O)=O)C=C2C(=C/CCN(C)C)\C2=CC=CC=C21 JBIMVDZLSHOPLA-LSCVHKIXSA-N 0.000 description 1
- 239000003002 pH adjusting agent Substances 0.000 description 1
- 229940124641 pain reliever Drugs 0.000 description 1
- FJKROLUGYXJWQN-UHFFFAOYSA-N papa-hydroxy-benzoic acid Natural products OC(=O)C1=CC=C(O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-N 0.000 description 1
- 229920001277 pectin Polymers 0.000 description 1
- 239000001814 pectin Substances 0.000 description 1
- 235000010987 pectin Nutrition 0.000 description 1
- 235000021317 phosphate Nutrition 0.000 description 1
- 239000002587 phosphodiesterase IV inhibitor Substances 0.000 description 1
- 150000003013 phosphoric acid derivatives Chemical class 0.000 description 1
- 229960001416 pilocarpine Drugs 0.000 description 1
- 229920001983 poloxamer Polymers 0.000 description 1
- 229920001993 poloxamer 188 Polymers 0.000 description 1
- 229920002432 poly(vinyl methyl ether) polymer Polymers 0.000 description 1
- 229940068918 polyethylene glycol 400 Drugs 0.000 description 1
- 229920005862 polyol Polymers 0.000 description 1
- 150000003077 polyols Chemical class 0.000 description 1
- 229920002451 polyvinyl alcohol Polymers 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 239000000700 radioactive tracer Substances 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 235000002639 sodium chloride Nutrition 0.000 description 1
- UKLNMMHNWFDKNT-UHFFFAOYSA-M sodium chlorite Chemical compound [Na+].[O-]Cl=O UKLNMMHNWFDKNT-UHFFFAOYSA-M 0.000 description 1
- 229960002218 sodium chlorite Drugs 0.000 description 1
- 235000010339 sodium tetraborate Nutrition 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 235000010199 sorbic acid Nutrition 0.000 description 1
- 239000004334 sorbic acid Substances 0.000 description 1
- 229940075582 sorbic acid Drugs 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 230000003637 steroidlike Effects 0.000 description 1
- 229960004492 suprofen Drugs 0.000 description 1
- AODPIQQILQLWGS-GXBDJPPSSA-N tetrahydrocortisol Chemical compound C1[C@H](O)CC[C@]2(C)[C@H]3[C@@H](O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CC[C@@H]21 AODPIQQILQLWGS-GXBDJPPSSA-N 0.000 description 1
- 229960004605 timolol Drugs 0.000 description 1
- 230000000451 tissue damage Effects 0.000 description 1
- 231100000827 tissue damage Toxicity 0.000 description 1
- NLVFBUXFDBBNBW-PBSUHMDJSA-N tobramycin Chemical compound N[C@@H]1C[C@H](O)[C@@H](CN)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O[C@@H]2[C@@H]([C@@H](N)[C@H](O)[C@@H](CO)O2)O)[C@H](N)C[C@@H]1N NLVFBUXFDBBNBW-PBSUHMDJSA-N 0.000 description 1
- 229960000707 tobramycin Drugs 0.000 description 1
- 239000012929 tonicity agent Substances 0.000 description 1
- 235000010487 tragacanth Nutrition 0.000 description 1
- 239000000196 tragacanth Substances 0.000 description 1
- 229940116362 tragacanth Drugs 0.000 description 1
- 230000001052 transient effect Effects 0.000 description 1
- WUUHFRRPHJEEKV-UHFFFAOYSA-N tripotassium borate Chemical compound [K+].[K+].[K+].[O-]B([O-])[O-] WUUHFRRPHJEEKV-UHFFFAOYSA-N 0.000 description 1
- BSVBQGMMJUBVOD-UHFFFAOYSA-N trisodium borate Chemical compound [Na+].[Na+].[Na+].[O-]B([O-])[O-] BSVBQGMMJUBVOD-UHFFFAOYSA-N 0.000 description 1
- 235000015112 vegetable and seed oil Nutrition 0.000 description 1
- 239000008158 vegetable oil Substances 0.000 description 1
- 230000002618 waking effect Effects 0.000 description 1
- 229920001285 xanthan gum Polymers 0.000 description 1
- 235000010493 xanthan gum Nutrition 0.000 description 1
- 239000000230 xanthan gum Substances 0.000 description 1
- 229940082509 xanthan gum Drugs 0.000 description 1
- UHVMMEOXYDMDKI-JKYCWFKZSA-L zinc;1-(5-cyanopyridin-2-yl)-3-[(1s,2s)-2-(6-fluoro-2-hydroxy-3-propanoylphenyl)cyclopropyl]urea;diacetate Chemical compound [Zn+2].CC([O-])=O.CC([O-])=O.CCC(=O)C1=CC=C(F)C([C@H]2[C@H](C2)NC(=O)NC=2N=CC(=CC=2)C#N)=C1O UHVMMEOXYDMDKI-JKYCWFKZSA-L 0.000 description 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/736—Glucomannans or galactomannans, e.g. locust bean gum, guar gum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
- A61K31/047—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates having two or more hydroxy groups, e.g. sorbitol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
- A61K31/728—Hyaluronic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/04—Artificial tears; Irrigation solutions
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Inorganic Chemistry (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Ophthalmology & Optometry (AREA)
- Dermatology (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Plant Substances (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261642901P | 2012-05-04 | 2012-05-04 | |
| PCT/US2013/039487 WO2013166399A1 (en) | 2012-05-04 | 2013-05-03 | Ophthalmic compositions with improved dessication protection and retention |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2761373T3 true ES2761373T3 (es) | 2020-05-19 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES13723623T Active ES2761373T3 (es) | 2012-05-04 | 2013-05-03 | Composiciones oftálmicas con protección contra la desecación y retención mejoradas |
Country Status (19)
| Country | Link |
|---|---|
| US (6) | US20130296264A1 (enExample) |
| EP (1) | EP2844226B1 (enExample) |
| KR (1) | KR102076033B1 (enExample) |
| CN (2) | CN104379131A (enExample) |
| AR (1) | AR090930A1 (enExample) |
| AU (1) | AU2013256144B2 (enExample) |
| BR (1) | BR112014027582B1 (enExample) |
| CA (1) | CA2872622C (enExample) |
| DK (1) | DK2844226T3 (enExample) |
| ES (1) | ES2761373T3 (enExample) |
| IN (1) | IN2014MN02248A (enExample) |
| MX (1) | MX362266B (enExample) |
| PH (1) | PH12014502571B1 (enExample) |
| PL (1) | PL2844226T3 (enExample) |
| PT (1) | PT2844226T (enExample) |
| RU (1) | RU2659207C2 (enExample) |
| UA (1) | UA113434C2 (enExample) |
| WO (1) | WO2013166399A1 (enExample) |
| ZA (1) | ZA201408490B (enExample) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PT3613423T (pt) | 2013-07-10 | 2022-12-07 | Matrix Biology Inst | Composições de hialuronano de elevada elasticidade e suas utilizações |
| US10245324B2 (en) * | 2014-10-31 | 2019-04-02 | Johnson & Johnson Consumer Inc. | Ophthalmic composition |
| CN105311042B (zh) * | 2015-09-07 | 2019-04-12 | 广州国宇医药科技有限公司 | 一种糖醇组合物在制备治疗干眼症的药物中的应用 |
| PT3352766T (pt) | 2015-09-24 | 2022-03-22 | Matrix Biology Inst | Composições de hialuronano de elevada elasticidade e processos para o seu uso |
| US10632202B2 (en) | 2016-03-04 | 2020-04-28 | Johnson & Johnson Consumer Inc. | Preservative containing compositions |
| TWI913170B (zh) * | 2018-02-21 | 2026-01-21 | 瑞士商愛爾康公司 | 基於脂質的眼用乳劑 |
| TWI826685B (zh) | 2019-05-02 | 2023-12-21 | 瑞士商愛爾康公司 | 可溶解聚合物眼睛插入物及其使用方法 |
| TWI757773B (zh) * | 2019-06-28 | 2022-03-11 | 瑞士商愛爾康公司 | 眼用組成物 |
| CN114191378A (zh) * | 2021-11-23 | 2022-03-18 | 温州医科大学附属眼视光医院 | 一种地夸磷索缓释凝胶及其制备方法与应用 |
| AU2025233965A1 (en) | 2024-03-04 | 2026-07-16 | Alcon Inc. | Carbamoylphenylboronic acid-containing acrylic monomers and uses thereof |
| WO2026115440A1 (en) | 2024-11-27 | 2026-06-04 | Alcon Inc. | Stable ophthalmic emulsion |
| US20260144812A1 (en) | 2024-11-27 | 2026-05-28 | Alcon Inc. | Antioxidant ophthalmic emulsion |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
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| JPH09227385A (ja) * | 1996-02-29 | 1997-09-02 | Ofutekusu:Kk | 眼手術用補助剤 |
| DE69818675T2 (de) | 1997-07-29 | 2004-07-29 | Alcon Laboratories, Inc., Fort Worth | Galaktomannanpolymere und borat enthaltende augenarzneimittel |
| US7947295B2 (en) * | 2003-06-13 | 2011-05-24 | Alcon, Inc. | Ophthalmic compositions containing a synergistic combination of two polymers |
| CA2839849C (en) * | 2003-06-13 | 2017-03-07 | Alcon, Inc. | Ophthalmic compositions containing a synergistic combination of two polymers |
| KR101555291B1 (ko) * | 2007-02-09 | 2015-09-30 | 알콘, 인코퍼레이티드 | 세가지 폴리머의 상승성 배합물을 함유하는 안과 조성물 |
| US20090036554A1 (en) | 2007-08-01 | 2009-02-05 | Burke Susan E | Ophthalmic compositions comprising a terpene compound |
| US9096819B2 (en) * | 2008-01-31 | 2015-08-04 | Bausch & Lomb Incorporated | Ophthalmic compositions with an amphoteric surfactant and an anionic biopolymer |
| AR071834A1 (es) * | 2008-04-26 | 2010-07-21 | Alcon Res Ltd | Sistema polimerico de lagrimas artificiales |
| US20100087550A1 (en) * | 2008-10-06 | 2010-04-08 | Zora Marlowe | Formulations with a Tertiary Amine Oxide |
| NZ603345A (en) * | 2010-05-05 | 2014-12-24 | Alcon Res Ltd | Stabilized ophthalmic galactomannan formulations |
-
2013
- 2013-03-05 UA UAA201412705A patent/UA113434C2/uk unknown
- 2013-05-03 AR ARP130101515A patent/AR090930A1/es unknown
- 2013-05-03 DK DK13723623.8T patent/DK2844226T3/da active
- 2013-05-03 BR BR112014027582-3A patent/BR112014027582B1/pt active IP Right Grant
- 2013-05-03 US US13/886,788 patent/US20130296264A1/en not_active Abandoned
- 2013-05-03 AU AU2013256144A patent/AU2013256144B2/en active Active
- 2013-05-03 PH PH1/2014/502571A patent/PH12014502571B1/en unknown
- 2013-05-03 KR KR1020147032805A patent/KR102076033B1/ko active Active
- 2013-05-03 PL PL13723623T patent/PL2844226T3/pl unknown
- 2013-05-03 MX MX2014013444A patent/MX362266B/es active IP Right Grant
- 2013-05-03 WO PCT/US2013/039487 patent/WO2013166399A1/en not_active Ceased
- 2013-05-03 CN CN201380031008.8A patent/CN104379131A/zh active Pending
- 2013-05-03 RU RU2014148758A patent/RU2659207C2/ru active
- 2013-05-03 CA CA2872622A patent/CA2872622C/en active Active
- 2013-05-03 CN CN201811311427.8A patent/CN109157539A/zh active Pending
- 2013-05-03 ES ES13723623T patent/ES2761373T3/es active Active
- 2013-05-03 PT PT137236238T patent/PT2844226T/pt unknown
- 2013-05-03 EP EP13723623.8A patent/EP2844226B1/en active Active
- 2013-05-03 IN IN2248MUN2014 patent/IN2014MN02248A/en unknown
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2014
- 2014-11-19 ZA ZA2014/08490A patent/ZA201408490B/en unknown
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2017
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2019
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2020
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2022
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2023
- 2023-05-17 US US18/319,196 patent/US20230285443A1/en not_active Abandoned
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