AU2013256144B2 - Ophthalmic compositions with improved dessication protection and retention - Google Patents

Ophthalmic compositions with improved dessication protection and retention Download PDF

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Publication number
AU2013256144B2
AU2013256144B2 AU2013256144A AU2013256144A AU2013256144B2 AU 2013256144 B2 AU2013256144 B2 AU 2013256144B2 AU 2013256144 A AU2013256144 A AU 2013256144A AU 2013256144 A AU2013256144 A AU 2013256144A AU 2013256144 B2 AU2013256144 B2 AU 2013256144B2
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AU
Australia
Prior art keywords
composition according
present
compositions
hyaluronic acid
composition
Prior art date
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Active
Application number
AU2013256144A
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English (en)
Other versions
AU2013256144A1 (en
Inventor
Elaine E Campbell
James W. Davis
Howard Allen Ketelson
David L. Meadows
Rekha Rangarajan
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Alcon Inc
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Alcon Inc
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Publication of AU2013256144A1 publication Critical patent/AU2013256144A1/en
Application granted granted Critical
Publication of AU2013256144B2 publication Critical patent/AU2013256144B2/en
Assigned to ALCON INC. reassignment ALCON INC. Request for Assignment Assignors: ALCON RESEARCH, LTD.
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/736—Glucomannans or galactomannans, e.g. locust bean gum, guar gum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/047—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates having two or more hydroxy groups, e.g. sorbitol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
    • A61K31/728—Hyaluronic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/04—Artificial tears; Irrigation solutions

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Inorganic Chemistry (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Ophthalmology & Optometry (AREA)
  • Dermatology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
AU2013256144A 2012-05-04 2013-05-03 Ophthalmic compositions with improved dessication protection and retention Active AU2013256144B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261642901P 2012-05-04 2012-05-04
US61/642,901 2012-05-04
PCT/US2013/039487 WO2013166399A1 (en) 2012-05-04 2013-05-03 Ophthalmic compositions with improved dessication protection and retention

Publications (2)

Publication Number Publication Date
AU2013256144A1 AU2013256144A1 (en) 2014-12-04
AU2013256144B2 true AU2013256144B2 (en) 2018-01-18

Family

ID=48464107

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2013256144A Active AU2013256144B2 (en) 2012-05-04 2013-05-03 Ophthalmic compositions with improved dessication protection and retention

Country Status (19)

Country Link
US (6) US20130296264A1 (enExample)
EP (1) EP2844226B1 (enExample)
KR (1) KR102076033B1 (enExample)
CN (2) CN104379131A (enExample)
AR (1) AR090930A1 (enExample)
AU (1) AU2013256144B2 (enExample)
BR (1) BR112014027582B1 (enExample)
CA (1) CA2872622C (enExample)
DK (1) DK2844226T3 (enExample)
ES (1) ES2761373T3 (enExample)
IN (1) IN2014MN02248A (enExample)
MX (1) MX362266B (enExample)
PH (1) PH12014502571B1 (enExample)
PL (1) PL2844226T3 (enExample)
PT (1) PT2844226T (enExample)
RU (1) RU2659207C2 (enExample)
UA (1) UA113434C2 (enExample)
WO (1) WO2013166399A1 (enExample)
ZA (1) ZA201408490B (enExample)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT3613423T (pt) 2013-07-10 2022-12-07 Matrix Biology Inst Composições de hialuronano de elevada elasticidade e suas utilizações
US10245324B2 (en) * 2014-10-31 2019-04-02 Johnson & Johnson Consumer Inc. Ophthalmic composition
CN105311042B (zh) * 2015-09-07 2019-04-12 广州国宇医药科技有限公司 一种糖醇组合物在制备治疗干眼症的药物中的应用
PT3352766T (pt) 2015-09-24 2022-03-22 Matrix Biology Inst Composições de hialuronano de elevada elasticidade e processos para o seu uso
US10632202B2 (en) 2016-03-04 2020-04-28 Johnson & Johnson Consumer Inc. Preservative containing compositions
TWI913170B (zh) * 2018-02-21 2026-01-21 瑞士商愛爾康公司 基於脂質的眼用乳劑
TWI826685B (zh) 2019-05-02 2023-12-21 瑞士商愛爾康公司 可溶解聚合物眼睛插入物及其使用方法
TWI757773B (zh) * 2019-06-28 2022-03-11 瑞士商愛爾康公司 眼用組成物
CN114191378A (zh) * 2021-11-23 2022-03-18 温州医科大学附属眼视光医院 一种地夸磷索缓释凝胶及其制备方法与应用
AU2025233965A1 (en) 2024-03-04 2026-07-16 Alcon Inc. Carbamoylphenylboronic acid-containing acrylic monomers and uses thereof
WO2026115440A1 (en) 2024-11-27 2026-06-04 Alcon Inc. Stable ophthalmic emulsion
US20260144812A1 (en) 2024-11-27 2026-05-28 Alcon Inc. Antioxidant ophthalmic emulsion

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH09227385A (ja) * 1996-02-29 1997-09-02 Ofutekusu:Kk 眼手術用補助剤
US20070128156A1 (en) * 2003-06-13 2007-06-07 Alcon, Inc. Ophthalmic compositions containing a synergistic combination of two polymers
US20090196845A1 (en) * 2008-01-31 2009-08-06 Erning Xia Opthalmic compositions with an amphoteric surfactant and an anionic biopolymer
US20090270345A1 (en) * 2008-04-26 2009-10-29 Alcon Research, Ltd. Polymeric artificial tear system
US20100087550A1 (en) * 2008-10-06 2010-04-08 Zora Marlowe Formulations with a Tertiary Amine Oxide
US20110275593A1 (en) * 2010-05-05 2011-11-10 Alcon Research, Ltd. Stabilized ophthalmic galactomannan formulations

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69818675T2 (de) 1997-07-29 2004-07-29 Alcon Laboratories, Inc., Fort Worth Galaktomannanpolymere und borat enthaltende augenarzneimittel
CA2839849C (en) * 2003-06-13 2017-03-07 Alcon, Inc. Ophthalmic compositions containing a synergistic combination of two polymers
KR101555291B1 (ko) * 2007-02-09 2015-09-30 알콘, 인코퍼레이티드 세가지 폴리머의 상승성 배합물을 함유하는 안과 조성물
US20090036554A1 (en) 2007-08-01 2009-02-05 Burke Susan E Ophthalmic compositions comprising a terpene compound

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH09227385A (ja) * 1996-02-29 1997-09-02 Ofutekusu:Kk 眼手術用補助剤
US20070128156A1 (en) * 2003-06-13 2007-06-07 Alcon, Inc. Ophthalmic compositions containing a synergistic combination of two polymers
US20090196845A1 (en) * 2008-01-31 2009-08-06 Erning Xia Opthalmic compositions with an amphoteric surfactant and an anionic biopolymer
US20090270345A1 (en) * 2008-04-26 2009-10-29 Alcon Research, Ltd. Polymeric artificial tear system
US20100087550A1 (en) * 2008-10-06 2010-04-08 Zora Marlowe Formulations with a Tertiary Amine Oxide
US20110275593A1 (en) * 2010-05-05 2011-11-10 Alcon Research, Ltd. Stabilized ophthalmic galactomannan formulations

Also Published As

Publication number Publication date
US20230285443A1 (en) 2023-09-14
PL2844226T3 (pl) 2020-04-30
CN109157539A (zh) 2019-01-08
US11376275B2 (en) 2022-07-05
KR102076033B1 (ko) 2020-02-11
IN2014MN02248A (enExample) 2015-07-24
PH12014502571A1 (en) 2015-01-21
US11672820B2 (en) 2023-06-13
PH12014502571B1 (en) 2022-04-29
AR090930A1 (es) 2014-12-17
CN104379131A (zh) 2015-02-25
ES2761373T3 (es) 2020-05-19
US20200138853A1 (en) 2020-05-07
MX362266B (es) 2019-01-10
BR112014027582A2 (pt) 2017-06-27
US20220273699A1 (en) 2022-09-01
EP2844226B1 (en) 2019-11-13
EP2844226A1 (en) 2015-03-11
AU2013256144A1 (en) 2014-12-04
CA2872622A1 (en) 2013-11-07
KR20150003868A (ko) 2015-01-09
US20170136057A1 (en) 2017-05-18
RU2014148758A (ru) 2016-06-27
US20210060056A1 (en) 2021-03-04
WO2013166399A1 (en) 2013-11-07
MX2014013444A (es) 2015-05-11
DK2844226T3 (da) 2020-01-02
PT2844226T (pt) 2019-12-16
CA2872622C (en) 2020-07-28
BR112014027582B1 (pt) 2022-05-10
UA113434C2 (uk) 2017-01-25
BR112014027582A8 (pt) 2021-06-15
RU2659207C2 (ru) 2018-06-28
US10828320B2 (en) 2020-11-10
US20130296264A1 (en) 2013-11-07
ZA201408490B (en) 2016-08-31

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PC Assignment registered

Owner name: ALCON INC.

Free format text: FORMER OWNER(S): ALCON RESEARCH, LTD.