CN104349779A - Pi-3激酶抑制剂的剂量方案 - Google Patents

Pi-3激酶抑制剂的剂量方案 Download PDF

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Publication number
CN104349779A
CN104349779A CN201380025377.6A CN201380025377A CN104349779A CN 104349779 A CN104349779 A CN 104349779A CN 201380025377 A CN201380025377 A CN 201380025377A CN 104349779 A CN104349779 A CN 104349779A
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China
Prior art keywords
cancer
substituted
groups
compound
pharmaceutically acceptable
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Pending
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CN201380025377.6A
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English (en)
Chinese (zh)
Inventor
S·希拉瓦特
C·马萨克斯
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Novartis AG
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Novartis AG
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=48626588&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CN104349779(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novartis AG filed Critical Novartis AG
Publication of CN104349779A publication Critical patent/CN104349779A/zh
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4196—1,2,4-Triazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CN201380025377.6A 2012-05-16 2013-05-14 Pi-3激酶抑制剂的剂量方案 Pending CN104349779A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261647654P 2012-05-16 2012-05-16
US61/647,654 2012-05-16
PCT/US2013/040877 WO2013173283A1 (en) 2012-05-16 2013-05-14 Dosage regimen for a pi-3 kinase inhibitor

Publications (1)

Publication Number Publication Date
CN104349779A true CN104349779A (zh) 2015-02-11

Family

ID=48626588

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201380025377.6A Pending CN104349779A (zh) 2012-05-16 2013-05-14 Pi-3激酶抑制剂的剂量方案

Country Status (19)

Country Link
US (2) US10213432B2 (https=)
EP (1) EP2849756A1 (https=)
JP (2) JP6381523B2 (https=)
KR (1) KR20150009540A (https=)
CN (1) CN104349779A (https=)
AU (1) AU2013263043B2 (https=)
BR (1) BR112014028420A2 (https=)
CA (1) CA2872526A1 (https=)
CL (1) CL2014003101A1 (https=)
HK (1) HK1202435A1 (https=)
IL (1) IL235567B (https=)
MX (1) MX360892B (https=)
NZ (1) NZ700924A (https=)
PH (1) PH12014502547A1 (https=)
RU (1) RU2630975C2 (https=)
SG (2) SG10201608469RA (https=)
TN (1) TN2014000433A1 (https=)
WO (1) WO2013173283A1 (https=)
ZA (1) ZA201407406B (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108472289A (zh) * 2015-11-02 2018-08-31 诺华股份有限公司 磷脂酰肌醇3-激酶抑制剂的给药方案

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KR20140069235A (ko) 2011-09-27 2014-06-09 노파르티스 아게 돌연변이체 idh의 억제제로서의 3-피리미딘-4-일-옥사졸리딘-2-온
UY34632A (es) 2012-02-24 2013-05-31 Novartis Ag Compuestos de oxazolidin- 2- ona y usos de los mismos
US9296733B2 (en) * 2012-11-12 2016-03-29 Novartis Ag Oxazolidin-2-one-pyrimidine derivative and use thereof for the treatment of conditions, diseases and disorders dependent upon PI3 kinases
EP2970240B1 (en) 2013-03-14 2018-01-10 Novartis AG 3-pyrimidin-4-yl-oxazolidin-2-ones as inhibitors of mutant idh
SI3076969T1 (sl) 2013-12-06 2021-12-31 Novartis Ag Režim omderjanja izooblike alfa selektivnega zaviralca fosfatidilino- zitol 3-kinaze
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WO2018009895A1 (en) * 2016-07-08 2018-01-11 Autotelic Llc Methods for trabedersen dosing by auc

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CN101389622A (zh) * 2006-01-20 2009-03-18 诺瓦提斯公司 用作pi-3激酶抑制剂的嘧啶衍生物

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108472289A (zh) * 2015-11-02 2018-08-31 诺华股份有限公司 磷脂酰肌醇3-激酶抑制剂的给药方案

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WO2013173283A1 (en) 2013-11-21
BR112014028420A2 (pt) 2017-09-19
NZ700924A (en) 2016-02-26
HK1202435A1 (en) 2015-10-02
MX2014013904A (es) 2015-01-16
ZA201407406B (en) 2015-11-25
TN2014000433A1 (en) 2016-03-30
RU2014150860A (ru) 2016-07-10
JP2015517523A (ja) 2015-06-22
US10213432B2 (en) 2019-02-26
US20150141426A1 (en) 2015-05-21
SG10201608469RA (en) 2016-11-29
AU2013263043A1 (en) 2014-10-30
SG11201406550QA (en) 2014-11-27
JP6381523B2 (ja) 2018-08-29
IL235567B (en) 2019-08-29
EP2849756A1 (en) 2015-03-25
KR20150009540A (ko) 2015-01-26
PH12014502547A1 (en) 2015-01-21
AU2013263043B2 (en) 2016-06-16
RU2630975C2 (ru) 2017-09-15
MX360892B (es) 2018-11-20
CA2872526A1 (en) 2013-11-21
JP2018108998A (ja) 2018-07-12
US20190134052A1 (en) 2019-05-09
CL2014003101A1 (es) 2015-02-27
IL235567A0 (en) 2015-01-29

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Application publication date: 20150211