CN104302358B - 3‑芳基‑5‑取代的异喹啉‑1‑酮化合物和它们的治疗用途 - Google Patents
3‑芳基‑5‑取代的异喹啉‑1‑酮化合物和它们的治疗用途 Download PDFInfo
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- CN104302358B CN104302358B CN201380023162.0A CN201380023162A CN104302358B CN 104302358 B CN104302358 B CN 104302358B CN 201380023162 A CN201380023162 A CN 201380023162A CN 104302358 B CN104302358 B CN 104302358B
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- 0 C=S*CN1CC(CCC2)N2CC1 Chemical compound C=S*CN1CC(CCC2)N2CC1 0.000 description 12
- JBIOAERYKYZUDO-UHFFFAOYSA-N CN(CC1CCN(C)CC1)C(c(cc1)ccc1C#N)=O Chemical compound CN(CC1CCN(C)CC1)C(c(cc1)ccc1C#N)=O JBIOAERYKYZUDO-UHFFFAOYSA-N 0.000 description 1
- OGPARKSIOIZLRP-GFCCVEGCSA-N C[C@H](Cc(cc1)ccc1C#N)N1CCOCC1 Chemical compound C[C@H](Cc(cc1)ccc1C#N)N1CCOCC1 OGPARKSIOIZLRP-GFCCVEGCSA-N 0.000 description 1
- NXTJPMBSFVOPPW-UHFFFAOYSA-N Cc1c(C=C(c(cc2)ccc2C(N(C)CC2CCN(C)CC2)=N)NC2=[U])c2ccc1 Chemical compound Cc1c(C=C(c(cc2)ccc2C(N(C)CC2CCN(C)CC2)=N)NC2=[U])c2ccc1 NXTJPMBSFVOPPW-UHFFFAOYSA-N 0.000 description 1
- PYZZLFVFTBBWEK-HWKANZROSA-N Cc1cc(F)ccc1/C=C/C(O)=O Chemical compound Cc1cc(F)ccc1/C=C/C(O)=O PYZZLFVFTBBWEK-HWKANZROSA-N 0.000 description 1
- ONVGXQRBWNWQQV-UHFFFAOYSA-N Cc1cccc2c1C=C(c(cc1)ccc1Br)NC2=O Chemical compound Cc1cccc2c1C=C(c(cc1)ccc1Br)NC2=O ONVGXQRBWNWQQV-UHFFFAOYSA-N 0.000 description 1
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
- C07D217/24—Oxygen atoms
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
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- A—HUMAN NECESSITIES
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- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
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- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
- C07D217/14—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals
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- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
- C07D217/14—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals
- C07D217/16—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals substituted by oxygen atoms
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- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
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- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/08—Bridged systems
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/10—Spiro-condensed systems
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- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
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- Public Health (AREA)
- Engineering & Computer Science (AREA)
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- Heart & Thoracic Surgery (AREA)
- Dermatology (AREA)
- Cardiology (AREA)
- Ophthalmology & Optometry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261607680P | 2012-03-07 | 2012-03-07 | |
| US61/607,680 | 2012-03-07 | ||
| PCT/GB2013/050561 WO2013132253A1 (en) | 2012-03-07 | 2013-03-07 | 3-aryl-5-substituted-isoquinolin-1-one compounds and their therapeutic use |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN104302358A CN104302358A (zh) | 2015-01-21 |
| CN104302358B true CN104302358B (zh) | 2017-12-05 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201380023162.0A Expired - Fee Related CN104302358B (zh) | 2012-03-07 | 2013-03-07 | 3‑芳基‑5‑取代的异喹啉‑1‑酮化合物和它们的治疗用途 |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US9193689B2 (enExample) |
| EP (1) | EP2822656B1 (enExample) |
| JP (1) | JP6082409B2 (enExample) |
| KR (1) | KR102104144B1 (enExample) |
| CN (1) | CN104302358B (enExample) |
| AU (1) | AU2013229229B2 (enExample) |
| CA (1) | CA2865511A1 (enExample) |
| DK (1) | DK2822656T3 (enExample) |
| ES (1) | ES2611504T3 (enExample) |
| IN (1) | IN2014MN01875A (enExample) |
| MX (1) | MX346147B (enExample) |
| RU (1) | RU2696572C2 (enExample) |
| WO (1) | WO2013132253A1 (enExample) |
Families Citing this family (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2822656B1 (en) | 2012-03-07 | 2016-10-19 | Institute of Cancer Research: Royal Cancer Hospital (The) | 3-aryl-5-substituted-isoquinolin-1-one compounds and their therapeutic use |
| DK2882714T3 (da) * | 2012-08-08 | 2020-01-20 | Merck Patent Gmbh | (aza-)isoquinolinonderivater |
| US9611223B2 (en) | 2013-09-11 | 2017-04-04 | Institute Of Cancer Research: Royal Cancer Hospital (The) | 3-aryl-5-substituted-isoquinolin-1-one compounds and their therapeutic use |
| CA3038280A1 (en) | 2015-09-30 | 2017-04-06 | Max-Planck-Gesellschaft Zur Forderung Der Wissenschaften E.V. - Generalverwaltung | Heteroaryl derivatives as sepiapterin reductase inhibitors |
| US10640497B2 (en) | 2015-12-02 | 2020-05-05 | Syngenta Participations Ag | Microbiocidal oxadiazole derivatives |
| UY37623A (es) | 2017-03-03 | 2018-09-28 | Syngenta Participations Ag | Derivados de oxadiazol tiofeno fungicidas |
| WO2018219773A1 (en) | 2017-06-02 | 2018-12-06 | Syngenta Participations Ag | Fungicidal compositions |
| US11447481B2 (en) | 2017-06-02 | 2022-09-20 | Syngenta Participations Ag | Microbiocidal oxadiazole derivatives |
| CN110799035A (zh) | 2017-06-28 | 2020-02-14 | 先正达参股股份有限公司 | 杀真菌组合物 |
| BR112020000456A2 (pt) | 2017-07-11 | 2020-07-21 | Syngenta Participations Ag | derivados oxadiazol microbiocidas |
| WO2019011928A1 (en) | 2017-07-11 | 2019-01-17 | Syngenta Participations Ag | MICROBIOCIDE OXADIAZOLE DERIVATIVES |
| WO2019011926A1 (en) | 2017-07-11 | 2019-01-17 | Syngenta Participations Ag | MICROBIOCIDE OXADIAZOLE DERIVATIVES |
| BR112020000465B1 (pt) | 2017-07-11 | 2024-02-20 | Syngenta Participations Ag | Derivados oxadiazol microbiocidas |
| BR112020000371A2 (pt) | 2017-07-12 | 2020-07-14 | Syngenta Participations Ag | derivados de oxadiazol microbiocidas |
| BR112020000463A2 (pt) | 2017-07-13 | 2020-07-21 | Syngenta Participations Ag | derivados oxadiazol microbiocidas |
| EP3459469A1 (en) | 2017-09-23 | 2019-03-27 | Universität Zürich | Medical occluder device |
| US12402885B2 (en) | 2017-09-23 | 2025-09-02 | Universität Zürich | Medical occlusion device |
| AR114136A1 (es) | 2017-10-10 | 2020-07-29 | Hoffmann La Roche | Compuestos heterocíclicos |
| US20210267204A1 (en) | 2018-07-16 | 2021-09-02 | Syngenta Crop Protection Ag | Microbiocidal oxadiazole derivatives |
| HUE064377T2 (hu) | 2019-04-12 | 2024-03-28 | Riboscience Llc | Biciklusos heteroaril-származékok mint ektonukleotid pirofoszfatáz foszfodiészteráz 1 inhibitorok |
| AR118673A1 (es) * | 2019-04-18 | 2021-10-20 | Syngenta Crop Protection Ag | Procedimiento para la preparación de derivados de oxadiazol microbiocidas |
| EP4033999B1 (en) | 2019-09-26 | 2024-11-27 | Universität Zürich | Left atrial appendage occlusion devices |
| KR102293986B1 (ko) * | 2019-10-30 | 2021-08-26 | 충남대학교산학협력단 | 이소퀴놀리논 유도체, 이의 제조방법 및 이를 유효성분으로 함유하는 폴리(adp-리보스)폴리머라제-1(parp-1) 관련 질환의 예방 또는 치료용 약학적 조성물 |
| WO2021191833A1 (en) | 2020-03-25 | 2021-09-30 | Universitat Zurich | Medical occluder delivery systems |
| US11972017B2 (en) | 2020-10-21 | 2024-04-30 | Verint Americas Inc. | System and method of automated determination of use of sensitive information and corrective action for improper use |
| WO2022194799A1 (de) | 2021-03-18 | 2022-09-22 | Merck Patent Gmbh | Heteroaromatische verbindungen für organische elektrolumineszenzvorrichtungen |
| CA3217775A1 (en) * | 2021-05-04 | 2022-11-10 | Stanton Mchardy | Indanone and tetralone-keto or hydroxyl oximes as cancer therapeutics |
| WO2023156386A2 (en) * | 2022-02-16 | 2023-08-24 | Duke Street Bio Limited | Pharmaceutical compound |
| CN115572262B (zh) * | 2022-10-27 | 2024-08-27 | 厦门沃克沃德医药科技有限公司 | 一种异喹啉衍生物及其制备方法 |
| WO2024238871A1 (en) * | 2023-05-18 | 2024-11-21 | Rectify Pharmaceuticals, Inc. | Aryl sulfonamide compounds and their use in treating medical conditions |
| GB2634228A (en) * | 2023-10-02 | 2025-04-09 | Duke Street Bio Ltd | PARP1 inhibitor compounds |
| WO2025136936A1 (en) * | 2023-12-19 | 2025-06-26 | Merck Sharp & Dohme Llc | Agonists of trem2 activity |
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| WO2004031171A1 (ja) * | 2002-10-01 | 2004-04-15 | Mitsubishi Pharma Corporation | イソキノリン化合物及びその医薬用途 |
| US20060173039A1 (en) * | 2002-07-24 | 2006-08-03 | Futoshi Shiga | 4-(Substituted aryl)-5-hydroxyisoquinolinone derivative |
| CN101316592A (zh) * | 2005-08-24 | 2008-12-03 | 伊诺泰克制药公司 | 茚并异喹啉酮类似物及其用法 |
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| US2851458A (en) | 1955-06-08 | 1958-09-09 | Burroughs Wellcome Co | Diquaternary compounds and the manufacture thereof |
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| US4678500A (en) | 1984-06-29 | 1987-07-07 | E. I. Du Pont De Nemours And Company | Herbicidal 2,6-disubstituted benzylsulfonamides and benzenesulfamates |
| US5177075A (en) | 1988-08-19 | 1993-01-05 | Warner-Lambert Company | Substituted dihydroisoquinolinones and related compounds as potentiators of the lethal effects of radiation and certain chemotherapeutic agents; selected compounds, analogs and process |
| US4942163A (en) | 1989-03-07 | 1990-07-17 | E. I. Du Pont De Nemours And Company | 1(2H)-isoquinolinones and 1-isoquinolineamines as cancer chemotherapeutic agents |
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| MY140680A (en) | 2002-05-20 | 2010-01-15 | Bristol Myers Squibb Co | Hepatitis c virus inhibitors |
| US7238725B2 (en) | 2002-10-23 | 2007-07-03 | Glenmark Pharmaceuticals Ltd. | Tricyclic compounds useful for the treatment of inflammatory and allergic disorders: process for their preparation and pharmaceutical compositions containing them |
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| US20060173039A1 (en) * | 2002-07-24 | 2006-08-03 | Futoshi Shiga | 4-(Substituted aryl)-5-hydroxyisoquinolinone derivative |
| WO2004031171A1 (ja) * | 2002-10-01 | 2004-04-15 | Mitsubishi Pharma Corporation | イソキノリン化合物及びその医薬用途 |
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| CN104302358A (zh) | 2015-01-21 |
| RU2014138194A (ru) | 2016-04-27 |
| EP2822656A1 (en) | 2015-01-14 |
| US9193689B2 (en) | 2015-11-24 |
| AU2013229229B2 (en) | 2017-10-19 |
| MX346147B (es) | 2017-03-09 |
| KR102104144B1 (ko) | 2020-04-23 |
| JP6082409B2 (ja) | 2017-02-15 |
| RU2696572C2 (ru) | 2019-08-05 |
| DK2822656T3 (en) | 2017-01-30 |
| EP2822656B1 (en) | 2016-10-19 |
| IN2014MN01875A (enExample) | 2015-07-03 |
| US20150099732A1 (en) | 2015-04-09 |
| WO2013132253A1 (en) | 2013-09-12 |
| JP2015512885A (ja) | 2015-04-30 |
| AU2013229229A1 (en) | 2014-09-25 |
| MX2014010509A (es) | 2014-10-14 |
| ES2611504T3 (es) | 2017-05-09 |
| CA2865511A1 (en) | 2013-09-12 |
| KR20150001734A (ko) | 2015-01-06 |
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