CN104302358B - 3‑芳基‑5‑取代的异喹啉‑1‑酮化合物和它们的治疗用途 - Google Patents
3‑芳基‑5‑取代的异喹啉‑1‑酮化合物和它们的治疗用途 Download PDFInfo
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- CN104302358B CN104302358B CN201380023162.0A CN201380023162A CN104302358B CN 104302358 B CN104302358 B CN 104302358B CN 201380023162 A CN201380023162 A CN 201380023162A CN 104302358 B CN104302358 B CN 104302358B
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- 0 C=S*CN1CC(CCC2)N2CC1 Chemical compound C=S*CN1CC(CCC2)N2CC1 0.000 description 12
- JBIOAERYKYZUDO-UHFFFAOYSA-N CN(CC1CCN(C)CC1)C(c(cc1)ccc1C#N)=O Chemical compound CN(CC1CCN(C)CC1)C(c(cc1)ccc1C#N)=O JBIOAERYKYZUDO-UHFFFAOYSA-N 0.000 description 1
- OGPARKSIOIZLRP-GFCCVEGCSA-N C[C@H](Cc(cc1)ccc1C#N)N1CCOCC1 Chemical compound C[C@H](Cc(cc1)ccc1C#N)N1CCOCC1 OGPARKSIOIZLRP-GFCCVEGCSA-N 0.000 description 1
- NXTJPMBSFVOPPW-UHFFFAOYSA-N Cc1c(C=C(c(cc2)ccc2C(N(C)CC2CCN(C)CC2)=N)NC2=[U])c2ccc1 Chemical compound Cc1c(C=C(c(cc2)ccc2C(N(C)CC2CCN(C)CC2)=N)NC2=[U])c2ccc1 NXTJPMBSFVOPPW-UHFFFAOYSA-N 0.000 description 1
- PYZZLFVFTBBWEK-HWKANZROSA-N Cc1cc(F)ccc1/C=C/C(O)=O Chemical compound Cc1cc(F)ccc1/C=C/C(O)=O PYZZLFVFTBBWEK-HWKANZROSA-N 0.000 description 1
- ONVGXQRBWNWQQV-UHFFFAOYSA-N Cc1cccc2c1C=C(c(cc1)ccc1Br)NC2=O Chemical compound Cc1cccc2c1C=C(c(cc1)ccc1Br)NC2=O ONVGXQRBWNWQQV-UHFFFAOYSA-N 0.000 description 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
- C07D217/24—Oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
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- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
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- A—HUMAN NECESSITIES
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- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P35/04—Antineoplastic agents specific for metastasis
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
- C07D217/14—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
- C07D217/14—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals
- C07D217/16—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals substituted by oxygen atoms
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- C07—ORGANIC CHEMISTRY
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- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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- C—CHEMISTRY; METALLURGY
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/08—Bridged systems
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/10—Spiro-condensed systems
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
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- Public Health (AREA)
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- Engineering & Computer Science (AREA)
- Diabetes (AREA)
- Hematology (AREA)
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- Neurology (AREA)
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- Oncology (AREA)
- Obesity (AREA)
- Endocrinology (AREA)
- Rheumatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Psychiatry (AREA)
- Communicable Diseases (AREA)
- Hospice & Palliative Care (AREA)
- Cardiology (AREA)
- Emergency Medicine (AREA)
- Child & Adolescent Psychology (AREA)
- Heart & Thoracic Surgery (AREA)
- Dermatology (AREA)
- Virology (AREA)
- Ophthalmology & Optometry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261607680P | 2012-03-07 | 2012-03-07 | |
| US61/607,680 | 2012-03-07 | ||
| PCT/GB2013/050561 WO2013132253A1 (en) | 2012-03-07 | 2013-03-07 | 3-aryl-5-substituted-isoquinolin-1-one compounds and their therapeutic use |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN104302358A CN104302358A (zh) | 2015-01-21 |
| CN104302358B true CN104302358B (zh) | 2017-12-05 |
Family
ID=47891779
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201380023162.0A Expired - Fee Related CN104302358B (zh) | 2012-03-07 | 2013-03-07 | 3‑芳基‑5‑取代的异喹啉‑1‑酮化合物和它们的治疗用途 |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US9193689B2 (enExample) |
| EP (1) | EP2822656B1 (enExample) |
| JP (1) | JP6082409B2 (enExample) |
| KR (1) | KR102104144B1 (enExample) |
| CN (1) | CN104302358B (enExample) |
| AU (1) | AU2013229229B2 (enExample) |
| CA (1) | CA2865511A1 (enExample) |
| DK (1) | DK2822656T3 (enExample) |
| ES (1) | ES2611504T3 (enExample) |
| IN (1) | IN2014MN01875A (enExample) |
| MX (1) | MX346147B (enExample) |
| RU (1) | RU2696572C2 (enExample) |
| WO (1) | WO2013132253A1 (enExample) |
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK2822656T3 (en) | 2012-03-07 | 2017-01-30 | Inst Of Cancer Research: Royal Cancer Hospital (The) | 3-aryl-5-substituted-isoquinolin-1-one compounds and their therapeutic use |
| US9376433B2 (en) | 2012-08-08 | 2016-06-28 | Merck Patent Gmbh | (AZA-)isoquinolinone derivatives |
| WO2015036759A1 (en) * | 2013-09-11 | 2015-03-19 | Institute Of Cancer Research: Royal Cancer Hospital (The) | 3-aryl-5-substituted-isoquinolin-1-one compounds and their therapeutic use |
| US9963462B2 (en) | 2015-09-30 | 2018-05-08 | Max-Planck-Gesellschaft Zur Forderung Der Wissenschaften E.V. | Sepiapterin reductase inhibitors |
| WO2017093348A1 (en) | 2015-12-02 | 2017-06-08 | Syngenta Participations Ag | Microbiocidal oxadiazole derivatives |
| UY37623A (es) | 2017-03-03 | 2018-09-28 | Syngenta Participations Ag | Derivados de oxadiazol tiofeno fungicidas |
| WO2018219773A1 (en) | 2017-06-02 | 2018-12-06 | Syngenta Participations Ag | Fungicidal compositions |
| EP3630753A1 (en) | 2017-06-02 | 2020-04-08 | Syngenta Participations AG | Microbiocidal oxadiazole derivatives |
| BR112019027900A2 (pt) | 2017-06-28 | 2020-07-21 | Syngenta Participations Ag | composições fungicidas |
| WO2019011923A1 (en) | 2017-07-11 | 2019-01-17 | Syngenta Participations Ag | MICROBIOCIDE OXADIAZOLE DERIVATIVES |
| WO2019011929A1 (en) | 2017-07-11 | 2019-01-17 | Syngenta Participations Ag | MICROBIOCIDE OXADIAZOLE DERIVATIVES |
| WO2019011926A1 (en) | 2017-07-11 | 2019-01-17 | Syngenta Participations Ag | MICROBIOCIDE OXADIAZOLE DERIVATIVES |
| WO2019011928A1 (en) | 2017-07-11 | 2019-01-17 | Syngenta Participations Ag | MICROBIOCIDE OXADIAZOLE DERIVATIVES |
| BR112020000371A2 (pt) | 2017-07-12 | 2020-07-14 | Syngenta Participations Ag | derivados de oxadiazol microbiocidas |
| WO2019012003A1 (en) | 2017-07-13 | 2019-01-17 | Syngenta Participations Ag | MICROBIOCIDE OXADIAZOLE DERIVATIVES |
| EP3459469A1 (en) | 2017-09-23 | 2019-03-27 | Universität Zürich | Medical occluder device |
| US12402885B2 (en) | 2017-09-23 | 2025-09-02 | Universität Zürich | Medical occlusion device |
| AR114136A1 (es) | 2017-10-10 | 2020-07-29 | Hoffmann La Roche | Compuestos heterocíclicos |
| US20210267204A1 (en) | 2018-07-16 | 2021-09-02 | Syngenta Crop Protection Ag | Microbiocidal oxadiazole derivatives |
| JP7598875B2 (ja) | 2019-04-12 | 2024-12-12 | リボサイエンス リミティド ライアビリティ カンパニー | エクトヌクレオチドピロホスファターゼホスホジエステラーゼ１阻害剤としての二環式ヘテロアリール誘導体 |
| AR118673A1 (es) | 2019-04-18 | 2021-10-20 | Syngenta Crop Protection Ag | Procedimiento para la preparación de derivados de oxadiazol microbiocidas |
| WO2021059273A2 (en) | 2019-09-26 | 2021-04-01 | Universitat Zurich | Left atrial appendage occlusion devices |
| MX2022005234A (es) * | 2019-10-30 | 2022-09-07 | Digmbio Inc | Derivados de isoquinolinona, procedimiento para su preparacion y composicion farmaceutica para la prevencion o el tratamiento de enfermedades relacionadas con la poli(adp-ribosa) polimerasa-1, que constituye los mismos como principio activo. |
| US11972017B2 (en) | 2020-10-21 | 2024-04-30 | Verint Americas Inc. | System and method of automated determination of use of sensitive information and corrective action for improper use |
| CN117043302A (zh) | 2021-03-18 | 2023-11-10 | 默克专利有限公司 | 用于有机电致发光器件的杂芳族化合物 |
| EP4334278A4 (en) * | 2021-05-04 | 2025-08-06 | Univ Texas | INDANONE AND TETRALONE-KETO OR HYDROXYL OXIMES AS CANCER THERAPEUTIC AGENTS |
| MX2024010096A (es) * | 2022-02-16 | 2024-08-28 | Duke Street Bio Ltd | Compuesto farmaceutico. |
| CN115572262B (zh) * | 2022-10-27 | 2024-08-27 | 厦门沃克沃德医药科技有限公司 | 一种异喹啉衍生物及其制备方法 |
| WO2024238871A1 (en) * | 2023-05-18 | 2024-11-21 | Rectify Pharmaceuticals, Inc. | Aryl sulfonamide compounds and their use in treating medical conditions |
| GB2634228A (en) * | 2023-10-02 | 2025-04-09 | Duke Street Bio Ltd | PARP1 inhibitor compounds |
| WO2025136936A1 (en) * | 2023-12-19 | 2025-06-26 | Merck Sharp & Dohme Llc | Agonists of trem2 activity |
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| WO2004031171A1 (ja) * | 2002-10-01 | 2004-04-15 | Mitsubishi Pharma Corporation | イソキノリン化合物及びその医薬用途 |
| US20060173039A1 (en) * | 2002-07-24 | 2006-08-03 | Futoshi Shiga | 4-(Substituted aryl)-5-hydroxyisoquinolinone derivative |
| CN101316592A (zh) * | 2005-08-24 | 2008-12-03 | 伊诺泰克制药公司 | 茚并异喹啉酮类似物及其用法 |
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- 2013-03-07 IN IN1875MUN2014 patent/IN2014MN01875A/en unknown
- 2013-03-07 CN CN201380023162.0A patent/CN104302358B/zh not_active Expired - Fee Related
- 2013-03-07 KR KR1020147026143A patent/KR102104144B1/ko not_active Expired - Fee Related
- 2013-03-07 AU AU2013229229A patent/AU2013229229B2/en not_active Ceased
- 2013-03-07 WO PCT/GB2013/050561 patent/WO2013132253A1/en not_active Ceased
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- 2013-03-07 RU RU2014138194A patent/RU2696572C2/ru not_active Application Discontinuation
- 2013-03-07 CA CA2865511A patent/CA2865511A1/en not_active Abandoned
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| AU2013229229B2 (en) | 2017-10-19 |
| AU2013229229A1 (en) | 2014-09-25 |
| MX346147B (es) | 2017-03-09 |
| KR102104144B1 (ko) | 2020-04-23 |
| JP2015512885A (ja) | 2015-04-30 |
| ES2611504T3 (es) | 2017-05-09 |
| WO2013132253A1 (en) | 2013-09-12 |
| US9193689B2 (en) | 2015-11-24 |
| RU2014138194A (ru) | 2016-04-27 |
| DK2822656T3 (en) | 2017-01-30 |
| CN104302358A (zh) | 2015-01-21 |
| EP2822656A1 (en) | 2015-01-14 |
| RU2696572C2 (ru) | 2019-08-05 |
| EP2822656B1 (en) | 2016-10-19 |
| KR20150001734A (ko) | 2015-01-06 |
| CA2865511A1 (en) | 2013-09-12 |
| JP6082409B2 (ja) | 2017-02-15 |
| US20150099732A1 (en) | 2015-04-09 |
| IN2014MN01875A (enExample) | 2015-07-03 |
| MX2014010509A (es) | 2014-10-14 |
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