CN104193660B - 取代的1,3-二苯基丙烷衍生物、它们的制备及用途 - Google Patents
取代的1,3-二苯基丙烷衍生物、它们的制备及用途 Download PDFInfo
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- CN104193660B CN104193660B CN201410016196.3A CN201410016196A CN104193660B CN 104193660 B CN104193660 B CN 104193660B CN 201410016196 A CN201410016196 A CN 201410016196A CN 104193660 B CN104193660 B CN 104193660B
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- C07C69/73—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids
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- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
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| FR0605540A FR2902789A1 (fr) | 2006-06-21 | 2006-06-21 | Derives de 1,3-diphenylpropane substitues, preparations et utilisations |
| FR0605540 | 2006-06-21 | ||
| CN200780030962.XA CN101506138B (zh) | 2006-06-21 | 2007-06-21 | 取代的1,3-二苯基丙烷衍生物、它们的制备及用途 |
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| CN2007800310203A Expired - Fee Related CN101506139B (zh) | 2006-06-21 | 2007-06-21 | 取代的1,3-二苯基丙烷衍生物、它们的制备及用途 |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| FR2902789A1 (fr) * | 2006-06-21 | 2007-12-28 | Genfit Sa | Derives de 1,3-diphenylpropane substitues, preparations et utilisations |
| FR2917084B1 (fr) * | 2007-06-05 | 2009-07-17 | Galderma Res & Dev | Nouveaux derives d'acide 3-phenyl propanoique activateurs des recpteurs de type ppar, leur methode de preparation et leur utilisation dans des compositions cosmetiques ou pharmaceutiques. |
| EA020849B1 (ru) | 2009-11-26 | 2015-02-27 | Женфит | Применение 1,3-дифенилпроп-2-ен-1-оновых производных для лечения заболеваний печени |
| US9221751B2 (en) * | 2009-11-26 | 2015-12-29 | Genfit | Use of 1,3-diphenylprop-2-en-1-one derivatives for treating liver disorders |
| US10722575B2 (en) | 2009-11-26 | 2020-07-28 | Genfit | Use of 1,3-diphenylprop-2-en-1-one derivatives for treating liver disorders |
| WO2011080276A1 (en) | 2009-12-29 | 2011-07-07 | Genfit | Pharmaceutical combinations comprising a dpp-4 inhibitor and a 1,3-diphenylprop-2-en-1-one derivative |
| SI2571843T1 (en) | 2010-05-17 | 2018-04-30 | Genfit | Improved preparation of calcium derivatives |
| WO2012007365A1 (en) * | 2010-07-12 | 2012-01-19 | F. Hoffmann-La Roche Ag | 1-hydroxyimino-3-phenyl-propanes |
| EP2780330B1 (en) * | 2011-11-14 | 2016-01-06 | F.Hoffmann-La Roche Ag | 1-pyridazinyl-hydroxyimino- 3- phenyl- propanes as gpbar1 agonists |
| SG11201403107TA (en) * | 2011-12-28 | 2014-09-26 | Genfit | 1,3-diphenylpropane derivatives, preparations and uses thereof |
| EP3416629A4 (en) * | 2016-02-16 | 2019-08-07 | CoNCERT Pharmaceuticals, Inc. | DEUTERATED GFT-505 |
| US12053445B2 (en) | 2016-03-31 | 2024-08-06 | Genfit | Methods of treatment of cholestatic diseases |
| IT201600098338A1 (it) * | 2016-09-30 | 2018-03-30 | Univ Degli Studi Padova | Composti 1-fenilpropanone e loro impiego |
| RU186145U1 (ru) * | 2018-08-08 | 2019-01-11 | Общество с ограниченной ответственностью "Научно-производственное объединение "Центротех" (ООО "НПО "Центротех") | Каркас виброрамы вибросита |
| US11634387B2 (en) | 2019-09-26 | 2023-04-25 | Abionyx Pharma Sa | Compounds useful for treating liver diseases |
| KR20220140762A (ko) | 2020-02-10 | 2022-10-18 | 장피트 | 엘라피브라노에 의한 원발 담즙성 담관염의 치료 |
| CN114901641B (zh) * | 2020-02-28 | 2025-06-17 | 四川科伦博泰生物医药股份有限公司 | 芳香族化合物及其药物组合物和用途 |
| AU2021275381A1 (en) | 2020-05-18 | 2022-11-24 | Genfit | Elafibranor for the treatment of primary sclerosing cholangitis |
| WO2022043367A1 (en) | 2020-08-26 | 2022-03-03 | Genfit | Compositions and methods for the treatment of primary biliary cholangitis |
| EP4337184A1 (en) | 2021-05-11 | 2024-03-20 | Genfit | Ppar-agonists for use in the treatment of liver failure |
| WO2022238451A1 (en) | 2021-05-11 | 2022-11-17 | Genfit | Elafibranor and 2-[2,6-dimethyl-4-[3-[4-(methylthio)phenyl]-3-oxo-propyl] phenoxy]-2-methylpropanoic acid analog as ppar-agonists for use in the treatment of sepsis |
| TW202527918A (zh) | 2023-10-13 | 2025-07-16 | 法商Genfit公司 | 原發性膽汁性膽管炎之治療方法 |
| WO2025088067A1 (en) | 2023-10-25 | 2025-05-01 | Genfit | Elafibranor for the treatment of primary biliary cholangitis |
| WO2025215081A1 (en) | 2024-04-09 | 2025-10-16 | Genfit | Elafibranor for use for long-term treatment of primary biliary cholangitis |
| WO2026047132A1 (en) | 2024-08-29 | 2026-03-05 | Genfit | Treatment of advanced primary biliary cholangitis |
| CN119490528A (zh) * | 2025-01-17 | 2025-02-21 | 山东第一医科大学附属肿瘤医院(山东省肿瘤防治研究院、山东省肿瘤医院) | 一种HSP90α选择性抑制剂及其合成方法和应用 |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN87104753A (zh) * | 1986-07-11 | 1988-06-15 | 奇诺英药物化学工厂有限公司 | 制备新的联二苯正丙胺衍生物及其盐的方法 |
| DE4121849A1 (de) * | 1991-07-02 | 1993-01-14 | Rhone Poulenc Rorer Gmbh | (4-((omega)-arylalkyl)-phenyl)alkansaeuren, ihre salze und/oder ihre derivate |
| CA2169187A1 (en) * | 1993-08-14 | 1995-02-23 | Ernst-Christian Witte | Use of phenols and phenol derivatives as pharmaceutical agents with a fibrinogen-lowering action |
| CN1373745A (zh) * | 1999-07-16 | 2002-10-09 | 格吕伦塔尔有限公司 | 3-氨基-2-苄基-1-苯基丙烷衍生物 |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2149070C3 (de) | 1971-10-01 | 1978-03-23 | Boehringer Mannheim Gmbh, 6800 Mannheim | Phenoxyalkylcarbonsäurederivate und deren Salze, Verfahren zu deren Herstellung und Arzneimittel |
| NZ515086A (en) * | 1999-04-28 | 2003-10-31 | Aventis Pharma Gmbh | Di-aryl acid derivatives as PPAR receptor ligands |
| FR2841900B1 (fr) | 2002-07-08 | 2007-03-02 | Genfit S A | Nouveaux derives de 1,3-diphenylprop-2-en-1-one substitues, preparation et utilisations |
| AU2004283147A1 (en) * | 2003-10-28 | 2005-05-06 | Dr. Reddy's Laboratories Ltd. | Novel compounds and their use in medicine: process for their preparation and pharmaceutical compositions containing them |
| MY147518A (en) * | 2004-09-15 | 2012-12-31 | Janssen Pharmaceutica Nv | 4-((phenoxyalkyl)thio)-phenoxyacetic acids and analogs |
| FR2902789A1 (fr) | 2006-06-21 | 2007-12-28 | Genfit Sa | Derives de 1,3-diphenylpropane substitues, preparations et utilisations |
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2006
- 2006-06-21 FR FR0605540A patent/FR2902789A1/fr not_active Withdrawn
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2007
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- 2007-06-21 WO PCT/EP2007/056224 patent/WO2007147879A1/fr not_active Ceased
- 2007-06-21 US US12/308,580 patent/US8258182B2/en active Active
- 2007-06-21 AU AU2007262938A patent/AU2007262938B2/en active Active
- 2007-06-21 WO PCT/EP2007/056225 patent/WO2007147880A1/fr not_active Ceased
- 2007-06-21 PL PL07730296T patent/PL2046715T3/pl unknown
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Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN87104753A (zh) * | 1986-07-11 | 1988-06-15 | 奇诺英药物化学工厂有限公司 | 制备新的联二苯正丙胺衍生物及其盐的方法 |
| DE4121849A1 (de) * | 1991-07-02 | 1993-01-14 | Rhone Poulenc Rorer Gmbh | (4-((omega)-arylalkyl)-phenyl)alkansaeuren, ihre salze und/oder ihre derivate |
| CA2169187A1 (en) * | 1993-08-14 | 1995-02-23 | Ernst-Christian Witte | Use of phenols and phenol derivatives as pharmaceutical agents with a fibrinogen-lowering action |
| CN1373745A (zh) * | 1999-07-16 | 2002-10-09 | 格吕伦塔尔有限公司 | 3-氨基-2-苄基-1-苯基丙烷衍生物 |
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| Synthesis and Hypolipidemic Activity of %-SubstitutedI sobutyric Acid Derivatives;Shin-ichi Morishita等;《J.Med.Chem.》;19881231;第31卷;第1206页table1 * |
| w-[(w-Arylalkyl)aryl]alkanoic Acids: A New Class of Specific LTA4 Hydrolase Inhibitors;Richard Labaudinikre等;《J.Med.Chem》;19921231;第35卷;全文 * |
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