DK2046716T3 - Substituerede 1,3-diphenylpropanderivater, fremstilling og anvendelser deraf - Google Patents

Substituerede 1,3-diphenylpropanderivater, fremstilling og anvendelser deraf

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Publication number
DK2046716T3
DK2046716T3 DK07786798.4T DK07786798T DK2046716T3 DK 2046716 T3 DK2046716 T3 DK 2046716T3 DK 07786798 T DK07786798 T DK 07786798T DK 2046716 T3 DK2046716 T3 DK 2046716T3
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Denmark
Prior art keywords
propander
diphenyl
derivatives
substituted
applications
Prior art date
Application number
DK07786798.4T
Other languages
English (en)
Inventor
Karine Caumont-Bertrand
Remy Hanf
Jean-Franacois Delhomel
Original Assignee
Genfit
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Filing date
Publication date
Application filed by Genfit filed Critical Genfit
Application granted granted Critical
Publication of DK2046716T3 publication Critical patent/DK2046716T3/da

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    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/52—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
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    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/76—Unsaturated compounds containing keto groups
    • C07C59/84—Unsaturated compounds containing keto groups containing six membered aromatic rings
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid 
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    • C07C251/34—Oximes with oxygen atoms of oxyimino groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
    • C07C251/48—Oximes with oxygen atoms of oxyimino groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals with the carbon atom of at least one of the oxyimino groups bound to a carbon atom of a six-membered aromatic ring
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    • C07C323/18—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton
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    • C07C323/22—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and doubly-bound oxygen atoms bound to the same carbon skeleton
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    • C07C323/23—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
    • C07C323/45—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having at least one of the nitrogen atoms doubly-bound to the carbon skeleton
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    • C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/62—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton
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    • C07C59/40—Unsaturated compounds
    • C07C59/58—Unsaturated compounds containing ether groups, groups, groups, or groups
    • C07C59/64—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings
    • C07C59/66—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings the non-carboxylic part of the ether containing six-membered aromatic rings
    • C07C59/68—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings the non-carboxylic part of the ether containing six-membered aromatic rings the oxygen atom of the ether group being bound to a non-condensed six-membered aromatic ring
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    • C07C59/40—Unsaturated compounds
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    • C07C69/73—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids
    • C07C69/734—Ethers
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    • C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
    • C07C69/73—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids
    • C07C69/734—Ethers
    • C07C69/736—Ethers the hydroxy group of the ester being etherified with a hydroxy compound having the hydroxy group bound to a carbon atom of a six-membered aromatic ring
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/28—Radicals substituted by singly-bound oxygen or sulphur atoms
    • C07D213/30—Oxygen atoms
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D335/00—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom
    • C07D335/04—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D335/06—Benzothiopyrans; Hydrogenated benzothiopyrans
DK07786798.4T 2006-06-21 2007-06-21 Substituerede 1,3-diphenylpropanderivater, fremstilling og anvendelser deraf DK2046716T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0605540A FR2902789A1 (fr) 2006-06-21 2006-06-21 Derives de 1,3-diphenylpropane substitues, preparations et utilisations
PCT/EP2007/056225 WO2007147880A1 (fr) 2006-06-21 2007-06-21 Derives de 1,3-diphenylpropane substitues, preparations et utilisations

Publications (1)

Publication Number Publication Date
DK2046716T3 true DK2046716T3 (da) 2013-11-04

Family

ID=37845179

Family Applications (2)

Application Number Title Priority Date Filing Date
DK07730296.6T DK2046715T5 (da) 2006-06-21 2007-06-21 Substituerede 1,3-diphenylpropanderivater, præparater og anvendelser deraf
DK07786798.4T DK2046716T3 (da) 2006-06-21 2007-06-21 Substituerede 1,3-diphenylpropanderivater, fremstilling og anvendelser deraf

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DK07730296.6T DK2046715T5 (da) 2006-06-21 2007-06-21 Substituerede 1,3-diphenylpropanderivater, præparater og anvendelser deraf

Country Status (22)

Country Link
US (2) US8258182B2 (da)
EP (2) EP2046715B1 (da)
JP (2) JP5350230B2 (da)
KR (2) KR101416262B1 (da)
CN (3) CN104193660B (da)
AU (2) AU2007262938B2 (da)
BR (1) BRPI0713600B1 (da)
CA (2) CA2655744C (da)
CY (2) CY1115082T1 (da)
DK (2) DK2046715T5 (da)
EA (1) EA018437B1 (da)
ES (2) ES2434071T3 (da)
FR (1) FR2902789A1 (da)
IL (2) IL196071A0 (da)
MX (1) MX2008016239A (da)
NO (1) NO341866B1 (da)
NZ (1) NZ573674A (da)
PL (2) PL2046716T3 (da)
PT (2) PT2046716E (da)
SI (2) SI2046716T1 (da)
WO (2) WO2007147880A1 (da)
ZA (1) ZA200810709B (da)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2902789A1 (fr) * 2006-06-21 2007-12-28 Genfit Sa Derives de 1,3-diphenylpropane substitues, preparations et utilisations
FR2917084B1 (fr) * 2007-06-05 2009-07-17 Galderma Res & Dev Nouveaux derives d'acide 3-phenyl propanoique activateurs des recpteurs de type ppar, leur methode de preparation et leur utilisation dans des compositions cosmetiques ou pharmaceutiques.
US9221751B2 (en) 2009-11-26 2015-12-29 Genfit Use of 1,3-diphenylprop-2-en-1-one derivatives for treating liver disorders
CN102647982B (zh) * 2009-11-26 2014-10-15 基恩菲特公司 使用1,3-二苯基丙-2-烯-1-酮衍生物治疗肝脏疾患
US10722575B2 (en) 2009-11-26 2020-07-28 Genfit Use of 1,3-diphenylprop-2-en-1-one derivatives for treating liver disorders
WO2011080276A1 (en) 2009-12-29 2011-07-07 Genfit Pharmaceutical combinations comprising a dpp-4 inhibitor and a 1,3-diphenylprop-2-en-1-one derivative
NZ603371A (en) 2010-05-17 2013-12-20 Genfit Improved preparation of chalcone derivatives
EP2593426B1 (en) * 2010-07-12 2014-08-20 F.Hoffmann-La Roche Ag 1-hydroxyimino-3-phenyl-propanes
EP2780330B1 (en) * 2011-11-14 2016-01-06 F.Hoffmann-La Roche Ag 1-pyridazinyl-hydroxyimino- 3- phenyl- propanes as gpbar1 agonists
KR102023667B1 (ko) * 2011-12-28 2019-09-23 장피트 1,3-디페닐프로판 유도체, 그 제조 및 용도
EP3416629A4 (en) * 2016-02-16 2019-08-07 CoNCERT Pharmaceuticals, Inc. DEUTERATED GFT-505
IT201600098338A1 (it) * 2016-09-30 2018-03-30 Univ Degli Studi Padova Composti 1-fenilpropanone e loro impiego
RU186145U1 (ru) * 2018-08-08 2019-01-11 Общество с ограниченной ответственностью "Научно-производственное объединение "Центротех" (ООО "НПО "Центротех") Каркас виброрамы вибросита
US11634387B2 (en) 2019-09-26 2023-04-25 Abionyx Pharma Sa Compounds useful for treating liver diseases
BR112022015800A2 (pt) 2020-02-10 2022-10-11 Genfit Tratamento de colangite biliar primária com elafibranor
CN114901641A (zh) * 2020-02-28 2022-08-12 四川科伦博泰生物医药股份有限公司 芳香族化合物及其药物组合物和用途
MX2022014364A (es) 2020-05-18 2022-12-15 Genfit Elafibranor para el tratamiento de la colangitis esclerosante primaria.
MX2023002159A (es) 2020-08-26 2023-03-01 Genfit Composiciones y metodos para el tratamiento de la colangitis biliar primaria.
WO2022238450A1 (en) 2021-05-11 2022-11-17 Genfit Ppar-agonists for use in the treatment of liver failure
WO2022238448A1 (en) 2021-05-11 2022-11-17 Genfit Elafibranor derivatives agonists of ppar for use in the treatment of sepsis

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2149070C3 (de) 1971-10-01 1978-03-23 Boehringer Mannheim Gmbh, 6800 Mannheim Phenoxyalkylcarbonsäurederivate und deren Salze, Verfahren zu deren Herstellung und Arzneimittel
HU200591B (en) * 1986-07-11 1990-07-28 Chinoin Gyogyszer Es Vegyeszet Process for producing new diphenyl propylamine derivatives and pharmaceutical compositions comprising such compounds
DE4121849A1 (de) * 1991-07-02 1993-01-14 Rhone Poulenc Rorer Gmbh (4-((omega)-arylalkyl)-phenyl)alkansaeuren, ihre salze und/oder ihre derivate
DE4327365A1 (de) * 1993-08-14 1995-02-16 Boehringer Mannheim Gmbh Verwendung von Phenolen und Phenolderivaten als Arzneimittel mit fibrinogensenkender Wirkung
EE200100556A (et) * 1999-04-28 2003-02-17 Aventis Pharma Deutschland Gmbh Diarüülhappe derivaat, seda sisaldav farmatseutiline kompositsioon ja ühendi kasutamine ravimite valmistamiseks
DE19933421A1 (de) * 1999-07-16 2001-01-25 Gruenenthal Gmbh 2-Benzyl-3-dimethylamino-1-phenyl-propanderi- vate
FR2841900B1 (fr) 2002-07-08 2007-03-02 Genfit S A Nouveaux derives de 1,3-diphenylprop-2-en-1-one substitues, preparation et utilisations
CN1867546A (zh) * 2003-10-28 2006-11-22 雷迪实验室有限公司 新颖化合物及其在药物中的用途、其制备方法以及含有它们的药物组合物
MY147518A (en) * 2004-09-15 2012-12-31 Janssen Pharmaceutica Nv 4-((phenoxyalkyl)thio)-phenoxyacetic acids and analogs
FR2902789A1 (fr) * 2006-06-21 2007-12-28 Genfit Sa Derives de 1,3-diphenylpropane substitues, preparations et utilisations

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BRPI0713600A2 (pt) 2012-11-06
AU2007262938A1 (en) 2007-12-27
DK2046715T5 (da) 2014-07-28
FR2902789A1 (fr) 2007-12-28
CN101506139A (zh) 2009-08-12
CA2655744C (fr) 2016-03-22
CA2655643A1 (fr) 2007-12-27
CN101506139B (zh) 2012-10-10
KR20090035535A (ko) 2009-04-09
EA200900044A1 (ru) 2009-06-30
EP2046716B1 (fr) 2013-08-14
SI2046715T1 (sl) 2014-08-29
KR101416257B1 (ko) 2014-07-16
JP2009541269A (ja) 2009-11-26
PT2046715E (pt) 2014-05-26
ZA200810709B (en) 2009-12-30
JP5350230B2 (ja) 2013-11-27
IL196071A0 (en) 2009-09-01
AU2007262939B2 (en) 2012-04-05
PL2046715T3 (pl) 2014-07-31
KR101416262B1 (ko) 2014-07-16
EA018437B1 (ru) 2013-08-30
JP5350231B2 (ja) 2013-11-27
NO20085338L (no) 2009-03-23
US20110136888A1 (en) 2011-06-09
US8258182B2 (en) 2012-09-04
KR20090059105A (ko) 2009-06-10
US20100286276A1 (en) 2010-11-11
NZ573674A (en) 2012-02-24
CA2655744A1 (fr) 2007-12-27
MX2008016239A (es) 2009-02-25
SI2046716T1 (sl) 2014-02-28
ES2434071T3 (es) 2013-12-13
DK2046715T3 (da) 2014-06-02
BRPI0713600B1 (pt) 2021-07-13
CN104193660A (zh) 2014-12-10
CN104193660B (zh) 2018-10-19
JP2009541270A (ja) 2009-11-26
IL196057A0 (en) 2009-09-01
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PT2046716E (pt) 2013-11-11
CY1115414T1 (el) 2017-01-04
IL196057A (en) 2012-07-31
EP2046716A1 (fr) 2009-04-15
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ES2466268T3 (es) 2014-06-09
WO2007147879A1 (fr) 2007-12-27
EP2046715A1 (fr) 2009-04-15
AU2007262939A1 (en) 2007-12-27
PL2046716T3 (pl) 2014-03-31
CY1115082T1 (el) 2016-12-14
US8188148B2 (en) 2012-05-29
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