CN114901641A - 芳香族化合物及其药物组合物和用途 - Google Patents
芳香族化合物及其药物组合物和用途 Download PDFInfo
- Publication number
- CN114901641A CN114901641A CN202180007741.0A CN202180007741A CN114901641A CN 114901641 A CN114901641 A CN 114901641A CN 202180007741 A CN202180007741 A CN 202180007741A CN 114901641 A CN114901641 A CN 114901641A
- Authority
- CN
- China
- Prior art keywords
- compound
- stereoisomer
- pharmaceutically acceptable
- polymorph
- metabolite
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/20—Oxygen atoms
- C07D215/22—Oxygen atoms attached in position 2 or 4
- C07D215/227—Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 2
Abstract
本申请公开了一种芳香族化合物及其药物组合物的用途，含有所述化合物的药物组合物，以及该类化合物及其中间体的制备方法。本申请还公开了所述化合物用于制备预防或治疗肝脏疾病和/或胆管疾病相关疾病或病症的药物用途。
Description
PCT国内申请，说明书已公开。
Claims (19)
- PCT国内申请，权利要求书已公开。
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202010130024 | 2020-02-28 | ||
| CN2020101300244 | 2020-02-28 | ||
| PCT/CN2021/075433 WO2021169769A1 (zh) | 2020-02-28 | 2021-02-05 | 芳香族化合物及其药物组合物和用途 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN114901641A true CN114901641A (zh) | 2022-08-12 |
Family
ID=77490664
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202180007741.0A Pending CN114901641A (zh) | 2020-02-28 | 2021-02-05 | 芳香族化合物及其药物组合物和用途 |
Country Status (2)
| Country | Link |
|---|---|
| CN (1) | CN114901641A (zh) |
| WO (1) | WO2021169769A1 (zh) |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1177187B1 (en) * | 1999-04-28 | 2007-07-25 | Sanofi-Aventis Deutschland GmbH | Di-aryl acid derivatives as ppar receptor ligands |
| AU2003207808A1 (en) * | 2002-02-21 | 2003-09-09 | Eli Lilly And Company | Peroxisome proliferator activated receptor modulators |
| ITRM20020629A1 (it) * | 2002-12-19 | 2004-06-20 | Sigma Tau Ind Farmaceuti | Uso di acidi alfa-feniltiocarbossilici e alfa-fenilossicarbossilici ad attivita' ipoglicemizzante e/o ipolipidemizzante. |
| WO2005040102A2 (en) * | 2003-10-28 | 2005-05-06 | Dr. Reddy's Laboratories Ltd. | Novel compounds and their use as antidiabetic and hypolipidemic agents, process for their preparation and pharmaceutical compositions containing them |
| FR2902789A1 (fr) * | 2006-06-21 | 2007-12-28 | Genfit Sa | Derives de 1,3-diphenylpropane substitues, preparations et utilisations |
| FR2910893A1 (fr) * | 2006-12-29 | 2008-07-04 | Genfit Sa | Derives de (phenylthiazolyl)-phenyl-propan-1-one et de (phenyloxazolyl)-phenyl-propan-1-one substitues, preparations et utilisations. |
| FR2910892A1 (fr) * | 2006-12-29 | 2008-07-04 | Genfit Sa | Derives de 1,3-diphenylpropane substitues, preparations et utilisations. |
| FR2910894A1 (fr) * | 2006-12-29 | 2008-07-04 | Genfit Sa | Derives de 3-phenyl-1-(phenylthienyl)propan-1-one et de 3-phenyl-1-(phenylfuranyl)propan-1-one substitues, preparation et utilisation. |
| WO2019105234A1 (zh) * | 2017-11-30 | 2019-06-06 | 四川科伦博泰生物医药股份有限公司 | 芳香族化合物及其药物组合物和用途 |
-
2021
- 2021-02-05 CN CN202180007741.0A patent/CN114901641A/zh active Pending
- 2021-02-05 WO PCT/CN2021/075433 patent/WO2021169769A1/zh active Application Filing
Also Published As
| Publication number | Publication date |
|---|---|
| WO2021169769A1 (zh) | 2021-09-02 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination |