NO345062B1 - 4-fenyl-6-(2,2,2-trifluor-1-fenyletoksy) pyrimidinbaserte forbindelser og anvendelse derav - Google Patents
4-fenyl-6-(2,2,2-trifluor-1-fenyletoksy) pyrimidinbaserte forbindelser og anvendelse deravInfo
- Publication number
- NO345062B1 NO345062B1 NO20092639A NO20092639A NO345062B1 NO 345062 B1 NO345062 B1 NO 345062B1 NO 20092639 A NO20092639 A NO 20092639A NO 20092639 A NO20092639 A NO 20092639A NO 345062 B1 NO345062 B1 NO 345062B1
- Authority
- NO
- Norway
- Prior art keywords
- phenylethoxy
- trifluoro
- pyrimidine
- phenyl
- based compounds
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
- A61K31/4152—1,2-Diazoles having oxo groups directly attached to the heterocyclic ring, e.g. antipyrine, phenylbutazone, sulfinpyrazone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/06—Anti-spasmodics, e.g. drugs for colics, esophagic dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/10—Laxatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/12—Antidiarrhoeals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/34—One oxygen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Epidemiology (AREA)
- Pulmonology (AREA)
- Diabetes (AREA)
- Pain & Pain Management (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Anesthesiology (AREA)
- Emergency Medicine (AREA)
- Physical Education & Sports Medicine (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Otolaryngology (AREA)
- Gastroenterology & Hepatology (AREA)
- Dermatology (AREA)
- Endocrinology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US87459606P | 2006-12-12 | 2006-12-12 | |
PCT/US2007/087068 WO2008073933A2 (en) | 2006-12-12 | 2007-12-11 | 4-phenyl-6-(2,2,2-trifluoro-1-phenylethoxy)pyrimidine-based compounds and methods of their use |
Publications (2)
Publication Number | Publication Date |
---|---|
NO20092639L NO20092639L (no) | 2009-09-11 |
NO345062B1 true NO345062B1 (no) | 2020-09-14 |
Family
ID=39432875
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO20092639A NO345062B1 (no) | 2006-12-12 | 2009-07-10 | 4-fenyl-6-(2,2,2-trifluor-1-fenyletoksy) pyrimidinbaserte forbindelser og anvendelse derav |
NO2021010C NO2021010I1 (no) | 2006-12-12 | 2021-03-01 | telostritat ethyl |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO2021010C NO2021010I1 (no) | 2006-12-12 | 2021-03-01 | telostritat ethyl |
Country Status (25)
Country | Link |
---|---|
US (4) | US7553840B2 (no) |
EP (4) | EP2091940B3 (no) |
JP (1) | JP5361734B2 (no) |
KR (1) | KR101464391B1 (no) |
AR (1) | AR064279A1 (no) |
AU (1) | AU2007333120B2 (no) |
BR (1) | BRPI0720270B8 (no) |
CA (1) | CA2672233C (no) |
CO (1) | CO6220855A2 (no) |
DK (2) | DK3176159T3 (no) |
EA (1) | EA018150B1 (no) |
EC (1) | ECSP099413A (no) |
ES (3) | ES2562775T7 (no) |
HU (3) | HUE053098T2 (no) |
IL (2) | IL198806A (no) |
MX (1) | MX2009006195A (no) |
NL (1) | NL300929I2 (no) |
NO (2) | NO345062B1 (no) |
NZ (1) | NZ577004A (no) |
PL (2) | PL2091940T6 (no) |
PT (2) | PT2091940E (no) |
TW (1) | TWI412365B (no) |
UA (1) | UA99270C2 (no) |
WO (1) | WO2008073933A2 (no) |
ZA (1) | ZA200903367B (no) |
Families Citing this family (40)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7897763B2 (en) * | 2005-12-29 | 2011-03-01 | Lexicon Pharmaceuticals, Inc. | Process for the preparation of substituted phenylalanines |
US7855291B2 (en) * | 2005-12-29 | 2010-12-21 | Lexicon Pharmaceuticals, Inc. | Process for the preparation of substituted phenylalanines |
WO2007089335A2 (en) * | 2005-12-29 | 2007-08-09 | Lexicon Pharmaceutical Inc. | Multicyclic amino acid derivatives and methods of their use |
UA99270C2 (en) * | 2006-12-12 | 2012-08-10 | Лексикон Фармасьютикалз, Инк. | 4-phenyl-6-(2,2,2-trifluoro-1-phenylethoxy)pyrimidine-based compounds and methods of their use |
US20090005381A1 (en) | 2007-06-26 | 2009-01-01 | Philip Manton Brown | Methods of treating serotonin-mediated diseases and disorders |
KR20150038726A (ko) * | 2007-06-26 | 2015-04-08 | 렉시컨 파마슈티컬스 인코퍼레이티드 | 트립토판 히드록실라제 억제제를 포함하는 조성물 |
WO2009009561A1 (en) * | 2007-07-11 | 2009-01-15 | Lexicon Pharmaceuticals, Inc. | Methods and compositions for treating pulmonary hypertension and related diseases and disorders |
CA2694443A1 (en) * | 2007-07-26 | 2009-01-29 | Lexicon Pharmaceuticals, Inc. | Methods of affecting gastrointestinal transit and gastric emptying, and compounds useful therein |
WO2009029499A1 (en) * | 2007-08-24 | 2009-03-05 | Lexicon Pharmaceuticals, Inc. | Methods of preparing 4-phenyl-6-(2,2,2-trifluoro-1-phenylethoxy)pyrimidine-based compounds |
TWI439457B (zh) | 2007-09-28 | 2014-06-01 | Lexicon Pharmaceuticals Inc | (s)-2-胺基-3-(4-(2-胺基-6-((r)-1-(4-氯-2-(3-甲基-1h-吡唑-1-基)苯基)-2,2,2-三氟乙氧)-嘧啶-4-基)苯基)丙酸乙酯之固體形式與其使用方法 |
TW200932729A (en) * | 2007-10-08 | 2009-08-01 | Lexicon Pharmaceuticals Inc | Solid forms of (S)-2-amino-3-(4-(2-amino-6-((R)-2,2,2-trifluoro-1-(3'-methoxybiphenyl-4-yl)ethoxy)pyrimidin-4-yl)phenyl)propanoic acid and methods of their use |
BRPI0908719A2 (pt) * | 2008-03-31 | 2015-08-18 | Univ Columbia | Metodos de diagnóstico, prevenção e tratamento de doenças de massa óssea |
EP2358685A1 (en) * | 2008-10-24 | 2011-08-24 | Lexicon Pharmaceuticals, Inc. | Process for the preparation of substituted phenylalanines |
WO2010056992A1 (en) * | 2008-11-13 | 2010-05-20 | The Trustees Of Columbia University In The City Of New York | Methods of preventing and treating low bone mass diseases |
WO2010065333A1 (en) * | 2008-12-01 | 2010-06-10 | Lexicon Pharmaceuticals, Inc. | 4-phenyl-6-(2,2,2-trifluoro-1-phenylethoxy)pyrimidine-based compounds for the treatment of osteoporosis |
WO2011053977A1 (en) | 2009-11-02 | 2011-05-05 | The Trustees Of Columbia University In The City Of New York | Compounds and methods for inhibiting serotonin synthesis |
EP2496231A1 (en) | 2009-11-05 | 2012-09-12 | Lexicon Pharmaceuticals, Inc. | Tryptophan hydroxylase inhibitors for the treatment of cancer |
EP2501684A2 (en) | 2009-11-19 | 2012-09-26 | Lexicon Pharmaceuticals, Inc. | Process for the preparation of substituted phenylalanines |
US20120077831A1 (en) * | 2009-11-23 | 2012-03-29 | Philip Manton Brown | Methods and assays for the treatment of irritable bowel syndrome |
JP2013511544A (ja) | 2009-11-23 | 2013-04-04 | レクシコン ファーマシューティカルズ インコーポレイテッド | 過敏性腸症候群を治療するための方法及びアッセイ |
CA2789229A1 (en) | 2010-02-10 | 2011-08-18 | Lexicon Pharmaceuticals, Inc. | Tryptophan hydroxylase inhibitors for the treatment of metastatic bone disease |
WO2012009372A2 (en) * | 2010-07-12 | 2012-01-19 | Colorado State University Research Foundation | Triazolium carbene catalysts and processes for asymmetric carbon-carbon bond formation |
US20130338176A1 (en) * | 2010-10-29 | 2013-12-19 | The Trustees Of Columbia University In The City Of New York | Methods of preventing and treating hyperlipidemia or atherosclerosis |
TW201245183A (en) | 2010-11-05 | 2012-11-16 | Lexicon Pharmaceuticals Inc | Solid forms of (S)-2-amino-3-(4-(2-amino-6-((R)-1-(4-chloro-2-(3-methyl-1H-pyrazol-1-yl)phenyl)-2,2,2-trifluoroethoxy)pyrimidin-4-yl)phenyl)propanoic acid |
JP2012156602A (ja) * | 2011-01-21 | 2012-08-16 | Ricoh Co Ltd | 情報処理装置、通信制御方法、及び通信制御システム |
KR101682417B1 (ko) * | 2011-02-25 | 2016-12-06 | 주식회사유한양행 | 다이아미노피리미딘 유도체 및 그의 제조방법 |
AU2012326383B2 (en) | 2011-10-17 | 2017-07-27 | Tersera Therapeutics Llc | Solid dosage forms of (S)-ethyl 2-amino-3-(4-(2-amino-6-((R)-1-(4-chloro-2-(3-methyl-1H-pyrazol-1-yl)phenyl)-2,2,2-trifluoroethoxy)pyrimidin-4-yl)phenyl)propanoate |
WO2013148978A1 (en) | 2012-03-30 | 2013-10-03 | Lexicon Pharmaceuticals, Inc. | Methods and compositions for the treatment of necrotizing enterocolitis |
WO2014195847A2 (en) | 2013-06-03 | 2014-12-11 | Actelion Pharmaceuticals Ltd | Novel use of stable isotope labeled l-tryptophan |
UA119247C2 (uk) | 2013-09-06 | 2019-05-27 | РОЙВЕНТ САЙЕНСИЗ ҐмбГ | Спіроциклічні сполуки як інгібітори триптофангідроксилази |
AR098436A1 (es) * | 2013-11-19 | 2016-05-26 | Actelion Pharmaceuticals Ltd | Compuestos tricíclicos de piperidina |
WO2015075025A1 (en) | 2013-11-19 | 2015-05-28 | Actelion Pharmaceuticals Ltd | Tricyclic imidazole compounds as inhibitors of tryptophan hydroxylase |
US9611201B2 (en) | 2015-03-05 | 2017-04-04 | Karos Pharmaceuticals, Inc. | Processes for preparing (R)-1-(5-chloro-[1,1′-biphenyl]-2-yl)-2,2,2-trifluoroethanol and 1-(5-chloro-[1,1′-biphenyl]-2-yl)-2,2,2-trifluoroethanone |
US20180155344A1 (en) * | 2015-05-04 | 2018-06-07 | Actelion Pharmaceuticals Ltd | Tricyclic piperidine compounds |
WO2018060949A1 (en) | 2016-09-30 | 2018-04-05 | Roivant Sciences Gmbh | Tryptophan hydroxylase inhibitors for use in the treatment of liver diseases |
PE20210641A1 (es) | 2018-03-08 | 2021-03-23 | Incyte Corp | COMPUESTOS DIOLICOS DE AMINOPIRAZINA COMO INHIBIDORES DE PI3K-y |
US11046658B2 (en) | 2018-07-02 | 2021-06-29 | Incyte Corporation | Aminopyrazine derivatives as PI3K-γ inhibitors |
CN109180650A (zh) * | 2018-08-28 | 2019-01-11 | 湖南华腾制药有限公司 | 一种氘代色氨酸羟化酶抑制剂的晶型 |
CN109020958A (zh) * | 2018-08-28 | 2018-12-18 | 湖南华腾制药有限公司 | 一种氘代色氨酸羟化酶抑制剂 |
WO2023192003A1 (en) | 2022-04-01 | 2023-10-05 | Tersera Therapeutics Llc | Methods of reducing the likelihood of carcinoid heart disease in patients with neuroendocrine tumors |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2007089335A2 (en) * | 2005-12-29 | 2007-08-09 | Lexicon Pharmaceutical Inc. | Multicyclic amino acid derivatives and methods of their use |
Family Cites Families (28)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5145684A (en) | 1991-01-25 | 1992-09-08 | Sterling Drug Inc. | Surface modified drug nanoparticles |
AU660852B2 (en) | 1992-11-25 | 1995-07-06 | Elan Pharma International Limited | Method of grinding pharmaceutical substances |
TW384224B (en) | 1994-05-25 | 2000-03-11 | Nano Sys Llc | Method of preparing submicron particles of a therapeutic or diagnostic agent |
US5718388A (en) | 1994-05-25 | 1998-02-17 | Eastman Kodak | Continuous method of grinding pharmaceutical substances |
US5665331A (en) | 1995-01-10 | 1997-09-09 | Nanosystems L.L.C. | Co-microprecipitation of nanoparticulate pharmaceutical agents with crystal growth modifiers |
US5662883A (en) | 1995-01-10 | 1997-09-02 | Nanosystems L.L.C. | Microprecipitation of micro-nanoparticulate pharmaceutical agents |
US5534270A (en) | 1995-02-09 | 1996-07-09 | Nanosystems Llc | Method of preparing stable drug nanoparticles |
US5510118A (en) | 1995-02-14 | 1996-04-23 | Nanosystems Llc | Process for preparing therapeutic compositions containing nanoparticles |
US5543133A (en) | 1995-02-14 | 1996-08-06 | Nanosystems L.L.C. | Process of preparing x-ray contrast compositions containing nanoparticles |
US5718919A (en) | 1995-02-24 | 1998-02-17 | Nanosystems L.L.C. | Nanoparticles containing the R(-)enantiomer of ibuprofen |
US5834025A (en) | 1995-09-29 | 1998-11-10 | Nanosystems L.L.C. | Reduction of intravenously administered nanoparticulate-formulation-induced adverse physiological reactions |
US5958957A (en) | 1996-04-19 | 1999-09-28 | Novo Nordisk A/S | Modulators of molecules with phosphotyrosine recognition units |
WO2000072973A1 (en) | 1999-06-01 | 2000-12-07 | Elan Pharma International Ltd. | Small-scale mill and method thereof |
AU2001273040A1 (en) | 2000-06-27 | 2002-01-08 | Du Pont Pharmaceuticals Company | Factor xa inhibitors |
DE10112768A1 (de) | 2001-03-16 | 2002-09-19 | Merck Patent Gmbh | Phenylderivate 3 |
US6976647B2 (en) | 2001-06-05 | 2005-12-20 | Elan Pharma International, Limited | System and method for milling materials |
ATE401959T1 (de) | 2001-06-05 | 2008-08-15 | Elan Pharma Int Ltd | Mahlvorrichtung und verfahren zu deren betrieb |
US7206457B2 (en) * | 2001-11-27 | 2007-04-17 | Samsung Electronics Co., Ltd. | Method and apparatus for encoding and decoding key value data of coordinate interpolator |
PT1553927E (pt) | 2002-09-11 | 2010-11-22 | Elan Pharma Int Ltd | Composições de agentes activos em nanopartículas estabilizadas em gel |
WO2004080943A1 (ja) | 2003-03-11 | 2004-09-23 | Ono Pharmaceutical Co., Ltd. | シンナミルアルコール誘導体化合物およびその化合物を有効成分として含有する薬剤 |
US20050234066A1 (en) | 2004-04-15 | 2005-10-20 | Agouron Pharmaceuticals, Inc. | Alpha substituted carboxylic acids |
US20050187266A1 (en) | 2003-04-15 | 2005-08-25 | Pfizer Inc | Alpha substituted carboxylic acids |
CN102584813B (zh) | 2003-05-14 | 2016-07-06 | Ngc药物公司 | 化合物及其在调节淀粉样蛋白β中的用途 |
US20050042177A1 (en) | 2003-07-23 | 2005-02-24 | Elan Pharma International Ltd. | Novel compositions of sildenafil free base |
US7377637B2 (en) * | 2005-10-11 | 2008-05-27 | Synergeyes, Inc. | Hybrid contact lens system and method of fitting |
UA99270C2 (en) * | 2006-12-12 | 2012-08-10 | Лексикон Фармасьютикалз, Инк. | 4-phenyl-6-(2,2,2-trifluoro-1-phenylethoxy)pyrimidine-based compounds and methods of their use |
WO2009029499A1 (en) * | 2007-08-24 | 2009-03-05 | Lexicon Pharmaceuticals, Inc. | Methods of preparing 4-phenyl-6-(2,2,2-trifluoro-1-phenylethoxy)pyrimidine-based compounds |
TWI439457B (zh) * | 2007-09-28 | 2014-06-01 | Lexicon Pharmaceuticals Inc | (s)-2-胺基-3-(4-(2-胺基-6-((r)-1-(4-氯-2-(3-甲基-1h-吡唑-1-基)苯基)-2,2,2-三氟乙氧)-嘧啶-4-基)苯基)丙酸乙酯之固體形式與其使用方法 |
-
2007
- 2007-11-12 UA UAA200907262A patent/UA99270C2/uk unknown
- 2007-12-10 TW TW096147104A patent/TWI412365B/zh active
- 2007-12-11 DK DK16206493.5T patent/DK3176159T3/da active
- 2007-12-11 BR BRPI0720270A patent/BRPI0720270B8/pt active IP Right Grant
- 2007-12-11 ES ES07865487.8T patent/ES2562775T7/es active Active
- 2007-12-11 PL PL07865487T patent/PL2091940T6/pl unknown
- 2007-12-11 ES ES13153803.5T patent/ES2625083T3/es active Active
- 2007-12-11 AR ARP070105537A patent/AR064279A1/es active IP Right Grant
- 2007-12-11 EP EP07865487.8A patent/EP2091940B3/en active Active
- 2007-12-11 PT PT78654878T patent/PT2091940E/pt unknown
- 2007-12-11 ES ES16206493T patent/ES2856871T3/es active Active
- 2007-12-11 ZA ZA200903367A patent/ZA200903367B/xx unknown
- 2007-12-11 EA EA200970575A patent/EA018150B1/ru not_active IP Right Cessation
- 2007-12-11 PT PT162064935T patent/PT3176159T/pt unknown
- 2007-12-11 KR KR1020097012100A patent/KR101464391B1/ko active IP Right Grant
- 2007-12-11 EP EP13153803.5A patent/EP2589600B1/en active Active
- 2007-12-11 NZ NZ577004A patent/NZ577004A/en unknown
- 2007-12-11 DK DK07865487.8T patent/DK2091940T6/en active
- 2007-12-11 WO PCT/US2007/087068 patent/WO2008073933A2/en active Application Filing
- 2007-12-11 CA CA2672233A patent/CA2672233C/en not_active Expired - Fee Related
- 2007-12-11 PL PL16206493T patent/PL3176159T3/pl unknown
- 2007-12-11 HU HUE16206493A patent/HUE053098T2/hu unknown
- 2007-12-11 MX MX2009006195A patent/MX2009006195A/es active IP Right Grant
- 2007-12-11 EP EP20191197.1A patent/EP3808740A1/en not_active Withdrawn
- 2007-12-11 JP JP2009541514A patent/JP5361734B2/ja active Active
- 2007-12-11 AU AU2007333120A patent/AU2007333120B2/en active Active
- 2007-12-11 HU HUE07865487A patent/HUE027896T2/en unknown
- 2007-12-11 US US11/954,000 patent/US7553840B2/en active Active
- 2007-12-11 EP EP16206493.5A patent/EP3176159B1/en active Active
-
2009
- 2009-05-19 IL IL198806A patent/IL198806A/en active IP Right Grant
- 2009-05-20 US US12/468,974 patent/US7709493B2/en active Active
- 2009-06-12 EC EC2009009413A patent/ECSP099413A/es unknown
- 2009-06-12 CO CO09061621A patent/CO6220855A2/es not_active Application Discontinuation
- 2009-07-10 NO NO20092639A patent/NO345062B1/no active Protection Beyond IP Right Term
-
2010
- 2010-04-05 US US12/754,341 patent/US7968559B2/en active Active
-
2011
- 2011-06-17 US US13/162,989 patent/US8772482B2/en active Active
-
2014
- 2014-10-23 IL IL235288A patent/IL235288A/en active IP Right Grant
-
2018
- 2018-02-14 NL NL300929C patent/NL300929I2/nl unknown
- 2018-02-19 HU HUS1800010C patent/HUS1800010I1/hu unknown
-
2021
- 2021-03-01 NO NO2021010C patent/NO2021010I1/no unknown
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2007089335A2 (en) * | 2005-12-29 | 2007-08-09 | Lexicon Pharmaceutical Inc. | Multicyclic amino acid derivatives and methods of their use |
NO20083324L (no) * | 2005-12-29 | 2008-08-13 | Lexicon Pharmaceutical Inc | Multisykliske aminosyrederivater og anvendelse derav |
Non-Patent Citations (1)
Title |
---|
STOKES ALAN H ET AL, "p-Ethynylphenylalanine: A potent inhibitor of tryptophan hydroxylase", JOURNAL OF NEUROCHEMISTRY, (200005), vol. 74, no. 5, ISSN 0022-3042, pages 2067 - 2073, Dated: 01.01.0001 * |
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
NO345062B1 (no) | 4-fenyl-6-(2,2,2-trifluor-1-fenyletoksy) pyrimidinbaserte forbindelser og anvendelse derav | |
DK2079485T3 (da) | Phenylpropionamidforbindelser og anvendelsen deraf | |
DK1996557T3 (da) | Pyridazinon-forbindelse og anvendelse deraf som herbicid | |
DK1954140T3 (da) | Glycerollevulinatketaler og deres anvendelse | |
DK2081929T3 (da) | Substituerede 3-isobutyl-9,10-dimethoxy-1,3,4,6,7,11B-hexahydro-2H-pyrido[2,1-A]isoquinolin-2-ol-forbindelser og fremgangsmåder angående disse | |
DK1894567T3 (da) | Ledsagende farmaceutiske midler og anvendelse deraf | |
DK2069352T3 (da) | Bestemte kemiske enheder, sammensætninger og fremgangsmåder | |
DK1965646T3 (da) | Herbicid sammensætning | |
DK1765327T3 (da) | Forbindelser, sammensætninger og fremgangsmåder | |
DK2001556T3 (da) | Thioninium-forbindelser og anvendelse deraf | |
DK1846445T3 (da) | PYY-agonister og anvendelser deraf | |
ATE469145T1 (de) | 4-ä5-methoxy-6-(2-methyl-6-ä1,2,4ütriazol-1-yl- | |
DK2234985T3 (da) | 4-(4-cyano-2-thioaryl)-dihydropyrimidinoner og deres anvendelse | |
DK2046716T3 (da) | Substituerede 1,3-diphenylpropanderivater, fremstilling og anvendelser deraf | |
DK2038275T3 (da) | Ny pyridazinforbindelse og anvendelse heraf | |
DK2057153T3 (da) | (3-aryl-piperazin-1-yl)-derivater af 6,7 dialkoxyquinazolin, 6,7- dialkoxyphtalazin og 6,7-dialkoxyisoquinolin | |
DK2139334T3 (da) | Kondenserede heterocykliske 2-cyanophenylforbindelser og sammensætninger og anvendelser deraf | |
DK1885716T3 (da) | Thiazolderivater og anvendelse deraf | |
DE602007001681D1 (de) | 1,3-dioxan-carboxylsäuren | |
DK1863801T3 (da) | Benzimidazolderivat og anvendelse deraf | |
DE602006000612D1 (de) | Beidseitig tragbare Orthese | |
DK1958948T3 (da) | Pyridazinforbindelse og anvendelse deraf | |
DK1812120T3 (da) | Hudbeskyttende, alkalinitetskontrollerende præparat og anvendelsen deraf | |
DK1860945T3 (da) | Herbicidsammensætninger baseret på 3-phenyluraciler og 3-sulfonylisoxazoliner | |
DK1960510T3 (da) | Ammoniakspecifik 5'-xmp-aminasemutant |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
CHAD | Change of the owner's name or address (par. 44 patent law, par. patentforskriften) |
Owner name: TERSERA THERAPEUTICS LLC, US |
|
SPCF | Filing of supplementary protection certificate |
Free format text: PRODUCT NAME: TELOSTRITAT ETHYL; REG. NO/DATE: 20170918 Spc suppl protection certif: 2021010 Filing date: 20210301 |
|
SPCG | Granted supplementary protection certificate |
Free format text: PRODUCT NAME: TELOTRISTAT ETYL; REG. NO/DATE: 20170920 Spc suppl protection certif: 2021010 Filing date: 20210301 Extension date: 20320920 |