CN104066431B - 吡嗪激酶抑制剂 - Google Patents

吡嗪激酶抑制剂 Download PDF

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Publication number
CN104066431B
CN104066431B CN201280067711.XA CN201280067711A CN104066431B CN 104066431 B CN104066431 B CN 104066431B CN 201280067711 A CN201280067711 A CN 201280067711A CN 104066431 B CN104066431 B CN 104066431B
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ylamino
group
alkyl
amino
compound
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CN104066431A (zh
Inventor
宋永红
Q·徐
Z·J·贾
B·凯恩
S·M·鲍尔
A·潘迪
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Portola Pharmaceuticals LLC
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Portola Pharmaceuticals LLC
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    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pulmonology (AREA)
  • Dermatology (AREA)
  • Rheumatology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Oncology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Vascular Medicine (AREA)
  • Ophthalmology & Optometry (AREA)
  • Hospice & Palliative Care (AREA)
  • Obesity (AREA)
  • Endocrinology (AREA)
  • Psychiatry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Emergency Medicine (AREA)
  • Communicable Diseases (AREA)
  • Pain & Pain Management (AREA)
  • Transplantation (AREA)
  • Orthopedic Medicine & Surgery (AREA)
CN201280067711.XA 2011-11-23 2012-11-23 吡嗪激酶抑制剂 Expired - Fee Related CN104066431B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161563466P 2011-11-23 2011-11-23
US61/563,466 2011-11-23
PCT/US2012/066468 WO2013078466A1 (en) 2011-11-23 2012-11-23 Pyrazine kinase inhibitors

Publications (2)

Publication Number Publication Date
CN104066431A CN104066431A (zh) 2014-09-24
CN104066431B true CN104066431B (zh) 2017-03-08

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US (2) US8877760B2 (https=)
EP (1) EP2782579B1 (https=)
JP (1) JP6039683B2 (https=)
KR (1) KR102019530B1 (https=)
CN (1) CN104066431B (https=)
AU (1) AU2012340555B2 (https=)
BR (1) BR112014012396B1 (https=)
CA (2) CA2856301C (https=)
CL (1) CL2014001346A1 (https=)
CO (1) CO6990735A2 (https=)
EA (1) EA026939B1 (https=)
IL (1) IL232701A (https=)
IN (1) IN2014CN04065A (https=)
MX (1) MX363551B (https=)
SG (2) SG10201601352UA (https=)
WO (1) WO2013078466A1 (https=)
ZA (1) ZA201403651B (https=)

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US8138339B2 (en) 2008-04-16 2012-03-20 Portola Pharmaceuticals, Inc. Inhibitors of protein kinases
US8063058B2 (en) 2008-04-16 2011-11-22 Portola Pharmaceuticals, Inc. Inhibitors of syk and JAK protein kinases
MX363551B (es) 2011-11-23 2019-03-27 Portola Pharmaceuticals Inc Star Compuestos derivados de pirazina como inhibidores de cinasa.
UY34807A (es) * 2012-05-16 2013-12-31 Novartis Ag Derivados monocíclicos de heteroarilcicloalquil- diamina
WO2014060371A1 (en) * 2012-10-19 2014-04-24 F. Hoffmann-La Roche Ag Inhibitors of syk
US9382246B2 (en) * 2013-12-05 2016-07-05 Pharmacyclics Llc Inhibitors of Bruton's tyrosine kinase
WO2015138273A1 (en) * 2014-03-13 2015-09-17 Merck Sharp & Dohme Corp. 2-pyrazine carboxamides as spleen tyrosine kinase inhibitors
CZ306322B6 (cs) 2014-12-17 2016-11-30 Univerzita Karlova v Praze, Farmaceutická fakulta v Hradci Králové Substituovaný 2-(2-fenylhydrazinyl)pyrazin, způsob jeho přípravy, jeho použití a farmaceutický přípravek ho obsahující
MX2017015574A (es) * 2015-06-02 2018-08-09 Pharmacyclics Llc Inhibidores de tirosina quinasa de bruton.
EP3801525A4 (en) * 2018-06-08 2022-03-23 The General Hospital Corporation PROLYL TRNA SYNTHETASE INHIBITORS
CN112047899A (zh) * 2020-10-19 2020-12-08 成都睿智化学研究有限公司 一种合成3-取代氨基苯并[c]异噻唑衍生物的方法
CA3254208A1 (en) * 2022-03-14 2023-09-21 Purdue Research Foundation SPLEEN TYROSINE KINASE INHIBITOR, COMPOSITION AND METHODS OF USE

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EP1184376A1 (en) * 1999-06-09 2002-03-06 Yamanouchi Pharmaceutical Co. Ltd. Novel heterocyclic carboxamide derivatives
CN102159547A (zh) * 2008-09-18 2011-08-17 安斯泰来制药株式会社 杂环甲酰胺化合物

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