CN104053993A - 用于检测含组蛋白变体的核小体的方法 - Google Patents

用于检测含组蛋白变体的核小体的方法 Download PDF

Info

Publication number
CN104053993A
CN104053993A CN201280053594.1A CN201280053594A CN104053993A CN 104053993 A CN104053993 A CN 104053993A CN 201280053594 A CN201280053594 A CN 201280053594A CN 104053993 A CN104053993 A CN 104053993A
Authority
CN
China
Prior art keywords
histone
nucleosome
isotype
variants
sample
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201280053594.1A
Other languages
English (en)
Chinese (zh)
Inventor
J.V.米克莱夫
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Singapore Volition Pte Ltd
Original Assignee
Singapore Volition Pte Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Singapore Volition Pte Ltd filed Critical Singapore Volition Pte Ltd
Priority to CN201711384538.7A priority Critical patent/CN108107215A/zh
Publication of CN104053993A publication Critical patent/CN104053993A/zh
Pending legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/5308—Immunoassay; Biospecific binding assay; Materials therefor for analytes not provided for elsewhere, e.g. nucleic acids, uric acid, worms, mites
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57484—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites
    • G01N33/57488—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites involving compounds identifable in body fluids
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/577—Immunoassay; Biospecific binding assay; Materials therefor involving monoclonal antibodies binding reaction mechanisms characterised by the use of monoclonal antibodies; monoclonal antibodies per se are classified with their corresponding antigens
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6875—Nucleoproteins
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/06—Gastro-intestinal diseases
    • G01N2800/065—Bowel diseases, e.g. Crohn, ulcerative colitis, IBS
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/10—Musculoskeletal or connective tissue disorders
    • G01N2800/101—Diffuse connective tissue disease, e.g. Sjögren, Wegener's granulomatosis
    • G01N2800/102—Arthritis; Rheumatoid arthritis, i.e. inflammation of peripheral joints
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/10—Musculoskeletal or connective tissue disorders
    • G01N2800/101—Diffuse connective tissue disease, e.g. Sjögren, Wegener's granulomatosis
    • G01N2800/104—Lupus erythematosus [SLE]
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/12—Pulmonary diseases
    • G01N2800/122—Chronic or obstructive airway disorders, e.g. asthma COPD
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/32—Cardiovascular disorders
    • G01N2800/325—Heart failure or cardiac arrest, e.g. cardiomyopathy, congestive heart failure
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Cell Biology (AREA)
  • Medicinal Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Food Science & Technology (AREA)
  • Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Oncology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
CN201280053594.1A 2011-09-01 2012-08-31 用于检测含组蛋白变体的核小体的方法 Pending CN104053993A (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201711384538.7A CN108107215A (zh) 2011-09-01 2012-08-31 用于检测含组蛋白变体的核小体的方法

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201161530304P 2011-09-01 2011-09-01
US61/530,304 2011-09-01
GBGB1115098.4A GB201115098D0 (en) 2011-09-01 2011-09-01 Method for detecting nucleosomes containing histone variants
GB1115098.4 2011-09-01
PCT/GB2012/052131 WO2013030579A1 (en) 2011-09-01 2012-08-31 Method for detecting nucleosomes containing histone variants

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CN201711384538.7A Division CN108107215A (zh) 2011-09-01 2012-08-31 用于检测含组蛋白变体的核小体的方法

Publications (1)

Publication Number Publication Date
CN104053993A true CN104053993A (zh) 2014-09-17

Family

ID=44882049

Family Applications (2)

Application Number Title Priority Date Filing Date
CN201280053594.1A Pending CN104053993A (zh) 2011-09-01 2012-08-31 用于检测含组蛋白变体的核小体的方法
CN201711384538.7A Pending CN108107215A (zh) 2011-09-01 2012-08-31 用于检测含组蛋白变体的核小体的方法

Family Applications After (1)

Application Number Title Priority Date Filing Date
CN201711384538.7A Pending CN108107215A (zh) 2011-09-01 2012-08-31 用于检测含组蛋白变体的核小体的方法

Country Status (20)

Country Link
US (5) US9400276B2 (enExample)
EP (2) EP2751569B1 (enExample)
JP (2) JP2014529405A (enExample)
KR (1) KR102130855B1 (enExample)
CN (2) CN104053993A (enExample)
AU (1) AU2012300643B2 (enExample)
BR (1) BR112014004584B1 (enExample)
CA (1) CA2845994C (enExample)
DK (1) DK2751569T3 (enExample)
ES (2) ES2955475T3 (enExample)
GB (1) GB201115098D0 (enExample)
HR (1) HRP20180362T1 (enExample)
HU (1) HUE038517T2 (enExample)
MX (1) MX349561B (enExample)
PL (1) PL2751569T3 (enExample)
PT (1) PT2751569T (enExample)
RU (2) RU2716494C2 (enExample)
SG (2) SG10201601168QA (enExample)
WO (1) WO2013030579A1 (enExample)
ZA (1) ZA201401296B (enExample)

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107209190A (zh) * 2014-10-29 2017-09-26 比利时意志有限责任公司 用于富集循环肿瘤dna的方法
CN107250799A (zh) * 2015-02-10 2017-10-13 B.R.A.H.M.S 有限公司 作为生物标志物的游离组蛋白
CN108450000A (zh) * 2015-07-01 2018-08-24 比利时意志有限责任公司 痰液样本中无细胞的核小体作为生物标记的用途
CN108496083A (zh) * 2015-10-21 2018-09-04 比利时意志有限责任公司 用于检测包含组蛋白修饰和变体的核小体的方法
CN108603884A (zh) * 2015-10-21 2018-09-28 比利时意志有限责任公司 富集无细胞核小体的方法
CN109313192A (zh) * 2016-03-22 2019-02-05 比利时意志有限责任公司 核小体-转录因子复合体用于癌症检测的用途
CN109791154A (zh) * 2016-07-25 2019-05-21 比利时意志有限责任公司 结肠直肠癌的组合测试
TWI726009B (zh) * 2016-11-28 2021-05-01 比利時商比利時意志有限公司 用親和純化法分析生物樣品中源自腫瘤之無細胞核小體、分離生物樣品中純化之腫瘤dna、檢測生物樣品中源自腫瘤之核小體表觀遺傳表位或在動物或人類受試者中檢測癌症之方法或包括組蛋白h1結合劑之套組之用途

Families Citing this family (49)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB201115098D0 (en) 2011-09-01 2011-10-19 Belgian Volition Sa Method for detecting nucleosomes containing histone variants
GB201115095D0 (en) 2011-09-01 2011-10-19 Singapore Volition Pte Ltd Method for detecting nucleosomes containing nucleotides
EP3401399B1 (en) 2012-03-02 2020-04-22 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
WO2013184930A2 (en) * 2012-06-06 2013-12-12 Trustees Of Princeton University Dna barcoding of designer mononucleosome and chromatin array libraries for the profiling of chromatin readers, writers, erasers, and modulators thereof
EP3597774A1 (en) 2013-03-13 2020-01-22 Sequenom, Inc. Primers for dna methylation analysis
WO2015138774A1 (en) 2014-03-13 2015-09-17 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
GB201511542D0 (en) * 2015-07-01 2015-08-12 Singapore Volition Pte Ltd Use of cell free nucleosomes as biomarkers
EP3551753B1 (en) 2016-12-09 2022-06-29 The Broad Institute, Inc. Crispr effector system based diagnostics
JP2020513815A (ja) 2017-03-15 2020-05-21 ザ・ブロード・インスティテュート・インコーポレイテッド クラスター化短鎖反復回文配列エフェクター系に基づくウイルス検出用診断法
GB201721569D0 (en) 2017-12-21 2018-02-07 Belgian Volition Sprl Method for the detection and treatment of colorectal adenomas
CA3087362A1 (en) 2018-01-29 2019-08-01 The Broad Institute, Inc. Crispr effector system based diagnostics
AU2019228625B2 (en) * 2018-03-01 2024-11-07 Epicypher, Inc. Quantification of nucleosome modifications using chemically-defined recombinant nucleosomes
EP3775198A4 (en) 2018-04-02 2022-01-05 Grail, Inc. METHYLATION MARKERS AND TARGETED METHYLATION PROBE PANELS
CN113286881A (zh) 2018-09-27 2021-08-20 格里尔公司 甲基化标记和标靶甲基化探针板
GB201818965D0 (en) 2018-11-21 2019-01-09 Belgian Volition Sprl Method for the detection of colorectal cancer
GB201818963D0 (en) 2018-11-21 2019-01-09 Belgian Volition Sprl Methof for the detection of prostate cancer
GB201906199D0 (en) 2019-05-02 2019-06-19 Belgian Volition Sprl Method for the detection of cancer
GB201906201D0 (en) 2019-05-02 2019-06-19 Belgian Voltion Sprl Method for the detection of protate cancer
GB201912251D0 (en) 2019-08-27 2019-10-09 Belgian Volition Sprl Method of isolating circulating nucleosomes
WO2021038010A1 (en) 2019-08-27 2021-03-04 Belgian Volition Sprl Method of isolating circulating nucleosomes
JP7693670B2 (ja) 2019-12-02 2025-06-17 ベルジアン ボリション エスアールエル バイオマーカーとしての細胞外遊離ヌクレオソームの使用
JP2023520168A (ja) 2020-03-20 2023-05-16 ベルジアン ボリション エスアールエル 無細胞ヌクレオソームレベルを用いるトリアージ方法
EP4213909A1 (en) 2020-09-21 2023-07-26 Belgian Volition SRL Device for inline monitoring of free nucleosomes in blood
TW202238131A (zh) 2020-11-25 2022-10-01 比利時商比利時意志有限公司 測量無細胞核蛋白染色質片段之方法
TW202238132A (zh) 2020-12-08 2022-10-01 比利時商比利時意志有限公司 多發性硬化症之診斷方法
TW202242130A (zh) 2020-12-29 2022-11-01 比利時商比利時意志有限公司 循環轉錄因子分析
TW202242145A (zh) 2020-12-29 2022-11-01 比利時商比利時意志有限公司 核小體耗盡循環無細胞染色質片段之轉錄因子結合位點分析
TW202242146A (zh) 2021-01-13 2022-11-01 比利時商比利時意志有限公司 肺癌的檢測方法
GB202108185D0 (en) 2021-06-08 2021-07-21 Belgian Volition Sprl Standardisation of nucleosome assays using biologically derived calibrants
GB202108452D0 (en) 2021-06-14 2021-07-28 Belgian Volition Sprl Triaging method using cell free nucleosome levels
WO2023073179A1 (en) 2021-10-29 2023-05-04 Belgian Volition Srl Homogeneous immunoassay method
GB202117799D0 (en) 2021-12-09 2022-01-26 Belgian Volition Srl Method for the detection of blood cancer
EP4490323A1 (en) 2022-03-11 2025-01-15 Belgian Volition SRL Differential diagnosis method
GB202205212D0 (en) 2022-04-08 2022-05-25 Belgian Volition Sprl Method for transplant organ health assessment
EP4577833A1 (en) 2022-08-25 2025-07-02 Belgian Volition SRL Method for measuring cell free chromatin
WO2024042208A1 (en) 2022-08-25 2024-02-29 Belgian Volition Srl Method for the detection of dementia
EP4639165A1 (en) 2022-12-19 2025-10-29 Belgian Volition SRL Assessment of biological samples for nucleic acid analysis
WO2024133225A1 (en) 2022-12-19 2024-06-27 Belgian Volition Srl Calibration
GB202300607D0 (en) 2023-01-16 2023-03-01 Belgian Volition Srl Proteins and methods for isolating circulating nucleosomes
GB202303562D0 (en) 2023-03-10 2023-04-26 Belgian Volition Sprl Sample collection for liquid biopsy
WO2024213795A1 (en) 2023-04-14 2024-10-17 Belgian Volition Srl Diagnosis method using cell free nucleosome levels
WO2024223947A1 (en) 2023-04-28 2024-10-31 Belgian Volition Srl Use of cell free nucleosomes as biomarkers of carcinomas
GB202307768D0 (en) 2023-05-24 2023-07-05 Belgian Volition Srl Use of cell free nucleosomes as biomarkers
GB202310137D0 (en) 2023-07-03 2023-08-16 Belgian Volition Srl Method for the detection of cancer
WO2025012440A1 (en) 2023-07-13 2025-01-16 Belgian Volition Srl Method for detection of the potential of a body fluid sample to produce extracellular traps
WO2025061853A1 (en) 2023-09-19 2025-03-27 Belgian Volition Srl Lateral flow test device
WO2025093747A1 (en) 2023-11-02 2025-05-08 Belgian Volition Srl Novel rapid high-throughput method of netosis induction and inhibition with physiologically relevant molecules
WO2025181348A1 (en) 2024-03-01 2025-09-04 Belgian Volition Srl Method for determining the origin of circulating dna
WO2025253002A1 (en) 2024-06-07 2025-12-11 Belgian Volition Srl Sample collection for liquid biopsy

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002076377A2 (en) * 2001-03-23 2002-10-03 Yoshiyuki Kanai Mononucleosome and process for producing the same, method of assaying antibody specific to nucleosome, method of diagnosing autoimmune disease, process for producing nucleosome dna, dna plate, process for producing dna plate and method of assaying anti-dna antibody
WO2005019826A1 (en) * 2003-08-18 2005-03-03 Chroma Therapeutics Limited Detection of histone modification in cell-free nucleosomes
WO2005040814A1 (en) * 2003-10-14 2005-05-06 Cancer Research Technology Limited Methods and means of cancer detection by histone modification
US20050233322A1 (en) * 2002-02-15 2005-10-20 Waltraud Suer Method for producing a nucleosome preparation and use thereof in in vitro diagnosis of disseminated lupus erythematosus (dle)
WO2011000573A1 (en) * 2009-07-02 2011-01-06 Embl European Molecular Biology Laboratory Diagnostic method for predicting the risk of cancer recurrence based on histone macroh2a isoforms

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2005508302A (ja) * 2001-07-03 2005-03-31 ユニバーシティ オブ バージニア パテント ファウンデーション アルギニン３でのヒストンｈ４のメチル化
CA2476835A1 (en) * 2002-02-20 2003-08-28 University Of Virginia Patent Foundation A non-invasive diagnostic test utilizing histone modification markers
WO2007017065A2 (en) * 2005-07-27 2007-02-15 Oncomethylome Sciences Sa Angiogenesis inhibition based upon icam 1 or junb expression levels
EP1937706A4 (en) * 2005-09-09 2008-10-22 Univ Iowa Res Found ORGANIC MARKERS RELATED TO AGE DEPENDENT MAKULAR GENERATION
WO2010033658A2 (en) * 2008-09-17 2010-03-25 The Rockefeller University Cathepsin l proteolytically processes histone h3 during mouse embroyonic stem cell differentiation
GB201115098D0 (en) 2011-09-01 2011-10-19 Belgian Volition Sa Method for detecting nucleosomes containing histone variants

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002076377A2 (en) * 2001-03-23 2002-10-03 Yoshiyuki Kanai Mononucleosome and process for producing the same, method of assaying antibody specific to nucleosome, method of diagnosing autoimmune disease, process for producing nucleosome dna, dna plate, process for producing dna plate and method of assaying anti-dna antibody
US20050233322A1 (en) * 2002-02-15 2005-10-20 Waltraud Suer Method for producing a nucleosome preparation and use thereof in in vitro diagnosis of disseminated lupus erythematosus (dle)
WO2005019826A1 (en) * 2003-08-18 2005-03-03 Chroma Therapeutics Limited Detection of histone modification in cell-free nucleosomes
WO2005040814A1 (en) * 2003-10-14 2005-05-06 Cancer Research Technology Limited Methods and means of cancer detection by histone modification
WO2011000573A1 (en) * 2009-07-02 2011-01-06 Embl European Molecular Biology Laboratory Diagnostic method for predicting the risk of cancer recurrence based on histone macroh2a isoforms

Cited By (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107209190A (zh) * 2014-10-29 2017-09-26 比利时意志有限责任公司 用于富集循环肿瘤dna的方法
CN111505305A (zh) * 2014-10-29 2020-08-07 比利时意志有限责任公司 用于富集循环肿瘤dna的方法
CN111505305B (zh) * 2014-10-29 2023-10-17 比利时意志有限责任公司 用于富集循环肿瘤dna的方法
CN107250799A (zh) * 2015-02-10 2017-10-13 B.R.A.H.M.S 有限公司 作为生物标志物的游离组蛋白
CN107250799B (zh) * 2015-02-10 2019-09-10 B.R.A.H.M.S 有限公司 作为生物标志物的游离组蛋白
CN108450000A (zh) * 2015-07-01 2018-08-24 比利时意志有限责任公司 痰液样本中无细胞的核小体作为生物标记的用途
CN108496083A (zh) * 2015-10-21 2018-09-04 比利时意志有限责任公司 用于检测包含组蛋白修饰和变体的核小体的方法
CN108603884A (zh) * 2015-10-21 2018-09-28 比利时意志有限责任公司 富集无细胞核小体的方法
CN109313192A (zh) * 2016-03-22 2019-02-05 比利时意志有限责任公司 核小体-转录因子复合体用于癌症检测的用途
CN109313192B (zh) * 2016-03-22 2022-07-26 比利时意志有限责任公司 核小体-转录因子复合体用于癌症检测的用途
CN109791154A (zh) * 2016-07-25 2019-05-21 比利时意志有限责任公司 结肠直肠癌的组合测试
TWI726009B (zh) * 2016-11-28 2021-05-01 比利時商比利時意志有限公司 用親和純化法分析生物樣品中源自腫瘤之無細胞核小體、分離生物樣品中純化之腫瘤dna、檢測生物樣品中源自腫瘤之核小體表觀遺傳表位或在動物或人類受試者中檢測癌症之方法或包括組蛋白h1結合劑之套組之用途

Also Published As

Publication number Publication date
RU2716494C2 (ru) 2020-03-12
RU2018101257A3 (enExample) 2019-02-21
WO2013030579A1 (en) 2013-03-07
GB201115098D0 (en) 2011-10-19
KR20140078638A (ko) 2014-06-25
HK1253354A1 (en) 2019-06-14
US20200341006A1 (en) 2020-10-29
US10184945B2 (en) 2019-01-22
MX2014002444A (es) 2014-10-23
US9400276B2 (en) 2016-07-26
RU2018101257A (ru) 2019-02-21
AU2012300643B2 (en) 2017-06-15
CA2845994C (en) 2020-10-13
US20140206014A1 (en) 2014-07-24
RU2014112348A (ru) 2015-10-10
ZA201401296B (en) 2014-12-23
BR112014004584B1 (pt) 2021-07-06
US20160299152A1 (en) 2016-10-13
HUE038517T2 (hu) 2018-10-29
ES2955475T3 (es) 2023-12-01
EP2751569A1 (en) 2014-07-09
CA2845994A1 (en) 2013-03-07
MX349561B (es) 2017-08-02
EP3301449C0 (en) 2023-08-09
SG11201400202SA (en) 2014-03-28
EP3301449B1 (en) 2023-08-09
PT2751569T (pt) 2018-03-28
ES2662380T3 (es) 2018-04-06
SG10201601168QA (en) 2016-03-30
KR102130855B1 (ko) 2020-07-09
PL2751569T3 (pl) 2018-06-29
HRP20180362T1 (hr) 2018-06-01
US20230116530A1 (en) 2023-04-13
US20190120853A1 (en) 2019-04-25
JP2017215338A (ja) 2017-12-07
EP2751569B1 (en) 2017-12-27
CN108107215A (zh) 2018-06-01
BR112014004584A2 (pt) 2017-05-16
EP3301449A1 (en) 2018-04-04
JP2014529405A (ja) 2014-11-13
JP6494703B2 (ja) 2019-04-03
AU2012300643A1 (en) 2014-03-06
DK2751569T3 (en) 2018-03-12
HK1199758A1 (en) 2015-07-17

Similar Documents

Publication Publication Date Title
US20230116530A1 (en) Method for detecting nucleosomes containing histone variants
CN104067124B (zh) 用于检测含核苷酸的核小体的方法
US9222937B2 (en) Method for detecting nucleosomes
US20170003296A1 (en) Method for detecting histone modifications in nucleosomes
HK40008468A (en) Method for detecting nucleosomes containing nucleotides
HK1253354B (en) Method for detecting nucleosomes containing histone variants
HK1199758B (en) Method for detecting nucleosomes containing histone variants
HK1199760B (en) Method for detecting nucleosomes containing nucleotides

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
RJ01 Rejection of invention patent application after publication
RJ01 Rejection of invention patent application after publication

Application publication date: 20140917