MX349561B - Método para detectar nucleosomas que contienen variantes de histonas. - Google Patents
Método para detectar nucleosomas que contienen variantes de histonas.Info
- Publication number
- MX349561B MX349561B MX2014002444A MX2014002444A MX349561B MX 349561 B MX349561 B MX 349561B MX 2014002444 A MX2014002444 A MX 2014002444A MX 2014002444 A MX2014002444 A MX 2014002444A MX 349561 B MX349561 B MX 349561B
- Authority
- MX
- Mexico
- Prior art keywords
- histone variants
- nucleosomes containing
- containing histone
- detecting
- nucleosomes
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 4
- 108010033040 Histones Proteins 0.000 title abstract 3
- 108010047956 Nucleosomes Proteins 0.000 title abstract 2
- 210000001623 nucleosome Anatomy 0.000 title abstract 2
- 239000000090 biomarker Substances 0.000 abstract 2
- 238000001514 detection method Methods 0.000 abstract 2
- 238000003745 diagnosis Methods 0.000 abstract 2
- 201000010099 disease Diseases 0.000 abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- 238000005259 measurement Methods 0.000 abstract 1
Classifications
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6875—Nucleoproteins
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/5308—Immunoassay; Biospecific binding assay; Materials therefor for analytes not provided for elsewhere, e.g. nucleic acids, uric acid, worms, mites
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
- G01N33/57484—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites
- G01N33/57488—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites involving compounds identifable in body fluids
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/577—Immunoassay; Biospecific binding assay; Materials therefor involving monoclonal antibodies binding reaction mechanisms characterised by the use of monoclonal antibodies; monoclonal antibodies per se are classified with their corresponding antigens
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/06—Gastro-intestinal diseases
- G01N2800/065—Bowel diseases, e.g. Crohn, ulcerative colitis, IBS
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/10—Musculoskeletal or connective tissue disorders
- G01N2800/101—Diffuse connective tissue disease, e.g. Sjögren, Wegener's granulomatosis
- G01N2800/102—Arthritis; Rheumatoid arthritis, i.e. inflammation of peripheral joints
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/10—Musculoskeletal or connective tissue disorders
- G01N2800/101—Diffuse connective tissue disease, e.g. Sjögren, Wegener's granulomatosis
- G01N2800/104—Lupus erythematosus [SLE]
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/12—Pulmonary diseases
- G01N2800/122—Chronic or obstructive airway disorders, e.g. asthma COPD
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/32—Cardiovascular disorders
- G01N2800/325—Heart failure or cardiac arrest, e.g. cardiomyopathy, congestive heart failure
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Cell Biology (AREA)
- Food Science & Technology (AREA)
- General Health & Medical Sciences (AREA)
- Biotechnology (AREA)
- Pathology (AREA)
- General Physics & Mathematics (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Hospice & Palliative Care (AREA)
- Oncology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Tropical Medicine & Parasitology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161530304P | 2011-09-01 | 2011-09-01 | |
| GBGB1115098.4A GB201115098D0 (en) | 2011-09-01 | 2011-09-01 | Method for detecting nucleosomes containing histone variants |
| PCT/GB2012/052131 WO2013030579A1 (en) | 2011-09-01 | 2012-08-31 | Method for detecting nucleosomes containing histone variants |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MX2014002444A MX2014002444A (es) | 2014-10-23 |
| MX349561B true MX349561B (es) | 2017-08-02 |
Family
ID=44882049
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2014002444A MX349561B (es) | 2011-09-01 | 2012-08-31 | Método para detectar nucleosomas que contienen variantes de histonas. |
Country Status (20)
| Country | Link |
|---|---|
| US (5) | US9400276B2 (enExample) |
| EP (2) | EP3301449B1 (enExample) |
| JP (2) | JP2014529405A (enExample) |
| KR (1) | KR102130855B1 (enExample) |
| CN (2) | CN108107215A (enExample) |
| AU (1) | AU2012300643B2 (enExample) |
| BR (1) | BR112014004584B1 (enExample) |
| CA (1) | CA2845994C (enExample) |
| DK (1) | DK2751569T3 (enExample) |
| ES (2) | ES2955475T3 (enExample) |
| GB (1) | GB201115098D0 (enExample) |
| HR (1) | HRP20180362T1 (enExample) |
| HU (1) | HUE038517T2 (enExample) |
| MX (1) | MX349561B (enExample) |
| PL (1) | PL2751569T3 (enExample) |
| PT (1) | PT2751569T (enExample) |
| RU (2) | RU2014112348A (enExample) |
| SG (2) | SG10201601168QA (enExample) |
| WO (1) | WO2013030579A1 (enExample) |
| ZA (1) | ZA201401296B (enExample) |
Families Citing this family (56)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB201115095D0 (en) * | 2011-09-01 | 2011-10-19 | Singapore Volition Pte Ltd | Method for detecting nucleosomes containing nucleotides |
| GB201115098D0 (en) | 2011-09-01 | 2011-10-19 | Belgian Volition Sa | Method for detecting nucleosomes containing histone variants |
| EP3757210B1 (en) | 2012-03-02 | 2022-08-24 | Sequenom, Inc. | Methods for enriching cancer nucleic acid from a biological sample |
| WO2013184930A2 (en) * | 2012-06-06 | 2013-12-12 | Trustees Of Princeton University | Dna barcoding of designer mononucleosome and chromatin array libraries for the profiling of chromatin readers, writers, erasers, and modulators thereof |
| US11060145B2 (en) | 2013-03-13 | 2021-07-13 | Sequenom, Inc. | Methods and compositions for identifying presence or absence of hypermethylation or hypomethylation locus |
| EP3736344A1 (en) | 2014-03-13 | 2020-11-11 | Sequenom, Inc. | Methods and processes for non-invasive assessment of genetic variations |
| EP3809140A1 (en) | 2014-10-29 | 2021-04-21 | Belgian Volition SPRL | Method for the enrichment of circulating tumor dna |
| WO2016128383A1 (en) * | 2015-02-10 | 2016-08-18 | B.R.A.H.M.S Gmbh | Free histone proteins as biomarkers |
| GB201511542D0 (en) * | 2015-07-01 | 2015-08-12 | Singapore Volition Pte Ltd | Use of cell free nucleosomes as biomarkers |
| GB201511512D0 (en) * | 2015-07-01 | 2015-08-12 | Singapore Volition Pte Ltd | Use of cell-free nucleosomes as biomarkers |
| GB201518674D0 (en) | 2015-10-21 | 2015-12-02 | Singapore Volition Pte Ltd | Method for detecting nuleosomes containing histone modifications and variants |
| GB201518665D0 (en) | 2015-10-21 | 2015-12-02 | Singapore Volition Pte Ltd | Method for enrichment of cell free nucleosomes |
| GB201604806D0 (en) * | 2016-03-22 | 2016-05-04 | Singapore Volition Pte Ltd | Method of identifying a cancer of unknown origin |
| GB201612815D0 (en) * | 2016-07-25 | 2016-09-07 | Belgian Volition Sa | Novel combination test |
| TWI726009B (zh) * | 2016-11-28 | 2021-05-01 | 比利時商比利時意志有限公司 | 用親和純化法分析生物樣品中源自腫瘤之無細胞核小體、分離生物樣品中純化之腫瘤dna、檢測生物樣品中源自腫瘤之核小體表觀遺傳表位或在動物或人類受試者中檢測癌症之方法或包括組蛋白h1結合劑之套組之用途 |
| EP4119663B1 (en) | 2016-12-09 | 2024-11-27 | The Broad Institute, Inc. | Crispr effector system based diagnostics |
| CN111108220B (zh) | 2017-03-15 | 2024-11-19 | 博德研究所 | 用于病毒检测的基于crispr效应系统的诊断 |
| GB201721569D0 (en) | 2017-12-21 | 2018-02-07 | Belgian Volition Sprl | Method for the detection and treatment of colorectal adenomas |
| BR112020015093A2 (pt) | 2018-01-29 | 2020-12-08 | The Broad Institute, Inc. | Diagnóstico baseado no sistema de efetor crispr |
| AU2019228625B2 (en) * | 2018-03-01 | 2024-11-07 | Epicypher, Inc. | Quantification of nucleosome modifications using chemically-defined recombinant nucleosomes |
| CN119753091A (zh) | 2018-04-02 | 2025-04-04 | 格里尔公司 | 用于扩增与癌症相关联的cfDNA分子的化验板 |
| WO2020069350A1 (en) | 2018-09-27 | 2020-04-02 | Grail, Inc. | Methylation markers and targeted methylation probe panel |
| GB201818963D0 (en) | 2018-11-21 | 2019-01-09 | Belgian Volition Sprl | Methof for the detection of prostate cancer |
| GB201818965D0 (en) | 2018-11-21 | 2019-01-09 | Belgian Volition Sprl | Method for the detection of colorectal cancer |
| GB201906201D0 (en) | 2019-05-02 | 2019-06-19 | Belgian Voltion Sprl | Method for the detection of protate cancer |
| GB201906199D0 (en) | 2019-05-02 | 2019-06-19 | Belgian Volition Sprl | Method for the detection of cancer |
| GB201912251D0 (en) | 2019-08-27 | 2019-10-09 | Belgian Volition Sprl | Method of isolating circulating nucleosomes |
| WO2021038010A1 (en) | 2019-08-27 | 2021-03-04 | Belgian Volition Sprl | Method of isolating circulating nucleosomes |
| BR112022010774A2 (pt) | 2019-12-02 | 2022-08-23 | Belgian Volition Srl | Uso de nucleossomos livres de células como biomarcadores |
| EP4121551A1 (en) | 2020-03-20 | 2023-01-25 | Belgian Volition SRL | Triaging method using cell free nucleosome levels |
| US20230355851A1 (en) | 2020-09-21 | 2023-11-09 | Belgian Volition SRL (BE/BE) | Device for inline monitoring of free nucleosomes in blood |
| TW202238131A (zh) | 2020-11-25 | 2022-10-01 | 比利時商比利時意志有限公司 | 測量無細胞核蛋白染色質片段之方法 |
| TW202238132A (zh) | 2020-12-08 | 2022-10-01 | 比利時商比利時意志有限公司 | 多發性硬化症之診斷方法 |
| TW202242145A (zh) | 2020-12-29 | 2022-11-01 | 比利時商比利時意志有限公司 | 核小體耗盡循環無細胞染色質片段之轉錄因子結合位點分析 |
| TW202242130A (zh) | 2020-12-29 | 2022-11-01 | 比利時商比利時意志有限公司 | 循環轉錄因子分析 |
| TW202242146A (zh) | 2021-01-13 | 2022-11-01 | 比利時商比利時意志有限公司 | 肺癌的檢測方法 |
| GB202108185D0 (en) | 2021-06-08 | 2021-07-21 | Belgian Volition Sprl | Standardisation of nucleosome assays using biologically derived calibrants |
| GB202108452D0 (en) | 2021-06-14 | 2021-07-28 | Belgian Volition Sprl | Triaging method using cell free nucleosome levels |
| JP2024542996A (ja) | 2021-10-29 | 2024-11-19 | ベルジアン ボリション エスアールエル | 均一系免疫アッセイ法 |
| GB202117799D0 (en) | 2021-12-09 | 2022-01-26 | Belgian Volition Srl | Method for the detection of blood cancer |
| EP4490323A1 (en) | 2022-03-11 | 2025-01-15 | Belgian Volition SRL | Differential diagnosis method |
| GB202205212D0 (en) | 2022-04-08 | 2022-05-25 | Belgian Volition Sprl | Method for transplant organ health assessment |
| WO2024042210A1 (en) | 2022-08-25 | 2024-02-29 | Belgian Volition Srl | Method for measuring cell free chromatin |
| IL319155A (en) | 2022-08-25 | 2025-04-01 | Belgian Volition Srl | A method for detecting dementia |
| WO2024133225A1 (en) | 2022-12-19 | 2024-06-27 | Belgian Volition Srl | Calibration |
| EP4639165A1 (en) | 2022-12-19 | 2025-10-29 | Belgian Volition SRL | Assessment of biological samples for nucleic acid analysis |
| GB202300607D0 (en) | 2023-01-16 | 2023-03-01 | Belgian Volition Srl | Proteins and methods for isolating circulating nucleosomes |
| GB202303562D0 (en) | 2023-03-10 | 2023-04-26 | Belgian Volition Sprl | Sample collection for liquid biopsy |
| WO2024213795A1 (en) | 2023-04-14 | 2024-10-17 | Belgian Volition Srl | Diagnosis method using cell free nucleosome levels |
| WO2024223947A1 (en) | 2023-04-28 | 2024-10-31 | Belgian Volition Srl | Use of cell free nucleosomes as biomarkers of carcinomas |
| GB202307768D0 (en) | 2023-05-24 | 2023-07-05 | Belgian Volition Srl | Use of cell free nucleosomes as biomarkers |
| GB202310137D0 (en) | 2023-07-03 | 2023-08-16 | Belgian Volition Srl | Method for the detection of cancer |
| WO2025012440A1 (en) | 2023-07-13 | 2025-01-16 | Belgian Volition Srl | Method for detection of the potential of a body fluid sample to produce extracellular traps |
| WO2025061853A1 (en) | 2023-09-19 | 2025-03-27 | Belgian Volition Srl | Lateral flow test device |
| WO2025093747A1 (en) | 2023-11-02 | 2025-05-08 | Belgian Volition Srl | Novel rapid high-throughput method of netosis induction and inhibition with physiologically relevant molecules |
| WO2025181348A1 (en) | 2024-03-01 | 2025-09-04 | Belgian Volition Srl | Method for determining the origin of circulating dna |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4276843B2 (ja) * | 2001-03-23 | 2009-06-10 | 芳之 金井 | モノヌクレオソーム及びその製造方法、ヌクレオソームに特異的な抗体の測定方法、自己免疫病診断方法、ヌクレオソームｄｎａ製造方法、ｄｎａプレート、ｄｎａプレート製造方法、並びに抗ｄｎａ抗体測定法 |
| US20040186274A1 (en) | 2001-07-03 | 2004-09-23 | Allis C. David | Methylation of histone h4 at arginine 3 |
| DE10207735A1 (de) * | 2002-02-15 | 2003-08-28 | Euroimmun Gmbh | Verfahren zur Herstellung einer Nukleosomen-Präparation und deren Verwendung zur in vitro-Diagnose von Lupus erythematodes disseminatus (LED) |
| JP2005517431A (ja) * | 2002-02-20 | 2005-06-16 | ユニバーシティ オブ バージニア パテント ファウンデーション | ヒストン修飾マーカーを利用した非侵襲的診断検査 |
| GB0319376D0 (en) * | 2003-08-18 | 2003-09-17 | Chroma Therapeutics Ltd | Histone modification detection |
| WO2005040814A1 (en) * | 2003-10-14 | 2005-05-06 | Cancer Research Technology Limited | Methods and means of cancer detection by histone modification |
| EP1907856A2 (en) * | 2005-07-27 | 2008-04-09 | Oncomethylome Sciences SA | Angiogenesis inhibition based upon icam 1 or junb expression levels |
| EP2189541A3 (en) * | 2005-09-09 | 2010-09-08 | University of Iowa Research Foundation | Methods and reagents for treatment and diagnosis of age-related macular degeneration |
| US20110312897A1 (en) * | 2008-09-17 | 2011-12-22 | The Rockefeller University | Cathepsin l proteolytically processes histone h3 during mouse embryonic stem cell differentiation |
| EP2270510A1 (en) * | 2009-07-02 | 2011-01-05 | EMBL (European Molecular Biology Laboratory) | Diagnostic method for predicting the risk of cancer recurrence based on Histone macroH2A isoforms |
| GB201115098D0 (en) | 2011-09-01 | 2011-10-19 | Belgian Volition Sa | Method for detecting nucleosomes containing histone variants |
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2011
- 2011-09-01 GB GBGB1115098.4A patent/GB201115098D0/en not_active Ceased
-
2012
- 2012-08-31 HR HRP20180362TT patent/HRP20180362T1/hr unknown
- 2012-08-31 JP JP2014527738A patent/JP2014529405A/ja not_active Withdrawn
- 2012-08-31 CN CN201711384538.7A patent/CN108107215A/zh active Pending
- 2012-08-31 DK DK12762367.6T patent/DK2751569T3/en active
- 2012-08-31 PL PL12762367T patent/PL2751569T3/pl unknown
- 2012-08-31 BR BR112014004584-4A patent/BR112014004584B1/pt active IP Right Grant
- 2012-08-31 EP EP17201723.8A patent/EP3301449B1/en active Active
- 2012-08-31 MX MX2014002444A patent/MX349561B/es active IP Right Grant
- 2012-08-31 KR KR1020147008116A patent/KR102130855B1/ko active Active
- 2012-08-31 SG SG10201601168QA patent/SG10201601168QA/en unknown
- 2012-08-31 HU HUE12762367A patent/HUE038517T2/hu unknown
- 2012-08-31 US US14/239,779 patent/US9400276B2/en active Active
- 2012-08-31 SG SG11201400202SA patent/SG11201400202SA/en unknown
- 2012-08-31 ES ES17201723T patent/ES2955475T3/es active Active
- 2012-08-31 AU AU2012300643A patent/AU2012300643B2/en active Active
- 2012-08-31 WO PCT/GB2012/052131 patent/WO2013030579A1/en not_active Ceased
- 2012-08-31 CN CN201280053594.1A patent/CN104053993A/zh active Pending
- 2012-08-31 PT PT127623676T patent/PT2751569T/pt unknown
- 2012-08-31 EP EP12762367.6A patent/EP2751569B1/en active Active
- 2012-08-31 RU RU2014112348/15A patent/RU2014112348A/ru unknown
- 2012-08-31 RU RU2018101257A patent/RU2716494C2/ru active
- 2012-08-31 CA CA2845994A patent/CA2845994C/en active Active
- 2012-08-31 ES ES12762367.6T patent/ES2662380T3/es active Active
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2014
- 2014-02-20 ZA ZA2014/01296A patent/ZA201401296B/en unknown
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2016
- 2016-06-22 US US15/189,977 patent/US10184945B2/en active Active
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2017
- 2017-08-02 JP JP2017149809A patent/JP6494703B2/ja active Active
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2018
- 2018-12-14 US US16/221,411 patent/US20190120853A1/en not_active Abandoned
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2020
- 2020-07-09 US US16/925,125 patent/US20200341006A1/en not_active Abandoned
-
2022
- 2022-12-06 US US18/076,005 patent/US20230116530A1/en not_active Abandoned
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