CN104001165B - 包含肺炎球菌抗原的组合物 - Google Patents

包含肺炎球菌抗原的组合物 Download PDF

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Publication number
CN104001165B
CN104001165B CN201410192895.3A CN201410192895A CN104001165B CN 104001165 B CN104001165 B CN 104001165B CN 201410192895 A CN201410192895 A CN 201410192895A CN 104001165 B CN104001165 B CN 104001165B
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China
Prior art keywords
seq
amino acids
preferred
acid sequence
epitope
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Expired - Fee Related
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CN201410192895.3A
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English (en)
Chinese (zh)
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CN104001165A (zh
Inventor
C·多纳蒂
A·穆兹
V·马西格纳尼
F·巴格诺利
P·鲁格洛
M·巴罗奇
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GlaxoSmithKline Biologicals SA
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GlaxoSmithKline Biologicals SA
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/09—Lactobacillales, e.g. aerococcus, enterococcus, lactobacillus, lactococcus, streptococcus
    • A61K39/092—Streptococcus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A61K47/646—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent the entire peptide or protein drug conjugate elicits an immune response, e.g. conjugate vaccines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/315—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Streptococcus (G), e.g. Enterococci
    • C07K14/3156—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Streptococcus (G), e.g. Enterococci from Streptococcus pneumoniae (Pneumococcus)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/40—Fusion polypeptide containing a tag for immunodetection, or an epitope for immunisation
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Virology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Biochemistry (AREA)
  • Mycology (AREA)
  • Pulmonology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicinal Preparation (AREA)
CN201410192895.3A 2007-08-01 2008-08-01 包含肺炎球菌抗原的组合物 Expired - Fee Related CN104001165B (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
GBGB0714963.6A GB0714963D0 (en) 2007-08-01 2007-08-01 Compositions comprising antigens
GB0714963.6 2007-08-01
US96686607P 2007-08-29 2007-08-29
US60/966,866 2007-08-29
CN200880108017A CN101801409A (zh) 2007-08-01 2008-08-01 包含肺炎球菌抗原的组合物

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CN200880108017A Division CN101801409A (zh) 2007-08-01 2008-08-01 包含肺炎球菌抗原的组合物

Publications (2)

Publication Number Publication Date
CN104001165A CN104001165A (zh) 2014-08-27
CN104001165B true CN104001165B (zh) 2018-08-14

Family

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Family Applications (2)

Application Number Title Priority Date Filing Date
CN201410192895.3A Expired - Fee Related CN104001165B (zh) 2007-08-01 2008-08-01 包含肺炎球菌抗原的组合物
CN200880108017A Pending CN101801409A (zh) 2007-08-01 2008-08-01 包含肺炎球菌抗原的组合物

Family Applications After (1)

Application Number Title Priority Date Filing Date
CN200880108017A Pending CN101801409A (zh) 2007-08-01 2008-08-01 包含肺炎球菌抗原的组合物

Country Status (20)

Country Link
US (2) US20110243976A1 (https=)
EP (2) EP2197484A2 (https=)
JP (2) JP2010535025A (https=)
CN (2) CN104001165B (https=)
AP (1) AP2010005173A0 (https=)
AU (1) AU2008281438A1 (https=)
BR (1) BRPI0813892A2 (https=)
CA (1) CA2695169A1 (https=)
CO (1) CO6260103A2 (https=)
CY (1) CY1117689T1 (https=)
DK (1) DK2572726T3 (https=)
EA (1) EA018137B1 (https=)
ES (1) ES2580957T3 (https=)
GB (1) GB0714963D0 (https=)
HR (1) HRP20160685T1 (https=)
HU (1) HUE029670T2 (https=)
PL (1) PL2572726T3 (https=)
PT (1) PT2572726T (https=)
SI (1) SI2572726T1 (https=)
WO (1) WO2009016515A2 (https=)

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BRPI0813892A2 (pt) 2017-05-09
PT2572726T (pt) 2016-08-05
CY1117689T1 (el) 2017-05-17
EP2572726A1 (en) 2013-03-27
JP2010535025A (ja) 2010-11-18
JP5838193B2 (ja) 2016-01-06
ES2580957T3 (es) 2016-08-30
AU2008281438A1 (en) 2009-02-05
HUE029670T2 (en) 2017-03-28
US20110243976A1 (en) 2011-10-06
GB0714963D0 (en) 2007-09-12
CA2695169A1 (en) 2009-02-05
EP2572726B1 (en) 2016-05-04
HRP20160685T1 (hr) 2016-07-15
CN104001165A (zh) 2014-08-27
EA018137B1 (ru) 2013-05-30
CN101801409A (zh) 2010-08-11
EP2197484A2 (en) 2010-06-23
AP2010005173A0 (en) 2010-02-28
WO2009016515A2 (en) 2009-02-05
DK2572726T3 (en) 2016-07-04
PL2572726T3 (pl) 2016-12-30
WO2009016515A3 (en) 2009-08-13

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