CN103990107A - 用gnrh拮抗剂地加瑞克治疗前列腺癌的方法 - Google Patents
用gnrh拮抗剂地加瑞克治疗前列腺癌的方法 Download PDFInfo
- Publication number
- CN103990107A CN103990107A CN201410247166.3A CN201410247166A CN103990107A CN 103990107 A CN103990107 A CN 103990107A CN 201410247166 A CN201410247166 A CN 201410247166A CN 103990107 A CN103990107 A CN 103990107A
- Authority
- CN
- China
- Prior art keywords
- 4aph
- treatment
- ala
- 3pal
- 2nal
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 206010060862 Prostate cancer Diseases 0.000 title claims abstract description 18
- 208000000236 Prostatic Neoplasms Diseases 0.000 title claims abstract description 17
- 229940121381 gonadotrophin releasing hormone (gnrh) antagonists Drugs 0.000 title abstract description 22
- 238000000034 method Methods 0.000 title description 46
- 239000002474 gonadorelin antagonist Substances 0.000 title description 21
- 108010052004 acetyl-2-naphthylalanyl-3-chlorophenylalanyl-1-oxohexadecyl-seryl-4-aminophenylalanyl(hydroorotyl)-4-aminophenylalanyl(carbamoyl)-leucyl-ILys-prolyl-alaninamide Proteins 0.000 title description 3
- MEUCPCLKGZSHTA-XYAYPHGZSA-N degarelix Chemical compound C([C@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCNC(C)C)C(=O)N1[C@@H](CCC1)C(=O)N[C@H](C)C(N)=O)NC(=O)[C@H](CC=1C=CC(NC(=O)[C@H]2NC(=O)NC(=O)C2)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@@H](CC=1C=NC=CC=1)NC(=O)[C@@H](CC=1C=CC(Cl)=CC=1)NC(=O)[C@@H](CC=1C=C2C=CC=CC2=CC=1)NC(C)=O)C1=CC=C(NC(N)=O)C=C1 MEUCPCLKGZSHTA-XYAYPHGZSA-N 0.000 title description 3
- 229960002272 degarelix Drugs 0.000 title description 2
- 208000006820 Arthralgia Diseases 0.000 claims abstract description 24
- 208000019206 urinary tract infection Diseases 0.000 claims abstract description 15
- 238000011282 treatment Methods 0.000 claims description 333
- 239000003814 drug Substances 0.000 claims description 100
- 201000001514 prostate carcinoma Diseases 0.000 claims description 81
- 238000002360 preparation method Methods 0.000 claims description 44
- 238000012423 maintenance Methods 0.000 claims description 32
- 208000018631 connective tissue disease Diseases 0.000 claims description 14
- 208000014001 urinary system disease Diseases 0.000 claims description 14
- 208000023178 Musculoskeletal disease Diseases 0.000 claims description 8
- 201000003146 cystitis Diseases 0.000 claims description 8
- 208000017445 musculoskeletal system disease Diseases 0.000 claims description 8
- 230000002485 urinary effect Effects 0.000 claims description 7
- 208000015181 infectious disease Diseases 0.000 claims description 6
- 210000001635 urinary tract Anatomy 0.000 claims description 5
- 230000002458 infectious effect Effects 0.000 claims description 4
- MUMGGOZAMZWBJJ-DYKIIFRCSA-N Testostosterone Chemical compound O=C1CC[C@]2(C)[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CCC2=C1 MUMGGOZAMZWBJJ-DYKIIFRCSA-N 0.000 abstract description 156
- 230000000694 effects Effects 0.000 abstract description 92
- 229960003604 testosterone Drugs 0.000 abstract description 78
- 230000002526 effect on cardiovascular system Effects 0.000 abstract description 15
- 239000003098 androgen Substances 0.000 abstract description 7
- 238000011292 agonist therapy Methods 0.000 abstract description 5
- 108700012941 GNRH1 Proteins 0.000 abstract 1
- 230000001419 dependent effect Effects 0.000 abstract 1
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 249
- 238000011160 research Methods 0.000 description 81
- 239000000203 mixture Substances 0.000 description 80
- XLXSAKCOAKORKW-AQJXLSMYSA-N gonadorelin Chemical compound C([C@@H](C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1[C@@H](CCC1)C(=O)NCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@H]1NC(=O)CC1)C1=CC=C(O)C=C1 XLXSAKCOAKORKW-AQJXLSMYSA-N 0.000 description 54
- 239000000579 Gonadotropin-Releasing Hormone Substances 0.000 description 53
- 101000857870 Squalus acanthias Gonadoliberin Proteins 0.000 description 53
- 229940035638 gonadotropin-releasing hormone Drugs 0.000 description 53
- 230000002411 adverse Effects 0.000 description 46
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 45
- RGLRXNKKBLIBQS-XNHQSDQCSA-N leuprolide acetate Chemical compound CC(O)=O.CCNC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@H]1NC(=O)CC1)CC1=CC=C(O)C=C1 RGLRXNKKBLIBQS-XNHQSDQCSA-N 0.000 description 42
- 210000002966 serum Anatomy 0.000 description 42
- 208000024172 Cardiovascular disease Diseases 0.000 description 40
- 229960004338 leuprorelin Drugs 0.000 description 40
- 201000010099 disease Diseases 0.000 description 39
- 229940079593 drug Drugs 0.000 description 39
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 38
- 238000002347 injection Methods 0.000 description 38
- 239000007924 injection Substances 0.000 description 38
- 239000000556 agonist Substances 0.000 description 36
- 238000006243 chemical reaction Methods 0.000 description 32
- 238000011161 development Methods 0.000 description 32
- 230000009471 action Effects 0.000 description 30
- 238000002560 therapeutic procedure Methods 0.000 description 26
- 208000029078 coronary artery disease Diseases 0.000 description 24
- 238000004458 analytical method Methods 0.000 description 21
- 102000012673 Follicle Stimulating Hormone Human genes 0.000 description 16
- 108010079345 Follicle Stimulating Hormone Proteins 0.000 description 16
- 206010028980 Neoplasm Diseases 0.000 description 16
- 229940028334 follicle stimulating hormone Drugs 0.000 description 16
- 208000019622 heart disease Diseases 0.000 description 16
- 238000007920 subcutaneous administration Methods 0.000 description 16
- 206010022095 Injection Site reaction Diseases 0.000 description 15
- 108010072866 Prostate-Specific Antigen Proteins 0.000 description 15
- 102100038358 Prostate-specific antigen Human genes 0.000 description 15
- 238000009167 androgen deprivation therapy Methods 0.000 description 15
- 238000012360 testing method Methods 0.000 description 15
- 208000035211 Heart Murmurs Diseases 0.000 description 14
- 206010003119 arrhythmia Diseases 0.000 description 14
- 201000011510 cancer Diseases 0.000 description 14
- 230000006793 arrhythmia Effects 0.000 description 13
- 102000008238 LHRH Receptors Human genes 0.000 description 12
- 108010021290 LHRH Receptors Proteins 0.000 description 12
- 229940126602 investigational medicinal product Drugs 0.000 description 12
- 210000000056 organ Anatomy 0.000 description 12
- 206010008479 Chest Pain Diseases 0.000 description 11
- 206010060800 Hot flush Diseases 0.000 description 11
- 230000008859 change Effects 0.000 description 11
- 235000018102 proteins Nutrition 0.000 description 11
- 102000004169 proteins and genes Human genes 0.000 description 11
- 108090000623 proteins and genes Proteins 0.000 description 11
- 108010074051 C-Reactive Protein Proteins 0.000 description 10
- 102100032752 C-reactive protein Human genes 0.000 description 10
- 206010020772 Hypertension Diseases 0.000 description 10
- 230000037396 body weight Effects 0.000 description 10
- 208000010125 myocardial infarction Diseases 0.000 description 10
- 230000008569 process Effects 0.000 description 10
- 230000000391 smoking effect Effects 0.000 description 10
- 206010051055 Deep vein thrombosis Diseases 0.000 description 9
- 108010049003 Fibrinogen Proteins 0.000 description 9
- 102000008946 Fibrinogen Human genes 0.000 description 9
- 108010023302 HDL Cholesterol Proteins 0.000 description 9
- FFFHZYDWPBMWHY-VKHMYHEASA-N L-homocysteine Chemical compound OC(=O)[C@@H](N)CCS FFFHZYDWPBMWHY-VKHMYHEASA-N 0.000 description 9
- 108010028554 LDL Cholesterol Proteins 0.000 description 9
- 206010047249 Venous thrombosis Diseases 0.000 description 9
- 239000000051 antiandrogen Substances 0.000 description 9
- 235000012000 cholesterol Nutrition 0.000 description 9
- 229940012952 fibrinogen Drugs 0.000 description 9
- 230000036541 health Effects 0.000 description 9
- 230000001225 therapeutic effect Effects 0.000 description 9
- 230000002159 abnormal effect Effects 0.000 description 8
- 208000031225 myocardial ischemia Diseases 0.000 description 8
- 108090000765 processed proteins & peptides Proteins 0.000 description 8
- 208000024891 symptom Diseases 0.000 description 8
- 206010003671 Atrioventricular Block Diseases 0.000 description 7
- 102000009151 Luteinizing Hormone Human genes 0.000 description 7
- 108010073521 Luteinizing Hormone Proteins 0.000 description 7
- 230000008901 benefit Effects 0.000 description 7
- 201000001881 impotence Diseases 0.000 description 7
- 230000005764 inhibitory process Effects 0.000 description 7
- 238000012797 qualification Methods 0.000 description 7
- QNAYBMKLOCPYGJ-UWTATZPHSA-N D-alanine Chemical compound C[C@@H](N)C(O)=O QNAYBMKLOCPYGJ-UWTATZPHSA-N 0.000 description 6
- 208000010228 Erectile Dysfunction Diseases 0.000 description 6
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 6
- NTYJJOPFIAHURM-UHFFFAOYSA-N Histamine Chemical compound NCCC1=CN=CN1 NTYJJOPFIAHURM-UHFFFAOYSA-N 0.000 description 6
- -1 [Ac-D-2Nal 1 Chemical compound 0.000 description 6
- 108010023617 abarelix Proteins 0.000 description 6
- AIWRTTMUVOZGPW-HSPKUQOVSA-N abarelix Chemical compound C([C@@H](C(=O)N[C@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCNC(C)C)C(=O)N1[C@@H](CCC1)C(=O)N[C@H](C)C(N)=O)N(C)C(=O)[C@H](CO)NC(=O)[C@@H](CC=1C=NC=CC=1)NC(=O)[C@@H](CC=1C=CC(Cl)=CC=1)NC(=O)[C@@H](CC=1C=C2C=CC=CC2=CC=1)NC(C)=O)C1=CC=C(O)C=C1 AIWRTTMUVOZGPW-HSPKUQOVSA-N 0.000 description 6
- 229960002184 abarelix Drugs 0.000 description 6
- 208000035475 disorder Diseases 0.000 description 6
- 230000003203 everyday effect Effects 0.000 description 6
- 239000008103 glucose Substances 0.000 description 6
- 230000002650 habitual effect Effects 0.000 description 6
- 229940088597 hormone Drugs 0.000 description 6
- 239000005556 hormone Substances 0.000 description 6
- 210000003734 kidney Anatomy 0.000 description 6
- 210000004185 liver Anatomy 0.000 description 6
- 238000010254 subcutaneous injection Methods 0.000 description 6
- 239000007929 subcutaneous injection Substances 0.000 description 6
- DFZVZEMNPGABKO-SSDOTTSWSA-N (2r)-2-amino-3-pyridin-3-ylpropanoic acid Chemical compound OC(=O)[C@H](N)CC1=CC=CN=C1 DFZVZEMNPGABKO-SSDOTTSWSA-N 0.000 description 5
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical group CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 description 5
- 210000004204 blood vessel Anatomy 0.000 description 5
- 238000001514 detection method Methods 0.000 description 5
- 238000010586 diagram Methods 0.000 description 5
- 210000002216 heart Anatomy 0.000 description 5
- 238000007726 management method Methods 0.000 description 5
- 229940127554 medical product Drugs 0.000 description 5
- 230000008520 organization Effects 0.000 description 5
- 239000000047 product Substances 0.000 description 5
- 239000000243 solution Substances 0.000 description 5
- 238000011285 therapeutic regimen Methods 0.000 description 5
- 210000003462 vein Anatomy 0.000 description 5
- 239000008215 water for injection Substances 0.000 description 5
- 206010067484 Adverse reaction Diseases 0.000 description 4
- 206010020751 Hypersensitivity Diseases 0.000 description 4
- 206010022086 Injection site pain Diseases 0.000 description 4
- 108010000817 Leuprolide Proteins 0.000 description 4
- 108010033266 Lipoprotein(a) Proteins 0.000 description 4
- 102000057248 Lipoprotein(a) Human genes 0.000 description 4
- 201000001880 Sexual dysfunction Diseases 0.000 description 4
- 208000007536 Thrombosis Diseases 0.000 description 4
- 230000006838 adverse reaction Effects 0.000 description 4
- 208000026935 allergic disease Diseases 0.000 description 4
- 239000005557 antagonist Substances 0.000 description 4
- 210000004369 blood Anatomy 0.000 description 4
- 239000008280 blood Substances 0.000 description 4
- 230000036772 blood pressure Effects 0.000 description 4
- 210000004027 cell Anatomy 0.000 description 4
- 238000003745 diagnosis Methods 0.000 description 4
- 238000009261 endocrine therapy Methods 0.000 description 4
- 229940034984 endocrine therapy antineoplastic and immunomodulating agent Drugs 0.000 description 4
- 201000001421 hyperglycemia Diseases 0.000 description 4
- 238000007918 intramuscular administration Methods 0.000 description 4
- 238000011866 long-term treatment Methods 0.000 description 4
- 239000000843 powder Substances 0.000 description 4
- 210000002307 prostate Anatomy 0.000 description 4
- 238000001959 radiotherapy Methods 0.000 description 4
- 230000004044 response Effects 0.000 description 4
- 231100000872 sexual dysfunction Toxicity 0.000 description 4
- 238000007619 statistical method Methods 0.000 description 4
- 239000000126 substance Substances 0.000 description 4
- 230000004083 survival effect Effects 0.000 description 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 4
- 206010059245 Angiopathy Diseases 0.000 description 3
- 206010019280 Heart failures Diseases 0.000 description 3
- 208000008454 Hyperhidrosis Diseases 0.000 description 3
- 206010061216 Infarction Diseases 0.000 description 3
- 206010022061 Injection site erythema Diseases 0.000 description 3
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 description 3
- 241001465754 Metazoa Species 0.000 description 3
- 206010043298 Testicular atrophy Diseases 0.000 description 3
- 230000007815 allergy Effects 0.000 description 3
- 150000001413 amino acids Chemical group 0.000 description 3
- 230000002280 anti-androgenic effect Effects 0.000 description 3
- 206010003246 arthritis Diseases 0.000 description 3
- 201000010788 atrophy of testis Diseases 0.000 description 3
- 239000002585 base Substances 0.000 description 3
- 230000000975 bioactive effect Effects 0.000 description 3
- 208000030270 breast disease Diseases 0.000 description 3
- 230000007211 cardiovascular event Effects 0.000 description 3
- 230000036996 cardiovascular health Effects 0.000 description 3
- 230000004087 circulation Effects 0.000 description 3
- 238000002565 electrocardiography Methods 0.000 description 3
- 230000012010 growth Effects 0.000 description 3
- 201000000079 gynecomastia Diseases 0.000 description 3
- 229960001340 histamine Drugs 0.000 description 3
- 238000001794 hormone therapy Methods 0.000 description 3
- 230000037315 hyperhidrosis Effects 0.000 description 3
- 230000007574 infarction Effects 0.000 description 3
- 238000010255 intramuscular injection Methods 0.000 description 3
- 239000007927 intramuscular injection Substances 0.000 description 3
- 108010083551 iturelix Proteins 0.000 description 3
- QRYFGTULTGLGHU-NBERXCRTSA-N iturelix Chemical compound C([C@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCNC(C)C)C(=O)N1[C@@H](CCC1)C(=O)N[C@H](C)C(N)=O)NC(=O)[C@H](CCCCNC(=O)C=1C=NC=CC=1)NC(=O)[C@H](CO)NC(=O)[C@@H](CC=1C=NC=CC=1)NC(=O)[C@@H](CC=1C=CC(Cl)=CC=1)NC(=O)[C@@H](CC=1C=C2C=CC=CC2=CC=1)NC(C)=O)CCCNC(=O)C1=CC=CN=C1 QRYFGTULTGLGHU-NBERXCRTSA-N 0.000 description 3
- 239000000463 material Substances 0.000 description 3
- 230000000474 nursing effect Effects 0.000 description 3
- 238000012545 processing Methods 0.000 description 3
- 238000011471 prostatectomy Methods 0.000 description 3
- 230000001105 regulatory effect Effects 0.000 description 3
- 210000004994 reproductive system Anatomy 0.000 description 3
- 210000001519 tissue Anatomy 0.000 description 3
- 238000012384 transportation and delivery Methods 0.000 description 3
- 210000002700 urine Anatomy 0.000 description 3
- NOENHWMKHNSHGX-IZOOSHNJSA-N (2s)-1-[(2s)-2-[[(2s)-2-[[(2r)-2-[[(2r)-2-[[(2s)-2-[[(2r)-2-[[(2s)-2-[[(2r)-2-acetamido-3-naphthalen-2-ylpropanoyl]amino]-3-(4-chlorophenyl)propanoyl]amino]-3-pyridin-3-ylpropanoyl]amino]-3-hydroxypropanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-6-(ca Chemical compound C([C@H](C(=O)N[C@H](CCCCNC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCNC(C)C)C(=O)N1[C@@H](CCC1)C(=O)N[C@H](C)C(N)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](CC=1C=NC=CC=1)NC(=O)[C@H](CC=1C=CC(Cl)=CC=1)NC(=O)[C@@H](CC=1C=C2C=CC=CC2=CC=1)NC(C)=O)C1=CC=C(O)C=C1 NOENHWMKHNSHGX-IZOOSHNJSA-N 0.000 description 2
- LKJPYSCBVHEWIU-KRWDZBQOSA-N (R)-bicalutamide Chemical compound C([C@@](O)(C)C(=O)NC=1C=C(C(C#N)=CC=1)C(F)(F)F)S(=O)(=O)C1=CC=C(F)C=C1 LKJPYSCBVHEWIU-KRWDZBQOSA-N 0.000 description 2
- DSSYKIVIOFKYAU-XCBNKYQSSA-N (R)-camphor Chemical compound C1C[C@@]2(C)C(=O)C[C@@H]1C2(C)C DSSYKIVIOFKYAU-XCBNKYQSSA-N 0.000 description 2
- 206010003645 Atopy Diseases 0.000 description 2
- 208000008035 Back Pain Diseases 0.000 description 2
- 208000032170 Congenital Abnormalities Diseases 0.000 description 2
- 201000006306 Cor pulmonale Diseases 0.000 description 2
- 206010012735 Diarrhoea Diseases 0.000 description 2
- 208000030453 Drug-Related Side Effects and Adverse reaction Diseases 0.000 description 2
- 208000005189 Embolism Diseases 0.000 description 2
- 108010069236 Goserelin Proteins 0.000 description 2
- BLCLNMBMMGCOAS-URPVMXJPSA-N Goserelin Chemical compound C([C@@H](C(=O)N[C@H](COC(C)(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N1[C@@H](CCC1)C(=O)NNC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H](CC=1NC=NC=1)NC(=O)[C@H]1NC(=O)CC1)C1=CC=C(O)C=C1 BLCLNMBMMGCOAS-URPVMXJPSA-N 0.000 description 2
- 206010062767 Hypophysitis Diseases 0.000 description 2
- 208000022120 Jeavons syndrome Diseases 0.000 description 2
- KDXKERNSBIXSRK-YFKPBYRVSA-N L-lysine Chemical compound NCCCC[C@H](N)C(O)=O KDXKERNSBIXSRK-YFKPBYRVSA-N 0.000 description 2
- 206010027336 Menstruation delayed Diseases 0.000 description 2
- BKAYIFDRRZZKNF-VIFPVBQESA-N N-acetylcarnosine Chemical compound CC(=O)NCCC(=O)N[C@H](C(O)=O)CC1=CN=CN1 BKAYIFDRRZZKNF-VIFPVBQESA-N 0.000 description 2
- 206010030113 Oedema Diseases 0.000 description 2
- 208000002193 Pain Diseases 0.000 description 2
- 208000004186 Pulmonary Heart Disease Diseases 0.000 description 2
- 206010037596 Pyelonephritis Diseases 0.000 description 2
- 208000034189 Sclerosis Diseases 0.000 description 2
- 208000018452 Torsade de pointes Diseases 0.000 description 2
- 208000002363 Torsades de Pointes Diseases 0.000 description 2
- 206010047281 Ventricular arrhythmia Diseases 0.000 description 2
- 230000005856 abnormality Effects 0.000 description 2
- 239000008186 active pharmaceutical agent Substances 0.000 description 2
- 230000001154 acute effect Effects 0.000 description 2
- 235000001014 amino acid Nutrition 0.000 description 2
- 230000001548 androgenic effect Effects 0.000 description 2
- 108010070670 antarelix Proteins 0.000 description 2
- 239000000427 antigen Substances 0.000 description 2
- 102000036639 antigens Human genes 0.000 description 2
- 108091007433 antigens Proteins 0.000 description 2
- 229960000997 bicalutamide Drugs 0.000 description 2
- 230000015572 biosynthetic process Effects 0.000 description 2
- 210000000988 bone and bone Anatomy 0.000 description 2
- 230000037182 bone density Effects 0.000 description 2
- 229960000846 camphor Drugs 0.000 description 2
- 108700008462 cetrorelix Proteins 0.000 description 2
- SBNPWPIBESPSIF-MHWMIDJBSA-N cetrorelix Chemical compound C([C@@H](C(=O)N[C@H](CCCNC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1[C@@H](CCC1)C(=O)N[C@H](C)C(N)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](CC=1C=NC=CC=1)NC(=O)[C@@H](CC=1C=CC(Cl)=CC=1)NC(=O)[C@@H](CC=1C=C2C=CC=CC2=CC=1)NC(C)=O)C1=CC=C(O)C=C1 SBNPWPIBESPSIF-MHWMIDJBSA-N 0.000 description 2
- 229960003230 cetrorelix Drugs 0.000 description 2
- 230000001684 chronic effect Effects 0.000 description 2
- 230000002596 correlated effect Effects 0.000 description 2
- 230000000875 corresponding effect Effects 0.000 description 2
- 230000001186 cumulative effect Effects 0.000 description 2
- 230000002354 daily effect Effects 0.000 description 2
- 238000013461 design Methods 0.000 description 2
- 230000006866 deterioration Effects 0.000 description 2
- 230000035487 diastolic blood pressure Effects 0.000 description 2
- 230000000857 drug effect Effects 0.000 description 2
- 229940088679 drug related substance Drugs 0.000 description 2
- 238000002651 drug therapy Methods 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 230000007613 environmental effect Effects 0.000 description 2
- 231100000321 erythema Toxicity 0.000 description 2
- 230000029142 excretion Effects 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- 238000011010 flushing procedure Methods 0.000 description 2
- 229960002074 flutamide Drugs 0.000 description 2
- MKXKFYHWDHIYRV-UHFFFAOYSA-N flutamide Chemical compound CC(C)C(=O)NC1=CC=C([N+]([O-])=O)C(C(F)(F)F)=C1 MKXKFYHWDHIYRV-UHFFFAOYSA-N 0.000 description 2
- 230000006870 function Effects 0.000 description 2
- 229960002913 goserelin Drugs 0.000 description 2
- 230000006872 improvement Effects 0.000 description 2
- 208000027866 inflammatory disease Diseases 0.000 description 2
- 238000007689 inspection Methods 0.000 description 2
- 210000000244 kidney pelvis Anatomy 0.000 description 2
- 230000002045 lasting effect Effects 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 230000007774 longterm Effects 0.000 description 2
- 230000014759 maintenance of location Effects 0.000 description 2
- 238000005259 measurement Methods 0.000 description 2
- 230000004060 metabolic process Effects 0.000 description 2
- 210000004165 myocardium Anatomy 0.000 description 2
- 238000011474 orchiectomy Methods 0.000 description 2
- 238000001050 pharmacotherapy Methods 0.000 description 2
- 238000013439 planning Methods 0.000 description 2
- 238000011472 radical prostatectomy Methods 0.000 description 2
- 102000005962 receptors Human genes 0.000 description 2
- 108020003175 receptors Proteins 0.000 description 2
- 238000011084 recovery Methods 0.000 description 2
- 230000003578 releasing effect Effects 0.000 description 2
- 230000000630 rising effect Effects 0.000 description 2
- 230000028327 secretion Effects 0.000 description 2
- 239000002904 solvent Substances 0.000 description 2
- 230000002269 spontaneous effect Effects 0.000 description 2
- 239000000758 substrate Substances 0.000 description 2
- 208000011580 syndromic disease Diseases 0.000 description 2
- 230000035488 systolic blood pressure Effects 0.000 description 2
- 201000005060 thrombophlebitis Diseases 0.000 description 2
- 230000009466 transformation Effects 0.000 description 2
- 230000001052 transient effect Effects 0.000 description 2
- 238000002562 urinalysis Methods 0.000 description 2
- ZTAKYRNNPKFXGS-QMMMGPOBSA-N (2s)-2-amino-3-[4-(carbamoylamino)phenyl]propanoic acid Chemical class OC(=O)[C@@H](N)CC1=CC=C(NC(N)=O)C=C1 ZTAKYRNNPKFXGS-QMMMGPOBSA-N 0.000 description 1
- KHZVLGLEHBZEPO-QMMMGPOBSA-N (2s)-2-hydrazinyl-3-phenylpropanoic acid Chemical group NN[C@H](C(O)=O)CC1=CC=CC=C1 KHZVLGLEHBZEPO-QMMMGPOBSA-N 0.000 description 1
- NVKAWKQGWWIWPM-ABEVXSGRSA-N 17-β-hydroxy-5-α-Androstan-3-one Chemical compound C1C(=O)CC[C@]2(C)[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CC[C@H]21 NVKAWKQGWWIWPM-ABEVXSGRSA-N 0.000 description 1
- 239000002677 5-alpha reductase inhibitor Substances 0.000 description 1
- 208000012260 Accidental injury Diseases 0.000 description 1
- 102100035709 Acetyl-coenzyme A synthetase, cytoplasmic Human genes 0.000 description 1
- 206010061623 Adverse drug reaction Diseases 0.000 description 1
- KLSJWNVTNUYHDU-UHFFFAOYSA-N Amitrole Chemical compound NC1=NC=NN1 KLSJWNVTNUYHDU-UHFFFAOYSA-N 0.000 description 1
- 206010002198 Anaphylactic reaction Diseases 0.000 description 1
- PAYRUJLWNCNPSJ-UHFFFAOYSA-N Aniline Chemical compound NC1=CC=CC=C1 PAYRUJLWNCNPSJ-UHFFFAOYSA-N 0.000 description 1
- 102000004506 Blood Proteins Human genes 0.000 description 1
- 108010017384 Blood Proteins Proteins 0.000 description 1
- 208000020446 Cardiac disease Diseases 0.000 description 1
- 208000004652 Cardiovascular Abnormalities Diseases 0.000 description 1
- 206010008190 Cerebrovascular accident Diseases 0.000 description 1
- 206010009192 Circulatory collapse Diseases 0.000 description 1
- 206010010356 Congenital anomaly Diseases 0.000 description 1
- 208000001778 Coronary Occlusion Diseases 0.000 description 1
- 206010011086 Coronary artery occlusion Diseases 0.000 description 1
- 241000557626 Corvus corax Species 0.000 description 1
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 description 1
- KDXKERNSBIXSRK-RXMQYKEDSA-N D-lysine Chemical compound NCCCC[C@@H](N)C(O)=O KDXKERNSBIXSRK-RXMQYKEDSA-N 0.000 description 1
- 206010013710 Drug interaction Diseases 0.000 description 1
- 206010013975 Dyspnoeas Diseases 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 206010015150 Erythema Diseases 0.000 description 1
- 208000018522 Gastrointestinal disease Diseases 0.000 description 1
- 208000032843 Hemorrhage Diseases 0.000 description 1
- 101000783232 Homo sapiens Acetyl-coenzyme A synthetase, cytoplasmic Proteins 0.000 description 1
- 208000001953 Hypotension Diseases 0.000 description 1
- UETNIIAIRMUTSM-UHFFFAOYSA-N Jacareubin Natural products CC1(C)OC2=CC3Oc4c(O)c(O)ccc4C(=O)C3C(=C2C=C1)O UETNIIAIRMUTSM-UHFFFAOYSA-N 0.000 description 1
- AHLPHDHHMVZTML-BYPYZUCNSA-N L-Ornithine Chemical compound NCCC[C@H](N)C(O)=O AHLPHDHHMVZTML-BYPYZUCNSA-N 0.000 description 1
- QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical compound C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 description 1
- 102000004895 Lipoproteins Human genes 0.000 description 1
- 108090001030 Lipoproteins Proteins 0.000 description 1
- 206010058467 Lung neoplasm malignant Diseases 0.000 description 1
- 208000007433 Lymphatic Metastasis Diseases 0.000 description 1
- 239000004472 Lysine Substances 0.000 description 1
- 241000124008 Mammalia Species 0.000 description 1
- 229930195725 Mannitol Natural products 0.000 description 1
- 206010052904 Musculoskeletal stiffness Diseases 0.000 description 1
- 125000003047 N-acetyl group Chemical group 0.000 description 1
- CHJJGSNFBQVOTG-UHFFFAOYSA-N N-methyl-guanidine Natural products CNC(N)=N CHJJGSNFBQVOTG-UHFFFAOYSA-N 0.000 description 1
- 241001597008 Nomeidae Species 0.000 description 1
- AHLPHDHHMVZTML-UHFFFAOYSA-N Orn-delta-NH2 Natural products NCCCC(N)C(O)=O AHLPHDHHMVZTML-UHFFFAOYSA-N 0.000 description 1
- UTJLXEIPEHZYQJ-UHFFFAOYSA-N Ornithine Natural products OC(=O)C(C)CCCN UTJLXEIPEHZYQJ-UHFFFAOYSA-N 0.000 description 1
- 208000010191 Osteitis Deformans Diseases 0.000 description 1
- 208000027868 Paget disease Diseases 0.000 description 1
- 208000000450 Pelvic Pain Diseases 0.000 description 1
- 102000035195 Peptidases Human genes 0.000 description 1
- 108091005804 Peptidases Proteins 0.000 description 1
- 208000003251 Pruritus Diseases 0.000 description 1
- 208000006193 Pulmonary infarction Diseases 0.000 description 1
- 206010040047 Sepsis Diseases 0.000 description 1
- 206010041549 Spinal cord compression Diseases 0.000 description 1
- 208000006011 Stroke Diseases 0.000 description 1
- 206010042727 Swollen tongue Diseases 0.000 description 1
- 206010043345 Testicular pain Diseases 0.000 description 1
- 208000001435 Thromboembolism Diseases 0.000 description 1
- 238000008050 Total Bilirubin Reagent Methods 0.000 description 1
- 208000003443 Unconsciousness Diseases 0.000 description 1
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical group NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 description 1
- 238000002679 ablation Methods 0.000 description 1
- 238000010317 ablation therapy Methods 0.000 description 1
- 230000004913 activation Effects 0.000 description 1
- 108010070822 acyline Proteins 0.000 description 1
- ZWNUQDJANZGVFO-YHSALVGYSA-N acyline Chemical group C([C@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCNC(C)C)C(=O)N1[C@@H](CCC1)C(=O)N[C@H](C)C(N)=O)NC(=O)[C@H](CC=1C=CC(NC(C)=O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@@H](CC=1C=NC=CC=1)NC(=O)[C@@H](CC=1C=CC(Cl)=CC=1)NC(=O)[C@@H](CC=1C=C2C=CC=CC2=CC=1)NC(C)=O)C1=CC=C(NC(C)=O)C=C1 ZWNUQDJANZGVFO-YHSALVGYSA-N 0.000 description 1
- 210000000577 adipose tissue Anatomy 0.000 description 1
- 235000004279 alanine Nutrition 0.000 description 1
- 239000003513 alkali Substances 0.000 description 1
- 230000000172 allergic effect Effects 0.000 description 1
- 150000001408 amides Chemical class 0.000 description 1
- 239000002269 analeptic agent Substances 0.000 description 1
- 208000003455 anaphylaxis Diseases 0.000 description 1
- 210000003484 anatomy Anatomy 0.000 description 1
- ZRALSGWEFCBTJO-UHFFFAOYSA-N anhydrous guanidine Natural products NC(N)=N ZRALSGWEFCBTJO-UHFFFAOYSA-N 0.000 description 1
- 230000002547 anomalous effect Effects 0.000 description 1
- 230000008485 antagonism Effects 0.000 description 1
- 230000000844 anti-bacterial effect Effects 0.000 description 1
- 238000013459 approach Methods 0.000 description 1
- 208000006673 asthma Diseases 0.000 description 1
- 208000010668 atopic eczema Diseases 0.000 description 1
- 229940127233 azaline B Drugs 0.000 description 1
- 208000019804 backache Diseases 0.000 description 1
- 230000006399 behavior Effects 0.000 description 1
- 230000002146 bilateral effect Effects 0.000 description 1
- 210000003445 biliary tract Anatomy 0.000 description 1
- 230000033228 biological regulation Effects 0.000 description 1
- 229960000074 biopharmaceutical Drugs 0.000 description 1
- 230000007698 birth defect Effects 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
- 208000030303 breathing problems Diseases 0.000 description 1
- 238000004364 calculation method Methods 0.000 description 1
- 239000004202 carbamide Substances 0.000 description 1
- 125000001951 carbamoylamino group Chemical group C(N)(=O)N* 0.000 description 1
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 description 1
- 231100000504 carcinogenesis Toxicity 0.000 description 1
- 210000003169 central nervous system Anatomy 0.000 description 1
- 238000005352 clarification Methods 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 238000012790 confirmation Methods 0.000 description 1
- 230000008602 contraction Effects 0.000 description 1
- 210000004351 coronary vessel Anatomy 0.000 description 1
- 238000009223 counseling Methods 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 238000000586 desensitisation Methods 0.000 description 1
- QGBSISYHAICWAH-UHFFFAOYSA-N dicyandiamide Chemical class NC(N)=NC#N QGBSISYHAICWAH-UHFFFAOYSA-N 0.000 description 1
- 230000004069 differentiation Effects 0.000 description 1
- 238000009792 diffusion process Methods 0.000 description 1
- 208000010643 digestive system disease Diseases 0.000 description 1
- SWSQBOPZIKWTGO-UHFFFAOYSA-N dimethylaminoamidine Natural products CN(C)C(N)=N SWSQBOPZIKWTGO-UHFFFAOYSA-N 0.000 description 1
- 238000009826 distribution Methods 0.000 description 1
- 208000002173 dizziness Diseases 0.000 description 1
- 238000001647 drug administration Methods 0.000 description 1
- 238000009509 drug development Methods 0.000 description 1
- 238000003255 drug test Methods 0.000 description 1
- 230000007515 enzymatic degradation Effects 0.000 description 1
- 229940011871 estrogen Drugs 0.000 description 1
- 239000000262 estrogen Substances 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 238000009313 farming Methods 0.000 description 1
- 230000002349 favourable effect Effects 0.000 description 1
- 210000003608 fece Anatomy 0.000 description 1
- 210000003191 femoral vein Anatomy 0.000 description 1
- 238000011049 filling Methods 0.000 description 1
- 229940002006 firmagon Drugs 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 239000012634 fragment Substances 0.000 description 1
- 238000011990 functional testing Methods 0.000 description 1
- 230000002496 gastric effect Effects 0.000 description 1
- 208000018685 gastrointestinal system disease Diseases 0.000 description 1
- 238000001879 gelation Methods 0.000 description 1
- 210000004907 gland Anatomy 0.000 description 1
- 210000002149 gonad Anatomy 0.000 description 1
- 230000008821 health effect Effects 0.000 description 1
- 230000005802 health problem Effects 0.000 description 1
- 125000000623 heterocyclic group Chemical group 0.000 description 1
- 230000002962 histologic effect Effects 0.000 description 1
- 230000009610 hypersensitivity Effects 0.000 description 1
- 230000001631 hypertensive effect Effects 0.000 description 1
- 230000036543 hypotension Effects 0.000 description 1
- 210000003016 hypothalamus Anatomy 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 230000000977 initiatory effect Effects 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
- 238000001990 intravenous administration Methods 0.000 description 1
- 238000011835 investigation Methods 0.000 description 1
- 230000001788 irregular Effects 0.000 description 1
- 238000002372 labelling Methods 0.000 description 1
- 230000001665 lethal effect Effects 0.000 description 1
- GFIJNRVAKGFPGQ-LIJARHBVSA-N leuprolide Chemical compound CCNC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@H]1NC(=O)CC1)CC1=CC=C(O)C=C1 GFIJNRVAKGFPGQ-LIJARHBVSA-N 0.000 description 1
- 230000003908 liver function Effects 0.000 description 1
- 229940087857 lupron Drugs 0.000 description 1
- 210000001165 lymph node Anatomy 0.000 description 1
- 208000027202 mammary Paget disease Diseases 0.000 description 1
- 239000000594 mannitol Substances 0.000 description 1
- 235000010355 mannitol Nutrition 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 230000003340 mental effect Effects 0.000 description 1
- 239000002207 metabolite Substances 0.000 description 1
- 230000001394 metastastic effect Effects 0.000 description 1
- 208000037819 metastatic cancer Diseases 0.000 description 1
- 208000011575 metastatic malignant neoplasm Diseases 0.000 description 1
- 206010061289 metastatic neoplasm Diseases 0.000 description 1
- 208000010658 metastatic prostate carcinoma Diseases 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 210000003205 muscle Anatomy 0.000 description 1
- 230000035772 mutation Effects 0.000 description 1
- 230000001338 necrotic effect Effects 0.000 description 1
- 230000009826 neoplastic cell growth Effects 0.000 description 1
- 230000000683 nonmetastatic effect Effects 0.000 description 1
- 238000011275 oncology therapy Methods 0.000 description 1
- 229960003104 ornithine Drugs 0.000 description 1
- 238000012856 packing Methods 0.000 description 1
- 206010033675 panniculitis Diseases 0.000 description 1
- 230000007170 pathology Effects 0.000 description 1
- 210000004197 pelvis Anatomy 0.000 description 1
- 230000002085 persistent effect Effects 0.000 description 1
- 239000000825 pharmaceutical preparation Substances 0.000 description 1
- 230000003285 pharmacodynamic effect Effects 0.000 description 1
- 230000001766 physiological effect Effects 0.000 description 1
- 230000035479 physiological effects, processes and functions Effects 0.000 description 1
- 230000036470 plasma concentration Effects 0.000 description 1
- 239000002574 poison Substances 0.000 description 1
- 231100000614 poison Toxicity 0.000 description 1
- 210000003513 popliteal vein Anatomy 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 1
- 102000004196 processed proteins & peptides Human genes 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 201000005825 prostate adenocarcinoma Diseases 0.000 description 1
- 201000007094 prostatitis Diseases 0.000 description 1
- 230000002685 pulmonary effect Effects 0.000 description 1
- 230000007575 pulmonary infarction Effects 0.000 description 1
- 238000000306 qrs interval Methods 0.000 description 1
- 230000005855 radiation Effects 0.000 description 1
- 230000002285 radioactive effect Effects 0.000 description 1
- 239000002464 receptor antagonist Substances 0.000 description 1
- 229940044551 receptor antagonist Drugs 0.000 description 1
- 239000003087 receptor blocking agent Substances 0.000 description 1
- 208000017443 reproductive system disease Diseases 0.000 description 1
- 230000000284 resting effect Effects 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
- 208000013223 septicemia Diseases 0.000 description 1
- 208000012201 sexual and gender identity disease Diseases 0.000 description 1
- 208000015891 sexual disease Diseases 0.000 description 1
- 230000001568 sexual effect Effects 0.000 description 1
- 206010040560 shock Diseases 0.000 description 1
- 238000004088 simulation Methods 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 206010041823 squamous cell carcinoma Diseases 0.000 description 1
- 208000017572 squamous cell neoplasm Diseases 0.000 description 1
- 238000010561 standard procedure Methods 0.000 description 1
- 210000004304 subcutaneous tissue Anatomy 0.000 description 1
- NCEXYHBECQHGNR-QZQOTICOSA-N sulfasalazine Chemical group C1=C(O)C(C(=O)O)=CC(\N=N\C=2C=CC(=CC=2)S(=O)(=O)NC=2N=CC=CC=2)=C1 NCEXYHBECQHGNR-QZQOTICOSA-N 0.000 description 1
- 229960001940 sulfasalazine Drugs 0.000 description 1
- NCEXYHBECQHGNR-UHFFFAOYSA-N sulfasalazine Natural products C1=C(O)C(C(=O)O)=CC(N=NC=2C=CC(=CC=2)S(=O)(=O)NC=2N=CC=CC=2)=C1 NCEXYHBECQHGNR-UHFFFAOYSA-N 0.000 description 1
- 239000013589 supplement Substances 0.000 description 1
- 238000001356 surgical procedure Methods 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 230000008961 swelling Effects 0.000 description 1
- 230000002194 synthesizing effect Effects 0.000 description 1
- 231100001044 testicular atrophy Toxicity 0.000 description 1
- 210000001550 testis Anatomy 0.000 description 1
- 230000036962 time dependent Effects 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 231100000155 toxicity by organ Toxicity 0.000 description 1
- 230000007675 toxicity by organ Effects 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
- 230000007704 transition Effects 0.000 description 1
- 238000013519 translation Methods 0.000 description 1
- 210000005239 tubule Anatomy 0.000 description 1
- 230000004614 tumor growth Effects 0.000 description 1
- 210000000626 ureter Anatomy 0.000 description 1
- 210000003708 urethra Anatomy 0.000 description 1
- 206010046459 urethral obstruction Diseases 0.000 description 1
- 210000003932 urinary bladder Anatomy 0.000 description 1
- 230000036642 wellbeing Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/08—Peptides having 5 to 11 amino acids
- A61K38/09—Luteinising hormone-releasing hormone [LHRH], i.e. Gonadotropin-releasing hormone [GnRH]; Related peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/08—Peptides having 5 to 11 amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Reproductive Health (AREA)
- Endocrinology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Dermatology (AREA)
- Oncology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Steroid Compounds (AREA)
- Medicines Containing Plant Substances (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US2774108P | 2008-02-11 | 2008-02-11 | |
| US61/027,741 | 2008-02-11 | ||
| EP08250703 | 2008-02-29 | ||
| EP08250703.9 | 2008-02-29 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2009801127793A Division CN101998861A (zh) | 2008-02-11 | 2009-02-10 | 用gnrh拮抗剂地加瑞克治疗前列腺癌的方法 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN103990107A true CN103990107A (zh) | 2014-08-20 |
Family
ID=39718285
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201410247166.3A Pending CN103990107A (zh) | 2008-02-11 | 2009-02-10 | 用gnrh拮抗剂地加瑞克治疗前列腺癌的方法 |
| CN201710169651.7A Pending CN107412726A (zh) | 2008-02-11 | 2009-02-10 | 用gnrh拮抗剂地加瑞克治疗前列腺癌的方法 |
| CN200980104713XA Ceased CN101939020B (zh) | 2008-02-11 | 2009-02-10 | 地加瑞克在制备治疗转移期前列腺癌的药物中的应用 |
| CN2009801127793A Pending CN101998861A (zh) | 2008-02-11 | 2009-02-10 | 用gnrh拮抗剂地加瑞克治疗前列腺癌的方法 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201710169651.7A Pending CN107412726A (zh) | 2008-02-11 | 2009-02-10 | 用gnrh拮抗剂地加瑞克治疗前列腺癌的方法 |
| CN200980104713XA Ceased CN101939020B (zh) | 2008-02-11 | 2009-02-10 | 地加瑞克在制备治疗转移期前列腺癌的药物中的应用 |
| CN2009801127793A Pending CN101998861A (zh) | 2008-02-11 | 2009-02-10 | 用gnrh拮抗剂地加瑞克治疗前列腺癌的方法 |
Country Status (25)
| Country | Link |
|---|---|
| US (17) | US8841081B2 (https=) |
| EP (7) | EP2650012B1 (https=) |
| JP (12) | JP5876652B2 (https=) |
| KR (8) | KR101542480B1 (https=) |
| CN (4) | CN103990107A (https=) |
| AU (2) | AU2009213751B2 (https=) |
| BR (2) | BRPI0908127A2 (https=) |
| CA (3) | CA2714445C (https=) |
| CY (3) | CY1115561T1 (https=) |
| DK (3) | DK2249859T3 (https=) |
| EA (4) | EA036695B1 (https=) |
| ES (3) | ES2532709T3 (https=) |
| HK (1) | HK1198243A1 (https=) |
| HR (3) | HRP20140665T1 (https=) |
| IL (3) | IL207295A (https=) |
| JO (1) | JOP20090061B1 (https=) |
| MX (2) | MX2010008816A (https=) |
| NZ (4) | NZ587057A (https=) |
| PL (3) | PL2249859T3 (https=) |
| PT (3) | PT2249859E (https=) |
| RU (2) | RU2504394C2 (https=) |
| SI (3) | SI2249859T1 (https=) |
| TW (2) | TWI442932B (https=) |
| WO (2) | WO2009101530A1 (https=) |
| ZA (1) | ZA201005697B (https=) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0117057D0 (en) * | 2001-07-12 | 2001-09-05 | Ferring Bv | Pharmaceutical composition |
| JO3525B1 (ar) * | 2008-02-11 | 2020-07-05 | Ferring Int Center Sa | علاج سرطان البروستاتا في المرحلة النقيلية بدواء ديجاريليكس |
| TWI442932B (zh) * | 2008-02-11 | 2014-07-01 | Ferring Int Ct Sa | 以ＧｎＲＨ拮抗劑治療攝護腺癌的方法 |
| EP2424503B1 (en) * | 2009-05-01 | 2017-07-05 | Ferring BV | Composition for the treatment of prostate cancer |
| TW201043221A (en) * | 2009-05-06 | 2010-12-16 | Ferring Int Ct Sa | Kit and method for preparation of a Degarelix solution |
| US20110039787A1 (en) * | 2009-07-06 | 2011-02-17 | Ferring International Center S.A. | Compositions, kits and methods for treating benign prostate hyperplasia |
| FR2964323B1 (fr) * | 2010-09-08 | 2012-11-09 | Jean Pierre Raynaud | Utilisation de la testosterone chez un patient en deficit androgenique et atteint d'un cancer de la prostate |
| PT2632934T (pt) | 2010-10-27 | 2017-01-06 | Ferring Bv | Processo para o fabrico de degarelix e seus intermediários |
| EP2447276A1 (en) | 2010-10-27 | 2012-05-02 | Ferring B.V. | Process for the manufacture of Degarelix and its intermediates |
| JO3755B1 (ar) | 2011-01-26 | 2021-01-31 | Ferring Bv | تركيبات تستوستيرون |
| BR112013023050A8 (pt) * | 2011-03-09 | 2018-09-25 | G Pestell Richard | antagonista de ccr5, método para determinar se um indivíduo humano tendo câncer de próstata está sofrendo de ou sob o risco de desenvolver metástase, para identificar um antagonista de ccr5, método para determinar se um indivíduo humano tendo câncer de próstata está sofrendo de ou sob o risco de desenvolver metástase, para identificar um composto candidato, para produzir in vitro células epiteliais primárias, para diagnosticar câncer de próstata, para selecionar um tratamento para um indivíduo tendo um câncer/tumor de próstata, linhagem de célula, e, modelo animal |
| CN102204889B (zh) * | 2011-05-23 | 2013-09-18 | 蚌埠丰原涂山制药有限公司 | 一种醋酸地加瑞克冻干粉针剂及其制备方法 |
| WO2013104745A1 (en) * | 2012-01-13 | 2013-07-18 | Ferring Bv | Pharmaceutical composition |
| AU2013262977A1 (en) | 2012-05-14 | 2015-01-22 | Prostagene, Llc | Using modulators of CCR5 for treating cancer |
| SG11201407679PA (en) | 2012-06-01 | 2014-12-30 | Ferring Bv | Manufacture of degarelix |
| SG11201501870RA (en) | 2012-09-26 | 2015-04-29 | Aragon Pharmaceuticals Inc | Anti-androgens for the treatment of non-metastatic castrate-resistant prostate cancer |
| AR092707A1 (es) | 2012-09-28 | 2015-04-29 | Takeda Pharmaceuticals Co | Metodo de produccion de derivado de tienopirimidina |
| US10881659B2 (en) | 2013-03-15 | 2021-01-05 | Abbvie Inc. | Methods of treating heavy menstrual bleeding |
| WO2014186608A1 (en) * | 2013-05-15 | 2014-11-20 | Adverse Events, Inc. | System and method for surveillance and evaluation of safety risks associated with medical interventions |
| EP3185881B1 (en) * | 2014-08-26 | 2022-03-09 | Betanien Hospital | Methods, agents and compositions for treatment of inflammatory conditions |
| JP6941565B2 (ja) * | 2015-05-12 | 2021-09-29 | ドレクセル ユニバーシティ | がん転移を処置または防止するのに有用な化合物および組成物、ならびにこれらの使用法 |
| MA46361A (fr) | 2016-09-30 | 2021-03-31 | Myovant Sciences Gmbh | Traitement du cancer de la prostate |
| JP6990717B2 (ja) * | 2017-01-30 | 2022-02-03 | アンテヴ リミテッド | 少なくとも１種のｇｎｒｈアンタゴニストを含む組成物 |
| AU2018351714A1 (en) | 2017-10-16 | 2020-04-30 | Aragon Pharmaceuticals, Inc. | Anti-androgens for the treatment of non-metastatic castration-resistant prostate cancer |
| CN112261942A (zh) | 2018-04-19 | 2021-01-22 | 艾伯维公司 | 治疗重度月经出血的方法 |
| JP2021532160A (ja) * | 2018-08-01 | 2021-11-25 | アッヴィ・インコーポレイテッド | エラゴリックスに関する投与計画 |
| RU2731002C1 (ru) * | 2019-10-22 | 2020-08-26 | Государственное бюджетное учреждение здравоохранения Московской области "Московский областной научно-исследовательский клинический институт им. М.Ф. Владимирского" (ГБУЗ МО МОНИКИ им. М.Ф. Владимирского) | Способ лечения рака предстательной железы |
| CN116407494B (zh) * | 2023-03-02 | 2024-07-09 | 山东大学齐鲁医院 | 一种醋酸地加瑞克注射液及其制备方法、用途 |
Family Cites Families (58)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3773919A (en) * | 1969-10-23 | 1973-11-20 | Du Pont | Polylactide-drug mixtures |
| ZA735680B (en) * | 1972-09-21 | 1974-07-31 | Hoffmann La Roche | Polypeptides |
| US4072668A (en) | 1973-11-06 | 1978-02-07 | The Salk Institute For Biological Studies | LH-RH Analogs |
| EP0002749B2 (en) | 1977-12-26 | 1987-08-12 | IHARA CHEMICAL INDUSTRY Co., Ltd. | Process for producing aromatic monocarboxylic acid |
| US5296468A (en) | 1989-10-30 | 1994-03-22 | The Salk Institute For Biological Studies | GnRH analogs |
| DE69214818T2 (de) | 1991-04-25 | 1997-02-27 | Romano S.-Cergue Deghenghi | LHRH-Antagonisten |
| DE69330107T3 (de) | 1992-02-12 | 2004-12-30 | Daikyo Gomu Seiko, Ltd. | Medizinisches Gerät |
| GB9211268D0 (en) * | 1992-05-28 | 1992-07-15 | Ici Plc | Salts of basic peptides with carboxyterminated polyesters |
| SI9300468A (en) | 1992-10-14 | 1994-06-30 | Hoffmann La Roche | Injectable composition for the sustained release of biologically active compounds |
| DE4305225A1 (de) * | 1993-02-19 | 1994-08-25 | Asta Medica Ag | Neues Herstellverfahren für Cetrorelix Lyophilisat |
| US5506207A (en) | 1994-03-18 | 1996-04-09 | The Salk Institute For Biological Studies | GNRH antagonists XIII |
| US5595760A (en) * | 1994-09-02 | 1997-01-21 | Delab | Sustained release of peptides from pharmaceutical compositions |
| JP3688381B2 (ja) | 1995-03-10 | 2005-08-24 | 株式会社東芝 | 光ディスク原盤露光装置 |
| US6379669B1 (en) | 1995-08-04 | 2002-04-30 | Akhouri A. Sinha | Targeting of organs by immunoconjugates |
| US5710246A (en) | 1996-03-19 | 1998-01-20 | Abbott Laboratories | Process for intermediates for the synthesis of LHRH antagonists |
| US5860957A (en) | 1997-02-07 | 1999-01-19 | Sarcos, Inc. | Multipathway electronically-controlled drug delivery system |
| US5821230A (en) * | 1997-04-11 | 1998-10-13 | Ferring Bv | GnRH antagonist decapeptides |
| US5925730A (en) | 1997-04-11 | 1999-07-20 | Ferring Bv | GnRH antagonists |
| WO1999026964A1 (en) | 1997-11-20 | 1999-06-03 | Ortho-Mcneil Pharmaceutical, Inc. | LIQUID PHASE PROCESS FOR THE PREPARATION OF GnRH PEPTIDES |
| FR2776520B1 (fr) | 1998-03-25 | 2000-05-05 | Sod Conseils Rech Applic | Nouvelles compositions pharmaceutiques destinees a la liberation prolongee de peptides et leur procede de preparation |
| CA2336879C (en) | 1998-07-20 | 2010-06-01 | Peptech Limited | Sustained-release formulations comprising peptides, polypeptides, proteins or nucleic acids as active ingredients |
| CN1443195A (zh) * | 2000-03-14 | 2003-09-17 | 赞塔里斯股份公司 | 新型lhrh拮抗剂,其制备方法和药物用途 |
| US20040198706A1 (en) | 2003-03-11 | 2004-10-07 | Carrara Dario Norberto R. | Methods and formulations for transdermal or transmucosal application of active agents |
| US20020103131A1 (en) | 2001-01-26 | 2002-08-01 | Jacobson Jill D. | Prevention of diabetes by administration of GnRH antagonists |
| EP2277542B1 (en) * | 2001-06-01 | 2014-04-16 | Cornell Research Foundation Inc. | Modified antibodies to prostrate-specific membrane antigen and uses thereof |
| GB0117057D0 (en) | 2001-07-12 | 2001-09-05 | Ferring Bv | Pharmaceutical composition |
| US7229774B2 (en) | 2001-08-02 | 2007-06-12 | Regents Of The University Of Michigan | Expression profile of prostate cancer |
| US20060234918A1 (en) * | 2001-12-19 | 2006-10-19 | Voyager Pharmaceutical Corporation | Methods for treating and preventing cancers that express the hypothalamic-pituitary-gonadal axis of hormones and receptors |
| US20070015713A1 (en) | 2005-07-14 | 2007-01-18 | Voyager Pharmaceutical Corporation | Methods for treating prostate cancer |
| SE0104463D0 (sv) | 2001-12-29 | 2001-12-29 | Carlbiotech Ltd As | Mellanprodukter för syntes af LHRH-antagonister, sätt att framställa dem och sätt för framställning av LHRH-antagonister |
| CN1411803A (zh) | 2002-08-29 | 2003-04-23 | 四川大学 | 制备前体脂质体的方法及其装置 |
| RS52966B (sr) | 2002-09-27 | 2014-02-28 | Zentaris Gmbh | Oblik za terapijsku primenu aktivnih peptida sa produženim oslobađanjem aktivnog sastojka i postupak za njihovo dobijanje |
| GB0223367D0 (en) * | 2002-10-09 | 2002-11-13 | Astrazeneca Ab | Therapeutic treatment |
| AR042815A1 (es) | 2002-12-26 | 2005-07-06 | Alza Corp | Dispositivo de suministro de agente activo que tiene miembros compuestos |
| EP1674082A1 (de) | 2004-12-22 | 2006-06-28 | Zentaris GmbH | Verfahren zur Herstellung von sterilen Suspensionen oder Lyophilisaten schwerlöslicher basischer Peptidkomplexe, diese enthaltende pharmazeutische Formulierungen sowie ihre Verwendung als Arzneimittel |
| WO2006069779A1 (en) | 2004-12-30 | 2006-07-06 | F. Hoffmann-La Roche Ag | Preparing of peptides with excellent solubility |
| US8158152B2 (en) | 2005-11-18 | 2012-04-17 | Scidose Llc | Lyophilization process and products obtained thereby |
| WO2007130809A2 (en) | 2006-05-06 | 2007-11-15 | Volodymyr Brodskyy | An automatic injectable drug mixing device |
| EP1891964A1 (en) * | 2006-08-08 | 2008-02-27 | AEterna Zentaris GmbH | Application of initial doses of LHRH analogues and maintenance doses of LHRH antagonists for the treatment of hormone-dependent cancers and corresponding pharmaceutical kits |
| EP1967202A1 (en) | 2007-03-05 | 2008-09-10 | AEterna Zentaris GmbH | Use of LHRH Antagonists for the Treatment of Lower Urinary Tract Symptoms, in particular Overactive Bladder and/or Detrusor Overactivity |
| IL182922A0 (en) | 2007-05-02 | 2007-09-20 | Medimop Medical Projects Ltd | Automatic liquid drug reconstitution apparatus |
| US8283331B2 (en) | 2007-10-09 | 2012-10-09 | Children's Medical Center Corporation | Methods to regulate miRNA processing by targeting Lin-28 |
| WO2009090189A1 (en) | 2008-01-15 | 2009-07-23 | Abbott Gmbh & Co.Kg | Powdered protein compositions and methods of making same |
| TWI442932B (zh) | 2008-02-11 | 2014-07-01 | Ferring Int Ct Sa | 以ＧｎＲＨ拮抗劑治療攝護腺癌的方法 |
| US8105292B2 (en) * | 2008-02-11 | 2012-01-31 | Safety Syringes, Inc. | Reconstitution means for safety device |
| KR101621725B1 (ko) | 2009-04-24 | 2016-05-17 | 폴리펩타이드 라보라토리즈 에이/에스 | 데가렐릭스의 제조 방법 |
| EP2424503B1 (en) | 2009-05-01 | 2017-07-05 | Ferring BV | Composition for the treatment of prostate cancer |
| TW201043221A (en) | 2009-05-06 | 2010-12-16 | Ferring Int Ct Sa | Kit and method for preparation of a Degarelix solution |
| US20110039787A1 (en) | 2009-07-06 | 2011-02-17 | Ferring International Center S.A. | Compositions, kits and methods for treating benign prostate hyperplasia |
| WO2011066386A1 (en) | 2009-11-25 | 2011-06-03 | Novetide, Ltd. | Process for production of degarelix |
| IT1399892B1 (it) | 2010-03-15 | 2013-05-09 | Spi Tecno Srl | Sistema per l illuminazione pubblica |
| ES2385240B1 (es) | 2010-07-26 | 2013-09-23 | Gp-Pharm, S.A. | Cápsulas de principios activos farmacéuticos y ácidos grasos poliinsaturados para el tratamiento de enfermedades de la próstata. |
| PT2632934T (pt) | 2010-10-27 | 2017-01-06 | Ferring Bv | Processo para o fabrico de degarelix e seus intermediários |
| EP2447276A1 (en) | 2010-10-27 | 2012-05-02 | Ferring B.V. | Process for the manufacture of Degarelix and its intermediates |
| JO3755B1 (ar) | 2011-01-26 | 2021-01-31 | Ferring Bv | تركيبات تستوستيرون |
| CN102204889B (zh) | 2011-05-23 | 2013-09-18 | 蚌埠丰原涂山制药有限公司 | 一种醋酸地加瑞克冻干粉针剂及其制备方法 |
| EP2731607B1 (en) | 2011-07-15 | 2017-10-11 | Ferring B.V. | Method for timing a colonoscopy wherein a picosulate composition is administered |
| SG11201407679PA (en) | 2012-06-01 | 2014-12-30 | Ferring Bv | Manufacture of degarelix |
-
2009
- 2009-02-09 TW TW098104075A patent/TWI442932B/zh active
- 2009-02-09 TW TW098104073A patent/TWI539959B/zh active
- 2009-02-09 JO JOP/2009/0061A patent/JOP20090061B1/ar active
- 2009-02-10 EP EP13168404.5A patent/EP2650012B1/en not_active Revoked
- 2009-02-10 EA EA201300741A patent/EA036695B1/ru not_active IP Right Cessation
- 2009-02-10 ES ES12165896.7T patent/ES2532709T3/es active Active
- 2009-02-10 EA EA200901074A patent/EA017582B1/ru not_active IP Right Cessation
- 2009-02-10 JP JP2010545576A patent/JP5876652B2/ja active Active
- 2009-02-10 PL PL09711390T patent/PL2249859T3/pl unknown
- 2009-02-10 DK DK09711390.6T patent/DK2249859T3/da active
- 2009-02-10 KR KR1020107020035A patent/KR101542480B1/ko active Active
- 2009-02-10 KR KR1020227000962A patent/KR20220009504A/ko not_active Ceased
- 2009-02-10 PL PL13168404T patent/PL2650012T3/pl unknown
- 2009-02-10 CN CN201410247166.3A patent/CN103990107A/zh active Pending
- 2009-02-10 BR BRPI0908127-5A patent/BRPI0908127A2/pt not_active Application Discontinuation
- 2009-02-10 MX MX2010008816A patent/MX2010008816A/es active IP Right Grant
- 2009-02-10 CN CN201710169651.7A patent/CN107412726A/zh active Pending
- 2009-02-10 PT PT97113906T patent/PT2249859E/pt unknown
- 2009-02-10 US US12/368,713 patent/US8841081B2/en active Active
- 2009-02-10 DK DK12165896T patent/DK2505204T3/da active
- 2009-02-10 KR KR1020107020036A patent/KR20100123714A/ko not_active Ceased
- 2009-02-10 CA CA2714445A patent/CA2714445C/en not_active Expired - Fee Related
- 2009-02-10 AU AU2009213751A patent/AU2009213751B2/en active Active
- 2009-02-10 US US12/368,935 patent/US20090203623A1/en not_active Abandoned
- 2009-02-10 PT PT12165896T patent/PT2505204E/pt unknown
- 2009-02-10 NZ NZ587057A patent/NZ587057A/xx unknown
- 2009-02-10 EP EP14170557.4A patent/EP2799085A1/en not_active Ceased
- 2009-02-10 KR KR1020157020657A patent/KR20150091543A/ko not_active Ceased
- 2009-02-10 AU AU2009213748A patent/AU2009213748B9/en active Active
- 2009-02-10 EP EP23174353.5A patent/EP4257197A3/en active Pending
- 2009-02-10 EP EP09711390.6A patent/EP2249859B1/en not_active Revoked
- 2009-02-10 EA EA201300742A patent/EA026521B1/ru not_active IP Right Cessation
- 2009-02-10 WO PCT/IB2009/000350 patent/WO2009101530A1/en not_active Ceased
- 2009-02-10 ES ES09711390.6T patent/ES2479441T3/es active Active
- 2009-02-10 KR KR1020237019555A patent/KR20230088848A/ko not_active Ceased
- 2009-02-10 KR KR1020187030959A patent/KR20180118830A/ko not_active Ceased
- 2009-02-10 RU RU2010133480/15A patent/RU2504394C2/ru active
- 2009-02-10 PT PT131684045T patent/PT2650012E/pt unknown
- 2009-02-10 EP EP18151844.0A patent/EP3360565A1/en active Pending
- 2009-02-10 DK DK13168404.5T patent/DK2650012T3/da active
- 2009-02-10 BR BRPI0908129-1A patent/BRPI0908129A2/pt not_active Application Discontinuation
- 2009-02-10 RU RU2010133481/15A patent/RU2504393C2/ru active
- 2009-02-10 MX MX2010008817A patent/MX2010008817A/es active IP Right Grant
- 2009-02-10 NZ NZ587088A patent/NZ587088A/xx unknown
- 2009-02-10 WO PCT/IB2009/000370 patent/WO2009101533A1/en not_active Ceased
- 2009-02-10 NZ NZ603958A patent/NZ603958A/xx unknown
- 2009-02-10 SI SI200930942T patent/SI2249859T1/sl unknown
- 2009-02-10 EA EA200901075A patent/EA020543B1/ru unknown
- 2009-02-10 SI SI200931138T patent/SI2505204T1/sl unknown
- 2009-02-10 CA CA2714444A patent/CA2714444A1/en active Pending
- 2009-02-10 JP JP2010545575A patent/JP5924866B2/ja active Active
- 2009-02-10 PL PL12165896T patent/PL2505204T3/pl unknown
- 2009-02-10 KR KR1020257005826A patent/KR20250028541A/ko active Pending
- 2009-02-10 HR HRP20140665AT patent/HRP20140665T1/hr unknown
- 2009-02-10 EP EP09709538A patent/EP2249858A1/en not_active Ceased
- 2009-02-10 KR KR1020147030003A patent/KR20140130757A/ko not_active Ceased
- 2009-02-10 CN CN200980104713XA patent/CN101939020B/zh not_active Ceased
- 2009-02-10 CA CA3235099A patent/CA3235099A1/en active Pending
- 2009-02-10 EP EP12165896.7A patent/EP2505204B1/en not_active Revoked
- 2009-02-10 NZ NZ603932A patent/NZ603932A/en unknown
- 2009-02-10 ES ES13168404.5T patent/ES2540235T3/es active Active
- 2009-02-10 SI SI200931181T patent/SI2650012T1/sl unknown
- 2009-02-10 CN CN2009801127793A patent/CN101998861A/zh active Pending
-
2010
- 2010-07-29 IL IL207295A patent/IL207295A/en active IP Right Grant
- 2010-08-04 IL IL207400A patent/IL207400A/en active IP Right Grant
- 2010-08-10 ZA ZA2010/05697A patent/ZA201005697B/en unknown
- 2010-12-09 HK HK14111736.0A patent/HK1198243A1/en unknown
-
2012
- 2012-04-27 US US13/458,330 patent/US9415085B2/en active Active
- 2012-11-19 IL IL223124A patent/IL223124A0/en unknown
-
2013
- 2013-12-24 US US14/139,922 patent/US9579359B2/en active Active
-
2014
- 2014-03-14 JP JP2014051197A patent/JP6189234B2/ja active Active
- 2014-04-22 JP JP2014087895A patent/JP6254042B2/ja active Active
- 2014-07-18 CY CY20141100542T patent/CY1115561T1/el unknown
- 2014-08-08 US US14/454,825 patent/US9877999B2/en active Active
-
2015
- 2015-02-13 CY CY20151100155T patent/CY1116341T1/el unknown
- 2015-03-16 HR HRP20150290AT patent/HRP20150290T1/hr unknown
- 2015-05-14 CY CY20151100434T patent/CY1116289T1/el unknown
- 2015-06-12 HR HRP20150633TT patent/HRP20150633T1/hr unknown
-
2016
- 2016-05-11 JP JP2016095555A patent/JP2016193910A/ja active Pending
- 2016-05-18 JP JP2016099437A patent/JP2016216455A/ja active Pending
- 2016-07-08 US US15/205,108 patent/US10695398B2/en active Active
-
2017
- 2017-01-13 US US15/405,552 patent/US10729739B2/en active Active
- 2017-09-27 JP JP2017185676A patent/JP6618967B2/ja active Active
- 2017-12-18 US US15/845,391 patent/US20190167755A1/en not_active Abandoned
-
2020
- 2020-04-17 US US16/851,179 patent/US10973870B2/en active Active
- 2020-05-21 US US16/880,608 patent/US11766468B2/en active Active
-
2021
- 2021-03-12 US US17/199,733 patent/US12533387B2/en active Active
-
2022
- 2022-03-31 US US17/710,905 patent/US20220218783A1/en not_active Abandoned
- 2022-03-31 US US17/710,899 patent/US11826397B2/en active Active
- 2022-03-31 US US17/710,889 patent/US20220218782A1/en not_active Abandoned
- 2022-05-31 US US17/829,134 patent/US20220323538A1/en not_active Abandoned
- 2022-07-07 JP JP2022109616A patent/JP7400029B2/ja active Active
- 2022-09-08 JP JP2022142833A patent/JP2022184898A/ja active Pending
-
2023
- 2023-12-06 JP JP2023206150A patent/JP2024028869A/ja active Pending
-
2024
- 2024-05-30 US US18/679,184 patent/US20250134948A1/en active Pending
- 2024-05-31 US US18/680,542 patent/US12514898B2/en active Active
-
2025
- 2025-06-24 JP JP2025106071A patent/JP2025160167A/ja active Pending
- 2025-11-14 JP JP2025194876A patent/JP2026027448A/ja active Pending
Non-Patent Citations (2)
| Title |
|---|
| CHRISTIAN DOEHN等: "Drug evaluation: Degarelix-a potential new therapy for prostate cancer", 《IDRUGS》 * |
| TAMMELA T.等: "Degarelix-a phase 11 multicentre randomized dose-escalating study testing a novel gnrh receptor blocker in prostate cancer patients", 《EUROPEAN UROLOGY SUPPLEMENTS》 * |
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN103990107A (zh) | 用gnrh拮抗剂地加瑞克治疗前列腺癌的方法 | |
| KR20120038956A (ko) | 양성 전립성 비대증의 치료용 조성물 | |
| Sterling et al. | Intravenous beta-blockers in ST-segment elevation myocardial infarction: a systematic review and meta-analysis | |
| JP7104003B2 (ja) | Ｇｎｒｈアンタゴニストであるデガレリクスを用いる前立腺癌の治療方法 | |
| Maghfour et al. | Evaluating the impact of exclusion criteria on the generalizability of hidradenitis suppurativa treatment research | |
| HK1176552B (en) | Method of treating prostate cancer with the gnrh antagonist degarelix | |
| CN119997952A (zh) | 治疗重症肌无力的组合物和方法 | |
| Tauscher et al. | IBZM-SPECT shows low striatal D2 blockade under therapy with seroquel | |
| Wirschubsky | New alpha-blocker highly selective for urinary tract. | |
| HK1190912B (en) | Treatment of metastatic stage prostate cancer with degarelix |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20140820 |
|
| RJ01 | Rejection of invention patent application after publication |