CN103874686B - 用于抑制烟酰胺磷酸核糖基转移酶(nampt)的哌啶衍生物和组合物 - Google Patents

用于抑制烟酰胺磷酸核糖基转移酶(nampt)的哌啶衍生物和组合物 Download PDF

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CN103874686B
CN103874686B CN201180072205.5A CN201180072205A CN103874686B CN 103874686 B CN103874686 B CN 103874686B CN 201180072205 A CN201180072205 A CN 201180072205A CN 103874686 B CN103874686 B CN 103874686B
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pyridine
butyl
piperidin
carbonyl
pyrrolo
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CN103874686A (zh
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K.W.拜尔
T.鲍梅斯特
A.J.巴克梅尔特
K.H.克洛德菲尔特
B.韩
J.D.昆茨
J.林
D.J.雷诺兹
C.C.史密斯
Z.王
X.郑
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Forma TM LLC
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Forma TM LLC
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4365—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system having sulfur as a ring hetero atom, e.g. ticlopidine
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    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
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CN201180072205.5A 2011-05-09 2011-09-02 用于抑制烟酰胺磷酸核糖基转移酶(nampt)的哌啶衍生物和组合物 Expired - Fee Related CN103874686B (zh)

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CN201610403792.6A CN106083886A (zh) 2011-05-09 2011-09-02 用于抑制烟酰胺磷酸核糖基转移酶(nampt)的哌啶衍生物和组合物

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US201161483937P 2011-05-09 2011-05-09
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PCT/US2011/050303 WO2012154194A1 (en) 2011-05-09 2011-09-02 Piperidine derivatives and compositions for the inhibition of nicotinamide phosphoribosyltransferase (nampt)

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