CN103874496A - 作为bace抑制剂的2-螺-取代的亚氨基噻嗪类及其单和二氧化物、组合物及其用途 - Google Patents

作为bace抑制剂的2-螺-取代的亚氨基噻嗪类及其单和二氧化物、组合物及其用途 Download PDF

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Publication number
CN103874496A
CN103874496A CN201280051313.9A CN201280051313A CN103874496A CN 103874496 A CN103874496 A CN 103874496A CN 201280051313 A CN201280051313 A CN 201280051313A CN 103874496 A CN103874496 A CN 103874496A
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alkyl
cycloalkyl
compound
heteroaryl
group
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W-L.吴
D.A.伯内特
A.斯坦福德
J.N.卡明斯
T.阿斯贝罗姆
C.班尼特
T.K.萨西斯库马
J.D.斯科特
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Merck Sharp and Dohme LLC
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    • C07D279/14—1,4-Thiazines; Hydrogenated 1,4-thiazines condensed with carbocyclic rings or ring systems
    • C07D279/18—[b, e]-condensed with two six-membered rings
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  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
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CN201280051313.9A 2011-08-22 2012-08-21 作为bace抑制剂的2-螺-取代的亚氨基噻嗪类及其单和二氧化物、组合物及其用途 Pending CN103874496A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161526049P 2011-08-22 2011-08-22
US61/526049 2011-08-22
PCT/US2012/051687 WO2013028670A1 (en) 2011-08-22 2012-08-21 2-spiro-substituted iminothiazines and their mono-and dioxides as bace inhibitors, compositions and their use

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CN103874496A true CN103874496A (zh) 2014-06-18

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US (1) US9181236B2 (https=)
EP (1) EP2747769B1 (https=)
JP (1) JP2014524472A (https=)
KR (1) KR20140054295A (https=)
CN (1) CN103874496A (https=)
AU (1) AU2012298983A1 (https=)
BR (1) BR112014004181A2 (https=)
CA (1) CA2844988A1 (https=)
MX (1) MX2014002113A (https=)
RU (1) RU2014111055A (https=)
WO (1) WO2013028670A1 (https=)

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CN107406440A (zh) * 2015-03-20 2017-11-28 豪夫迈·罗氏有限公司 Bace1抑制剂
CN107613771A (zh) * 2015-04-21 2018-01-19 新源生物科技股份有限公司 化合物及其作为β‑分泌酶1抑制剂的用途
CN109180671A (zh) * 2018-09-21 2019-01-11 广东东阳光药业有限公司 亚氨基噻二嗪二氧化物衍生物及其用途
CN113105318A (zh) * 2021-02-23 2021-07-13 中山大学 一种2,2-二氟环丁烷-1-羧酸的制备方法及应用
CN116194112A (zh) * 2020-06-30 2023-05-30 4E治疗公司 表现出mnk抑制作用的吡啶-1,5-二酮及其使用方法

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CN103874496A (zh) 2011-08-22 2014-06-18 默沙东公司 作为bace抑制剂的2-螺-取代的亚氨基噻嗪类及其单和二氧化物、组合物及其用途
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WO2015095104A1 (en) * 2013-12-18 2015-06-25 Merck Sharp & Dohme Corp. Iminothiadiazepane dioxide compounds as bace inhibitors, compositions, and their use
WO2015094930A1 (en) * 2013-12-18 2015-06-25 Merck Sharp & Dohme Corp. C-6 spirocarbocyclic iminothiadiazine dioxides as bace inhibitors, compositions, and their use
CN105683199B (zh) * 2013-12-20 2018-06-26 豪夫迈·罗氏有限公司 5-芳基-1-亚氨基-1-氧代-[1，2，4]噻二嗪
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CN106795147B (zh) 2014-08-08 2020-09-22 美国安进公司 作为β-分泌酶抑制剂的环丙基稠合噻嗪-2-胺化合物和使用方法
WO2016085780A1 (en) * 2014-11-25 2016-06-02 Merck Sharp & Dohme Corp. C5-c6-oxacyclic fused iminopyrimidinone compounds as bace inhibitors, compositions, and their use
WO2017024180A1 (en) 2015-08-06 2017-02-09 Amgen Inc. Vinyl fluoride cyclopropyl fused thiazin-2-amine compounds as beta-secretase inhibitors and methods of use
JP6895424B2 (ja) * 2015-08-12 2021-06-30 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ Ｂａｃｅ１阻害剤
WO2017095759A1 (en) 2015-12-04 2017-06-08 Merck Sharp & Dohme Corp. C5-c6-carbocyclic fused iminothiadiazine dioxides as bace inhibitors, compositions, and their use
MX394391B (es) 2016-12-15 2025-03-24 Amgen Inc Derivados de tiazina y oxazina biciclicos como inhibidores de beta-secretasa y metodos de uso.
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