CN103842366B - 制备抗病毒核苷酸类似物的方法 - Google Patents
制备抗病毒核苷酸类似物的方法 Download PDFInfo
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- CN103842366B CN103842366B CN201280048965.7A CN201280048965A CN103842366B CN 103842366 B CN103842366 B CN 103842366B CN 201280048965 A CN201280048965 A CN 201280048965A CN 103842366 B CN103842366 B CN 103842366B
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- 0 C[C@](CNc1ncnc(N)c1N)OCP(*)(Oc1ccccc1)=* Chemical compound C[C@](CNc1ncnc(N)c1N)OCP(*)(Oc1ccccc1)=* 0.000 description 2
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
- C07F9/65616—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings containing the ring system having three or more than three double bonds between ring members or between ring members and non-ring members, e.g. purine or analogs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
- C07F9/6509—Six-membered rings
- C07F9/6512—Six-membered rings having the nitrogen atoms in positions 1 and 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
- C07F9/65583—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system each of the hetero rings containing nitrogen as ring hetero atom
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Virology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Priority Applications (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710365515.5A CN107266498B (zh) | 2011-10-07 | 2012-10-03 | 制备抗病毒核苷酸类似物的方法 |
| CN202110408116.9A CN113264959A (zh) | 2011-10-07 | 2012-10-03 | 制备抗病毒核苷酸类似物的方法 |
| CN202311252160.0A CN117343101A (zh) | 2011-10-07 | 2012-10-03 | 制备抗病毒核苷酸类似物的方法 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US61/544,950 | 2011-10-07 | ||
| PCT/US2012/000441 WO2013052094A2 (en) | 2011-10-07 | 2012-10-03 | Methods for preparing anti-viral nucleotide analogs |
| US201161544950P | 2014-04-11 | 2014-04-11 |
Related Child Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202110408116.9A Division CN113264959A (zh) | 2011-10-07 | 2012-10-03 | 制备抗病毒核苷酸类似物的方法 |
| CN201710365515.5A Division CN107266498B (zh) | 2011-10-07 | 2012-10-03 | 制备抗病毒核苷酸类似物的方法 |
| CN202311252160.0A Division CN117343101A (zh) | 2011-10-07 | 2012-10-03 | 制备抗病毒核苷酸类似物的方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN103842366A CN103842366A (zh) | 2014-06-04 |
| CN103842366B true CN103842366B (zh) | 2017-06-16 |
Family
ID=47297386
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202110408116.9A Pending CN113264959A (zh) | 2011-10-07 | 2012-10-03 | 制备抗病毒核苷酸类似物的方法 |
| CN201710365515.5A Active CN107266498B (zh) | 2011-10-07 | 2012-10-03 | 制备抗病毒核苷酸类似物的方法 |
| CN201280048965.7A Active CN103842366B (zh) | 2011-10-07 | 2012-10-03 | 制备抗病毒核苷酸类似物的方法 |
| CN202311252160.0A Pending CN117343101A (zh) | 2011-10-07 | 2012-10-03 | 制备抗病毒核苷酸类似物的方法 |
Family Applications Before (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202110408116.9A Pending CN113264959A (zh) | 2011-10-07 | 2012-10-03 | 制备抗病毒核苷酸类似物的方法 |
| CN201710365515.5A Active CN107266498B (zh) | 2011-10-07 | 2012-10-03 | 制备抗病毒核苷酸类似物的方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202311252160.0A Pending CN117343101A (zh) | 2011-10-07 | 2012-10-03 | 制备抗病毒核苷酸类似物的方法 |
Country Status (25)
| Country | Link |
|---|---|
| US (4) | US8664386B2 (enExample) |
| EP (2) | EP2764002B1 (enExample) |
| JP (2) | JP6190372B2 (enExample) |
| KR (3) | KR20200090975A (enExample) |
| CN (4) | CN113264959A (enExample) |
| AR (1) | AR088109A1 (enExample) |
| AU (3) | AU2012319172B2 (enExample) |
| BR (2) | BR112014011340A2 (enExample) |
| CA (2) | CA2850466C (enExample) |
| CL (1) | CL2014000827A1 (enExample) |
| CO (1) | CO6940431A2 (enExample) |
| CR (1) | CR20140204A (enExample) |
| EA (1) | EA027086B1 (enExample) |
| EC (1) | ECSP14000074A (enExample) |
| ES (2) | ES2661705T3 (enExample) |
| HK (1) | HK1255222B (enExample) |
| IL (1) | IL231879B (enExample) |
| MX (1) | MX353064B (enExample) |
| PE (1) | PE20141160A1 (enExample) |
| PL (1) | PL3333173T3 (enExample) |
| PT (2) | PT2764002T (enExample) |
| SI (1) | SI3333173T1 (enExample) |
| TW (4) | TWI613211B (enExample) |
| UY (1) | UY34361A (enExample) |
| WO (1) | WO2013052094A2 (enExample) |
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| TWI516499B (zh) | 2011-08-16 | 2016-01-11 | 吉李德科學股份有限公司 | 泰諾福韋（ｔｅｎｏｆｏｖｉｒ）亞拉芬醯胺（ａｌａｆｅｎａｍｉｄｅ）之半反式丁烯二酸鹽 |
| CN107312039B (zh) | 2012-08-30 | 2019-06-25 | 江苏豪森药业集团有限公司 | 一种替诺福韦前药的制备方法 |
| EP2764002B1 (en) * | 2012-10-03 | 2018-02-28 | Gilead Sciences, Inc. | Methods for preparing anti-viral nucleotide analogs |
| IN2013MU01967A (enExample) * | 2013-06-07 | 2015-06-12 | Cipla Ltd | |
| CN104628773B (zh) * | 2013-11-06 | 2018-10-23 | 杭州和泽医药科技有限公司 | (r)-9-[2-(磷酰苯酚基甲氧基)丙基]腺嘌呤的制备方法 |
| IN2013CH05455A (enExample) * | 2013-11-27 | 2015-08-07 | Laurus Labs Private Ltd | |
| ES2842123T3 (es) * | 2014-01-14 | 2021-07-12 | Mylan Laboratories Ltd | Purificación de tenofovir alafenamida y sus intermedios |
| TWI660965B (zh) | 2014-01-15 | 2019-06-01 | 美商基利科學股份有限公司 | 泰諾福韋之固體形式 |
| CN105531281B (zh) * | 2014-04-21 | 2017-12-15 | 四川海思科制药有限公司 | 一种核苷类似物及其中间体的制备方法 |
| WO2015197006A1 (zh) * | 2014-06-25 | 2015-12-30 | 四川海思科制药有限公司 | 一种取代的氨基酸硫酯类化合物、其组合物及应用 |
| CN105399771B (zh) * | 2014-07-21 | 2020-11-24 | 江苏豪森药业集团有限公司 | 替诺福韦前药晶型及其制备方法和用途 |
| CN108148094A (zh) * | 2014-11-12 | 2018-06-12 | 四川海思科制药有限公司 | 一种替诺福韦艾拉酚胺富马酸盐晶型c及其制备方法和用途 |
| CN104817593B (zh) * | 2015-04-27 | 2016-11-16 | 广州同隽医药科技有限公司 | 半富马酸替诺福韦艾拉酚胺关键中间体的合成工艺 |
| MA44209B1 (fr) | 2015-08-05 | 2022-03-31 | Eisai R&D Man Co Ltd | Procede de preparation d'un oligomere phosphorodiamidate substantiellement diastereomeriquement pure, un oligomere phosphorodiamidate faite par un tel procede et une composition pharmaceutique comprenant un tel oligomere phosphorodiamidate |
| TWI616452B (zh) * | 2015-08-26 | 2018-03-01 | Preparation method of nucleoside analog and intermediate thereof | |
| CN105330700A (zh) * | 2015-12-17 | 2016-02-17 | 中国药科大学 | 富马酸替诺福韦艾拉酚胺杂质的制备方法 |
| WO2017118928A1 (en) | 2016-01-06 | 2017-07-13 | Lupin Limited | Process for the separation of diastereomers of tenofovir alafenamide |
| CZ2016156A3 (cs) * | 2016-03-17 | 2017-09-27 | Zentiva, K.S. | Způsob přípravy diastereomerně čistého Tenofoviru Alafenamidu nebo jeho solí |
| CN107286190A (zh) * | 2016-04-13 | 2017-10-24 | 刘沛 | 核苷之烃氧基苄基氨基磷酸/膦酸酯衍生物的制备及其医药用途 |
| EP3454856B1 (en) | 2016-05-10 | 2024-09-11 | C4 Therapeutics, Inc. | Heterocyclic degronimers for target protein degradation |
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| EP3455218A4 (en) | 2016-05-10 | 2019-12-18 | C4 Therapeutics, Inc. | C3 CARBON-BASED GLUTARIMIDE DEGRONIMERS FOR TARGET PROTEIN REDUCTION |
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| CN106946935B (zh) * | 2017-04-28 | 2020-01-07 | 福建广生堂药业股份有限公司 | 一种非对映异构体核苷衍生物的制备方法 |
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| CN109942632B (zh) * | 2017-12-20 | 2021-08-31 | 上海博志研新药物研究有限公司 | 替诺福韦艾拉酚胺中间体的制备方法 |
| CN109942633B (zh) * | 2017-12-20 | 2021-08-31 | 上海新礼泰药业有限公司 | 替诺福韦艾拉酚胺中间体的制备方法 |
| CN110092803A (zh) * | 2018-01-31 | 2019-08-06 | 北京睿创康泰医药研究院有限公司 | 替诺福韦艾拉酚胺富马酸盐工艺杂质的制备及其应用 |
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