CN103635451B - 用于制备七氟烷的方法 - Google Patents

用于制备七氟烷的方法 Download PDF

Info

Publication number
CN103635451B
CN103635451B CN201280032651.8A CN201280032651A CN103635451B CN 103635451 B CN103635451 B CN 103635451B CN 201280032651 A CN201280032651 A CN 201280032651A CN 103635451 B CN103635451 B CN 103635451B
Authority
CN
China
Prior art keywords
sevoflurane
reaction mixture
initial reaction
amine
chlorohexafluoroether
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CN201280032651.8A
Other languages
English (en)
Chinese (zh)
Other versions
CN103635451A (zh
Inventor
利纳斯·库德玛
罗纳德·贝尔
曾永宪
利奥尼德·A·罗佐夫
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Baxter Healthcare SA
Baxter International Inc
Original Assignee
Baxter Healthcare SA
Baxter International Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Baxter Healthcare SA, Baxter International Inc filed Critical Baxter Healthcare SA
Publication of CN103635451A publication Critical patent/CN103635451A/zh
Application granted granted Critical
Publication of CN103635451B publication Critical patent/CN103635451B/zh
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C41/00—Preparation of ethers; Preparation of compounds having groups, groups or groups
    • C07C41/01—Preparation of ethers
    • C07C41/18—Preparation of ethers by reactions not forming ether-oxygen bonds
    • C07C41/22—Preparation of ethers by reactions not forming ether-oxygen bonds by introduction of halogens; by substitution of halogen atoms by other halogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C41/00—Preparation of ethers; Preparation of compounds having groups, groups or groups
    • C07C41/01—Preparation of ethers
    • C07C41/34—Separation; Purification; Stabilisation; Use of additives
    • C07C41/38—Separation; Purification; Stabilisation; Use of additives by liquid-liquid treatment
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C41/00—Preparation of ethers; Preparation of compounds having groups, groups or groups
    • C07C41/01—Preparation of ethers
    • C07C41/34—Separation; Purification; Stabilisation; Use of additives
    • C07C41/40—Separation; Purification; Stabilisation; Use of additives by change of physical state, e.g. by crystallisation
    • C07C41/42—Separation; Purification; Stabilisation; Use of additives by change of physical state, e.g. by crystallisation by distillation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C43/00—Ethers; Compounds having groups, groups or groups
    • C07C43/02—Ethers
    • C07C43/03—Ethers having all ether-oxygen atoms bound to acyclic carbon atoms
    • C07C43/04—Saturated ethers
    • C07C43/12—Saturated ethers containing halogen
    • C07C43/123—Saturated ethers containing halogen both carbon chains are substituted by halogen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Saccharide Compounds (AREA)
CN201280032651.8A 2011-08-15 2012-08-03 用于制备七氟烷的方法 Active CN103635451B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US13/210,272 US8729313B2 (en) 2011-08-15 2011-08-15 Process for the manufacturing of sevoflurane
US13/210,272 2011-08-15
PCT/US2012/049558 WO2013025377A1 (en) 2011-08-15 2012-08-03 Process for the manufacturing of sevoflurane

Publications (2)

Publication Number Publication Date
CN103635451A CN103635451A (zh) 2014-03-12
CN103635451B true CN103635451B (zh) 2016-08-24

Family

ID=46924518

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201280032651.8A Active CN103635451B (zh) 2011-08-15 2012-08-03 用于制备七氟烷的方法

Country Status (9)

Country Link
US (1) US8729313B2 (OSRAM)
EP (1) EP2744772B1 (OSRAM)
JP (1) JP5926802B2 (OSRAM)
CN (1) CN103635451B (OSRAM)
AU (1) AU2012295410B2 (OSRAM)
BR (1) BR112013033851A2 (OSRAM)
MX (1) MX353760B (OSRAM)
PL (1) PL2744772T3 (OSRAM)
WO (1) WO2013025377A1 (OSRAM)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9102604B1 (en) * 2010-02-15 2015-08-11 Baxter International Inc. Methods for cleaning distilling columns
CA3014020C (en) 2016-02-23 2021-01-05 Sagetech Medical Equipment Limited Improvements to the manufacture and remanufacture of volatile anaesthetic agents using supercritical fluids
US10035745B1 (en) 2016-07-30 2018-07-31 Baxter International Inc. Methods of purifying crude sevoflurane
JP6299905B1 (ja) * 2017-02-06 2018-03-28 セントラル硝子株式会社 セボフルランの製造方法
CN108689808B (zh) * 2017-04-06 2021-11-16 江苏恒瑞医药股份有限公司 一种氯甲基六氟异丙醚的制备方法
CN114671742A (zh) * 2020-12-24 2022-06-28 鲁南制药集团股份有限公司 一种七氟烷的制备方法
CN113943214B (zh) * 2021-11-11 2023-12-19 福建海西联合药业有限公司 一种运用于七氟烷生产的工艺
CN119661328B (zh) * 2024-12-13 2025-07-08 河北一品制药股份有限公司 一种七氟烷的清洁生产工艺

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3476860A (en) 1966-12-08 1969-11-04 Air Reduction Halomethyl fluoroisopropyl ethers as anesthetic agents
US3527814A (en) 1968-03-08 1970-09-08 Air Reduction Halomethyl fluoroisopropyl ethers
US4250334A (en) 1979-12-26 1981-02-10 Baxter Travenol Laboratories, Inc. Method of synthesizing fluoromethylhexafluoroisopropyl ether
US4469898A (en) 1979-12-26 1984-09-04 Baxter Travenol Laboratories, Inc. Method of synthesizing fluoromethylhexafluoroisopropyl ether
US5233098A (en) 1990-05-30 1993-08-03 Central Glass Company, Limited Method for removing and recovering fluorinated alcohol from waste gas
JP2865554B2 (ja) 1994-04-08 1999-03-08 セントラル硝子株式会社 フルオロメチル−１，１，１，３，３，３−ヘキサフルオロイソプロピルエーテルのガスクロマトグラフ分析
GB9600072D0 (en) 1996-01-04 1996-03-06 Ici Plc Process for the production of fluoromethylhexafluoroisopropylether
DE69708544T3 (de) 1996-02-21 2005-02-03 Central Glass Co., Ltd., Ube Verfahren zur herstellung von fluoromethyl-(1,1,1,3,3,3)-hexafluoroisopropylether
US5969193A (en) * 1997-08-18 1999-10-19 Medeva Pharmaceuticals Pa, Inc. Method for the preparation of sevoflurane
US5886239A (en) * 1997-11-21 1999-03-23 Baxter International Inc. Method of preparing monofluoromethyl ethers
US6100434A (en) 1999-03-26 2000-08-08 Abbott Laboratories Method for synthesizing sevoflurane and an intermediate thereof
US6469219B1 (en) 2000-03-16 2002-10-22 Halocarbon Products Corporation Production of fluoromethyl 2,2,2-trifluoro-1-(trifluoromethyl)ethyl ether
GB0031301D0 (en) 2000-12-21 2001-01-31 Ici Plc Process for the production of fluoromethyl hexafluoroisopropyl ether
GB0031310D0 (en) 2000-12-21 2001-01-31 Ici Plc Process for the purification of fluoromethyl hexafluoroisopropyl ether
WO2004065340A1 (en) 2003-01-14 2004-08-05 Baxter International Inc. Process for recovery of 1,1,1,3,3,3-hexafluoroisopropanol from the waste stream of sevoflurane synthesis
KR20060132685A (ko) 2004-01-05 2006-12-21 할로카본 프로덕츠 코포레이션 제조 공정 중 및 최종 세보플란에서의 분석용크로마토그래피 방법
PL1812368T3 (pl) * 2004-11-17 2013-07-31 Piramal Critical Care Inc Sposób wytwarzania sewofluranu
JP5021745B2 (ja) * 2006-09-29 2012-09-12 クリスタリア プロデュトス キミコス ファーマシューティコス リミターダ フルオロメチル２，２，２−トリフロオロ−１−（トリフルオロメチル）エチルエーテルの製造方法
CN101337863B (zh) * 2007-07-06 2012-04-25 江苏恒瑞医药股份有限公司 一种制备七氟烷的方法
CN101314560B (zh) * 2008-07-02 2011-06-15 鲁南制药集团股份有限公司 七氟烷的合成方法

Also Published As

Publication number Publication date
AU2012295410B2 (en) 2014-10-30
EP2744772B1 (en) 2015-07-01
US8729313B2 (en) 2014-05-20
WO2013025377A1 (en) 2013-02-21
US20130046117A1 (en) 2013-02-21
MX2014001828A (es) 2014-02-27
JP2014525409A (ja) 2014-09-29
JP5926802B2 (ja) 2016-05-25
MX353760B (es) 2018-01-26
PL2744772T3 (pl) 2015-11-30
CN103635451A (zh) 2014-03-12
EP2744772A1 (en) 2014-06-25
BR112013033851A2 (pt) 2017-02-07
AU2012295410A1 (en) 2013-05-02

Similar Documents

Publication Publication Date Title
CN103635451B (zh) 用于制备七氟烷的方法
WO2009040367A1 (en) Process for the preparation of fluorine containing organic compound
US8058482B2 (en) Method for the preparation of sevoflurane
AU1420599A (en) Method of preparing monofluoromethyl ethers
US10913696B2 (en) Method for aromatic fluorination
CN101878192B (zh) 4-全氟异丙基苯胺类的制造方法
EP2289875A1 (en) Process for producing perfluoroalkanesulfinic acid salt
JP4722327B2 (ja) アセチレンジオール化合物の製造方法
EP3878845B1 (en) Perfluoro(2-methylene-4-methyl-1,3-dioxolane) production method
TWI689486B (zh) 氟化烷之製造方法、脒鹼之分離、回收方法、及回收的脒鹼之使用方法
JP4922181B2 (ja) １，２，２，２−テトラフルオロエチルジフルオロメチルエーテルの製造のための方法
JP6643735B2 (ja) 含フッ素α−ケトカルボン酸エステル類の実用的な製造方法
JP6225788B2 (ja) １，１，１，５，５，５−ヘキサフルオロアセチルアセトンの製造方法
JP2009155248A (ja) 酸弗化物類の製造方法
JP6361786B2 (ja) 有機化合物の精製方法
TW201605781A (zh) 2,2,2-三氟乙硫醇之合成
TWI705055B (zh) 製備5-氟-1h-吡唑-4-羰基氟化物之方法
EP1254103B1 (en) Method of making 3,5-difluoroaniline from 1,3,5-trichlorobenzene
JP6922924B2 (ja) 含窒素化合物の製造方法
JP2019094286A (ja) 酢酸（２，２，２−トリフルオロエチル）及びその製造方法
JP4717203B2 (ja) ２−フルオロ−３−オキソアルキルカルボン酸エステルの精製方法
JP2017008006A (ja) ３，３−ジフルオロ−１−クロロ−２−プロパノンの実用的な製造方法
WO2023171326A1 (ja) アルケンの製造方法
JP2024112596A (ja) ２，２，６，６－テトラメチルピペリジン－４－オンの製造方法
JP4717204B2 (ja) ２−フルオロ−３−オキソアルキルカルボン酸エステルの製造方法

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C14 Grant of patent or utility model
GR01 Patent grant