MX353760B - Proceso para la fabricacion de sevoflurano. - Google Patents

Proceso para la fabricacion de sevoflurano.

Info

Publication number
MX353760B
MX353760B MX2014001828A MX2014001828A MX353760B MX 353760 B MX353760 B MX 353760B MX 2014001828 A MX2014001828 A MX 2014001828A MX 2014001828 A MX2014001828 A MX 2014001828A MX 353760 B MX353760 B MX 353760B
Authority
MX
Mexico
Prior art keywords
sevoflurane
reaction mixture
initial reaction
present
forming
Prior art date
Application number
MX2014001828A
Other languages
English (en)
Other versions
MX2014001828A (es
Inventor
Kudzma Linas
Bell Ronald
Zeng Yongxian
A Rozov Leonid
Original Assignee
Baxter Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Baxter Int filed Critical Baxter Int
Publication of MX2014001828A publication Critical patent/MX2014001828A/es
Publication of MX353760B publication Critical patent/MX353760B/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C41/00—Preparation of ethers; Preparation of compounds having groups, groups or groups
    • C07C41/01—Preparation of ethers
    • C07C41/18—Preparation of ethers by reactions not forming ether-oxygen bonds
    • C07C41/22—Preparation of ethers by reactions not forming ether-oxygen bonds by introduction of halogens; by substitution of halogen atoms by other halogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C41/00—Preparation of ethers; Preparation of compounds having groups, groups or groups
    • C07C41/01—Preparation of ethers
    • C07C41/34—Separation; Purification; Stabilisation; Use of additives
    • C07C41/38—Separation; Purification; Stabilisation; Use of additives by liquid-liquid treatment
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C41/00—Preparation of ethers; Preparation of compounds having groups, groups or groups
    • C07C41/01—Preparation of ethers
    • C07C41/34—Separation; Purification; Stabilisation; Use of additives
    • C07C41/40—Separation; Purification; Stabilisation; Use of additives by change of physical state, e.g. by crystallisation
    • C07C41/42—Separation; Purification; Stabilisation; Use of additives by change of physical state, e.g. by crystallisation by distillation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C43/00—Ethers; Compounds having groups, groups or groups
    • C07C43/02—Ethers
    • C07C43/03—Ethers having all ether-oxygen atoms bound to acyclic carbon atoms
    • C07C43/04—Saturated ethers
    • C07C43/12—Saturated ethers containing halogen
    • C07C43/123—Saturated ethers containing halogen both carbon chains are substituted by halogen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Saccharide Compounds (AREA)

Abstract

La presente invención proporciona un método para formar sevoflurano comprendiendo (i) combinar clorosevo éter, un reactivo de fluoruro nucleofílico, y un solvente comprendiendo sevoflurano para formar una mezcla de reacción inicial, y (ii) hacer reaccionar la mezcla de reacción inicial para formar sevoflurano adicional relativo a la cantidad de sevoflurano presente en la mezcla de reacción inicial. La presente descripción también es dirigida a un método para formar sevoflurano, que comprende: iniciar una reacción entre clorosevo éter y un reactivo de fluoruro nucleofílico en una mezcla de reacción inicial que comprende además un solvente comprendiendo sevoflurano, formando por ello sevoflurano adicional en relación a la cantidad de sevoflurano presente en la mezcla de reacción inicial.
MX2014001828A 2011-08-15 2012-08-03 Proceso para la fabricacion de sevoflurano. MX353760B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US13/210,272 US8729313B2 (en) 2011-08-15 2011-08-15 Process for the manufacturing of sevoflurane
PCT/US2012/049558 WO2013025377A1 (en) 2011-08-15 2012-08-03 Process for the manufacturing of sevoflurane

Publications (2)

Publication Number Publication Date
MX2014001828A MX2014001828A (es) 2014-02-27
MX353760B true MX353760B (es) 2018-01-26

Family

ID=46924518

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2014001828A MX353760B (es) 2011-08-15 2012-08-03 Proceso para la fabricacion de sevoflurano.

Country Status (9)

Country Link
US (1) US8729313B2 (es)
EP (1) EP2744772B1 (es)
JP (1) JP5926802B2 (es)
CN (1) CN103635451B (es)
AU (1) AU2012295410B2 (es)
BR (1) BR112013033851A2 (es)
MX (1) MX353760B (es)
PL (1) PL2744772T3 (es)
WO (1) WO2013025377A1 (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9102604B1 (en) * 2010-02-15 2015-08-11 Baxter International Inc. Methods for cleaning distilling columns
CA3014020C (en) 2016-02-23 2021-01-05 Sagetech Medical Equipment Limited Improvements to the manufacture and remanufacture of volatile anaesthetic agents using supercritical fluids
US10035745B1 (en) 2016-07-30 2018-07-31 Baxter International Inc. Methods of purifying crude sevoflurane
JP6299905B1 (ja) * 2017-02-06 2018-03-28 セントラル硝子株式会社 セボフルランの製造方法
CN108689808B (zh) * 2017-04-06 2021-11-16 江苏恒瑞医药股份有限公司 一种氯甲基六氟异丙醚的制备方法
CN113943214B (zh) * 2021-11-11 2023-12-19 福建海西联合药业有限公司 一种运用于七氟烷生产的工艺

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3476860A (en) 1966-12-08 1969-11-04 Air Reduction Halomethyl fluoroisopropyl ethers as anesthetic agents
US3527814A (en) 1968-03-08 1970-09-08 Air Reduction Halomethyl fluoroisopropyl ethers
US4250334A (en) 1979-12-26 1981-02-10 Baxter Travenol Laboratories, Inc. Method of synthesizing fluoromethylhexafluoroisopropyl ether
US4469898A (en) 1979-12-26 1984-09-04 Baxter Travenol Laboratories, Inc. Method of synthesizing fluoromethylhexafluoroisopropyl ether
US5233098A (en) 1990-05-30 1993-08-03 Central Glass Company, Limited Method for removing and recovering fluorinated alcohol from waste gas
JP2865554B2 (ja) 1994-04-08 1999-03-08 セントラル硝子株式会社 フルオロメチル−１，１，１，３，３，３−ヘキサフルオロイソプロピルエーテルのガスクロマトグラフ分析
GB9600072D0 (en) 1996-01-04 1996-03-06 Ici Plc Process for the production of fluoromethylhexafluoroisopropylether
JP3441735B2 (ja) 1996-02-21 2003-09-02 セントラル硝子株式会社 フルオロメチル−１，１，１，３，３，３−ヘキサフルオロイソプロピルエーテルの製造方法
US5969193A (en) * 1997-08-18 1999-10-19 Medeva Pharmaceuticals Pa, Inc. Method for the preparation of sevoflurane
US5886239A (en) 1997-11-21 1999-03-23 Baxter International Inc. Method of preparing monofluoromethyl ethers
US6100434A (en) 1999-03-26 2000-08-08 Abbott Laboratories Method for synthesizing sevoflurane and an intermediate thereof
US6469219B1 (en) 2000-03-16 2002-10-22 Halocarbon Products Corporation Production of fluoromethyl 2,2,2-trifluoro-1-(trifluoromethyl)ethyl ether
GB0031301D0 (en) 2000-12-21 2001-01-31 Ici Plc Process for the production of fluoromethyl hexafluoroisopropyl ether
GB0031310D0 (en) 2000-12-21 2001-01-31 Ici Plc Process for the purification of fluoromethyl hexafluoroisopropyl ether
US6987204B2 (en) 2003-01-14 2006-01-17 Baxter International Inc. Process for recovery of 1,1,1,3,3,3-hexafluoroisopropanol from the waste stream of sevoflurane synthesis
PL380525A1 (pl) 2004-01-05 2007-02-19 Halocarbon Products Corporation Chromatograficzna metoda analizy zarówno w sposobie wytwarzania sewofluranu, jak też w końcowym sewofluranie
JP4875626B2 (ja) * 2004-11-17 2012-02-15 ピラマル クリティカル ケアー インコーポレイテッド セボフルランの調製のための方法
WO2008037040A2 (en) * 2006-09-29 2008-04-03 Cristália Produtos Químicos Farmacêuticos Ltda. Process for the preparation of fluoromethyl 2,2,2-trifluoro-1-(trifluoromethyl) ethyl ether
CN101337863B (zh) * 2007-07-06 2012-04-25 江苏恒瑞医药股份有限公司 一种制备七氟烷的方法
CN101314560B (zh) * 2008-07-02 2011-06-15 鲁南制药集团股份有限公司 七氟烷的合成方法

Also Published As

Publication number Publication date
US20130046117A1 (en) 2013-02-21
MX2014001828A (es) 2014-02-27
JP2014525409A (ja) 2014-09-29
AU2012295410B2 (en) 2014-10-30
JP5926802B2 (ja) 2016-05-25
AU2012295410A1 (en) 2013-05-02
US8729313B2 (en) 2014-05-20
WO2013025377A1 (en) 2013-02-21
PL2744772T3 (pl) 2015-11-30
EP2744772B1 (en) 2015-07-01
BR112013033851A2 (pt) 2017-02-07
CN103635451A (zh) 2014-03-12
CN103635451B (zh) 2016-08-24
EP2744772A1 (en) 2014-06-25

Similar Documents

Publication Publication Date Title
MX353760B (es) Proceso para la fabricacion de sevoflurano.
PH12018501094A1 (en) Process for the preparation of an apoptosis-inducing agent
WO2012129420A3 (en) Chlorine dioxide precursor and methods of using same
MY180098A (en) Novel process for preparing silicas
PH12014502764A1 (en) Method
MX2014014138A (es) Procedimiento nuevo para la preparacion de acido 2-ciclopentil-6-metoxi-isonicotinico.
MY172658A (en) Process for preparing methylmercaptopropionaldehyde
GEP201706690B (en) Novel process for making compounds for use in treatment of cancer
IN2015DN01811A (es)
MX2016004485A (es) Metodo para la produccion de compuestos fluorados.
MX2013007567A (es) Procedimiento para preparar poliestereteroles.
IN2014DN05739A (es)
IN2014CN01897A (es)
PL2588439T3 (pl) Sposób wytwarzania kwasu mrówkowego drogą reakcji ditlenku węgla z wodorem
MX2015013589A (es) Proceso e intermediario para la preparacion de pregabalina.
MY183980A (en) Commercial scale process for production of prrsv
IN2014DN03469A (es)
AR095548A1 (es) Preparación de ácido 4-amino-2,4-dioxobutanoico
GT201300078A (es) Proceso para la preparacion de inhibidores de pan-cdk de la formula ( i ), e intermediarios de la preparacion
WO2014064712A3 (en) An improved process for the preparation of fulvestrant
MY173388A (en) Mixed oxide compositions and methods for production of isoolefins
MY160047A (en) Process for the preparation and work-up of a reaction mixture containing triacetone amine
MX2016003164A (es) Proceso mejorado para la manufactura de tetrahidrofurano.
WO2013096976A3 (en) Process conditions for producing acrylic acid
GB201019701D0 (en) Reaction process

Legal Events

Date Code Title Description
FG Grant or registration