CN103596985A - 对磷脂酰肌醇蛋白聚糖3特异的人单克隆抗体及其用途 - Google Patents
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- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/33—Fusion polypeptide fusions for targeting to specific cell types, e.g. tissue specific targeting, targeting of a bacterial subspecies
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/55—Fusion polypeptide containing a fusion with a toxin, e.g. diphteria toxin
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2400/00—Assays, e.g. immunoassays or enzyme assays, involving carbohydrates
- G01N2400/10—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- G01N2400/38—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence, e.g. gluco- or galactomannans, Konjac gum, Locust bean gum or Guar gum
- G01N2400/40—Glycosaminoglycans, i.e. GAG or mucopolysaccharides, e.g. chondroitin sulfate, dermatan sulfate, hyaluronic acid, heparin, heparan sulfate, and related sulfated polysaccharides
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Abstract
Description
CDR | DNA序列(SEQ ID NO:1) | 蛋白质序列(SEQ ID NO:2) |
CDR1 | 核苷酸91-105 | 氨基酸31-35 |
CDR2 | 核苷酸148-195 | 氨基酸50-65 |
CDR3 | 核苷酸286-315 | 氨基酸96-105 |
CDR | DNA序列(SEQ ID NO:1) | 蛋白质序列(SEQ ID NO:2) |
CDR1 | 核苷酸76-99 | 氨基酸26-33 |
CDR2 | 核苷酸151-171 | 氨基酸51-57 |
CDR3 | 核苷酸286-315 | 氨基酸96-105 |
CDR | DNA序列(SEQ ID NO:13) | 蛋白质序列(SEQ ID NO:14) |
CDR1 | 核苷酸91-105 | 氨基酸31-35 |
CDR2 | 核苷酸148-198 | 氨基酸50-66 |
CDR3 | 核苷酸289-315 | 氨基酸97-105 |
CDR | DNA序列(SEQ ID NO:13) | 蛋白质序列(SEQ ID NO:14) |
CDR1 | 核苷酸76-99 | 氨基酸26-33 |
CDR2 | 核苷酸151-174 | 氨基酸51-58 |
CDR3 | 核苷酸289-315 | 氨基酸97-105 |
Claims (52)
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CN201610290837.3A CN105968209B (zh) | 2011-04-19 | 2012-04-19 | 对磷脂酰肌醇蛋白聚糖3特异的人单克隆抗体及其用途 |
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US201161477020P | 2011-04-19 | 2011-04-19 | |
US61/477,020 | 2011-04-19 | ||
PCT/US2012/034186 WO2012145469A1 (en) | 2011-04-19 | 2012-04-19 | Human monoclonal antibodies specific for glypican-3 and use thereof |
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CN201610290837.3A Division CN105968209B (zh) | 2011-04-19 | 2012-04-19 | 对磷脂酰肌醇蛋白聚糖3特异的人单克隆抗体及其用途 |
Publications (2)
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CN103596985A true CN103596985A (zh) | 2014-02-19 |
CN103596985B CN103596985B (zh) | 2016-06-08 |
Family
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CN201610290837.3A Active CN105968209B (zh) | 2011-04-19 | 2012-04-19 | 对磷脂酰肌醇蛋白聚糖3特异的人单克隆抗体及其用途 |
CN201280029201.3A Active CN103596985B (zh) | 2011-04-19 | 2012-04-19 | 对磷脂酰肌醇蛋白聚糖3特异的人单克隆抗体及其用途 |
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Country Status (6)
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US (4) | US9206257B2 (zh) |
EP (3) | EP2998320B1 (zh) |
CN (2) | CN105968209B (zh) |
ES (1) | ES2666550T3 (zh) |
HK (1) | HK1219965A1 (zh) |
WO (1) | WO2012145469A1 (zh) |
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EP3070104A1 (en) | 2016-09-21 |
EP2699603B1 (en) | 2016-03-02 |
HK1219965A1 (zh) | 2017-04-21 |
EP2699603A1 (en) | 2014-02-26 |
US10640571B2 (en) | 2020-05-05 |
ES2666550T3 (es) | 2018-05-07 |
US9206257B2 (en) | 2015-12-08 |
EP3070104B1 (en) | 2017-12-27 |
WO2012145469A8 (en) | 2013-11-07 |
US20140044714A1 (en) | 2014-02-13 |
US20150368340A1 (en) | 2015-12-24 |
US9932406B2 (en) | 2018-04-03 |
EP2998320A1 (en) | 2016-03-23 |
US20160208015A1 (en) | 2016-07-21 |
US20180134800A1 (en) | 2018-05-17 |
CN103596985B (zh) | 2016-06-08 |
EP2998320B1 (en) | 2018-07-18 |
WO2012145469A1 (en) | 2012-10-26 |
CN105968209B (zh) | 2021-08-03 |
US9394364B2 (en) | 2016-07-19 |
CN105968209A (zh) | 2016-09-28 |
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