BR112021011107A2 - Anticorpos para o fator de complemento humano c2b e métodos de uso - Google Patents
Anticorpos para o fator de complemento humano c2b e métodos de usoInfo
- Publication number
- BR112021011107A2 BR112021011107A2 BR112021011107A BR112021011107A BR112021011107A2 BR 112021011107 A2 BR112021011107 A2 BR 112021011107A2 BR 112021011107 A BR112021011107 A BR 112021011107A BR 112021011107 A BR112021011107 A BR 112021011107A BR 112021011107 A2 BR112021011107 A2 BR 112021011107A2
- Authority
- BR
- Brazil
- Prior art keywords
- antibodies
- antigen
- binding fragments
- methods
- human
- Prior art date
Links
- 230000000295 complement effect Effects 0.000 title abstract 3
- 238000000034 method Methods 0.000 title abstract 3
- 239000000427 antigen Substances 0.000 abstract 8
- 102000036639 antigens Human genes 0.000 abstract 8
- 108091007433 antigens Proteins 0.000 abstract 8
- 239000012634 fragment Substances 0.000 abstract 7
- 230000037361 pathway Effects 0.000 abstract 3
- 102000004856 Lectins Human genes 0.000 abstract 2
- 108090001090 Lectins Proteins 0.000 abstract 2
- 230000024203 complement activation Effects 0.000 abstract 2
- 239000002523 lectin Substances 0.000 abstract 2
- 150000007523 nucleic acids Chemical class 0.000 abstract 2
- 102000039446 nucleic acids Human genes 0.000 abstract 2
- 108020004707 nucleic acids Proteins 0.000 abstract 2
- 239000013598 vector Substances 0.000 abstract 2
- 230000004913 activation Effects 0.000 abstract 1
- 230000004154 complement system Effects 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/472—Complement proteins, e.g. anaphylatoxin, C3a, C5a
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/40—Immunoglobulins specific features characterized by post-translational modification
- C07K2317/41—Glycosylation, sialylation, or fucosylation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Transplantation (AREA)
- Endocrinology (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
anticorpos para o fator de complemento humano c2b e métodos de uso. são providos anticorpos e fragmentos de ligação ao antígeno dos mesmos que se ligam especificamente ao fator do complemento humano c2 e são capazes de inibir a ativação das vias clássica e da lectina do sistema do complemento. os anticorpos e o fragmento de ligação ao antígeno apresentam capacidade de fabricação, farmacocinética e varredura de antígeno melhoradas. também são providas composições farmacêuticas que compreendem os anticorpos e fragmentos de ligação ao antígeno, ácidos nucleicos e vetores que codificam os anticorpos e fragmentos de ligação ao antígeno, células hospedeiras que compreendem os ácidos nucleicos ou vetores, e métodos de produção e uso dos anticorpos e fragmentos de ligação ao antígeno. os anticorpos e fragmentos de ligação ao antígeno podem ser usados para inibir a via clássica de ativação do complemento em um indivíduo, por exemplo, um humano. os anticorpos e fragmentos de ligação ao antígeno também podem ser usados para inibir a via da lectina de ativação do complemento em um indivíduo, por exemplo, um humano.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862779102P | 2018-12-13 | 2018-12-13 | |
| PCT/IB2019/060802 WO2020121282A1 (en) | 2018-12-13 | 2019-12-13 | Antibodies to human complement factor c2b and methods of use |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR112021011107A2 true BR112021011107A2 (pt) | 2021-12-14 |
Family
ID=69143627
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112021011107A BR112021011107A2 (pt) | 2018-12-13 | 2019-12-13 | Anticorpos para o fator de complemento humano c2b e métodos de uso |
Country Status (13)
| Country | Link |
|---|---|
| US (4) | US11161900B2 (pt) |
| EP (2) | EP4375297A2 (pt) |
| JP (2) | JP7110491B2 (pt) |
| KR (1) | KR20210100688A (pt) |
| CN (1) | CN113260375A (pt) |
| AU (2) | AU2019397614B2 (pt) |
| BR (1) | BR112021011107A2 (pt) |
| CA (1) | CA3119655A1 (pt) |
| EA (1) | EA202191658A1 (pt) |
| IL (1) | IL283916A (pt) |
| MX (1) | MX2021006864A (pt) |
| SG (1) | SG11202105195PA (pt) |
| WO (1) | WO2020121282A1 (pt) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2020121282A1 (en) | 2018-12-13 | 2020-06-18 | Argenx Bvba | Antibodies to human complement factor c2b and methods of use |
| GB2584105B (en) * | 2019-05-21 | 2023-08-02 | Argenx Bvba | Methods of treating neuropathy |
Family Cites Families (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2001070818A1 (en) | 2000-03-23 | 2001-09-27 | Tanox, Inc. | Anti-c2/c2a inhibitors of complement activation |
| US8501705B2 (en) | 2003-09-11 | 2013-08-06 | The Board Of Regents Of The University Of Texas System | Methods and materials for treating autoimmune and/or complement mediated diseases and conditions |
| EP1896503B1 (en) | 2005-05-31 | 2014-10-29 | Board of Regents, The University of Texas System | IgG1 ANTIBODIES WITH MUTATED Fc PORTION FOR INCREASED BINDING TO FcRn RECEPTOR AND USES TEHEREOF |
| US9399061B2 (en) | 2006-04-10 | 2016-07-26 | Abbvie Biotechnology Ltd | Methods for determining efficacy of TNF-α inhibitors for treatment of rheumatoid arthritis |
| NZ573646A (en) * | 2006-06-12 | 2012-04-27 | Wyeth Llc | Single-chain multivalent binding proteins with effector function |
| US8703136B2 (en) | 2006-10-10 | 2014-04-22 | Regenesance B.V. | Complement inhibition for improved nerve regeneration |
| KR20170023209A (ko) * | 2008-05-05 | 2017-03-02 | 노비뮨 에스 에이 | 항-ｉｌ-１７ａ／ｉｌ-１７ｆ 교차-반응성 항체 및 그의 사용 방법 |
| WO2010056399A1 (en) | 2008-11-17 | 2010-05-20 | Incode Biopharmaceutics, Inc. | Method and composition for modulating the immune system and various inflammatory conditions comprising complement depletors |
| AU2011270959A1 (en) * | 2010-06-22 | 2013-01-10 | Musc Foundation For Research Development | Antibodies to the C3d fragment of complement component 3 |
| KR102024016B1 (ko) * | 2011-05-04 | 2019-11-04 | 오메로스 코포레이션 | Masp-2 의존적 보체 활성화를 억제하는 조성물 |
| EP2753636B1 (en) | 2011-09-07 | 2019-10-23 | The Trustees Of The University Of Pennsylvania | Compstatin analogs with improved pharmacokinetic properties |
| WO2014096958A1 (en) | 2012-11-02 | 2014-06-26 | Academisch Medisch Centrum | Inosine monophosphate and salts thereof for use in the treatment of complement-related disorders |
| RS63212B1 (sr) * | 2012-11-02 | 2022-06-30 | Bioverativ Usa Inc | Antikomplementna c1s antitela i njihove primene |
| EP2997045A4 (en) | 2013-05-15 | 2016-11-23 | Annexon Inc | ANTI-FACTOR C1S ANTIBODIES OF THE COMPLEMENT AND USES THEREOF |
| EP2999714B1 (en) * | 2013-05-23 | 2020-04-01 | Broteio Pharma B.V. | Binding molecules that bind human complement factor c2 and uses thereof |
| CA2859114A1 (en) | 2013-08-29 | 2015-02-28 | International Automotive Components Group North America, Inc. | Formed articles comprising carbon and natural fibers, methods of manufacture and use thereof |
| AU2014329609B2 (en) * | 2013-10-02 | 2019-09-12 | Humabs Biomed Sa | Neutralizing anti-influenza A antibodies and uses thereof |
| JP2016539919A (ja) * | 2013-10-17 | 2016-12-22 | オメロス コーポレーション | Ｍａｓｐ−２依存性補体活性化に関連した状態を治療するための方法 |
| WO2015089368A2 (en) | 2013-12-12 | 2015-06-18 | Alnylam Pharmaceuticals, Inc. | Complement component irna compositions and methods of use thereof |
| BR112017009297B1 (pt) | 2014-11-05 | 2024-02-15 | Annexon, Inc | Anticorpos antifator de complemento c1q humanizados, composição farmacêutica e kit compreendendo os mesmos, uso terapêutico destes,polinucleotídeo isolado, célula hospedeira isolada, bem como métodos in vitro para detectar sinapses |
| TW201726747A (zh) | 2015-11-19 | 2017-08-01 | 艾伯維史坦森特瑞斯有限責任公司 | 新穎抗ｅｍｒ２抗體及使用方法 |
| AU2016361517C1 (en) | 2015-11-24 | 2024-06-06 | Annexon, Inc. | Anti-complement factor C1q Fab fragments and uses thereof |
| MA53248A (fr) | 2016-01-25 | 2022-02-16 | Takeda Pharmaceuticals Co | Anticorps anti-c5 à commutation ph améliorée |
| CA3012037A1 (en) | 2016-01-27 | 2017-08-03 | Csl Behring Recombinant Facility Ag | Recombinant igg fc multimers |
| WO2017196960A1 (en) | 2016-05-10 | 2017-11-16 | Annexon, Inc. | Anti-complement factor c4/c4b antibodies and uses thereof |
| WO2018107109A1 (en) | 2016-12-09 | 2018-06-14 | Abbvie Stemcentrx Llc | Novel anti-kremen2 antibodies and methods of use |
| CA3055781A1 (en) | 2017-03-14 | 2018-09-20 | Bioverativ Usa Inc. | Methods for treating complement-mediated diseases and disorders |
| WO2018193427A1 (en) | 2017-04-21 | 2018-10-25 | Staten Biotechnology B.V. | Anti-apoc3 antibodies and methods of use thereof |
| AU2018360697A1 (en) | 2017-11-01 | 2020-05-14 | Alnylam Pharmaceuticals, Inc. | Complement component C3 iRNA compositions and methods of use thereof |
| WO2020121282A1 (en) | 2018-12-13 | 2020-06-18 | Argenx Bvba | Antibodies to human complement factor c2b and methods of use |
-
2019
- 2019-12-13 WO PCT/IB2019/060802 patent/WO2020121282A1/en unknown
- 2019-12-13 US US16/714,264 patent/US11161900B2/en active Active
- 2019-12-13 CN CN201980082826.8A patent/CN113260375A/zh active Pending
- 2019-12-13 MX MX2021006864A patent/MX2021006864A/es unknown
- 2019-12-13 JP JP2021533300A patent/JP7110491B2/ja active Active
- 2019-12-13 BR BR112021011107A patent/BR112021011107A2/pt unknown
- 2019-12-13 EA EA202191658A patent/EA202191658A1/ru unknown
- 2019-12-13 AU AU2019397614A patent/AU2019397614B2/en active Active
- 2019-12-13 EP EP24164880.7A patent/EP4375297A2/en active Pending
- 2019-12-13 SG SG11202105195PA patent/SG11202105195PA/en unknown
- 2019-12-13 CA CA3119655A patent/CA3119655A1/en active Pending
- 2019-12-13 KR KR1020217021353A patent/KR20210100688A/ko not_active Application Discontinuation
- 2019-12-13 EP EP19832737.1A patent/EP3893924A1/en active Pending
-
2021
- 2021-06-10 IL IL283916A patent/IL283916A/en unknown
- 2021-10-01 US US17/491,656 patent/US11591386B2/en active Active
-
2022
- 2022-01-10 US US17/572,518 patent/US11708403B2/en active Active
- 2022-07-20 JP JP2022115252A patent/JP2022160479A/ja active Pending
- 2022-12-15 AU AU2022287637A patent/AU2022287637A1/en active Pending
-
2023
- 2023-06-07 US US18/330,903 patent/US20240002484A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| EP3893924A1 (en) | 2021-10-20 |
| AU2019397614A1 (en) | 2021-06-03 |
| KR20210100688A (ko) | 2021-08-17 |
| US20220267424A1 (en) | 2022-08-25 |
| JP2022160479A (ja) | 2022-10-19 |
| US11708403B2 (en) | 2023-07-25 |
| IL283916A (en) | 2021-07-29 |
| EA202191658A1 (ru) | 2021-11-03 |
| US20200239554A1 (en) | 2020-07-30 |
| US11161900B2 (en) | 2021-11-02 |
| CA3119655A1 (en) | 2020-06-18 |
| US20240002484A1 (en) | 2024-01-04 |
| AU2019397614B2 (en) | 2022-09-15 |
| EP4375297A2 (en) | 2024-05-29 |
| WO2020121282A1 (en) | 2020-06-18 |
| CN113260375A (zh) | 2021-08-13 |
| US20220119509A1 (en) | 2022-04-21 |
| AU2022287637A1 (en) | 2023-02-02 |
| MX2021006864A (es) | 2021-07-02 |
| JP2022512223A (ja) | 2022-02-02 |
| US11591386B2 (en) | 2023-02-28 |
| JP7110491B2 (ja) | 2022-08-01 |
| SG11202105195PA (en) | 2021-06-29 |
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