HK1219965A1 - 對磷脂醯肌醇蛋白聚糖 特異的人單克隆抗體及其用途 - Google Patents

對磷脂醯肌醇蛋白聚糖 特異的人單克隆抗體及其用途

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Publication number
HK1219965A1
HK1219965A1 HK16108042.3A HK16108042A HK1219965A1 HK 1219965 A1 HK1219965 A1 HK 1219965A1 HK 16108042 A HK16108042 A HK 16108042A HK 1219965 A1 HK1219965 A1 HK 1219965A1
Authority
HK
Hong Kong
Prior art keywords
glypican
monoclonal antibodies
human monoclonal
antibodies specific
human
Prior art date
Application number
HK16108042.3A
Other languages
English (en)
Inventor
Mitchell Ho
Mingqian Feng
Wei Gao
Heungnam Kim
Dimiter S Dimitrov
Original Assignee
The Us
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by The Us filed Critical The Us
Publication of HK1219965A1 publication Critical patent/HK1219965A1/zh

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/3076—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells against structure-related tumour-associated moieties
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    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
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    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
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    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
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    • C07K14/21—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Pseudomonadaceae (F)
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HK16108042.3A 2011-04-19 2016-07-11 對磷脂醯肌醇蛋白聚糖 特異的人單克隆抗體及其用途 HK1219965A1 (zh)

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US (4) US9206257B2 (zh)
EP (3) EP2998320B1 (zh)
CN (2) CN103596985B (zh)
ES (1) ES2666550T3 (zh)
HK (1) HK1219965A1 (zh)
WO (1) WO2012145469A1 (zh)

Families Citing this family (58)

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Publication number Priority date Publication date Assignee Title
US20070087005A1 (en) 2005-10-14 2007-04-19 Lazar Gregory A Anti-glypican-3 antibody
WO2013070468A1 (en) * 2011-11-08 2013-05-16 The Trustees Of The University Of Pennsylvania Glypican-3-specific antibody and uses thereof
WO2013181543A1 (en) 2012-06-01 2013-12-05 The United States Of America, As Represented By The Secretary, Dept. Of Health And Human Services High-affinity monoclonal antibodies to glypican-3 and use thereof
CN105121467B (zh) * 2012-12-03 2019-07-05 诺夫免疫股份有限公司 抗cd47抗体及其使用方法
TWI693073B (zh) 2012-12-21 2020-05-11 日商中外製藥股份有限公司 對ｇｐｃ３標的治療劑療法為有效之患者投與的ｇｐｃ３標的治療劑
EP3557260B1 (en) * 2012-12-21 2022-05-18 Chugai Seiyaku Kabushiki Kaisha Gpc3-targeting drug which is administered to patient responsive to gpc3-targeting drug therapy
CN104140974B (zh) * 2013-05-08 2017-09-29 科济生物医药（上海）有限公司 编码gpc‑3嵌合抗原受体蛋白的核酸及表达gpc‑3嵌合抗原受体蛋白的t淋巴细胞
AR100353A1 (es) 2014-05-08 2016-09-28 Chugai Pharmaceutical Co Ltd Droga de direccionamiento a glipicano 3 (gpc3) que se administra a un paciente que responde a la terapia con drogas de direccionamiento a gpc3
BR112016027222A2 (pt) * 2014-05-22 2018-01-30 Genentech Inc anticorpos isolados, ácido nucleico isolado, célula hospedeira, método de produção de um anticorpo, imunoconjugado, formulação farmacêutica, métodos de tratamento de um indivíduo com um câncer, de inibição da proliferação de uma célula, de detecção de gpc3 humano e de detecção de um câncer
WO2016036973A1 (en) 2014-09-04 2016-03-10 The Trustees Of The University Of Pennsylvania Glypican-3 antibody and uses thereof
MA40764A (fr) 2014-09-26 2017-08-01 Chugai Pharmaceutical Co Ltd Agent thérapeutique induisant une cytotoxicité
WO2016049459A1 (en) 2014-09-26 2016-03-31 Baylor College Of Medicine Glypican-3 specific chimeric antigen receptors for adoptive immunotherapy
JP7096667B2 (ja) 2015-07-01 2022-07-06 中外製薬株式会社 Ｇｐｃ３標的治療剤が有効である患者に投与されるｇｐｃ３標的治療剤
ES2883240T3 (es) * 2015-08-03 2021-12-07 Cafa Therapeutics Ltd Anticuerpo contra glipicano-3 y aplicación del mismo
CN108738347B (zh) * 2016-03-10 2022-01-14 国立癌症研究中心 辅助肝细胞癌患者的再发风险预测的方法、装置、计算机程序制品及试剂盒
CN109414512A (zh) 2016-04-22 2019-03-01 科济生物医药（上海）有限公司 用于细胞免疫疗法的组合物和方法
US20170326249A1 (en) 2016-05-10 2017-11-16 Bristol-Myers Squibb Company Antibody-drug conjugate of an anti-glypican-3 antibody and a tubulysin analog, preparation and uses
WO2017196847A1 (en) * 2016-05-10 2017-11-16 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Variable new antigen receptor (vnar) antibodies and antibody conjugates targeting tumor and viral antigens
CN106084041A (zh) * 2016-06-24 2016-11-09 安徽未名细胞治疗有限公司 一种全人源抗GPC3的全分子IgG抗体及其应用
SG11201900634VA (en) 2016-07-26 2019-02-27 Tessa Therapeutics Pte Ltd Chimeric antigen receptor
WO2018131586A1 (ja) 2017-01-10 2018-07-19 国立大学法人山口大学 抗ｇｐｃ３抗体
CN110612119A (zh) 2017-02-07 2019-12-24 西雅图儿童医院（Dba西雅图儿童研究所） 磷脂醚(ple)car t细胞肿瘤靶向(ctct)剂
EP3589295A4 (en) 2017-02-28 2020-11-04 Endocyte, Inc. COMPOSITIONS AND METHODS OF T CAR LYMPHOCYTE THERAPY
WO2018195339A1 (en) 2017-04-19 2018-10-25 Board Of Regents, The University Of Texas System Immune cells expressing engineered antigen receptors
JP7295030B2 (ja) 2017-04-26 2023-06-20 ユーリカ セラピューティックス， インコーポレイテッド グリピカン３を特異的に認識するコンストラクト及びその使用
US20200283510A1 (en) * 2017-06-20 2020-09-10 Savid Therapeutics Inc. Antisulfataed glycosaminoglycan antibody
CN111683962A (zh) 2017-11-10 2020-09-18 美国政府(由卫生和人类服务部的部长所代表) 靶向肿瘤抗原的嵌合抗原受体
CN109988240B (zh) * 2017-12-29 2022-06-28 安源医药科技（上海）有限公司 抗gpc-3抗体及其用途
WO2019144095A1 (en) 2018-01-22 2019-07-25 Seattle Children's Hospital (dba Seattle Children's Research Institute) Methods of use for car t cells
US20220227848A1 (en) * 2018-02-07 2022-07-21 Nordic Bioscience A/S Type XXIII Collagen Assay
US20210253734A1 (en) * 2018-03-06 2021-08-19 Imcare Biotech, Llc Serine protease inhibitor kazal (spik) compositions and methods
CN108191973B (zh) * 2018-03-06 2021-04-27 中国科学院武汉病毒研究所 一种靶向埃博拉病毒囊膜蛋白的高亲和力单域抗体及其制备方法与应用
SG11202011751WA (en) 2018-06-22 2021-01-28 Kite Pharma Inc Chimeric transmembrane proteins and uses thereof
US20210253713A1 (en) * 2018-07-23 2021-08-19 Abexxa Biologics, Inc. Antibodies targeting a complex comprising non-classical hla-i and neoantigen and their methods of use
CN113286808A (zh) 2018-10-23 2021-08-20 蜻蜓疗法股份有限公司 异二聚体Fc融合蛋白
CN109584960B (zh) * 2018-12-14 2021-07-30 序康医疗科技（苏州）有限公司 预测肿瘤新生抗原的方法、装置及存储介质
SG11202106990PA (en) 2018-12-28 2021-07-29 Kyowa Kirin Co Ltd BISPECIFIC ANTIBODY BINDING TO TfR
WO2020190902A1 (en) * 2019-03-19 2020-09-24 H. Lee Moffitt Cancer Center And Research Institute Inc. Chimeric antigen receptors with enhanced tumor infiltration
SG11202110390XA (en) * 2019-03-21 2021-10-28 Agency Science Tech & Res Composition
US20220220216A1 (en) 2019-05-15 2022-07-14 Kyowa Kirin Co., Ltd. Bispecific antibody binding to cd40 and gpc3
CN112175085B (zh) * 2019-06-14 2022-11-04 厦门大学 抗gpc3抗体及其用途
KR20220083665A (ko) * 2019-08-01 2022-06-20 알.피.쉐러 테크놀러지즈 엘엘씨 Gpc3에 특이적인 항체 및 그것의 사용 방법
CN116063528A (zh) * 2019-08-16 2023-05-05 原启生物科技(上海)有限责任公司 一种分离的抗原结合蛋白及其用途
CN110551222B (zh) * 2019-08-27 2023-06-06 重庆市畜牧科学院 一种新型双功能抗体及其用途
WO2021110095A1 (zh) * 2019-12-05 2021-06-10 上海翰森生物医药科技有限公司 抗gpc3抗体、其抗原结合片段及其医药用途
CN111116749B (zh) * 2019-12-31 2023-02-17 南京拂晓生物科技有限公司 重组的人源化gpc3抗体及其制备和应用
CN111662385B (zh) * 2020-04-08 2022-11-22 重庆金迈博生物科技有限公司 全人源抗人gpc3单克隆抗体及其用途
JP2023522972A (ja) 2020-04-22 2023-06-01 ドラゴンフライ セラピューティクス， インコーポレイテッド ヘテロ二量体Ｆｃ融合タンパク質のための製剤、投薬量レジメン、及び製造工程
US11976120B2 (en) 2020-06-01 2024-05-07 Boehringer Ingelheim International Gmbh Antibodies targeting a complex comprising non-classical HLA-I and neoantigen and their methods of use
US10981996B1 (en) 2020-06-01 2021-04-20 Abexxa Biologics, Inc. Antibodies targeting a complex comprising non-classical HLA-I and neoantigen and their methods of use
US10981997B1 (en) 2020-06-01 2021-04-20 Abexxa Biologics, Inc. Antibodies targeting a complex comprising non-classical HLA-I and neoantigen and their methods of use
CN114478780A (zh) * 2020-10-23 2022-05-13 华中农业大学 识别磷脂酰肌醇蛋白聚糖3多个不同表位的抗体及其应用
CN114478779A (zh) * 2020-10-26 2022-05-13 华中农业大学 人源化的磷脂酰肌醇蛋白聚糖3的单克隆抗体及其应用
JP2024500847A (ja) 2020-12-18 2024-01-10 センチュリー セラピューティクス，インコーポレイテッド 適合可能な受容体特異性を有するキメラ抗原受容体システム
CN113072643B (zh) * 2021-03-22 2021-10-15 南京医科大学 抗Glypican-3耐酸性全人源抗体、其免疫毒素、其嵌合抗原受体细胞及应用
WO2023086829A1 (en) 2021-11-09 2023-05-19 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Igg4 hinge-containing chimeric antigen receptors targeting glypican-3 (gpc3) and use thereof
WO2023100944A1 (ja) * 2021-12-01 2023-06-08 株式会社Epsilon Molecular Engineering ランダム領域搭載用フレームワーク配列を有するペプチド及びそのペプチドで構成されるペプチドライブラリ
WO2024067764A1 (zh) * 2022-09-30 2024-04-04 信立泰(成都)生物技术有限公司 抗gpc3单克隆抗体/双特异性抗体或其抗原结合片段及其用途

Family Cites Families (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4036945A (en) 1976-05-03 1977-07-19 The Massachusetts General Hospital Composition and method for determining the size and location of myocardial infarcts
US4235871A (en) 1978-02-24 1980-11-25 Papahadjopoulos Demetrios P Method of encapsulating biologically active materials in lipid vesicles
US4331647A (en) 1980-03-03 1982-05-25 Goldenberg Milton David Tumor localization and therapy with labeled antibody fragments specific to tumor-associated markers
US4501728A (en) 1983-01-06 1985-02-26 Technology Unlimited, Inc. Masking of liposomes from RES recognition
US4957735A (en) 1984-06-12 1990-09-18 The University Of Tennessee Research Corporation Target-sensitive immunoliposomes- preparation and characterization
US5019369A (en) 1984-10-22 1991-05-28 Vestar, Inc. Method of targeting tumors in humans
US5079163A (en) 1985-03-29 1992-01-07 Cetus Corporation Recombinant ricin toxin fragments
US4689401A (en) 1986-03-06 1987-08-25 Cetus Corporation Method of recovering microbially produced recombinant ricin toxin a chain
US4902505A (en) 1986-07-30 1990-02-20 Alkermes Chimeric peptides for neuropeptide delivery through the blood-brain barrier
US4892827A (en) 1986-09-24 1990-01-09 The United States Of America As Represented By The Department Of Health And Human Services Recombinant pseudomonas exotoxins: construction of an active immunotoxin with low side effects
US4837028A (en) 1986-12-24 1989-06-06 Liposome Technology, Inc. Liposomes with enhanced circulation time
US5004697A (en) 1987-08-17 1991-04-02 Univ. Of Ca Cationized antibodies for delivery through the blood-brain barrier
US5530101A (en) 1988-12-28 1996-06-25 Protein Design Labs, Inc. Humanized immunoglobulins
US5055303A (en) 1989-01-31 1991-10-08 Kv Pharmaceutical Company Solid controlled release bioadherent emulsions
US5271961A (en) 1989-11-06 1993-12-21 Alkermes Controlled Therapeutics, Inc. Method for producing protein microspheres
US5188837A (en) 1989-11-13 1993-02-23 Nova Pharmaceutical Corporation Lipsopheres for controlled delivery of substances
US5061620A (en) 1990-03-30 1991-10-29 Systemix, Inc. Human hematopoietic stem cell
US5268164A (en) 1990-04-23 1993-12-07 Alkermes, Inc. Increasing blood-brain barrier permeability with permeabilizer peptides
WO1991018100A1 (en) 1990-05-11 1991-11-28 THE UNITED SATES OF AMERICA, represented by THE SECRETARY, UNITED STATES DEPARTMENT OF COMMERCE Improved pseudomonas exotoxins of low animal toxicity and high cytocidal activity
US5608039A (en) 1990-10-12 1997-03-04 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Single chain B3 antibody fusion proteins and their uses
US5254342A (en) 1991-09-30 1993-10-19 University Of Southern California Compositions and methods for enhanced transepithelial and transendothelial transport or active agents
EP0630234B1 (en) 1992-03-12 1997-06-11 Alkermes Controlled Therapeutics, Inc. Controlled release acth containing microspheres
AU675440B2 (en) 1992-06-18 1997-02-06 United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services, The Recombinant (pseudomonas) exotoxin with increased activity
US5534496A (en) 1992-07-07 1996-07-09 University Of Southern California Methods and compositions to enhance epithelial drug transport
US5514670A (en) 1993-08-13 1996-05-07 Pharmos Corporation Submicron emulsions for delivery of peptides
US6809184B1 (en) 1997-12-01 2004-10-26 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Antibodies, including FV molecules, and immunoconjugates having high binding affinity for mesothelin and methods for their use
US6296843B1 (en) 1998-04-03 2001-10-02 The Penn State Research Foundation Mutagenized IL 13-based chimeric molecules
AU2710400A (en) 1998-12-31 2000-07-24 Schering Corporation Monocyte-derived nucleic acids and related compositions and methods
MXPA01011950A (es) 1999-05-27 2002-05-06 Gov Health & Human Serv Inmunoconjugados que tienen alta afinidad de enlace.
MXPA05000511A (es) 2001-07-12 2005-09-30 Jefferson Foote Anticuepros super humanizados.
AU2003224073C1 (en) 2002-04-22 2010-03-11 AgroProtect GmbH Antibodies, recombinant antibodies, recombinant antibody fragments and fusions mediated plant disease resistance against fungi
WO2004056875A1 (en) 2002-12-23 2004-07-08 Wyeth Antibodies against pd-1 and uses therefor
CA2552523C (en) 2004-01-09 2019-11-26 Pfizer Inc. Monoclonal antibodies to mucosal addressin cell adhesion molecule(madcam)
CN103130895A (zh) 2004-03-29 2013-06-05 阿伯丁大学理事会 抗突触泡蛋白的特异结合成员
EP2314317A3 (en) * 2004-07-09 2011-06-29 Chugai Seiyaku Kabushiki Kaisha Anti-glypican 3 antibody
EP3006458B1 (en) 2005-07-29 2017-11-22 The Government of the United States of America, as represented by the Secretary of Health and Human Services Mutated pseudomonas exotoxins with reduced antigenicity
WO2008123999A2 (en) 2007-04-02 2008-10-16 Amgen Fremont Inc. Anti-ige antibodies
ES2562790T3 (es) * 2007-07-17 2016-03-08 E. R. Squibb & Sons, L.L.C. Anticuerpos monoclonales contra Glipicano-3
US8871906B2 (en) 2007-09-04 2014-10-28 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Deletions in domain II of pseudomonas exotoxin a that remove immunogenic epitopes
EP2475398B1 (en) 2009-09-11 2015-05-20 The Government of the United States of America as represented by The Secretary of the Department of Health and Human Services Improved pseudomonas exotoxin a with reduced immunogenicity

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