CN103429228B - 万古霉素的喷雾干燥 - Google Patents

万古霉素的喷雾干燥 Download PDF

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Publication number
CN103429228B
CN103429228B CN201280011863.8A CN201280011863A CN103429228B CN 103429228 B CN103429228 B CN 103429228B CN 201280011863 A CN201280011863 A CN 201280011863A CN 103429228 B CN103429228 B CN 103429228B
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CN
China
Prior art keywords
weight
peg
spray
vancomycin
powder
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Expired - Fee Related
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CN201280011863.8A
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English (en)
Chinese (zh)
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CN103429228A (zh
Inventor
C.弗拉加尔
D.布吕克
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Hospira Inc
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Hospira Inc
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Expired - Fee Related legal-status Critical Current
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/14—Peptides containing saccharide radicals; Derivatives thereof, e.g. bleomycin, phleomycin, muramylpeptides or vancomycin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A61K9/1623—Sugars or sugar alcohols, e.g. lactose; Derivatives thereof; Homeopathic globules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Dermatology (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CN201280011863.8A 2011-01-05 2012-01-04 万古霉素的喷雾干燥 Expired - Fee Related CN103429228B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161429844P 2011-01-05 2011-01-05
US61/429,844 2011-01-05
PCT/US2012/020160 WO2012094381A2 (en) 2011-01-05 2012-01-04 Spray drying vancomycin

Publications (2)

Publication Number Publication Date
CN103429228A CN103429228A (zh) 2013-12-04
CN103429228B true CN103429228B (zh) 2016-10-26

Family

ID=46457949

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201280011863.8A Expired - Fee Related CN103429228B (zh) 2011-01-05 2012-01-04 万古霉素的喷雾干燥

Country Status (10)

Country Link
US (3) US8709310B2 (https=)
EP (1) EP2661254B1 (https=)
JP (1) JP5913367B2 (https=)
CN (1) CN103429228B (https=)
AU (1) AU2012204462A1 (https=)
CA (1) CA2823628A1 (https=)
DK (1) DK2661254T3 (https=)
ES (1) ES2645769T3 (https=)
TW (1) TW201309346A (https=)
WO (1) WO2012094381A2 (https=)

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ITLO20110001A1 (it) * 2011-05-03 2012-11-04 Fisiopharma Srl Flaconi di vancomicina cloroidrata con stabilità migliorata
US8952105B2 (en) 2012-05-23 2015-02-10 Baker Hughes Incorporated Variable TG article, method of making, and use of same
CN104043104B (zh) * 2013-03-15 2018-07-10 浙江创新生物有限公司 含盐酸万古霉素的喷雾干粉及其工业化制备方法
TW201516023A (zh) * 2013-09-30 2015-05-01 Daiichi Sankyo Co Ltd 使用噴霧乾燥法之Ｄ－甘露醇α型結晶之選擇性製造方法
EP4000628B1 (en) 2014-03-14 2025-09-24 Azurity Pharmaceuticals, Inc. Composition and method for vancomycin oral liquid
PT107568B (pt) 2014-03-31 2018-11-05 Hovione Farm S A Processo de secagem por atomização para a produção de pós com propriedades melhoradas.
CA3132923A1 (en) * 2019-03-08 2020-09-17 Emphascience, Inc. Stable pharmaceutical formulations of peptide and protein drugs
CN114432339B (zh) * 2022-02-18 2023-05-26 重庆希尔安药业有限公司 一种聚乙二醇钠钾散及其制备方法
CN119745821B (zh) * 2024-11-28 2025-10-03 时森海(杭州)医药科技有限公司 一种盐酸万古霉素固体胶囊及其制备方法

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CN101622302A (zh) * 2007-01-26 2010-01-06 Isp投资公司 生产喷雾干燥产品的制剂工艺方法

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Also Published As

Publication number Publication date
US20140235530A1 (en) 2014-08-21
ES2645769T3 (es) 2017-12-07
CN103429228A (zh) 2013-12-04
WO2012094381A2 (en) 2012-07-12
AU2012204462A1 (en) 2013-07-11
EP2661254A2 (en) 2013-11-13
US9023258B2 (en) 2015-05-05
CA2823628A1 (en) 2012-07-12
TW201309346A (zh) 2013-03-01
US9763997B2 (en) 2017-09-19
EP2661254A4 (en) 2015-01-28
JP5913367B2 (ja) 2016-04-27
US20150231197A1 (en) 2015-08-20
DK2661254T3 (da) 2017-11-06
US8709310B2 (en) 2014-04-29
US20130009330A1 (en) 2013-01-10
JP2014501781A (ja) 2014-01-23
WO2012094381A3 (en) 2013-06-20
EP2661254B1 (en) 2017-08-02

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