CN103429228B - 万古霉素的喷雾干燥 - Google Patents

万古霉素的喷雾干燥 Download PDF

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Publication number
CN103429228B
CN103429228B CN201280011863.8A CN201280011863A CN103429228B CN 103429228 B CN103429228 B CN 103429228B CN 201280011863 A CN201280011863 A CN 201280011863A CN 103429228 B CN103429228 B CN 103429228B
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CN
China
Prior art keywords
weight
peg
spray
vancomycin
powder
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Expired - Fee Related
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CN201280011863.8A
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English (en)
Chinese (zh)
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CN103429228A (zh
Inventor
C.弗拉加尔
D.布吕克
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Hospira Inc
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Hospira Inc
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Expired - Fee Related legal-status Critical Current
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/14—Peptides containing saccharide radicals; Derivatives thereof, e.g. bleomycin, phleomycin, muramylpeptides or vancomycin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A61K9/1623—Sugars or sugar alcohols, e.g. lactose; Derivatives thereof; Homeopathic globules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Dermatology (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CN201280011863.8A 2011-01-05 2012-01-04 万古霉素的喷雾干燥 Expired - Fee Related CN103429228B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161429844P 2011-01-05 2011-01-05
US61/429,844 2011-01-05
PCT/US2012/020160 WO2012094381A2 (en) 2011-01-05 2012-01-04 Spray drying vancomycin

Publications (2)

Publication Number Publication Date
CN103429228A CN103429228A (zh) 2013-12-04
CN103429228B true CN103429228B (zh) 2016-10-26

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
CN201280011863.8A Expired - Fee Related CN103429228B (zh) 2011-01-05 2012-01-04 万古霉素的喷雾干燥

Country Status (10)

Country Link
US (3) US8709310B2 (cg-RX-API-DMAC7.html)
EP (1) EP2661254B1 (cg-RX-API-DMAC7.html)
JP (1) JP5913367B2 (cg-RX-API-DMAC7.html)
CN (1) CN103429228B (cg-RX-API-DMAC7.html)
AU (1) AU2012204462A1 (cg-RX-API-DMAC7.html)
CA (1) CA2823628A1 (cg-RX-API-DMAC7.html)
DK (1) DK2661254T3 (cg-RX-API-DMAC7.html)
ES (1) ES2645769T3 (cg-RX-API-DMAC7.html)
TW (1) TW201309346A (cg-RX-API-DMAC7.html)
WO (1) WO2012094381A2 (cg-RX-API-DMAC7.html)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ITLO20110001A1 (it) * 2011-05-03 2012-11-04 Fisiopharma Srl Flaconi di vancomicina cloroidrata con stabilità migliorata
US8952105B2 (en) 2012-05-23 2015-02-10 Baker Hughes Incorporated Variable TG article, method of making, and use of same
CN104043104B (zh) 2013-03-15 2018-07-10 浙江创新生物有限公司 含盐酸万古霉素的喷雾干粉及其工业化制备方法
JP6480866B2 (ja) * 2013-09-30 2019-03-13 第一三共株式会社 スプレードライ法を用いたＤ−マンニトールα型結晶の選択的製造方法
ES2903419T3 (es) 2014-03-14 2022-04-01 Azurity Pharmaceuticals Inc Composición y método para líquido oral de vancomicina
PT107568B (pt) 2014-03-31 2018-11-05 Hovione Farm S A Processo de secagem por atomização para a produção de pós com propriedades melhoradas.
CA3132923A1 (en) * 2019-03-08 2020-09-17 Emphascience, Inc. Stable pharmaceutical formulations of peptide and protein drugs
CN114432339B (zh) * 2022-02-18 2023-05-26 重庆希尔安药业有限公司 一种聚乙二醇钠钾散及其制备方法
CN119745821B (zh) * 2024-11-28 2025-10-03 时森海(杭州)医药科技有限公司 一种盐酸万古霉素固体胶囊及其制备方法

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006055950A1 (en) * 2004-11-18 2006-05-26 Nektar Therapeutics Pharmaceutical dry powder formulation on the basis particles comprising multiple active agents
CN1857716A (zh) * 2006-03-14 2006-11-08 浙江大学 注射用盐酸万古霉素及其制备方法
US20090221471A1 (en) * 2002-11-12 2009-09-03 Enzon Pharmaceuticals, Inc. Prodrugs of vancomycin with hydrolysis resistant polymer linkages
CN101613396A (zh) * 2008-06-26 2009-12-30 浙江医药股份有限公司新昌制药厂 无结晶型态盐酸万古霉素及其制备方法和用途、以及它的药物组合物
CN101622302A (zh) * 2007-01-26 2010-01-06 Isp投资公司 生产喷雾干燥产品的制剂工艺方法

Family Cites Families (78)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2911036A (en) 1955-01-03 1959-11-03 Melvin E Lazar Spray-drying apparatus
DE3013839A1 (de) 1979-04-13 1980-10-30 Freunt Ind Co Ltd Verfahren zur herstellung einer aktivierten pharmazeutischen zusammensetzung
US4831015A (en) 1987-08-13 1989-05-16 American Cyanamid Company High potency biomass-free avoparcin and a method for its preparation
NZ232763A (en) 1989-03-06 1991-09-25 Lilly Co Eli Parenteral formulation comprising daptomycin with a buffer to maintain ph between 6.0 and 8.0
JPH03193735A (ja) * 1989-12-22 1991-08-23 Shionogi & Co Ltd グリコペプチド系抗生物質の安定化組成物
JPH04142149A (ja) 1990-10-02 1992-05-15 Canon Inc ファクシミリ装置
DE69230613T2 (de) 1991-07-02 2000-12-28 Inhale Inc Verfahren und vorrichtung zum abgeben von medikamenten in aerosolform
US6582728B1 (en) 1992-07-08 2003-06-24 Inhale Therapeutic Systems, Inc. Spray drying of macromolecules to produce inhaleable dry powders
US6673335B1 (en) 1992-07-08 2004-01-06 Nektar Therapeutics Compositions and methods for the pulmonary delivery of aerosolized medicaments
US5785049A (en) 1994-09-21 1998-07-28 Inhale Therapeutic Systems Method and apparatus for dispersion of dry powder medicaments
AU688283B2 (en) 1992-09-29 1998-03-12 Novartis Ag Pulmonary delivery of active fragments of parathyroid hormone
US6051256A (en) 1994-03-07 2000-04-18 Inhale Therapeutic Systems Dispersible macromolecule compositions and methods for their preparation and use
GB9406769D0 (en) 1994-04-06 1994-05-25 Btr Plc Valve system
AU680356B2 (en) 1994-05-06 1997-07-24 Pfizer Inc. Controlled-release dosage forms of azithromycin
CA2190502A1 (en) 1994-05-18 1995-11-23 Robert M. Platz Methods and compositions for the dry powder formulation of interferons
FI971533A7 (fi) 1994-10-13 1997-04-11 Wakamoto Pharma Co Ltd Lyofilisoituja farmaseuttisia valmisteita, jotka kykenevät muodostamaa n vesipitoisen lääkekoostumuksen, jolla on palautuvan, lämpökovettuvan geelittymisen ominaisuus
IL116085A (en) 1994-12-16 1999-12-31 Ortho Pharma Corp Spray dried erythropoietin
SI9500039B (sl) * 1995-02-07 2002-02-28 Lek, Nov kombiniran postopek čiščenja Vankomicin hidroklorida
US6433344B1 (en) 1996-05-22 2002-08-13 Purepulse Technologies, Inc. Pulsed light sterilization of drinking water and drinking water containers
US7038219B2 (en) 1996-05-22 2006-05-02 Purepulse Technologies, Inc. Sterilization of packages and their contents using light
WO1998029141A1 (en) 1996-12-31 1998-07-09 Inhale Therapeutic Systems, Inc. Processes for spray drying solutions of hydrophobic drugs with hydrophilic excipients and compositions prepared by such processes
US20020039594A1 (en) * 1997-05-13 2002-04-04 Evan C. Unger Solid porous matrices and methods of making and using the same
JPH115743A (ja) * 1997-06-16 1999-01-12 Kayaku:Kk バンコマイシン注射剤
JP4142149B2 (ja) 1997-07-10 2008-08-27 明治製菓株式会社 バンコマイシンの凍結乾燥製剤
US6413556B1 (en) * 1999-01-08 2002-07-02 Sky High, Llc Aqueous anti-apoptotic compositions
US6706283B1 (en) 1999-02-10 2004-03-16 Pfizer Inc Controlled release by extrusion of solid amorphous dispersions of drugs
ES2235854T3 (es) * 1999-04-05 2005-07-16 Emisphere Technologies, Inc. Sales disodicas, monohidratos y solvatos etanolicos para aportar agentes activos.
US6253463B1 (en) 1999-04-26 2001-07-03 Niro A/S Method of spray drying
US6223455B1 (en) 1999-05-03 2001-05-01 Acusphere, Inc. Spray drying apparatus and methods of use
US6395300B1 (en) 1999-05-27 2002-05-28 Acusphere, Inc. Porous drug matrices and methods of manufacture thereof
US6576224B1 (en) 1999-07-06 2003-06-10 Sinuspharma, Inc. Aerosolized anti-infectives, anti-inflammatories, and decongestants for the treatment of sinusitis
CN1188111C (zh) 1999-10-29 2005-02-09 耐科塔医药公司 分散性得到改进的干粉组合物
KR100558239B1 (ko) 1999-12-23 2006-03-10 화이자 프로덕츠 인크. 증가된 약물 농도를 제공하는 제약학적 조성물
WO2001047542A1 (en) * 1999-12-28 2001-07-05 Meiji Seika Kaisha, Ltd. Vancomycin preparations
US6696412B1 (en) 2000-01-20 2004-02-24 Cubist Pharmaceuticals, Inc. High purity lipopeptides, Lipopeptide micelles and processes for preparing same
US6730923B1 (en) 2000-05-05 2004-05-04 Purepulse Technologies, Inc. Transmissive conveyor for use in pulsed light sterilization
JP4081987B2 (ja) 2000-05-30 2008-04-30 株式会社村田製作所 金属粉末の製造方法，金属粉末，これを用いた導電性ペーストならびにこれを用いた積層セラミック電子部品
DE10036871A1 (de) 2000-07-28 2002-02-14 Pharmasol Gmbh Dispersionen zur Formulierung wenig oder schwer löslicher Wirkstoffe
EP1313749B1 (en) 2000-08-23 2005-10-12 Wockhardt Limited Process for preparation of anhydrous azithromycin
PT1341528E (pt) 2000-12-07 2012-03-20 Nycomed Gmbh Comprimido de desintegração rápida compreendendo um ingrediente activo lábil a ácido
US20030045678A1 (en) 2000-12-18 2003-03-06 Dennis Keith Methods for preparing purified lipopeptides
WO2002059145A1 (en) 2000-12-18 2002-08-01 Cubist Pharmaceuticals, Inc. Methods for preparing purified lipopeptides
US20060014674A1 (en) 2000-12-18 2006-01-19 Dennis Keith Methods for preparing purified lipopeptides
FR2834212B1 (fr) 2001-12-27 2004-07-09 Besins Int Belgique Utilisation d'une poudre a liberation immediate dans des compositions pharmaceutiques et nutraceutiques
WO2003063821A2 (en) 2002-02-01 2003-08-07 Pfizer Products Inc. Method for making homogeneous spray-dried solid amorphous drug dispersions using pressure nozzles
IL162819A0 (en) 2002-02-01 2005-11-20 Pfizer Prod Inc Method for making homogeneous spray-dried solid amorphous drug dispersions utilizing modified spray-drying apparatus
JP2006512102A (ja) * 2002-04-11 2006-04-13 メディミューン・ヴァクシンズ・インコーポレーテッド 噴霧乾燥による生物活性材料の防腐
US7148211B2 (en) 2002-09-18 2006-12-12 Genzyme Corporation Formulation for lipophilic agents
US20040121003A1 (en) 2002-12-19 2004-06-24 Acusphere, Inc. Methods for making pharmaceutical formulations comprising deagglomerated microparticles
US20050026813A1 (en) 2003-07-30 2005-02-03 Olstein Alan D. Antibiotic-metal complexes in the detection of gram-positive bacteria and other biological analytes
WO2005025535A2 (en) 2003-09-15 2005-03-24 Vectura Limited Methods for preparing pharmaceutical compositions
US20050101547A1 (en) 2003-11-06 2005-05-12 Sadatrezaei Mohsen Stabilized azithromycin composition
CA2547597A1 (en) 2003-12-04 2005-06-16 Pfizer Products Inc. Multiparticulate compositions with improved stability
US7723306B2 (en) 2004-05-10 2010-05-25 Boehringer Ingelheim Pharma Gmbh & Co. Kg Spray-dried powder comprising at least one 1,4 O-linked saccharose-derivative and methods for their preparation
EP1782816B1 (en) 2004-07-02 2011-10-19 Wakamoto Pharmaceutical Co., Ltd. Water-based medicinal composition containing azithromycin and method of preparing the same
EP1781257B1 (en) * 2004-08-13 2018-12-19 Emisphere Technologies, Inc. Pharmaceutical formulations containing microparticles or nanoparticles of a delivery agent
US20080194820A1 (en) 2004-12-14 2008-08-14 Venkataraman Sundaram Process For Preparing Voriconazole
CN101080221A (zh) 2005-02-14 2007-11-28 维纳斯药业有限公司 抗药性细菌感染疾病的肠胃外综合治疗
US20060228251A1 (en) 2005-04-06 2006-10-12 Jagaji Holdings, Llc Pulsed high-intensity light sterilization
NZ563271A (en) 2005-04-29 2009-12-24 Cubist Pharm Inc Therapeutic compositions
US20070026073A1 (en) 2005-07-28 2007-02-01 Doney John A Amorphous efavirenz and the production thereof
JP2009519973A (ja) * 2005-12-15 2009-05-21 アキュスフィア， インコーポレイテッド 粒子ベースの非経口投与用製薬剤形の製造方法
US7931859B2 (en) 2005-12-22 2011-04-26 Intelligent Hospital Systems Ltd. Ultraviolet sanitization in pharmacy environments
US7621921B2 (en) 2006-01-25 2009-11-24 Symmetry Medical, Inc Split thread orthopaedic implant impactor
AR061889A1 (es) 2006-07-13 2008-10-01 Medichem Sa Proceso mejorado para la preparacion de voriconazol
US8834929B2 (en) 2006-07-21 2014-09-16 Bend Research, Inc. Drying of drug-containing particles
DK2158029T3 (da) * 2007-04-10 2019-08-19 Gea Process Eng Inc Procesgasfilter og fremgangsmåde til rensning af dette
PL2200588T3 (pl) 2007-09-25 2019-09-30 Solubest Ltd. Kompozycje zawierające lipofilowe związki aktywne i sposób ich wytwarzania
US7795231B2 (en) 2007-10-04 2010-09-14 Insite Vision Incorporated Concentrated aqueous azalide formulations
EP2303338A4 (en) 2008-06-04 2011-08-03 Triton Thalassic Technologies Inc METHODS, SYSTEMS AND APPARATUS FOR MONOCHROMATIC ULTRAVIOLET LIGHT STERILIZATION
US20100049322A1 (en) 2008-08-19 2010-02-25 Warsaw Orthopedic, Inc. Osteochondral repair implants and methods
US20100057910A1 (en) 2008-09-02 2010-03-04 International Business Machines Corporation Concept for trusting client-side storage and distribution of asynchronous includes in an application server environment
CN101444510B (zh) 2008-12-31 2011-03-09 南京卡文迪许生物工程技术有限公司 含有伏立康唑的药物制剂及其制备方法
KR101101663B1 (ko) * 2009-01-13 2011-12-30 (주) 제노텍 반코마이신 습체의 정제방법
GB0902324D0 (en) 2009-02-12 2009-04-01 Powder Systems Ltd Improvements relating to valves
WO2011035108A1 (en) 2009-09-17 2011-03-24 Eagle Pharmaceuticals, Inc. Formulations of daptomycin
CA2781666C (en) 2009-11-23 2017-02-21 Cubist Pharmaceuticals, Inc. Lipopeptide compositions and related methods
EP2504020A4 (en) 2009-11-23 2013-05-29 Eagle Pharmaceuticals Inc Daptomycin FORMULATIONS

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20090221471A1 (en) * 2002-11-12 2009-09-03 Enzon Pharmaceuticals, Inc. Prodrugs of vancomycin with hydrolysis resistant polymer linkages
WO2006055950A1 (en) * 2004-11-18 2006-05-26 Nektar Therapeutics Pharmaceutical dry powder formulation on the basis particles comprising multiple active agents
CN1857716A (zh) * 2006-03-14 2006-11-08 浙江大学 注射用盐酸万古霉素及其制备方法
CN101622302A (zh) * 2007-01-26 2010-01-06 Isp投资公司 生产喷雾干燥产品的制剂工艺方法
CN101613396A (zh) * 2008-06-26 2009-12-30 浙江医药股份有限公司新昌制药厂 无结晶型态盐酸万古霉素及其制备方法和用途、以及它的药物组合物

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EP2661254A2 (en) 2013-11-13
DK2661254T3 (da) 2017-11-06
JP5913367B2 (ja) 2016-04-27
WO2012094381A3 (en) 2013-06-20
EP2661254A4 (en) 2015-01-28
US20130009330A1 (en) 2013-01-10
JP2014501781A (ja) 2014-01-23
CA2823628A1 (en) 2012-07-12
AU2012204462A1 (en) 2013-07-11
US9763997B2 (en) 2017-09-19
US20140235530A1 (en) 2014-08-21
TW201309346A (zh) 2013-03-01
ES2645769T3 (es) 2017-12-07
CN103429228A (zh) 2013-12-04
US9023258B2 (en) 2015-05-05
US20150231197A1 (en) 2015-08-20
US8709310B2 (en) 2014-04-29
EP2661254B1 (en) 2017-08-02
WO2012094381A2 (en) 2012-07-12

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