CN1034176C - 用于预防和治疗糖尿病并发症的药物组合物的制备方法 - Google Patents

用于预防和治疗糖尿病并发症的药物组合物的制备方法 Download PDF

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Publication number
CN1034176C
CN1034176C CN92108832A CN92108832A CN1034176C CN 1034176 C CN1034176 C CN 1034176C CN 92108832 A CN92108832 A CN 92108832A CN 92108832 A CN92108832 A CN 92108832A CN 1034176 C CN1034176 C CN 1034176C
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CN
China
Prior art keywords
compound
formula
pyrazine
active ingredient
hydrogen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
CN92108832A
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English (en)
Chinese (zh)
Other versions
CN1068825A (zh
Inventor
根来利行
村田诚
上田升三
藤谷武一
小野善幸
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Sumitomo Pharma Co Ltd
Original Assignee
Dainippon Pharmaceutical Co Ltd
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Filing date
Publication date
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Publication of CN1068825A publication Critical patent/CN1068825A/zh
Application granted granted Critical
Publication of CN1034176C publication Critical patent/CN1034176C/zh
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/20—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • General Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pyrrole Compounds (AREA)
CN92108832A 1991-06-26 1992-06-26 用于预防和治疗糖尿病并发症的药物组合物的制备方法 Expired - Lifetime CN1034176C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP03183185 1991-06-26
JP183185/91 1991-06-26

Publications (2)

Publication Number Publication Date
CN1068825A CN1068825A (zh) 1993-02-10
CN1034176C true CN1034176C (zh) 1997-03-05

Family

ID=16131263

Family Applications (1)

Application Number Title Priority Date Filing Date
CN92108832A Expired - Lifetime CN1034176C (zh) 1991-06-26 1992-06-26 用于预防和治疗糖尿病并发症的药物组合物的制备方法

Country Status (21)

Country Link
US (1) US5258382A (enExample)
EP (1) EP0520320B1 (enExample)
JP (1) JP2516147B2 (enExample)
KR (1) KR100241196B1 (enExample)
CN (1) CN1034176C (enExample)
AT (1) ATE157980T1 (enExample)
AU (1) AU648901B2 (enExample)
CA (1) CA2071273C (enExample)
DE (1) DE69222096T2 (enExample)
DK (1) DK0520320T3 (enExample)
ES (1) ES2108717T3 (enExample)
FI (1) FI98066C (enExample)
GR (1) GR3024870T3 (enExample)
HK (1) HK1001728A1 (enExample)
HU (1) HU218214B (enExample)
IE (1) IE921891A1 (enExample)
MX (1) MX9203231A (enExample)
NO (1) NO300637B1 (enExample)
NZ (1) NZ243255A (enExample)
TW (1) TW202450B (enExample)
ZA (1) ZA924425B (enExample)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3195455B2 (ja) * 1993-01-06 2001-08-06 ウェルファイド株式会社 キノリン−３−酢酸誘導体、その製造法と用途
JP3681082B2 (ja) * 1996-06-27 2005-08-10 住友ベークライト株式会社 イミド環含有エポキシ樹脂及びエポキシ樹脂組成物
CZ299018B6 (cs) 1997-10-20 2008-04-02 Dainippon Sumitomo Pharma Co., Ltd. Rychlerozpustný farmaceutický prípravek
AU9461898A (en) * 1997-10-20 1999-05-10 Dainippon Pharmaceutical Co. Ltd. Stable drug composition
JP2007246539A (ja) * 1997-10-20 2007-09-27 Dainippon Sumitomo Pharma Co Ltd 速溶性医薬組成物
EP1243266A4 (en) * 1999-11-11 2007-03-07 Kyorin Seiyaku Kk SOLIDS PREPARATION FOR ORAL APPLICATION
AU1464101A (en) 1999-12-21 2001-07-03 Gpi Nil Holdings, Inc. Hydantoin derivative compounds, pharmaceutical compositions, and methods of using same
AU2003280767A1 (en) * 2002-11-14 2004-06-03 Ono Pharmaceutical Co., Ltd. Remedies for vertebral canal stenosis
JP5130212B2 (ja) * 2006-07-07 2013-01-30 大日本住友製薬株式会社 光学活性３−アミノ−２，５−ジオキソピロリジン−３−カルボキシレート類およびその製造方法ならびに該化合物の使用
WO2008026678A1 (en) * 2006-08-31 2008-03-06 Dainippon Sumitomo Pharma Co., Ltd. Succinic acid diester derivative, process for production thereof, and use of the derivative in the production of pharmaceutical preparation
WO2008035735A1 (fr) 2006-09-20 2008-03-27 Nissan Chemical Industries, Ltd. Procédé de production d'un composé de succinimide optiquement actif
EP2077261A4 (en) * 2006-09-27 2010-04-14 Nissan Chemical Ind Ltd PROCESS FOR PRODUCING SUCCINIMIDE COMPOUND
JP5113070B2 (ja) * 2006-09-29 2013-01-09 大日本住友製薬株式会社 ２，５−ジオキソピロリジン−３−カルボキシレート類の製造方法
KR20090081407A (ko) 2006-10-25 2009-07-28 다이닛본 스미토모 세이야꾸 가부시끼가이샤 고결 방지 과립상 제제
WO2008081860A1 (ja) * 2006-12-28 2008-07-10 Dainippon Sumitomo Pharma Co., Ltd. 光学活性コハク酸イミド誘導体およびその製造方法ならびにその使用
WO2008136527A1 (ja) * 2007-05-08 2008-11-13 Dainippon Sumitomo Pharma Co., Ltd. 光学活性ジオキソピロリジン誘導体の精製方法
US20100222354A1 (en) * 2007-07-13 2010-09-02 Eisai R & D Management Co., Ltd. AMPA Receptor Antagonists and Aldose Reductase Inhibitors for Neuropathic Pain
JP2011026201A (ja) * 2007-10-17 2011-02-10 Mitsubishi Tanabe Pharma Corp 光学活性ピロリル−コハク酸イミド誘導体の立体選択的な製造方法
EP2395097A1 (en) 2009-02-06 2011-12-14 Dainippon Sumitomo Pharma Co., Ltd. Method for producing optically active succinimide derivative and intermediate thereof
JP5844257B2 (ja) 2010-07-29 2016-01-13 大日本住友製薬株式会社 光学活性スクシンイミド誘導体の製造方法
EP2671589A4 (en) 2011-02-02 2014-11-19 Public Univ Corp Nagoya City Univ MEDICAMENT FOR PREVENTING OR TREATING DISEASES RELATED TO INTRAOCULAR NEOVASCULARIZATION AND / OR INTRAOCULAR VASCULAR HYPERPERMEABILITY
TWI707684B (zh) * 2014-09-11 2020-10-21 日商大日本住友製藥股份有限公司 點眼用懸濁製劑
CN106928234A (zh) * 2017-02-07 2017-07-07 上海合全药业股份有限公司 （2‑苄基‑1,2,3,4‑四氢吡咯并[1,2‑a]吡嗪）‑4‑甲醇的合成方法

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0147805A2 (en) * 1983-12-28 1985-07-10 Kyorin Pharmaceutical Co., Ltd. Spiro-linked pyrrolidine-2,5-diones and process for their preparation
EP0173497A1 (en) * 1984-08-14 1986-03-05 Pfizer Inc. Tetracyclic spiro-hydantoin aldose reductase inhibitors

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS63132889A (ja) * 1986-11-21 1988-06-04 Tanabe Seiyaku Co Ltd キナゾリノン誘導体
AU617541B2 (en) * 1988-10-20 1991-11-28 Wyeth Spiro-isoquinoline-pyrrolidine tetrones and analogs thereof useful as aldose reductase inhibitors

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0147805A2 (en) * 1983-12-28 1985-07-10 Kyorin Pharmaceutical Co., Ltd. Spiro-linked pyrrolidine-2,5-diones and process for their preparation
EP0173497A1 (en) * 1984-08-14 1986-03-05 Pfizer Inc. Tetracyclic spiro-hydantoin aldose reductase inhibitors

Also Published As

Publication number Publication date
NO922512D0 (no) 1992-06-25
DE69222096D1 (de) 1997-10-16
FI922848L (fi) 1992-12-27
IE921891A1 (en) 1992-12-30
HUT63424A (en) 1993-08-30
HU9202105D0 (en) 1992-10-28
GR3024870T3 (en) 1998-01-30
JP2516147B2 (ja) 1996-07-10
ES2108717T3 (es) 1998-01-01
MX9203231A (es) 1993-08-01
CA2071273A1 (en) 1992-12-27
NO922512L (no) 1992-12-28
AU648901B2 (en) 1994-05-05
CN1068825A (zh) 1993-02-10
TW202450B (enExample) 1993-03-21
DK0520320T3 (da) 1997-10-13
EP0520320A3 (en) 1993-03-24
DE69222096T2 (de) 1998-01-22
EP0520320A2 (en) 1992-12-30
KR100241196B1 (ko) 2000-03-02
HK1001728A1 (en) 1998-07-03
ATE157980T1 (de) 1997-09-15
ZA924425B (en) 1993-03-31
NO300637B1 (no) 1997-06-30
NZ243255A (en) 1994-03-25
CA2071273C (en) 2002-08-20
JPH05186472A (ja) 1993-07-27
AU1848392A (en) 1993-01-14
FI98066C (fi) 1997-04-10
US5258382A (en) 1993-11-02
FI922848A0 (fi) 1992-06-18
KR930000519A (ko) 1993-01-15
EP0520320B1 (en) 1997-09-10
FI98066B (fi) 1996-12-31
HU218214B (hu) 2000-06-28

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Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C14 Grant of patent or utility model
GR01 Patent grant
C15 Extension of patent right duration from 15 to 20 years for appl. with date before 31.12.1992 and still valid on 11.12.2001 (patent law change 1993)
OR01 Other related matters
C56 Change in the name or address of the patentee

Owner name: NIPPO SUMITOMO PHARMACEUTICALS CO., LTD.

Free format text: FORMER NAME OR ADDRESS: DAINIPPON PHARMACEUTICAL CO., LTD.

CP01 Change in the name or title of a patent holder

Address after: Osaka City, Osaka of Japan

Patentee after: Dainippon Sumitomo Pharma Co.,Ltd.

Address before: Osaka City, Osaka of Japan

Patentee before: DAINIPPON PHARMACEUTICAL Co.,Ltd.

C17 Cessation of patent right
CX01 Expiry of patent term

Expiration termination date: 20120626

Granted publication date: 19970305