MX9203231A - Derivados de tetrahidropiprrol[1,2-a]pirazina-4-spiro-3'-pirrolidina, proceso para su obtencion y composicion farmaceutica que los contiene - Google Patents
Derivados de tetrahidropiprrol[1,2-a]pirazina-4-spiro-3'-pirrolidina, proceso para su obtencion y composicion farmaceutica que los contieneInfo
- Publication number
- MX9203231A MX9203231A MX9203231A MX9203231A MX9203231A MX 9203231 A MX9203231 A MX 9203231A MX 9203231 A MX9203231 A MX 9203231A MX 9203231 A MX9203231 A MX 9203231A MX 9203231 A MX9203231 A MX 9203231A
- Authority
- MX
- Mexico
- Prior art keywords
- spiro
- pharmaceutical composition
- derivatives
- tetrahidropiprrol
- pirrolidina
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 3
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 102000016912 Aldehyde Reductase Human genes 0.000 abstract 1
- 108010053754 Aldehyde reductase Proteins 0.000 abstract 1
- 208000002249 Diabetes Complications Diseases 0.000 abstract 1
- 206010012655 Diabetic complications Diseases 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- USIPCBPGIIPILV-UHFFFAOYSA-N spiro[2,3-dihydro-1h-pyrrolo[1,2-a]pyrazine-4,3'-pyrrolidine] Chemical class C1NCCC21N1C=CC=C1CNC2 USIPCBPGIIPILV-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
- C07D487/20—Spiro-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Diabetes (AREA)
- General Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pyrrole Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP03183185 | 1991-06-26 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX9203231A true MX9203231A (es) | 1993-08-01 |
Family
ID=16131263
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX9203231A MX9203231A (es) | 1991-06-26 | 1992-06-24 | Derivados de tetrahidropiprrol[1,2-a]pirazina-4-spiro-3'-pirrolidina, proceso para su obtencion y composicion farmaceutica que los contiene |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US5258382A (enExample) |
| EP (1) | EP0520320B1 (enExample) |
| JP (1) | JP2516147B2 (enExample) |
| KR (1) | KR100241196B1 (enExample) |
| CN (1) | CN1034176C (enExample) |
| AT (1) | ATE157980T1 (enExample) |
| AU (1) | AU648901B2 (enExample) |
| CA (1) | CA2071273C (enExample) |
| DE (1) | DE69222096T2 (enExample) |
| DK (1) | DK0520320T3 (enExample) |
| ES (1) | ES2108717T3 (enExample) |
| FI (1) | FI98066C (enExample) |
| GR (1) | GR3024870T3 (enExample) |
| HK (1) | HK1001728A1 (enExample) |
| HU (1) | HU218214B (enExample) |
| IE (1) | IE921891A1 (enExample) |
| MX (1) | MX9203231A (enExample) |
| NO (1) | NO300637B1 (enExample) |
| NZ (1) | NZ243255A (enExample) |
| TW (1) | TW202450B (enExample) |
| ZA (1) | ZA924425B (enExample) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP3195455B2 (ja) * | 1993-01-06 | 2001-08-06 | ウェルファイド株式会社 | キノリン−３−酢酸誘導体、その製造法と用途 |
| JP3681082B2 (ja) * | 1996-06-27 | 2005-08-10 | 住友ベークライト株式会社 | イミド環含有エポキシ樹脂及びエポキシ樹脂組成物 |
| JP2007246539A (ja) * | 1997-10-20 | 2007-09-27 | Dainippon Sumitomo Pharma Co Ltd | 速溶性医薬組成物 |
| NZ503796A (en) | 1997-10-20 | 2001-11-30 | Dainippon Pharmaceutical Co | Fast-dissolving pharmaceutical composition comprising micronised (R)-2-(4-bromo-2-fluorobenzyl)-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazine-4-spiro-3'-pyrrolidine-1,2',3,5'-tetrone (AS-3201) |
| JP3995414B2 (ja) * | 1997-10-20 | 2007-10-24 | 大日本住友製薬株式会社 | 安定な医薬組成物 |
| WO2001034148A1 (en) * | 1999-11-11 | 2001-05-17 | Kyorin Pharmaceutical Co., Ltd. | Solid preparations for oral use |
| EP1244670B1 (en) | 1999-12-21 | 2006-03-08 | MGI GP, Inc. | Hydantoin derivative compounds, pharmaceutical compositions, and methods of using same |
| AU2003280767A1 (en) * | 2002-11-14 | 2004-06-03 | Ono Pharmaceutical Co., Ltd. | Remedies for vertebral canal stenosis |
| WO2008004415A1 (fr) * | 2006-07-07 | 2008-01-10 | Dainippon Sumitomo Pharma Co., Ltd. | 3-hydrazino-2,5-dioxopyrrolidine-3-carboxylate, son procédé de production et son utilisation |
| WO2008026678A1 (en) * | 2006-08-31 | 2008-03-06 | Dainippon Sumitomo Pharma Co., Ltd. | Succinic acid diester derivative, process for production thereof, and use of the derivative in the production of pharmaceutical preparation |
| US7994342B2 (en) | 2006-09-20 | 2011-08-09 | Nissan Chemical Industries, Ltd. | Method for producing optically active succinimide compound |
| EP2077261A4 (en) * | 2006-09-27 | 2010-04-14 | Nissan Chemical Ind Ltd | METHOD FOR PRODUCING A SUCCINIMIDE COMPOUND |
| JP5113070B2 (ja) * | 2006-09-29 | 2013-01-09 | 大日本住友製薬株式会社 | ２，５−ジオキソピロリジン−３−カルボキシレート類の製造方法 |
| JP5315056B2 (ja) | 2006-10-25 | 2013-10-16 | 大日本住友製薬株式会社 | 固結抑制粒状製剤 |
| WO2008081860A1 (ja) * | 2006-12-28 | 2008-07-10 | Dainippon Sumitomo Pharma Co., Ltd. | 光学活性コハク酸イミド誘導体およびその製造方法ならびにその使用 |
| WO2008136527A1 (ja) * | 2007-05-08 | 2008-11-13 | Dainippon Sumitomo Pharma Co., Ltd. | 光学活性ジオキソピロリジン誘導体の精製方法 |
| EP2164488A1 (en) * | 2007-07-13 | 2010-03-24 | Eisai R&D Management Co., Ltd. | Ampa receptor antagonists and aldose reductase inhibitors for neuropathic pain |
| JP2011026201A (ja) * | 2007-10-17 | 2011-02-10 | Mitsubishi Tanabe Pharma Corp | 光学活性ピロリル−コハク酸イミド誘導体の立体選択的な製造方法 |
| US8633001B2 (en) | 2009-02-06 | 2014-01-21 | Dainippon Sumitomo Pharma Co., Ltd. | Process for producing optically active succinimide derivatives and intermediates thereof |
| WO2012014953A1 (ja) | 2010-07-29 | 2012-02-02 | 大日本住友製薬株式会社 | 光学活性スクシンイミド誘導体の製造方法 |
| US20140302009A1 (en) | 2011-02-02 | 2014-10-09 | Sanwa Kagaku Kenkyusho Co., Ltd. | Medicinal Agent for Prevention or Treatment of Diseases Associated with Intraocular Neovascularization and/or Intraocular Vascular Hyperpermeability |
| CN106714803B (zh) * | 2014-09-11 | 2020-12-11 | 大日本住友制药株式会社 | 眼用混悬液制剂 |
| CN106928234A (zh) * | 2017-02-07 | 2017-07-07 | 上海合全药业股份有限公司 | （2‑苄基‑1,2,3,4‑四氢吡咯并[1,2‑a]吡嗪）‑4‑甲醇的合成方法 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS60142984A (ja) * | 1983-12-28 | 1985-07-29 | Kyorin Pharmaceut Co Ltd | 新規なスピロピロリジン−２，５−ジオン誘導体およびその製造法 |
| WO1986001107A1 (en) * | 1984-08-14 | 1986-02-27 | Pfizer Inc. | Tetracyclic spiro-hydantoin aldose reductase inhibitors, compositions and methods of making |
| JPS63132889A (ja) * | 1986-11-21 | 1988-06-04 | Tanabe Seiyaku Co Ltd | キナゾリノン誘導体 |
| AU617541B2 (en) * | 1988-10-20 | 1991-11-28 | Wyeth | Spiro-isoquinoline-pyrrolidine tetrones and analogs thereof useful as aldose reductase inhibitors |
-
1992
- 1992-06-13 TW TW081104635A patent/TW202450B/zh active
- 1992-06-15 CA CA002071273A patent/CA2071273C/en not_active Expired - Lifetime
- 1992-06-17 DK DK92110270.3T patent/DK0520320T3/da active
- 1992-06-17 ZA ZA924425A patent/ZA924425B/xx unknown
- 1992-06-17 EP EP92110270A patent/EP0520320B1/en not_active Expired - Lifetime
- 1992-06-17 ES ES92110270T patent/ES2108717T3/es not_active Expired - Lifetime
- 1992-06-17 DE DE69222096T patent/DE69222096T2/de not_active Expired - Lifetime
- 1992-06-17 AT AT92110270T patent/ATE157980T1/de active
- 1992-06-18 FI FI922848A patent/FI98066C/fi not_active IP Right Cessation
- 1992-06-19 KR KR1019920010679A patent/KR100241196B1/ko not_active Expired - Lifetime
- 1992-06-19 US US07/901,029 patent/US5258382A/en not_active Expired - Lifetime
- 1992-06-22 NZ NZ243255A patent/NZ243255A/en not_active IP Right Cessation
- 1992-06-24 HU HU9202105A patent/HU218214B/hu unknown
- 1992-06-24 AU AU18483/92A patent/AU648901B2/en not_active Expired
- 1992-06-24 MX MX9203231A patent/MX9203231A/es unknown
- 1992-06-25 NO NO922512A patent/NO300637B1/no not_active IP Right Cessation
- 1992-06-25 JP JP4193074A patent/JP2516147B2/ja not_active Expired - Lifetime
- 1992-06-26 CN CN92108832A patent/CN1034176C/zh not_active Expired - Lifetime
- 1992-07-01 IE IE189192A patent/IE921891A1/en not_active IP Right Cessation
-
1997
- 1997-09-26 GR GR970402515T patent/GR3024870T3/el unknown
-
1998
- 1998-01-23 HK HK98100610A patent/HK1001728A1/en not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| HUT63424A (en) | 1993-08-30 |
| FI98066B (fi) | 1996-12-31 |
| GR3024870T3 (en) | 1998-01-30 |
| DE69222096T2 (de) | 1998-01-22 |
| EP0520320A2 (en) | 1992-12-30 |
| CA2071273C (en) | 2002-08-20 |
| EP0520320A3 (en) | 1993-03-24 |
| ATE157980T1 (de) | 1997-09-15 |
| EP0520320B1 (en) | 1997-09-10 |
| AU648901B2 (en) | 1994-05-05 |
| CN1034176C (zh) | 1997-03-05 |
| US5258382A (en) | 1993-11-02 |
| NO922512D0 (no) | 1992-06-25 |
| KR100241196B1 (ko) | 2000-03-02 |
| KR930000519A (ko) | 1993-01-15 |
| NO922512L (no) | 1992-12-28 |
| TW202450B (enExample) | 1993-03-21 |
| FI922848L (fi) | 1992-12-27 |
| CN1068825A (zh) | 1993-02-10 |
| FI98066C (fi) | 1997-04-10 |
| DE69222096D1 (de) | 1997-10-16 |
| FI922848A0 (fi) | 1992-06-18 |
| HK1001728A1 (en) | 1998-07-03 |
| NO300637B1 (no) | 1997-06-30 |
| AU1848392A (en) | 1993-01-14 |
| JPH05186472A (ja) | 1993-07-27 |
| ES2108717T3 (es) | 1998-01-01 |
| DK0520320T3 (da) | 1997-10-13 |
| ZA924425B (en) | 1993-03-31 |
| HU9202105D0 (en) | 1992-10-28 |
| NZ243255A (en) | 1994-03-25 |
| JP2516147B2 (ja) | 1996-07-10 |
| HU218214B (hu) | 2000-06-28 |
| CA2071273A1 (en) | 1992-12-27 |
| IE921891A1 (en) | 1992-12-30 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| NO944335L (no) | Nye mercaptoacetylamido-pyridazo[1,2Åpyridazin, pyrazolo[1,2Åpyridazin, pyridazo[1,2-aÅ[1,2Ådiazepin og pyrazolo[1,2-aÅ[1,2Ådiazepinderivater som er anvendbare som inhibitorer av enkefalinase og ACE | |
| FI894477A7 (fi) | Menetelmä terapeuttisesti aktiivisten 7-substituoitujen 3,5-dihydroksihept-6-yynihappojen ja niiden johdannaisten valmistamiseksi ja välituotteina käyttökelpoiset yhdisteet | |
| PH22691A (en) | Novel structural derivatives t3 and t4 | |
| RU94046306A (ru) | Производные индолокарбазолимида, смесь их изомеров или отдельные изомеры и их соли и фармацевтическая композиция с активностью, ингибирующей протеинкиназу с или киназу легкой миозиновой цепи или подавляющей иммунные реакции | |
| ATE157980T1 (de) | Tetrahydropyrrolo(1,2-a>pyrazin-4-spiro-3'- pyrrolidin-derivate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische zubereitungen | |
| EP0266992A3 (en) | Prevention of glucocorticoid-induced skin atrophy | |
| ATE3865T1 (de) | Hydantoinamine und deren pharmazeutische zusammensetzungen. | |
| IE890153L (en) | Dideoxydidehydrocarbocylic nucleosides | |
| PT81893A (de) | Verfahren zur herstellung von labdan-derivaten und ihre verwendung als arzneimittel | |
| FI97134B (fi) | Menetelmä ja välituotteet terapeuttisesti hyödyllisten hydantoiinijohdannaisten valmistamiseksi | |
| IE893204L (en) | N-imidazolyl- and n-imidazolylmethyl-derivatives of¹substituted bicyclic compounds | |
| AR003456A1 (es) | Un compuesto analogo de distamicina y sus sales, procedimiento para su preparacion, composicion farmaceutica que lo contiene y usos del mismo. | |
| RU95104939A (ru) | Тетрациклические соединения, способ их получения и промежуточные соединения для этого и применение их в качестве противоопухолевых веществ | |
| ES2192263T3 (es) | Derivados de benzo(c)quinolizina, su preparacion y empleo como inhibidores de 5-alfa-reductasas. | |
| RU94000725A (ru) | Производные 9н-имидазо (1,2-a) бензимидазол-3-ацетамида, способ их получения, фармацевтическая композиция на их основе и промежуточные соединения синтеза | |
| ES2075180T3 (es) | Nuevos derivados de la piridona, su procedimiento de preparacion, los nuevos productos intermedios obtenidos, su aplicacion como medicamentos y las composiciones farmaceuticas que los contienen. | |
| NO892002L (no) | Fremgangsmaate ved fremstilling av enantiomere glutaramidderivater. | |
| FI890478A7 (fi) | Menetelmä uusien terapeuttisesti käyttökelpoisten 4-okso-4H-pyrido/1,2-a/pyrimidiini-3-karboksamidijohdannaisten valmistamiseksi | |
| WO1998003540A3 (en) | 1,2-substituted cycloalkane derivatives as thrombine inhibitors, a process for the preparation thereof and the use thereof in pharmaceutical formulations | |
| UA12840A1 (uk) | Спосіб одержаhhя правообертових похідhих оксиізоіhдоліhіла або їх фармацевтичhо прийhятhих солей | |
| EP0924204A4 (en) | 2-PHENYLMORPHOLIN-5-ON DERIVATIVES AND PHARMACEUTICAL PREPARATIONS CONTAINING THE SAME | |
| PT98186A (pt) | Processo para a preparacao de purinil- e de pirimidinil-tetra-hidrofuranos e de composicoes farmaceuticas que os contem | |
| NO176963C (no) | Fremgangsmåte for fremstilling av optisk aktive isomerer av 6-substituerte purinylpiperazinderivater | |
| ES2056801T3 (es) | Oxirano-seudooligosacaridos, procedimiento para su preparacion, su utilizacion y preparados farmaceuticos. | |
| HUT38920A (en) | Process for producing anticonvulsive tetrahydro-1,2,4-oxadiazine-5-thion derivatives |