ES2075180T3 - Nuevos derivados de la piridona, su procedimiento de preparacion, los nuevos productos intermedios obtenidos, su aplicacion como medicamentos y las composiciones farmaceuticas que los contienen. - Google Patents

Nuevos derivados de la piridona, su procedimiento de preparacion, los nuevos productos intermedios obtenidos, su aplicacion como medicamentos y las composiciones farmaceuticas que los contienen.

Info

Publication number
ES2075180T3
ES2075180T3 ES90402899T ES90402899T ES2075180T3 ES 2075180 T3 ES2075180 T3 ES 2075180T3 ES 90402899 T ES90402899 T ES 90402899T ES 90402899 T ES90402899 T ES 90402899T ES 2075180 T3 ES2075180 T3 ES 2075180T3
Authority
ES
Spain
Prior art keywords
optionally substituted
image
alkyl
medicines
new
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES90402899T
Other languages
English (en)
Inventor
Francois Clemence
Michel Fortin
Martret Odile Le
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Aventis France
Original Assignee
Roussel Uclaf SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Roussel Uclaf SA filed Critical Roussel Uclaf SA
Application granted granted Critical
Publication of ES2075180T3 publication Critical patent/ES2075180T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
    • C07D295/135—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D211/72—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D211/74—Oxygen atoms
    • C07D211/76—Oxygen atoms attached in position 2 or 6
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
    • C07D211/86—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
    • C07D295/125—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurosurgery (AREA)
  • Cardiology (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

COMPUESTOS DE FORMULAS (1): LA CUAL REPRESENTA: A) EN LA CUAL R REPRESENTA HIDROGENO, ALKYLO, ALKENILO O ALKINILO EVENTUALMENTE SUSTITUIDO, CARBOXY LIBRE, ESTERIFICADO O SALIFICADO, ALCOXY , HIDROXY, AMINO, ALKYLAMINO, DIALKYLAMINO, ACYLOXY, CYANO, CARBAMOYLE HALOGENO. -Y REPRESENTA ARYLES CARBOCICLICOS HETEROMONOCICLICOS, HETEROCYCLICOS CONDENSADOS, EVENTUALMENTE SUSTITUIDOS, -SEA E REPRESENTA -CO SUB 2 R SUB 3 EN LA CUAL R SUB 3 REPRESENTA HIDROGENO O ALKYLO Y G REPRESENTA TA: SEA DONDE B REPRESENTA: CLOALKYLO EVENTUALMENTE SUSTITUIDOS LO O ALKYLOXY, EVENTUALMENTE SUSTITUIDOS, REPRESENTAN HIDROGENO ALKYLO, ALKENYLO O ALKYNILO EVENTUALMENTE SUSTITUIDOS, DONDE R SUB 1 Y R SUB 2 FORMAN CON EL ATOMO DE NITROGENO UN HETEROCICLO DE 5, 6 O 7 ESLABONES INCLUYENDO EVENTUALMENTE OTRO HETEROATOMO Y EVENTUALMENTE SUSTITUIDO, SU PREPARACION Y APLICACION COMO MEDICAMENTOS.
ES90402899T 1989-10-17 1990-10-16 Nuevos derivados de la piridona, su procedimiento de preparacion, los nuevos productos intermedios obtenidos, su aplicacion como medicamentos y las composiciones farmaceuticas que los contienen. Expired - Lifetime ES2075180T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR8913545A FR2653123B1 (fr) 1989-10-17 1989-10-17 Nouveaux derives de la pyridone, leur procede de preparation, les nouveaux intermediaires obtenus, leur application a titre de medicaments et les compositions pharmaceutiques les renfermant.

Publications (1)

Publication Number Publication Date
ES2075180T3 true ES2075180T3 (es) 1995-10-01

Family

ID=9386472

Family Applications (1)

Application Number Title Priority Date Filing Date
ES90402899T Expired - Lifetime ES2075180T3 (es) 1989-10-17 1990-10-16 Nuevos derivados de la piridona, su procedimiento de preparacion, los nuevos productos intermedios obtenidos, su aplicacion como medicamentos y las composiciones farmaceuticas que los contienen.

Country Status (16)

Country Link
US (3) US5356907A (es)
EP (1) EP0437120B1 (es)
JP (1) JP3032274B2 (es)
KR (1) KR0169717B1 (es)
AT (1) ATE125796T1 (es)
AU (1) AU642434B2 (es)
CA (1) CA2027702A1 (es)
DE (1) DE69021355T2 (es)
DK (1) DK0437120T3 (es)
ES (1) ES2075180T3 (es)
FR (1) FR2653123B1 (es)
GR (1) GR3017022T3 (es)
HU (1) HU208007B (es)
IE (1) IE69342B1 (es)
RU (1) RU2078082C1 (es)
ZA (1) ZA907736B (es)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2714291B1 (fr) * 1993-12-24 1996-03-01 Roussel Uclaf Application des dérivés de la pyridone à titre de médicaments anesthésiques.
US20040039030A1 (en) * 1996-09-27 2004-02-26 Hoechst Akeengesellschaft Use of 1-hydroxy-2-pyridones for the treatment of seborrheic dermatitis
DE19639816A1 (de) * 1996-09-27 1998-04-02 Hoechst Ag Antimykotische Mittel mit hoher Wirkstofffreisetzung
TW200508224A (en) * 2003-02-12 2005-03-01 Bristol Myers Squibb Co Cyclic derivatives as modulators of chemokine receptor activity
CA2565630C (en) 2004-05-07 2013-05-28 Janssen Pharmaceutica N.V. Pyrrolidin-2-one and piperidin-2-one derivatives as 11-beta hydroxysteroid dehydrogenase inhibitors
WO2006024628A1 (en) 2004-08-30 2006-03-09 Janssen Pharmaceutica N.V. Tricyclic lactam derivatives as 11-beta hydroxysteroid dehydrogenase inhibitors
DE602005017159D1 (de) 2004-08-30 2009-11-26 Janssen Pharmaceutica Nv Oxysteroid-dehydrogenase-inhibitoren
JP5208505B2 (ja) 2004-08-30 2013-06-12 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ １１−ベータヒドロキシステロイドデヒドロゲナーゼ阻害剤としてのｎ−２アダマンタニル−２−フェノキシ−アセトアミド誘導体
US8173666B2 (en) 2007-03-12 2012-05-08 Nektar Therapeutics Oligomer-opioid agonist conjugates
US10512644B2 (en) 2007-03-12 2019-12-24 Inheris Pharmaceuticals, Inc. Oligomer-opioid agonist conjugates

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3058986A (en) * 1962-10-16 N-ammoalkyl-x-phenyl-x-lower alkyl-z-
BE571915A (es) * 1957-10-10
US3213098A (en) * 1963-08-30 1965-10-19 Upjohn Co Amino substituted 3h-azepines and their preparation
PH12617A (en) * 1973-04-13 1979-07-05 Thomae Gmbh Dr K Aminobenzyl-amides and salts thereof
GB1532957A (en) * 1974-11-04 1978-11-22 Glaxo Lab Ltd Bis(aminomethyl)naphthalene derivatives
DE2862170D1 (en) * 1977-12-22 1983-03-03 Wyeth John & Brother Ltd Hexahydroazepine, piperidine and pyrrolidine derivatives and processes for preparing them
DK704488D0 (da) * 1988-12-19 1988-12-19 Novo Industri As Nye n-substituerede azaheterocykliske carboxylsyrer
IE61631B1 (en) * 1988-05-20 1994-11-16 Zambon Spa Compounds with central analgesic activity, process for their preparation and pharmaceutical compositions containing them

Also Published As

Publication number Publication date
AU642434B2 (en) 1993-10-21
GR3017022T3 (en) 1995-11-30
EP0437120B1 (fr) 1995-08-02
JPH03133957A (ja) 1991-06-07
EP0437120A1 (fr) 1991-07-17
DE69021355D1 (de) 1995-09-07
FR2653123A1 (fr) 1991-04-19
KR910007912A (ko) 1991-05-30
DK0437120T3 (da) 1996-04-09
AU6466990A (en) 1991-04-26
FR2653123B1 (fr) 1992-01-17
DE69021355T2 (de) 1996-01-25
HU906459D0 (en) 1991-04-29
ATE125796T1 (de) 1995-08-15
IE69342B1 (en) 1996-09-04
US5356907A (en) 1994-10-18
RU2078082C1 (ru) 1997-04-27
US5395843A (en) 1995-03-07
KR0169717B1 (ko) 1999-01-15
HU208007B (en) 1993-07-28
JP3032274B2 (ja) 2000-04-10
IE903704A1 (en) 1991-04-24
US5559130A (en) 1996-09-24
ZA907736B (en) 1991-11-27
HUT55379A (en) 1991-05-28
CA2027702A1 (fr) 1991-04-18

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