DE69222096D1 - Tetrahydropyrrolo[1,2-a]Pyrazin-4-Spiro-3'-Pyrrolidin-Derivate, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Zubereitungen - Google Patents

Tetrahydropyrrolo[1,2-a]Pyrazin-4-Spiro-3'-Pyrrolidin-Derivate, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Zubereitungen

Info

Publication number
DE69222096D1
DE69222096D1 DE69222096T DE69222096T DE69222096D1 DE 69222096 D1 DE69222096 D1 DE 69222096D1 DE 69222096 T DE69222096 T DE 69222096T DE 69222096 T DE69222096 T DE 69222096T DE 69222096 D1 DE69222096 D1 DE 69222096D1
Authority
DE
Germany
Prior art keywords
tetrahydropyrrolo
pyrazine
spiro
processes
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69222096T
Other languages
English (en)
Other versions
DE69222096T2 (de
Inventor
Toshiyuki Negoro
Makoto Murata
Shozo Ueda
Buichi Fujitani
Yoshiyuki Ono
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sumitomo Pharma Co Ltd
Original Assignee
Dainippon Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dainippon Pharmaceutical Co Ltd filed Critical Dainippon Pharmaceutical Co Ltd
Application granted granted Critical
Publication of DE69222096D1 publication Critical patent/DE69222096D1/de
Publication of DE69222096T2 publication Critical patent/DE69222096T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/20—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • General Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pyrrole Compounds (AREA)
DE69222096T 1991-06-26 1992-06-17 Tetrahydropyrrolo[1,2-a]Pyrazin-4-Spiro-3'-Pyrrolidin-Derivate, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Zubereitungen Expired - Lifetime DE69222096T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP03183185 1991-06-26

Publications (2)

Publication Number Publication Date
DE69222096D1 true DE69222096D1 (de) 1997-10-16
DE69222096T2 DE69222096T2 (de) 1998-01-22

Family

ID=16131263

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69222096T Expired - Lifetime DE69222096T2 (de) 1991-06-26 1992-06-17 Tetrahydropyrrolo[1,2-a]Pyrazin-4-Spiro-3'-Pyrrolidin-Derivate, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Zubereitungen

Country Status (21)

Country Link
US (1) US5258382A (de)
EP (1) EP0520320B1 (de)
JP (1) JP2516147B2 (de)
KR (1) KR100241196B1 (de)
CN (1) CN1034176C (de)
AT (1) ATE157980T1 (de)
AU (1) AU648901B2 (de)
CA (1) CA2071273C (de)
DE (1) DE69222096T2 (de)
DK (1) DK0520320T3 (de)
ES (1) ES2108717T3 (de)
FI (1) FI98066C (de)
GR (1) GR3024870T3 (de)
HK (1) HK1001728A1 (de)
HU (1) HU218214B (de)
IE (1) IE921891A1 (de)
MX (1) MX9203231A (de)
NO (1) NO300637B1 (de)
NZ (1) NZ243255A (de)
TW (1) TW202450B (de)
ZA (1) ZA924425B (de)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3195455B2 (ja) * 1993-01-06 2001-08-06 ウェルファイド株式会社 キノリン−３−酢酸誘導体、その製造法と用途
JP3681082B2 (ja) * 1996-06-27 2005-08-10 住友ベークライト株式会社 イミド環含有エポキシ樹脂及びエポキシ樹脂組成物
JP2007246539A (ja) * 1997-10-20 2007-09-27 Dainippon Sumitomo Pharma Co Ltd 速溶性医薬組成物
BR9814090A (pt) 1997-10-20 2000-10-03 Dainippon Pharmaceutical Co Composição de drogas rapidamente solúvel
DK1038525T3 (da) * 1997-10-20 2004-08-02 Dainippon Pharmaceutical Co Stabiliseret farmaceutisk præparat af tetrahydropyrrolo[1,2-a]pyrazin-4-spiro-3'-pyrrolidin
AU1304601A (en) * 1999-11-11 2001-06-06 Kyorin Pharmaceutical Co. Ltd. Solid preparations for oral use
DE60026568D1 (de) 1999-12-21 2006-05-04 Mgi Gp Inc Hydantoin derivate, pharmazeutische zusammensetzungen und verfahren zu ihrer verwendung
US20060058310A1 (en) * 2002-11-14 2006-03-16 Yoshifumi Takenobu Remedies for vertebral canal stenosis
WO2008004416A1 (fr) * 2006-07-07 2008-01-10 Dainippon Sumitomo Pharma Co., Ltd. 3-amino-2,5-dioxopyrrolidine-3-carboxylate optiquement actif, procédé de production du composé, et utilisation du composé
EP2058300B1 (de) * 2006-08-31 2013-01-09 Dainippon Sumitomo Pharma Co., Ltd. Bernsteinsäurediesterderivat, verfahren zu dessen herstellung und verwendung des derivats bei der herstellung einer pharmazeutischen zubereitung
EP2071033A4 (de) * 2006-09-20 2010-05-26 Nissan Chemical Ind Ltd Verfahren zur herstellung einer optisch aktiven succinimid-verbindung
CN101516843B (zh) * 2006-09-27 2011-06-15 日产化学工业株式会社 琥珀酰亚胺化合物的制造方法
US20110190497A1 (en) * 2006-09-29 2011-08-04 Daisuke Tanaka Process for production of 2,5 dioxopyrrolidine 3 carboxylate
JP5315056B2 (ja) 2006-10-25 2013-10-16 大日本住友製薬株式会社 固結抑制粒状製剤
WO2008081860A1 (ja) * 2006-12-28 2008-07-10 Dainippon Sumitomo Pharma Co., Ltd. 光学活性コハク酸イミド誘導体およびその製造方法ならびにその使用
JPWO2008136527A1 (ja) * 2007-05-08 2010-07-29 大日本住友製薬株式会社 光学活性ジオキソピロリジン誘導体の精製方法
WO2009011410A1 (en) * 2007-07-13 2009-01-22 Eisai R & D Management Co., Ltd. Ampa receptor antagonists and aldose reductase inhibitors for neuropathic pain
JP2011026201A (ja) * 2007-10-17 2011-02-10 Mitsubishi Tanabe Pharma Corp 光学活性ピロリル−コハク酸イミド誘導体の立体選択的な製造方法
JP5697998B2 (ja) 2009-02-06 2015-04-08 大日本住友製薬株式会社 光学活性スクシンイミド誘導体の製造方法及びその中間体
JP5844257B2 (ja) 2010-07-29 2016-01-13 大日本住友製薬株式会社 光学活性スクシンイミド誘導体の製造方法
EP2671589A4 (de) 2011-02-02 2014-11-19 Public Univ Corp Nagoya City Univ Arzneimittel zur vorbeugung oder behandlung von erkrankungen im zusammenhang mit intraokularer neovaskularisierung und/oder intraokularer vaskulärer hyperpermeabilität
TWI707684B (zh) * 2014-09-11 2020-10-21 日商大日本住友製藥股份有限公司 點眼用懸濁製劑
CN106928234A (zh) * 2017-02-07 2017-07-07 上海合全药业股份有限公司 （2‑苄基‑1,2,3,4‑四氢吡咯并[1,2‑a]吡嗪）‑4‑甲醇的合成方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS60142984A (ja) * 1983-12-28 1985-07-29 Kyorin Pharmaceut Co Ltd 新規なスピロピロリジン−２，５−ジオン誘導体およびその製造法
US4656169A (en) * 1984-08-14 1987-04-07 Pfizer Inc. Tetracyclic spiro-hydantoin aldose reductase inhibitors and compositions
JPS63132889A (ja) * 1986-11-21 1988-06-04 Tanabe Seiyaku Co Ltd キナゾリノン誘導体
AU617541B2 (en) * 1988-10-20 1991-11-28 Wyeth Spiro-isoquinoline-pyrrolidine tetrones and analogs thereof useful as aldose reductase inhibitors

Also Published As

Publication number Publication date
FI922848A0 (fi) 1992-06-18
GR3024870T3 (en) 1998-01-30
US5258382A (en) 1993-11-02
NO300637B1 (no) 1997-06-30
NO922512D0 (no) 1992-06-25
AU648901B2 (en) 1994-05-05
CN1034176C (zh) 1997-03-05
IE921891A1 (en) 1992-12-30
KR100241196B1 (ko) 2000-03-02
DK0520320T3 (da) 1997-10-13
ES2108717T3 (es) 1998-01-01
FI98066C (fi) 1997-04-10
EP0520320B1 (de) 1997-09-10
HU9202105D0 (en) 1992-10-28
CA2071273A1 (en) 1992-12-27
DE69222096T2 (de) 1998-01-22
MX9203231A (es) 1993-08-01
HU218214B (hu) 2000-06-28
CA2071273C (en) 2002-08-20
FI98066B (fi) 1996-12-31
FI922848A (fi) 1992-12-27
TW202450B (de) 1993-03-21
EP0520320A2 (de) 1992-12-30
HUT63424A (en) 1993-08-30
AU1848392A (en) 1993-01-14
CN1068825A (zh) 1993-02-10
ZA924425B (en) 1993-03-31
EP0520320A3 (en) 1993-03-24
JP2516147B2 (ja) 1996-07-10
NO922512L (no) 1992-12-28
HK1001728A1 (en) 1998-07-03
JPH05186472A (ja) 1993-07-27
ATE157980T1 (de) 1997-09-15
NZ243255A (en) 1994-03-25
KR930000519A (ko) 1993-01-15

Similar Documents

Publication Publication Date Title
DE69222096D1 (de) Tetrahydropyrrolo[1,2-a]Pyrazin-4-Spiro-3'-Pyrrolidin-Derivate, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Zubereitungen
CA2029420A1 (en) Pharmaceutical compositions and methods for inhibition of maillard's reaction
TW377352B (en) Pyrido[2,3-d]pyrimidine derivatives and pharmaceutical compositions thereof
CA2174969A1 (en) Short-acting dihydropyridines
DE69030616T2 (de) Pharmazeutische Zusammensetzungen zur Hemmung der Maillardreaktion
ATE305473T1 (de) Pdgf-rezeptor-kinase hemmende verbindungen, deren herstellung, reinigung und diese verbindungen enthaltende pharmazeutische zusammensetzungen
CA2042113A1 (en) Spiro-isoquinoline-pyrrolidines and analogs thereof useful as aldose reductase inhibitors
ES2068216T3 (es) Compuestos de tienotriazolodiazepina y usos farmaceuticos de los mismos.
ATE38982T1 (de) Guanidinmethylcyclohexancarbonsaeure-derivate, verfahren zur herstellung und pharmazeutische mittel.
CA2140781A1 (en) Pharmocologically active .alpha.-¬tertiary-aminomethyl|- benzenemethanol derivatives
GB8608893D0 (en) D-nor-7-ergoline derivatives
KR910020018A (ko) 피리도[3, 4-b] 피롤로[1, 2-e][1, 4, 5]옥사디아제핀 및 이의 관련 동족체 이의 제조방법 및 약제로서의 이의 용도
EP0919233B8 (de) Therapeutisches mittel zur behandlung von nierenerkrankungen
AU5893398A (en) Pharmaceutical composition for the treatment of so-called restless legs
AU586089B2 (en) Phosphodiesterace type 111 inhibitors having a thiadiazinone ring as part of a tricyclic structure
TH13247EX (th) อนุพันธ์เททราไฮโดรฟิร์โรโล [1,2-a]ไพราชีน-4-สไพโร-3'-พิริโรลิดีน กรรมวิธีสำหรับเตรียมสารนั้นและสารผสมในทางเภสัชกรรมซึ่งมีสารนั้น
DE69419083D1 (de) Salmycine, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
DE69218626T2 (de) 1'-amino-2[(benzothiazolyl)methyl] spiro [isochinolin-4(1h), 3'-pyrrolidine]-1,2',3,5'-tetrone und analoge davon verwendbar als aldosereduktase luhibitoren
RU98111593A (ru) Производные пиридо[2,3-]пиримидина и их фармацевтические композиции

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: DAINIPPON SUMITOMO PHARMA CO., LTD., OSAKA, JP

R071 Expiry of right

Ref document number: 520320

Country of ref document: EP