CN103228652B - 单环内酰胺类 - Google Patents

单环内酰胺类 Download PDF

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Publication number
CN103228652B
CN103228652B CN201180057264.5A CN201180057264A CN103228652B CN 103228652 B CN103228652 B CN 103228652B CN 201180057264 A CN201180057264 A CN 201180057264A CN 103228652 B CN103228652 B CN 103228652B
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China
Prior art keywords
mmol
formula
compound
preparation
treated
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Expired - Fee Related
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CN201180057264.5A
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English (en)
Chinese (zh)
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CN103228652A (zh
Inventor
M·F·布朗
M·J·米顿-弗赖伊
S·韩
M·拉尔
M·S·普卢默
H·L·里斯利
V·桑穆加孙达拉姆
J·T·斯塔尔
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Pfizer Corp SRL
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Pfizer Corp SRL
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Publication of CN103228652A publication Critical patent/CN103228652A/zh
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Communicable Diseases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
CN201180057264.5A 2010-11-29 2011-11-15 单环内酰胺类 Expired - Fee Related CN103228652B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US41757510P 2010-11-29 2010-11-29
US61/417,575 2010-11-29
PCT/IB2011/055104 WO2012073138A1 (en) 2010-11-29 2011-11-15 Monobactams

Publications (2)

Publication Number Publication Date
CN103228652A CN103228652A (zh) 2013-07-31
CN103228652B true CN103228652B (zh) 2015-02-18

Family

ID=45315854

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201180057264.5A Expired - Fee Related CN103228652B (zh) 2010-11-29 2011-11-15 单环内酰胺类

Country Status (17)

Country Link
US (3) US20120302542A1 (enExample)
EP (1) EP2646436B1 (enExample)
JP (1) JP5777725B2 (enExample)
KR (1) KR101514587B1 (enExample)
CN (1) CN103228652B (enExample)
AR (1) AR084001A1 (enExample)
AU (1) AU2011336209B2 (enExample)
CA (1) CA2815821C (enExample)
DK (1) DK2646436T3 (enExample)
ES (1) ES2542431T3 (enExample)
IL (1) IL226052A0 (enExample)
MX (1) MX2013005994A (enExample)
SG (1) SG190007A1 (enExample)
TW (1) TW201247661A (enExample)
UY (1) UY33754A (enExample)
WO (1) WO2012073138A1 (enExample)
ZA (1) ZA201304479B (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11230543B2 (en) 2015-12-15 2022-01-25 Merck Sharp & Dohme Corp. Biaryl monobactam compounds and methods of use thereof for the treatment of bacterial infections

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* Cited by examiner, † Cited by third party
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US9988373B2 (en) 2013-12-26 2018-06-05 Shionogi & Co., Ltd. Nitrogen-containing six-membered cyclic derivatives and pharmaceutical composition comprising the same
MA39777B1 (fr) 2014-03-24 2019-03-29 Novartis Ag Composes organiques de la famille des monobactams pour le traitement d'infections bactériennes
RU2754180C2 (ru) * 2015-09-23 2021-08-30 Новартис Аг Соли и твердые формы монобактамного антибиотика
CN105481812B (zh) * 2015-11-30 2020-04-21 重庆天奕恒化科技有限公司 一种5-苄氧基-4-氧代-4h-吡喃-2-羧酸的制备方法
KR102408800B1 (ko) 2016-03-07 2022-06-13 머크 샤프 앤드 돔 코포레이션 비시클릭 아릴 모노박탐 화합물 및 박테리아 감염의 치료를 위한 그의 사용 방법
US10047077B2 (en) 2016-04-13 2018-08-14 Skyline Antiinfectives, Inc. Deuterated O-sulfated beta-lactam hydroxamic acids and deuterated N-sulfated beta-lactams
CN107641119B (zh) 2016-07-21 2019-11-08 中国科学院上海药物研究所 单环β-内酰胺-铁载体轭合物及其制备方法和用途
JP7235718B2 (ja) 2017-08-02 2023-03-08 ノバルティス アーゲー モノバクタム系抗生物質およびその中間体を製造するための化学的方法
KR102425959B1 (ko) 2017-10-02 2022-07-27 머크 샤프 앤드 돔 코포레이션 박테리아 감염의 치료를 위한 크로만 모노박탐 화합물
US10513504B2 (en) 2018-03-08 2019-12-24 Apotex Inc. Processes for the preparation of apalutamide and intermediates thereof
US12516049B2 (en) 2019-11-22 2026-01-06 Suzhou Erye Pharmaceutical Co., Ltd Sulfonylurea ring substituted monocyclic β-lactam antibiotics
FI4069691T3 (fi) 2019-12-06 2024-11-13 Vertex Pharma Substituoituja tetrahydrofuraaneja natriumkanavien modulaattoreina
CN111303144B (zh) * 2019-12-13 2020-11-27 苏州信诺维医药科技有限公司 一种治疗细菌感染的化合物
AU2022250095B2 (en) 2021-03-31 2023-11-23 Fedora Pharmaceuticals Inc. Lactivicin compounds, their preparation and use as antibacterial agents
US12528804B2 (en) 2021-03-31 2026-01-20 Fedora Pharmaceuticals Inc. Lactivicin compounds, their preparation and use as antibacterial agents
WO2022235077A1 (ko) * 2021-05-07 2022-11-10 한국생명공학연구원 신규 사이드로포어 화합물 및 이를 이용한 금속 나노입자 복합체
CR20230586A (es) 2021-06-04 2024-05-07 Vertex Pharma N-(hydroxyalquil (hetero)aril) tetrahidrofurano carboxamidas como moduladores de canales de sodio
AU2022391635B2 (en) 2021-11-18 2025-10-02 Merck Sharp & Dohme Llc Chromane amidine monobactam antibiotics
JP7671398B2 (ja) * 2021-11-18 2025-05-01 メルク・シャープ・アンド・ドーム・エルエルシー クロマンアミジンモノバクタム抗生物質
JP2025513455A (ja) 2022-04-22 2025-04-24 バーテックス ファーマシューティカルズ インコーポレイテッド 疼痛の治療のためのヘテロアリール化合物
CN115304594B (zh) * 2022-10-12 2023-02-14 苏州二叶制药有限公司 磺酰脲环取代的化合物的盐型及其晶型

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101410111A (zh) * 2005-12-07 2009-04-15 巴斯利尔药物股份公司 单环-内酰胺类抗生素与β-内酰胺酶抑制剂的有效的联合应用
WO2010070523A1 (en) * 2008-12-19 2010-06-24 Pfizer Inc. Monocarbams

Family Cites Families (2)

* Cited by examiner, † Cited by third party
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KR880701238A (ko) * 1986-05-23 1988-07-26 로버트 에이 아르미티즈 N-1 치환 설포닐아미노카르보닐,c-4 치환 모노박탐
AU2008232262B2 (en) 2007-03-28 2013-02-14 Apotex Inc. Fluorinated derivatives of deferiprone

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101410111A (zh) * 2005-12-07 2009-04-15 巴斯利尔药物股份公司 单环-内酰胺类抗生素与β-内酰胺酶抑制剂的有效的联合应用
WO2010070523A1 (en) * 2008-12-19 2010-06-24 Pfizer Inc. Monocarbams

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11230543B2 (en) 2015-12-15 2022-01-25 Merck Sharp & Dohme Corp. Biaryl monobactam compounds and methods of use thereof for the treatment of bacterial infections

Also Published As

Publication number Publication date
CA2815821C (en) 2015-07-07
HK1184462A1 (en) 2014-01-24
IL226052A0 (en) 2013-06-27
MX2013005994A (es) 2013-07-15
KR20130112054A (ko) 2013-10-11
EP2646436A1 (en) 2013-10-09
AU2011336209B2 (en) 2015-03-19
AR084001A1 (es) 2013-04-17
JP2013544276A (ja) 2013-12-12
DK2646436T3 (en) 2015-06-29
WO2012073138A1 (en) 2012-06-07
JP5777725B2 (ja) 2015-09-09
CN103228652A (zh) 2013-07-31
SG190007A1 (en) 2013-06-28
TW201247661A (en) 2012-12-01
ES2542431T3 (es) 2015-08-05
UY33754A (es) 2012-06-29
AU2011336209A1 (en) 2013-05-30
EP2646436B1 (en) 2015-05-27
US20150148326A1 (en) 2015-05-28
KR101514587B1 (ko) 2015-04-22
US20120302542A1 (en) 2012-11-29
ZA201304479B (en) 2014-03-26
CA2815821A1 (en) 2012-06-07
US20130252935A1 (en) 2013-09-26

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