CN103228652B - 单环内酰胺类 - Google Patents

单环内酰胺类 Download PDF

Info

Publication number
CN103228652B
CN103228652B CN201180057264.5A CN201180057264A CN103228652B CN 103228652 B CN103228652 B CN 103228652B CN 201180057264 A CN201180057264 A CN 201180057264A CN 103228652 B CN103228652 B CN 103228652B
Authority
CN
China
Prior art keywords
mmol
formula
compound
preparation
treated
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CN201180057264.5A
Other languages
English (en)
Chinese (zh)
Other versions
CN103228652A (zh
Inventor
M·F·布朗
M·J·米顿-弗赖伊
S·韩
M·拉尔
M·S·普卢默
H·L·里斯利
V·桑穆加孙达拉姆
J·T·斯塔尔
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Inc
Original Assignee
Pfizer Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Inc filed Critical Pfizer Inc
Publication of CN103228652A publication Critical patent/CN103228652A/zh
Application granted granted Critical
Publication of CN103228652B publication Critical patent/CN103228652B/zh
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Communicable Diseases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
CN201180057264.5A 2010-11-29 2011-11-15 单环内酰胺类 Expired - Fee Related CN103228652B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US41757510P 2010-11-29 2010-11-29
US61/417,575 2010-11-29
PCT/IB2011/055104 WO2012073138A1 (en) 2010-11-29 2011-11-15 Monobactams

Publications (2)

Publication Number Publication Date
CN103228652A CN103228652A (zh) 2013-07-31
CN103228652B true CN103228652B (zh) 2015-02-18

Family

ID=45315854

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201180057264.5A Expired - Fee Related CN103228652B (zh) 2010-11-29 2011-11-15 单环内酰胺类

Country Status (17)

Country Link
US (3) US20120302542A1 (enExample)
EP (1) EP2646436B1 (enExample)
JP (1) JP5777725B2 (enExample)
KR (1) KR101514587B1 (enExample)
CN (1) CN103228652B (enExample)
AR (1) AR084001A1 (enExample)
AU (1) AU2011336209B2 (enExample)
CA (1) CA2815821C (enExample)
DK (1) DK2646436T3 (enExample)
ES (1) ES2542431T3 (enExample)
IL (1) IL226052A0 (enExample)
MX (1) MX2013005994A (enExample)
SG (1) SG190007A1 (enExample)
TW (1) TW201247661A (enExample)
UY (1) UY33754A (enExample)
WO (1) WO2012073138A1 (enExample)
ZA (1) ZA201304479B (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11230543B2 (en) 2015-12-15 2022-01-25 Merck Sharp & Dohme Corp. Biaryl monobactam compounds and methods of use thereof for the treatment of bacterial infections

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9988373B2 (en) 2013-12-26 2018-06-05 Shionogi & Co., Ltd. Nitrogen-containing six-membered cyclic derivatives and pharmaceutical composition comprising the same
HUE042134T2 (hu) * 2014-03-24 2019-06-28 Novartis Ag Monobaktám szerves vegyületek bakteriális fertõzések kezelésére
AU2016327264B2 (en) 2015-09-23 2019-06-27 Novartis Ag Salts and solid forms of monobactam antibiotic
CN105481812B (zh) * 2015-11-30 2020-04-21 重庆天奕恒化科技有限公司 一种5-苄氧基-4-氧代-4h-吡喃-2-羧酸的制备方法
US10407421B2 (en) 2016-03-07 2019-09-10 Merck Sharp & Dohme Corp Bicyclic aryl monobactam compounds and methods of use thereof for the treatment of bacterial infections
US10047077B2 (en) 2016-04-13 2018-08-14 Skyline Antiinfectives, Inc. Deuterated O-sulfated beta-lactam hydroxamic acids and deuterated N-sulfated beta-lactams
CN107641119B (zh) 2016-07-21 2019-11-08 中国科学院上海药物研究所 单环β-内酰胺-铁载体轭合物及其制备方法和用途
ES2912656T3 (es) 2017-08-02 2022-05-26 Novartis Ag Proceso para preparar ácido 1-(((Z)-(1-(2-aminotiazol-4-il)-2-oxo-2-(((3S,4R)-2-oxo-4-((2-oxooxazolidin-3-il)metil)-1-sulfoacetidin-3-il)amino)etiliden)amino)oxi)ciclopropano carboxílico
GEAP202215303A (en) 2017-10-02 2022-04-11 Merck Sharp & Dohme Chromane monobactam compounds for the treatment of bacterial infections
US10513504B2 (en) 2018-03-08 2019-12-24 Apotex Inc. Processes for the preparation of apalutamide and intermediates thereof
KR102786898B1 (ko) * 2019-11-22 2025-03-25 쑤저우 얼예 파마슈티칼 컴퍼니 리미티드 설포닐우레아 고리 치환 모노시클릭 β-락탐계 항생제
PH12022551379A1 (en) 2019-12-06 2023-05-03 Vertex Pharma Substituted tetrahydrofurans as modulators of sodium channels
CN111303144B (zh) * 2019-12-13 2020-11-27 苏州信诺维医药科技有限公司 一种治疗细菌感染的化合物
US12528804B2 (en) 2021-03-31 2026-01-20 Fedora Pharmaceuticals Inc. Lactivicin compounds, their preparation and use as antibacterial agents
US11780832B2 (en) 2021-03-31 2023-10-10 Fedora Pharmaceuticals Inc. Lactivicin compounds, their preparation and use as antibacterial agents
KR102781293B1 (ko) * 2021-05-07 2025-03-17 한국생명공학연구원 신규 사이드로포어 화합물 및 이를 이용한 금속 나노입자 복합체
SI4347031T1 (sl) 2021-06-04 2026-01-30 Vertex Pharmaceuticals Incorporated N-(hidroksialkil (hetero)aril) tetrahidrofuran karboksamidi kot modulatorji natrijevih kanalčkov
CR20240212A (es) 2021-11-18 2024-07-01 Merck Sharp & Dohme Llc Compuestos monobactámicos de cromano amidina para tratar las infecciones bacterianas
JP7671398B2 (ja) * 2021-11-18 2025-05-01 メルク・シャープ・アンド・ドーム・エルエルシー クロマンアミジンモノバクタム抗生物質
JP2025513455A (ja) 2022-04-22 2025-04-24 バーテックス ファーマシューティカルズ インコーポレイテッド 疼痛の治療のためのヘテロアリール化合物
CN115304594B (zh) * 2022-10-12 2023-02-14 苏州二叶制药有限公司 磺酰脲环取代的化合物的盐型及其晶型
WO2026043829A1 (en) * 2024-08-21 2026-02-26 Merck Sharp & Dohme Llc Chromane cyclic amidine monobactam compounds for the treatment of bacterial infections

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101410111A (zh) * 2005-12-07 2009-04-15 巴斯利尔药物股份公司 单环-内酰胺类抗生素与β-内酰胺酶抑制剂的有效的联合应用
WO2010070523A1 (en) * 2008-12-19 2010-06-24 Pfizer Inc. Monocarbams

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH01502660A (ja) * 1986-05-23 1989-09-14 ジ・アップジョン・カンパニー Ｎ―１置換スルホニルアミノカルボニル、ｃ―４置換モノバクタム類
WO2008116301A1 (en) 2007-03-28 2008-10-02 Apotex Technologies Inc. Fluorinated derivatives of deferiprone

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101410111A (zh) * 2005-12-07 2009-04-15 巴斯利尔药物股份公司 单环-内酰胺类抗生素与β-内酰胺酶抑制剂的有效的联合应用
WO2010070523A1 (en) * 2008-12-19 2010-06-24 Pfizer Inc. Monocarbams

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11230543B2 (en) 2015-12-15 2022-01-25 Merck Sharp & Dohme Corp. Biaryl monobactam compounds and methods of use thereof for the treatment of bacterial infections

Also Published As

Publication number Publication date
AR084001A1 (es) 2013-04-17
DK2646436T3 (en) 2015-06-29
US20150148326A1 (en) 2015-05-28
ZA201304479B (en) 2014-03-26
EP2646436A1 (en) 2013-10-09
AU2011336209A1 (en) 2013-05-30
UY33754A (es) 2012-06-29
JP5777725B2 (ja) 2015-09-09
CA2815821A1 (en) 2012-06-07
JP2013544276A (ja) 2013-12-12
KR101514587B1 (ko) 2015-04-22
KR20130112054A (ko) 2013-10-11
IL226052A0 (en) 2013-06-27
CA2815821C (en) 2015-07-07
HK1184462A1 (en) 2014-01-24
TW201247661A (en) 2012-12-01
US20130252935A1 (en) 2013-09-26
AU2011336209B2 (en) 2015-03-19
MX2013005994A (es) 2013-07-15
WO2012073138A1 (en) 2012-06-07
EP2646436B1 (en) 2015-05-27
CN103228652A (zh) 2013-07-31
ES2542431T3 (es) 2015-08-05
US20120302542A1 (en) 2012-11-29
SG190007A1 (en) 2013-06-28

Similar Documents

Publication Publication Date Title
JP5777725B2 (ja) モノバクタム
CN109715630B (zh) β-内酰胺酶抑制剂化合物
CN107207487A (zh) 用于提高cftr活性的化合物、组合物和方法
JPWO1998017625A1 (ja) 新規な感染症治療薬
KR20090071668A (ko) 암치료에 유용한 폴로형 키나아제 억제제로서 프테리딘 유도체
EP3519411B1 (en) Heterocyclic compounds and their use in preventing or treating bacterial infections
WO2018177302A1 (zh) 含氮杂环取代的苯并噁嗪噁唑烷酮类化合物及其制备方法和用途
WO1997037996A1 (en) Cephem compounds and drugs containing the compounds
CN112135830A (zh) 氧代取代化合物
CA3119394A1 (en) Monobactam compounds and use therefor
HK1184462B (en) Monobactams
JP6986089B2 (ja) 新規な２−カルボキシペナム化合物またはその塩、それらを含有する医薬組成物およびその応用
CN107922436A (zh) 具有亚磺酰基或磺酰基的三环性化合物
CN102471333A (zh) 新型噻吩甲酰胺衍生物及其药物用途
HUP0202340A2 (hu) Hatóanyagként kondenzált heterociklusos vegyületeket tartalmazó gyógyszerkészítmények és alkalmazásuk
TW201036962A (en) Novel 2, 5-disubstituted pyrrole derivative
HK40099768A (en) Lactivicin compounds, their preparation and use as antibacterial agents
WO2020138499A1 (ja) アルキル置換化合物
HK40043668A (en) Oxo-substituted compound
HK40011101B (en) Beta-lactamase inhibitor compounds
HK40011101A (en) Beta-lactamase inhibitor compounds
HK1168350A (en) Novel thiophene carboxamide derivative and medicinal use of same
WO1998034937A1 (en) Tricyclic heterocyclic compounds
JP2012006899A (ja) 新規チオフェンカルボキサミド誘導体及びその医薬用途

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
REG Reference to a national code

Ref country code: HK

Ref legal event code: DE

Ref document number: 1184462

Country of ref document: HK

C14 Grant of patent or utility model
GR01 Patent grant
REG Reference to a national code

Ref country code: HK

Ref legal event code: GR

Ref document number: 1184462

Country of ref document: HK

CF01 Termination of patent right due to non-payment of annual fee
CF01 Termination of patent right due to non-payment of annual fee

Granted publication date: 20150218

Termination date: 20161115