CN103228652B - 单环内酰胺类 - Google Patents

单环内酰胺类 Download PDF

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Publication number
CN103228652B
CN103228652B CN201180057264.5A CN201180057264A CN103228652B CN 103228652 B CN103228652 B CN 103228652B CN 201180057264 A CN201180057264 A CN 201180057264A CN 103228652 B CN103228652 B CN 103228652B
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China
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mmol
formula
compound
preparation
treated
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Expired - Fee Related
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CN201180057264.5A
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English (en)
Chinese (zh)
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CN103228652A (zh
Inventor
M·F·布朗
M·J·米顿-弗赖伊
S·韩
M·拉尔
M·S·普卢默
H·L·里斯利
V·桑穆加孙达拉姆
J·T·斯塔尔
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Pfizer Corp SRL
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Pfizer Corp SRL
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Publication of CN103228652A publication Critical patent/CN103228652A/zh
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Expired - Fee Related legal-status Critical Current
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Communicable Diseases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
CN201180057264.5A 2010-11-29 2011-11-15 单环内酰胺类 Expired - Fee Related CN103228652B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US41757510P 2010-11-29 2010-11-29
US61/417,575 2010-11-29
PCT/IB2011/055104 WO2012073138A1 (en) 2010-11-29 2011-11-15 Monobactams

Publications (2)

Publication Number Publication Date
CN103228652A CN103228652A (zh) 2013-07-31
CN103228652B true CN103228652B (zh) 2015-02-18

Family

ID=45315854

Family Applications (1)

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CN201180057264.5A Expired - Fee Related CN103228652B (zh) 2010-11-29 2011-11-15 单环内酰胺类

Country Status (17)

Country Link
US (3) US20120302542A1 (enExample)
EP (1) EP2646436B1 (enExample)
JP (1) JP5777725B2 (enExample)
KR (1) KR101514587B1 (enExample)
CN (1) CN103228652B (enExample)
AR (1) AR084001A1 (enExample)
AU (1) AU2011336209B2 (enExample)
CA (1) CA2815821C (enExample)
DK (1) DK2646436T3 (enExample)
ES (1) ES2542431T3 (enExample)
IL (1) IL226052A0 (enExample)
MX (1) MX2013005994A (enExample)
SG (1) SG190007A1 (enExample)
TW (1) TW201247661A (enExample)
UY (1) UY33754A (enExample)
WO (1) WO2012073138A1 (enExample)
ZA (1) ZA201304479B (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11230543B2 (en) 2015-12-15 2022-01-25 Merck Sharp & Dohme Corp. Biaryl monobactam compounds and methods of use thereof for the treatment of bacterial infections

Families Citing this family (19)

* Cited by examiner, † Cited by third party
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WO2015099107A1 (ja) 2013-12-26 2015-07-02 塩野義製薬株式会社 含窒素６員環誘導体およびそれらを含有する医薬組成物
SI3122745T1 (sl) 2014-03-24 2019-05-31 Novartis Ag Organske spojine monobaktama za zdravljenje bakterijskih infekcij
HRP20201423T1 (hr) * 2015-09-23 2020-12-11 Novartis Ag Soli i čvrsti oblici antibiotika monobaktam
CN105481812B (zh) * 2015-11-30 2020-04-21 重庆天奕恒化科技有限公司 一种5-苄氧基-4-氧代-4h-吡喃-2-羧酸的制备方法
MA43811A (fr) 2016-03-07 2018-11-28 Merck Sharp & Dohme Composés d'arylmonobactame bicycliques et leurs méthodes d'utilisation pour le traitement des infections bactériennes
WO2017180794A1 (en) * 2016-04-13 2017-10-19 Skyline Antiinfectives, Inc. Deuterated o-sulfated beta-lactam hydroxamic acids and deuterated n-sulfated beta-lactams
CN107641119B (zh) 2016-07-21 2019-11-08 中国科学院上海药物研究所 单环β-内酰胺-铁载体轭合物及其制备方法和用途
AU2018311521B2 (en) 2017-08-02 2022-03-03 Novartis Ag Process for preparing 1 -(((Z)-(1 -(2-aminothiazol-4-yl)-2-oxo-2-(((3S,4R)-2-oxo-4-((2-oxooxazolidin-3-y l)methyl)-1 -sulfoazetidin-3- yl)amino)ethylidene)amino)oxy)cyclopropane carboxylic acid
ES2968467T3 (es) 2017-10-02 2024-05-09 Merck Sharp & Dohme Llc Compuestos monobactámicos de cromano para el tratamiento de infecciones bacterianas
US10513504B2 (en) 2018-03-08 2019-12-24 Apotex Inc. Processes for the preparation of apalutamide and intermediates thereof
WO2021098840A1 (zh) * 2019-11-22 2021-05-27 南京明德新药研发有限公司 磺酰脲环取代的单环β-内酰胺类抗生素
CR20220316A (es) 2019-12-06 2022-10-07 Vertex Pharma Tetrahidrofuranos sustituidos como moduladores de canales de sodio
CN111303144B (zh) * 2019-12-13 2020-11-27 苏州信诺维医药科技有限公司 一种治疗细菌感染的化合物
US11780832B2 (en) 2021-03-31 2023-10-10 Fedora Pharmaceuticals Inc. Lactivicin compounds, their preparation and use as antibacterial agents
WO2022235077A1 (ko) * 2021-05-07 2022-11-10 한국생명공학연구원 신규 사이드로포어 화합물 및 이를 이용한 금속 나노입자 복합체
JP2024522292A (ja) 2021-06-04 2024-06-13 バーテックス ファーマシューティカルズ インコーポレイテッド ナトリウムチャネルのモジュレーターとしてのｎ－（ヒドロキシアルキル（ヘテロ）アリール）テトラヒドロフランカルボキサミド
JP7671398B2 (ja) * 2021-11-18 2025-05-01 メルク・シャープ・アンド・ドーム・エルエルシー クロマンアミジンモノバクタム抗生物質
MX2024006075A (es) 2021-11-18 2024-05-30 Merck Sharp & Dohme Llc Antibioticos monobactamicos de cromano amidina.
CN115304594B (zh) * 2022-10-12 2023-02-14 苏州二叶制药有限公司 磺酰脲环取代的化合物的盐型及其晶型

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101410111A (zh) * 2005-12-07 2009-04-15 巴斯利尔药物股份公司 单环-内酰胺类抗生素与β-内酰胺酶抑制剂的有效的联合应用
WO2010070523A1 (en) * 2008-12-19 2010-06-24 Pfizer Inc. Monocarbams

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0246786A1 (en) * 1986-05-23 1987-11-25 The Upjohn Company N-1 subsituted sulfonylaminocarbonyl, C-4 substituted monobactams
CN102964296B (zh) 2007-03-28 2015-03-25 阿普泰克斯科技公司 去铁酮的氟化衍生物

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101410111A (zh) * 2005-12-07 2009-04-15 巴斯利尔药物股份公司 单环-内酰胺类抗生素与β-内酰胺酶抑制剂的有效的联合应用
WO2010070523A1 (en) * 2008-12-19 2010-06-24 Pfizer Inc. Monocarbams

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11230543B2 (en) 2015-12-15 2022-01-25 Merck Sharp & Dohme Corp. Biaryl monobactam compounds and methods of use thereof for the treatment of bacterial infections

Also Published As

Publication number Publication date
DK2646436T3 (en) 2015-06-29
SG190007A1 (en) 2013-06-28
JP5777725B2 (ja) 2015-09-09
HK1184462A1 (en) 2014-01-24
CN103228652A (zh) 2013-07-31
CA2815821A1 (en) 2012-06-07
US20150148326A1 (en) 2015-05-28
AR084001A1 (es) 2013-04-17
MX2013005994A (es) 2013-07-15
ZA201304479B (en) 2014-03-26
IL226052A0 (en) 2013-06-27
TW201247661A (en) 2012-12-01
UY33754A (es) 2012-06-29
ES2542431T3 (es) 2015-08-05
CA2815821C (en) 2015-07-07
AU2011336209B2 (en) 2015-03-19
US20120302542A1 (en) 2012-11-29
AU2011336209A1 (en) 2013-05-30
US20130252935A1 (en) 2013-09-26
EP2646436B1 (en) 2015-05-27
EP2646436A1 (en) 2013-10-09
KR101514587B1 (ko) 2015-04-22
WO2012073138A1 (en) 2012-06-07
JP2013544276A (ja) 2013-12-12
KR20130112054A (ko) 2013-10-11

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