KR101514587B1 - 모노박탐 - Google Patents
모노박탐 Download PDFInfo
- Publication number
- KR101514587B1 KR101514587B1 KR1020137016718A KR20137016718A KR101514587B1 KR 101514587 B1 KR101514587 B1 KR 101514587B1 KR 1020137016718 A KR1020137016718 A KR 1020137016718A KR 20137016718 A KR20137016718 A KR 20137016718A KR 101514587 B1 KR101514587 B1 KR 101514587B1
- Authority
- KR
- South Korea
- Prior art keywords
- mmol
- formula
- compound
- give
- solution
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 0 CNC1=S*C(C(C(NC(C(CO)N2)C2=O)=O)=N*)=N1 Chemical compound CNC1=S*C(C(C(NC(C(CO)N2)C2=O)=O)=N*)=N1 0.000 description 8
- NNEDRWCGFQMNLA-UHFFFAOYSA-N OCc(nc1)cc(OCc2ccccc2)c1OCc1ccccc1 Chemical compound OCc(nc1)cc(OCc2ccccc2)c1OCc1ccccc1 NNEDRWCGFQMNLA-UHFFFAOYSA-N 0.000 description 3
- WCBARZVICRSPNN-IYYRVEMSSA-N CC(/N=C\C=C(\C(O[C@H](C1)[C@@]1(C1(CC1)C1=O)N1S(O)(=O)=O)=O)/NC)OC/C(/O)=C\N Chemical compound CC(/N=C\C=C(\C(O[C@H](C1)[C@@]1(C1(CC1)C1=O)N1S(O)(=O)=O)=O)/NC)OC/C(/O)=C\N WCBARZVICRSPNN-IYYRVEMSSA-N 0.000 description 1
- GVNWTYWLEFDCCL-WLRTZDKTSA-N CC(C)(C(O)=O)/[N+](/[O-])=C(\C(N)=O)/c1c[s]c(N)n1 Chemical compound CC(C)(C(O)=O)/[N+](/[O-])=C(\C(N)=O)/c1c[s]c(N)n1 GVNWTYWLEFDCCL-WLRTZDKTSA-N 0.000 description 1
- PZYHYCIMGPLART-ACAGNQJTSA-N CC(C)(C(O)=O)O/N=C(\C(N)=O)/c1c[s]c(N)n1 Chemical compound CC(C)(C(O)=O)O/N=C(\C(N)=O)/c1c[s]c(N)n1 PZYHYCIMGPLART-ACAGNQJTSA-N 0.000 description 1
- YTXVUWJCSSPWMS-LNUHHFGISA-N CC(C)(C(O)=O)O/N=C(\C(NC([C@@H](CNC(CCC(NCC(N(C=C1O)O)=CC1=O)=O)=O)N1S(O)(=O)=O)C1=O)=O)/c1c[s]c(N)n1 Chemical compound CC(C)(C(O)=O)O/N=C(\C(NC([C@@H](CNC(CCC(NCC(N(C=C1O)O)=CC1=O)=O)=O)N1S(O)(=O)=O)C1=O)=O)/c1c[s]c(N)n1 YTXVUWJCSSPWMS-LNUHHFGISA-N 0.000 description 1
- KFWSRENEOZLXAS-VBWNREENSA-N CC(C)(C(O)=O)O/N=C(\C(N[C@@H](C(C1)([C@@H]1NC(OCc1cc(C(N(C=C2O)O)=CC2=O)n[o]1)=O)N1S(O)(=O)=O)C1=O)=O)/c1c[s]c(N)n1 Chemical compound CC(C)(C(O)=O)O/N=C(\C(N[C@@H](C(C1)([C@@H]1NC(OCc1cc(C(N(C=C2O)O)=CC2=O)n[o]1)=O)N1S(O)(=O)=O)C1=O)=O)/c1c[s]c(N)n1 KFWSRENEOZLXAS-VBWNREENSA-N 0.000 description 1
- RRXMTURADCPROV-OUXGGDMYSA-N CC(C)(C(O)=O)O/N=C(\C(N[C@@H](CC[C@H](CN1S(O)(=O)=O)OC(/C(/O)=C/C(/C(C=CC2=O)NC=C2O)=C/C)=O)C1=O)=O)/c1c[s]c(N)n1 Chemical compound CC(C)(C(O)=O)O/N=C(\C(N[C@@H](CC[C@H](CN1S(O)(=O)=O)OC(/C(/O)=C/C(/C(C=CC2=O)NC=C2O)=C/C)=O)C1=O)=O)/c1c[s]c(N)n1 RRXMTURADCPROV-OUXGGDMYSA-N 0.000 description 1
- QRUGTYQOEMOLKM-KIJUPEPGSA-N CC(C)(C)OC(C(C)(C)/[N+](/[O-])=C(\C(NC([C@@H](CNC(Nc(nc1)cc(OCc2ccccc2)c1OCc1ccccc1)=O)N1)C1=O)=O)/c1c[s]c(NC(OC(C)(C)C)=O)n1)=O Chemical compound CC(C)(C)OC(C(C)(C)/[N+](/[O-])=C(\C(NC([C@@H](CNC(Nc(nc1)cc(OCc2ccccc2)c1OCc1ccccc1)=O)N1)C1=O)=O)/c1c[s]c(NC(OC(C)(C)C)=O)n1)=O QRUGTYQOEMOLKM-KIJUPEPGSA-N 0.000 description 1
- NLSCZVFLSYWTSR-AFVZFQQJSA-N CC(C)(C)OC(C(C)(C)O/N=C(\C(N[C@@H]([C@](C1)(C1O)N1)C1=O)=O)/c1c[s]c(NC(OC(C)(C)C)=O)n1)=O Chemical compound CC(C)(C)OC(C(C)(C)O/N=C(\C(N[C@@H]([C@](C1)(C1O)N1)C1=O)=O)/c1c[s]c(NC(OC(C)(C)C)=O)n1)=O NLSCZVFLSYWTSR-AFVZFQQJSA-N 0.000 description 1
- GAMWQDHSGHRBBH-UHFFFAOYSA-N CC(C)(C)OC(Nc1nc(C(C(N)=O)=N)c[s]1)=O Chemical compound CC(C)(C)OC(Nc1nc(C(C(N)=O)=N)c[s]1)=O GAMWQDHSGHRBBH-UHFFFAOYSA-N 0.000 description 1
- IGTMHCNCSBLVQO-WYHYQAIOSA-O CC(C)(C)OC(Nc1nc(C(C(N[C@@H]([C@](C2)(C2OC(c2cc(-c(cc3OCc4ccccc4)ncc3OCc3ccccc3)n[o]2)=O)N2)C2=O)=O)=[NH2+])c[s]1)=O Chemical compound CC(C)(C)OC(Nc1nc(C(C(N[C@@H]([C@](C2)(C2OC(c2cc(-c(cc3OCc4ccccc4)ncc3OCc3ccccc3)n[o]2)=O)N2)C2=O)=O)=[NH2+])c[s]1)=O IGTMHCNCSBLVQO-WYHYQAIOSA-O 0.000 description 1
- YLLIIHCYNUXOAZ-QKKYUHAQSA-O COC(/C(/[OH2+])=C/C(C(NC1)=CC(OCc2ccccc2)=C1OCc1ccccc1)=N)=O Chemical compound COC(/C(/[OH2+])=C/C(C(NC1)=CC(OCc2ccccc2)=C1OCc1ccccc1)=N)=O YLLIIHCYNUXOAZ-QKKYUHAQSA-O 0.000 description 1
- AVWHEOJWRLLKOZ-UHFFFAOYSA-N COCc(nc1)cc(OCc2ccccc2)c1OCc1ccccc1 Chemical compound COCc(nc1)cc(OCc2ccccc2)c1OCc1ccccc1 AVWHEOJWRLLKOZ-UHFFFAOYSA-N 0.000 description 1
- RPULUIMPNYEOFI-UHFFFAOYSA-O NC(C(c1c[s]c(N)n1)=[NH2+])=O Chemical compound NC(C(c1c[s]c(N)n1)=[NH2+])=O RPULUIMPNYEOFI-UHFFFAOYSA-O 0.000 description 1
- ANYPRQGZEVNTPA-UHFFFAOYSA-N NCc([n+](O)c1)cc(OCc2ccccc2)c1OCc1ccccc1 Chemical compound NCc([n+](O)c1)cc(OCc2ccccc2)c1OCc1ccccc1 ANYPRQGZEVNTPA-UHFFFAOYSA-N 0.000 description 1
- BKPWVBVFGRYCBH-FMDKYWOUSA-N Nc1nc(/C(/C(N[C@@H]([C@@H](CNC(NCC(N(C=C2O)O)=CC2=O)=O)N2S(O)(=O)=O)C2=O)=O)=N/OC2(CCCC2)C(O)=O)c[s]1 Chemical compound Nc1nc(/C(/C(N[C@@H]([C@@H](CNC(NCC(N(C=C2O)O)=CC2=O)=O)N2S(O)(=O)=O)C2=O)=O)=N/OC2(CCCC2)C(O)=O)c[s]1 BKPWVBVFGRYCBH-FMDKYWOUSA-N 0.000 description 1
- NYIVUQGAZANBQW-WSDLNYQXSA-N O/N=C/c(nc1)cc(OCc2ccccc2)c1OCc1ccccc1 Chemical compound O/N=C/c(nc1)cc(OCc2ccccc2)c1OCc1ccccc1 NYIVUQGAZANBQW-WSDLNYQXSA-N 0.000 description 1
- GYZWHOMEDJANIF-UHFFFAOYSA-N O=C(c1ccccc11)N(Cc(nc2)cc(OCc3ccccc3)c2OCc2ccccc2)C1=O Chemical compound O=C(c1ccccc11)N(Cc(nc2)cc(OCc3ccccc3)c2OCc2ccccc2)C1=O GYZWHOMEDJANIF-UHFFFAOYSA-N 0.000 description 1
- QNRQPVLVOPFUBM-UHFFFAOYSA-N OC(c1cc(-c(nc2)cc(OCc3ccccc3)c2OCc2ccccc2)n[o]1)=O Chemical compound OC(c1cc(-c(nc2)cc(OCc3ccccc3)c2OCc2ccccc2)n[o]1)=O QNRQPVLVOPFUBM-UHFFFAOYSA-N 0.000 description 1
- NYSLBXVXZBJIJZ-QHQKPKPBSA-N OC1C#CNC(c2nc(C(NC(C3)[C@@]3(C34CC3)NC4=O)=O)c[o]2)=CC1=O Chemical compound OC1C#CNC(c2nc(C(NC(C3)[C@@]3(C34CC3)NC4=O)=O)c[o]2)=CC1=O NYSLBXVXZBJIJZ-QHQKPKPBSA-N 0.000 description 1
- LYAXUHHZQVCCKI-UHFFFAOYSA-N [O-][n+](c(CN(C(c1ccccc11)=O)C1=O)c1)cc(OCc2ccccc2)c1OCc1ccccc1 Chemical compound [O-][n+](c(CN(C(c1ccccc11)=O)C1=O)c1)cc(OCc2ccccc2)c1OCc1ccccc1 LYAXUHHZQVCCKI-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
- C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Oncology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Communicable Diseases (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US41757510P | 2010-11-29 | 2010-11-29 | |
| US61/417,575 | 2010-11-29 | ||
| PCT/IB2011/055104 WO2012073138A1 (en) | 2010-11-29 | 2011-11-15 | Monobactams |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| KR20130112054A KR20130112054A (ko) | 2013-10-11 |
| KR101514587B1 true KR101514587B1 (ko) | 2015-04-22 |
Family
ID=45315854
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020137016718A Expired - Fee Related KR101514587B1 (ko) | 2010-11-29 | 2011-11-15 | 모노박탐 |
Country Status (17)
| Country | Link |
|---|---|
| US (3) | US20120302542A1 (enExample) |
| EP (1) | EP2646436B1 (enExample) |
| JP (1) | JP5777725B2 (enExample) |
| KR (1) | KR101514587B1 (enExample) |
| CN (1) | CN103228652B (enExample) |
| AR (1) | AR084001A1 (enExample) |
| AU (1) | AU2011336209B2 (enExample) |
| CA (1) | CA2815821C (enExample) |
| DK (1) | DK2646436T3 (enExample) |
| ES (1) | ES2542431T3 (enExample) |
| IL (1) | IL226052A0 (enExample) |
| MX (1) | MX2013005994A (enExample) |
| SG (1) | SG190007A1 (enExample) |
| TW (1) | TW201247661A (enExample) |
| UY (1) | UY33754A (enExample) |
| WO (1) | WO2012073138A1 (enExample) |
| ZA (1) | ZA201304479B (enExample) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2015099107A1 (ja) | 2013-12-26 | 2015-07-02 | 塩野義製薬株式会社 | 含窒素６員環誘導体およびそれらを含有する医薬組成物 |
| SI3122745T1 (sl) | 2014-03-24 | 2019-05-31 | Novartis Ag | Organske spojine monobaktama za zdravljenje bakterijskih infekcij |
| HRP20201423T1 (hr) * | 2015-09-23 | 2020-12-11 | Novartis Ag | Soli i čvrsti oblici antibiotika monobaktam |
| CN105481812B (zh) * | 2015-11-30 | 2020-04-21 | 重庆天奕恒化科技有限公司 | 一种5-苄氧基-4-氧代-4h-吡喃-2-羧酸的制备方法 |
| EP3390357B1 (en) * | 2015-12-15 | 2021-11-10 | Merck Sharp & Dohme Corp. | Biaryl monobactam compounds for the treatment of bacterial infections |
| MA43811A (fr) | 2016-03-07 | 2018-11-28 | Merck Sharp & Dohme | Composés d'arylmonobactame bicycliques et leurs méthodes d'utilisation pour le traitement des infections bactériennes |
| WO2017180794A1 (en) * | 2016-04-13 | 2017-10-19 | Skyline Antiinfectives, Inc. | Deuterated o-sulfated beta-lactam hydroxamic acids and deuterated n-sulfated beta-lactams |
| CN107641119B (zh) | 2016-07-21 | 2019-11-08 | 中国科学院上海药物研究所 | 单环β-内酰胺-铁载体轭合物及其制备方法和用途 |
| AU2018311521B2 (en) | 2017-08-02 | 2022-03-03 | Novartis Ag | Process for preparing 1 -(((Z)-(1 -(2-aminothiazol-4-yl)-2-oxo-2-(((3S,4R)-2-oxo-4-((2-oxooxazolidin-3-y l)methyl)-1 -sulfoazetidin-3- yl)amino)ethylidene)amino)oxy)cyclopropane carboxylic acid |
| ES2968467T3 (es) | 2017-10-02 | 2024-05-09 | Merck Sharp & Dohme Llc | Compuestos monobactámicos de cromano para el tratamiento de infecciones bacterianas |
| US10513504B2 (en) | 2018-03-08 | 2019-12-24 | Apotex Inc. | Processes for the preparation of apalutamide and intermediates thereof |
| WO2021098840A1 (zh) * | 2019-11-22 | 2021-05-27 | 南京明德新药研发有限公司 | 磺酰脲环取代的单环β-内酰胺类抗生素 |
| CR20220316A (es) | 2019-12-06 | 2022-10-07 | Vertex Pharma | Tetrahidrofuranos sustituidos como moduladores de canales de sodio |
| CN111303144B (zh) * | 2019-12-13 | 2020-11-27 | 苏州信诺维医药科技有限公司 | 一种治疗细菌感染的化合物 |
| US11780832B2 (en) | 2021-03-31 | 2023-10-10 | Fedora Pharmaceuticals Inc. | Lactivicin compounds, their preparation and use as antibacterial agents |
| WO2022235077A1 (ko) * | 2021-05-07 | 2022-11-10 | 한국생명공학연구원 | 신규 사이드로포어 화합물 및 이를 이용한 금속 나노입자 복합체 |
| JP2024522292A (ja) | 2021-06-04 | 2024-06-13 | バーテックス ファーマシューティカルズ インコーポレイテッド | ナトリウムチャネルのモジュレーターとしてのｎ－（ヒドロキシアルキル（ヘテロ）アリール）テトラヒドロフランカルボキサミド |
| JP7671398B2 (ja) * | 2021-11-18 | 2025-05-01 | メルク・シャープ・アンド・ドーム・エルエルシー | クロマンアミジンモノバクタム抗生物質 |
| MX2024006075A (es) | 2021-11-18 | 2024-05-30 | Merck Sharp & Dohme Llc | Antibioticos monobactamicos de cromano amidina. |
| CN115304594B (zh) * | 2022-10-12 | 2023-02-14 | 苏州二叶制药有限公司 | 磺酰脲环取代的化合物的盐型及其晶型 |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2010070523A1 (en) | 2008-12-19 | 2010-06-24 | Pfizer Inc. | Monocarbams |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0246786A1 (en) * | 1986-05-23 | 1987-11-25 | The Upjohn Company | N-1 subsituted sulfonylaminocarbonyl, C-4 substituted monobactams |
| EP2484680B1 (en) * | 2005-12-07 | 2013-06-26 | Basilea Pharmaceutica AG | Useful Combinations of Monobactam Antibiotics with beta-Lac-tamase Inhibitors |
| CN102964296B (zh) | 2007-03-28 | 2015-03-25 | 阿普泰克斯科技公司 | 去铁酮的氟化衍生物 |
-
2011
- 2011-11-15 CA CA2815821A patent/CA2815821C/en not_active Expired - Fee Related
- 2011-11-15 KR KR1020137016718A patent/KR101514587B1/ko not_active Expired - Fee Related
- 2011-11-15 JP JP2013541445A patent/JP5777725B2/ja not_active Expired - Fee Related
- 2011-11-15 ES ES11794237.5T patent/ES2542431T3/es active Active
- 2011-11-15 CN CN201180057264.5A patent/CN103228652B/zh not_active Expired - Fee Related
- 2011-11-15 EP EP11794237.5A patent/EP2646436B1/en not_active Not-in-force
- 2011-11-15 SG SG2013031752A patent/SG190007A1/en unknown
- 2011-11-15 WO PCT/IB2011/055104 patent/WO2012073138A1/en not_active Ceased
- 2011-11-15 DK DK11794237.5T patent/DK2646436T3/en active
- 2011-11-15 AU AU2011336209A patent/AU2011336209B2/en not_active Ceased
- 2011-11-15 MX MX2013005994A patent/MX2013005994A/es active IP Right Grant
- 2011-11-24 TW TW100143172A patent/TW201247661A/zh unknown
- 2011-11-25 AR ARP110104404A patent/AR084001A1/es not_active Application Discontinuation
- 2011-11-28 UY UY0001033754A patent/UY33754A/es not_active Application Discontinuation
- 2011-11-29 US US13/306,581 patent/US20120302542A1/en not_active Abandoned
-
2013
- 2013-02-27 US US13/778,670 patent/US20130252935A1/en not_active Abandoned
- 2013-04-29 IL IL226052A patent/IL226052A0/en unknown
- 2013-06-18 ZA ZA2013/04479A patent/ZA201304479B/en unknown
-
2015
- 2015-01-29 US US14/608,826 patent/US20150148326A1/en not_active Abandoned
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2010070523A1 (en) | 2008-12-19 | 2010-06-24 | Pfizer Inc. | Monocarbams |
Also Published As
| Publication number | Publication date |
|---|---|
| DK2646436T3 (en) | 2015-06-29 |
| CN103228652B (zh) | 2015-02-18 |
| SG190007A1 (en) | 2013-06-28 |
| JP5777725B2 (ja) | 2015-09-09 |
| HK1184462A1 (en) | 2014-01-24 |
| CN103228652A (zh) | 2013-07-31 |
| CA2815821A1 (en) | 2012-06-07 |
| US20150148326A1 (en) | 2015-05-28 |
| AR084001A1 (es) | 2013-04-17 |
| MX2013005994A (es) | 2013-07-15 |
| ZA201304479B (en) | 2014-03-26 |
| IL226052A0 (en) | 2013-06-27 |
| TW201247661A (en) | 2012-12-01 |
| UY33754A (es) | 2012-06-29 |
| ES2542431T3 (es) | 2015-08-05 |
| CA2815821C (en) | 2015-07-07 |
| AU2011336209B2 (en) | 2015-03-19 |
| US20120302542A1 (en) | 2012-11-29 |
| AU2011336209A1 (en) | 2013-05-30 |
| US20130252935A1 (en) | 2013-09-26 |
| EP2646436B1 (en) | 2015-05-27 |
| EP2646436A1 (en) | 2013-10-09 |
| WO2012073138A1 (en) | 2012-06-07 |
| JP2013544276A (ja) | 2013-12-12 |
| KR20130112054A (ko) | 2013-10-11 |
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