CN103159692B - 四唑取代的芳基酰胺类 - Google Patents
四唑取代的芳基酰胺类 Download PDFInfo
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- CN103159692B CN103159692B CN201310005567.3A CN201310005567A CN103159692B CN 103159692 B CN103159692 B CN 103159692B CN 201310005567 A CN201310005567 A CN 201310005567A CN 103159692 B CN103159692 B CN 103159692B
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- Prior art keywords
- alkyl
- methyl
- ylmethyl
- propyl
- pyridin
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- 0 *C(*)(*)NC(c1cc(*)c(*)c(*)c1)=O Chemical compound *C(*)(*)NC(c1cc(*)c(*)c(*)c1)=O 0.000 description 5
- PDYJNMWBCLFQOE-SNAWJCMRSA-N C/C=C(\C=C)/[N+]([O-])=O Chemical compound C/C=C(\C=C)/[N+]([O-])=O PDYJNMWBCLFQOE-SNAWJCMRSA-N 0.000 description 1
- KSHZAKDFKZEZJQ-UHFFFAOYSA-N CC1(C)OB(c2cc(C(OC)=O)cc([N+]([O-])=O)c2)OC1(C)C Chemical compound CC1(C)OB(c2cc(C(OC)=O)cc([N+]([O-])=O)c2)OC1(C)C KSHZAKDFKZEZJQ-UHFFFAOYSA-N 0.000 description 1
- VJGUTRISZISMOA-UHFFFAOYSA-N CCC/[O]=C(/C(C1)=CC([N+]([O-])=O)=CC1I)\O Chemical compound CCC/[O]=C(/C(C1)=CC([N+]([O-])=O)=CC1I)\O VJGUTRISZISMOA-UHFFFAOYSA-N 0.000 description 1
- GHZUTMKPZFZYSP-UHFFFAOYSA-N COC(c1cc([N+]([O-])=O)cc(I)c1)=O Chemical compound COC(c1cc([N+]([O-])=O)cc(I)c1)=O GHZUTMKPZFZYSP-UHFFFAOYSA-N 0.000 description 1
- YWTUCRBEYQHQGN-UHFFFAOYSA-N Cc1ccc(-c2cc(C(OC)=O)cc(N)c2)nc1 Chemical compound Cc1ccc(-c2cc(C(OC)=O)cc(N)c2)nc1 YWTUCRBEYQHQGN-UHFFFAOYSA-N 0.000 description 1
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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| EP2234989B1 (en) * | 2007-12-17 | 2014-08-13 | F. Hoffmann-La Roche AG | Tetrazole-substituted arylamide derivatives and their use as p2x3 and/or p2x2/3 purinergic receptor antagonists |
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| AU2010229144B2 (en) | 2009-03-23 | 2012-07-12 | Merck Sharp & Dohme Corp. | P2X3, receptor antagonists for treatment of pain |
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| EP2445889B1 (en) * | 2009-06-22 | 2016-08-10 | F.Hoffmann-La Roche Ag | Novel benzoxazolone -substituted arylamides |
| CN102574778B (zh) * | 2009-06-22 | 2015-01-07 | 弗·哈夫曼-拉罗切有限公司 | 新的联苯基和苯基-吡啶酰胺类化合物 |
| AU2011261375B2 (en) * | 2010-06-04 | 2016-09-22 | Albany Molecular Research, Inc. | Glycine transporter-1 inhibitors, methods of making them, and uses thereof |
| US9598409B2 (en) * | 2013-01-31 | 2017-03-21 | Neomed Institute | Imidazopyridine compounds and uses thereof |
| HUE058009T2 (hu) | 2014-12-09 | 2022-06-28 | Bayer Ag | 1,3-Tiazol-2-il szubsztituált benzamid-származékok |
| US10183937B2 (en) | 2014-12-09 | 2019-01-22 | Bayer Aktiengesellschaft | 1,3-thiazol-2-yl substituted benzamides |
| CN107207449B (zh) * | 2015-04-23 | 2020-11-10 | 豪夫迈·罗氏有限公司 | 用于治疗精神障碍的四唑衍生物 |
| JP6877359B2 (ja) * | 2015-06-04 | 2021-05-26 | エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft | イミダゾール誘導体 |
| CN108137566B (zh) * | 2015-10-06 | 2021-05-25 | 豪夫迈·罗氏有限公司 | 三唑衍生物 |
| EP3411365B1 (en) | 2016-02-02 | 2019-11-20 | H. Hoffnabb-La Roche Ag | Pyrazol-pyridine derivatives as eaat3 inhibitors |
| TWI696615B (zh) * | 2016-05-05 | 2020-06-21 | 瑞士商伊蘭科動物健康公司 | 雜芳基-1,2,4-三唑及雜芳基-三唑化合物 |
| EP3464246B1 (en) | 2016-05-27 | 2020-07-08 | H. Hoffnabb-La Roche Ag | Pyrazol compounds as eaat3 inhibitors |
| CN109563049B (zh) | 2016-10-14 | 2022-11-29 | 豪夫迈·罗氏有限公司 | 作为eaat3抑制剂的咪唑化合物 |
| TWI741040B (zh) * | 2016-10-20 | 2021-10-01 | 德商拜耳作物科學公司 | 製備3-烷基硫基-2-氯-n-(1-烷基-1h-四唑-5-基)-4-三氟甲基苯甲醯胺之方法 |
| RU2650780C1 (ru) | 2016-12-06 | 2018-04-17 | Общество с ограниченной ответственностью "Анальгетики будущего" | Пептидный модулятор пуринергических рецепторов |
| CN114222741B (zh) | 2019-05-31 | 2025-12-30 | 奇斯药制品公司 | 作为p2x3抑制剂的吡啶并嘧啶类衍生物 |
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| AU2021388923A1 (en) | 2020-11-27 | 2023-05-25 | Chiesi Farmaceutici S.P.A. | Amino quinazoline derivatives as p2x3 inhibitors |
| KR20230113289A (ko) | 2020-11-27 | 2023-07-28 | 키에시 파르마슈티시 엣스. 피. 에이. | P2x3 억제제로서 프탈라진 유도체 |
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