MX2008016423A - Arilamidas sustituidas con tetrazol. - Google Patents
Arilamidas sustituidas con tetrazol.Info
- Publication number
- MX2008016423A MX2008016423A MX2008016423A MX2008016423A MX2008016423A MX 2008016423 A MX2008016423 A MX 2008016423A MX 2008016423 A MX2008016423 A MX 2008016423A MX 2008016423 A MX2008016423 A MX 2008016423A MX 2008016423 A MX2008016423 A MX 2008016423A
- Authority
- MX
- Mexico
- Prior art keywords
- sub
- optionally substituted
- compounds
- tetrazole
- methods
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 abstract 3
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 230000001404 mediated effect Effects 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 125000004076 pyridyl group Chemical group 0.000 abstract 1
- 239000002464 receptor antagonist Substances 0.000 abstract 1
- 229940044551 receptor antagonist Drugs 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000003831 tetrazolyl group Chemical group 0.000 abstract 1
- 125000001544 thienyl group Chemical group 0.000 abstract 1
Classifications
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4965—Non-condensed pyrazines
- A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
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- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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- Pain & Pain Management (AREA)
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- Endocrinology (AREA)
- Reproductive Health (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
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Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US81729806P | 2006-06-29 | 2006-06-29 | |
| PCT/EP2007/055997 WO2008000645A1 (en) | 2006-06-29 | 2007-06-18 | Tetrazole-substituted arylamides |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2008016423A true MX2008016423A (es) | 2009-01-22 |
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Family Applications (1)
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| MX2008016423A MX2008016423A (es) | 2006-06-29 | 2007-06-18 | Arilamidas sustituidas con tetrazol. |
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| EP (2) | EP2038264B1 (https=) |
| JP (2) | JP5021734B2 (https=) |
| KR (1) | KR101103143B1 (https=) |
| CN (2) | CN101479250B (https=) |
| AR (1) | AR061667A1 (https=) |
| AU (1) | AU2007263809B2 (https=) |
| BR (2) | BRPI0714315B8 (https=) |
| CA (1) | CA2654915C (https=) |
| CL (1) | CL2007001887A1 (https=) |
| ES (2) | ES2596706T3 (https=) |
| IL (2) | IL195786A (https=) |
| MX (1) | MX2008016423A (https=) |
| TW (1) | TWI334414B (https=) |
| WO (1) | WO2008000645A1 (https=) |
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| CN101528717B (zh) * | 2006-11-09 | 2013-04-24 | 弗·哈夫曼-拉罗切有限公司 | 噻唑和*唑-取代的芳基酰胺类化合物 |
| US8501933B2 (en) | 2006-11-09 | 2013-08-06 | Roche Palo Alto Llc | Thiazole and oxazole-substituted arylamides as P2X3 and P2X2/3 antagonists |
| MX2010003156A (es) * | 2007-10-04 | 2010-04-01 | Hoffmann La Roche | Derivados de aril amida substituida con tetrazol y usos de los mismos. |
| CA2703915C (en) * | 2007-10-31 | 2015-02-24 | Merck Sharp & Dohme Corp. | P2x3 receptor antagonists for treatment of pain |
| JP2011502148A (ja) * | 2007-10-31 | 2011-01-20 | メルク・シャープ・エンド・ドーム・コーポレイション | 疼痛の治療用としてのp2x3受容体アンタゴニスト |
| CA2708791C (en) * | 2007-12-17 | 2016-06-21 | F. Hoffmann-La Roche Ag | Imidazole-substituted arylamides and uses thereof as p2x receptor antagonists |
| WO2009077371A1 (en) * | 2007-12-17 | 2009-06-25 | F. Hoffmann-La Roche Ag | Tetrazole-substituted arylamide derivatives and their use as p2x3 and/or p2x2/3 purinergic receptor antagonists |
| AU2013273626B2 (en) * | 2007-12-17 | 2016-04-28 | F.Hoffmann-La Roche Ag | Triazole-substituted arylamide derivatives and their use as P2X3 and /or P2X2/3 purinergic receptor antagonists |
| ES2541662T3 (es) | 2007-12-17 | 2015-07-23 | F. Hoffmann-La Roche Ag | Derivados arilamida sustituidos con triazol y utilización de los mismos como antagonistas de receptores purinérgicos P2X3 y/o P2X2/3 |
| DK2234976T3 (da) | 2007-12-17 | 2013-06-24 | Hoffmann La Roche | Nye pyrazol-substituerede arylamider |
| CA2715835C (en) | 2008-02-29 | 2017-03-21 | Renovis, Inc. | Amide compounds, compositions and uses thereof |
| JP5608655B2 (ja) * | 2008-09-18 | 2014-10-15 | エヴォテック アーゲー | P2x3受容体活性のモジュレーター |
| MX2011004570A (es) | 2008-10-31 | 2011-06-17 | Merck Sharp & Dohme | Antagonistas del receptor p2x3 para el tratamiento del dolor. |
| WO2010069794A1 (en) * | 2008-12-16 | 2010-06-24 | F. Hoffmann-La Roche Ag | Thiadiazole-substituted arylamides |
| US8569512B2 (en) | 2009-03-23 | 2013-10-29 | Merck Sharp & Dohme Corp. | P2X3 receptor antagonists for treatment of pain |
| WO2010111059A1 (en) | 2009-03-23 | 2010-09-30 | Merck Sharp & Dohme Corp. | P2x3 receptor antagonists for treatment of pain |
| AU2010229142A1 (en) | 2009-03-23 | 2011-10-13 | Merck Sharp & Dohme Corp. | P2X3, receptor antagonists for treatment of pain |
| EP2246259B1 (en) | 2009-04-29 | 2012-12-12 | Eurocopter Deutschland GmbH | Rotor wing with integrated tension-torque-transmission element and method for its production |
| CN105254557A (zh) * | 2009-05-29 | 2016-01-20 | 拉夸里亚创药株式会社 | 作为钙或钠通道阻滞剂的芳基取代羧酰胺衍生物 |
| TW201103904A (en) * | 2009-06-11 | 2011-02-01 | Hoffmann La Roche | Janus kinase inhibitor compounds and methods |
| SG177308A1 (en) | 2009-06-22 | 2012-02-28 | Hoffmann La Roche | Novel biphenyl and phenyl-pyridine amides |
| CN102438989B (zh) | 2009-06-22 | 2015-05-27 | 霍夫曼-拉罗奇有限公司 | 噁唑酮和吡咯烷酮取代的芳基酰胺 |
| US8476457B2 (en) | 2009-06-22 | 2013-07-02 | Roche Palo Alto Llc | Indole, indazole and benzimidazole arylamides as P2X3 and P2X2/3 antagonists |
| WO2011153359A1 (en) * | 2010-06-04 | 2011-12-08 | Albany Molecular Research, Inc. | Glycine transporter-1 inhibitors, methods of making them, and uses thereof |
| DK3381917T3 (da) * | 2013-01-31 | 2021-10-18 | Bellus Health Cough Inc | Imidazopyridinforbindelser og anvendelser deraf |
| EP3230281B1 (en) | 2014-12-09 | 2021-05-26 | Bayer Aktiengesellschaft | 1,3-thiazol-2-yl substituted benzamides |
| US10183937B2 (en) | 2014-12-09 | 2019-01-22 | Bayer Aktiengesellschaft | 1,3-thiazol-2-yl substituted benzamides |
| WO2016169902A1 (en) * | 2015-04-23 | 2016-10-27 | F. Hoffmann-La Roche Ag | Tetrazole derivatives for use in the treatment of psychiatric disorders |
| EP3303299B1 (en) * | 2015-06-04 | 2019-04-24 | H. Hoffnabb-La Roche Ag | Imidazole derivatives |
| WO2017060202A1 (en) * | 2015-10-06 | 2017-04-13 | F. Hoffmann-La Roche Ag | Triazole derivatives |
| CN108473462B (zh) | 2016-02-02 | 2021-06-22 | 豪夫迈·罗氏有限公司 | 作为eaat3抑制剂的吡唑-吡啶衍生物 |
| AR108222A1 (es) * | 2016-05-05 | 2018-08-01 | Elanco Tiergesundheit Ag | Compuestos heteroaril-1,2,4-triazol y heteroaril-tetrazol |
| WO2017202896A1 (en) | 2016-05-27 | 2017-11-30 | F. Hoffmann-La Roche Ag | Pyrazol compounds as eaat3 inhibitors |
| JP7068277B2 (ja) | 2016-10-14 | 2022-05-16 | エフ.ホフマン-ラ ロシュ アーゲー | Eaat3阻害剤としてのイミダゾール化合物 |
| TWI741040B (zh) * | 2016-10-20 | 2021-10-01 | 德商拜耳作物科學公司 | 製備3-烷基硫基-2-氯-n-(1-烷基-1h-四唑-5-基)-4-三氟甲基苯甲醯胺之方法 |
| RU2650780C1 (ru) | 2016-12-06 | 2018-04-17 | Общество с ограниченной ответственностью "Анальгетики будущего" | Пептидный модулятор пуринергических рецепторов |
| JP7797204B2 (ja) | 2019-05-31 | 2026-01-13 | キエシ・フアルマチエウテイチ・ソチエタ・ペル・アチオニ | P2x3阻害剤としてのピリドピリミジン誘導体 |
| CA3139018A1 (en) | 2019-05-31 | 2020-12-03 | Chiesi Farmaceutici S.P.A. | Amino quinazoline derivatives as p2x3 inhibitors |
| WO2022112490A1 (en) | 2020-11-27 | 2022-06-02 | Chiesi Farmaceutici S.P.A. | Amino quinazoline derivatives as p2x3 inhibitors |
| CA3196335A1 (en) | 2020-11-27 | 2022-06-02 | Chiesi Farmaceutici S.P.A. | Phthalazine derivatives as p2x3 inhibitors |
| JP2023550830A (ja) | 2020-11-27 | 2023-12-05 | キエシ・フアルマチエウテイチ・ソチエタ・ペル・アチオニ | P2x3阻害剤としての(アザ)キノリン4-アミン誘導体 |
| PY2405420A (es) * | 2023-01-30 | 2024-11-14 | Eurofarma Laboratorios S A | Amidas bloqueadoras de nav 1.7 y/o nav 1.8, sus procesos de obtención, composiciones, usos, métodos de tratamiento de los mismos y kits |
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| IL109570A0 (en) * | 1993-05-17 | 1994-08-26 | Fujisawa Pharmaceutical Co | Guanidine derivatives, pharmaceutical compositions containing the same and processes for the preparation thereof |
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| JP2000281664A (ja) * | 1999-03-30 | 2000-10-10 | Otsuka Pharmaceut Co Ltd | チアゾール誘導体 |
| EP1194421B1 (en) | 1999-06-30 | 2005-10-12 | H. Lundbeck A/S | Selective npy (y5) antagonists |
| WO2002000647A1 (en) | 2000-06-23 | 2002-01-03 | Bristol-Myers Squibb Pharma Company | Heteroaryl-phenyl substituted factor xa inhibitors |
| DE10055713A1 (de) | 2000-11-10 | 2002-05-23 | Dingwei Tim Yu | Neue Klasse von Antifungimitteln |
| PA8557501A1 (es) * | 2001-11-12 | 2003-06-30 | Pfizer Prod Inc | Benzamida, heteroarilamida y amidas inversas |
| AR037460A1 (es) * | 2001-11-30 | 2004-11-10 | Smithkline Beecham Plc | Compuesto de hidroxietileno, composicion farmaceutica que lo comprende, uso del mismo para la fabricacion de un medicamento y procedimiento para su preparacion |
| WO2003063787A2 (en) * | 2002-01-30 | 2003-08-07 | Entremed, Inc. | Non-steroidal analogs of 2-methoxyestradiol |
| US20050154202A1 (en) * | 2002-04-05 | 2005-07-14 | Hagmann William K. | Substituted aryl amides |
| US7078423B2 (en) * | 2002-07-18 | 2006-07-18 | Inotek Pharmaceuticals Corporation | 5-Aryltetrazole compounds, compositions thereof, and uses therefor |
| JP2005533852A (ja) | 2002-07-18 | 2005-11-10 | セレテック エルエルシー | Edg−1受容体に関連した症状の治療方法 |
| DE10312963A1 (de) * | 2003-03-24 | 2004-10-07 | Aventis Pharma Deutschland Gmbh | Substituierte 4-Phenyltetrahydroisochinoline, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament, sowie sie enthaltendes Medikament |
| CA2522476A1 (en) | 2003-04-18 | 2004-11-04 | Merck & Co., Inc. | Biaryl substituted thiazoles, oxazoles and imidazoles as sodium channel blockers |
| WO2006002474A1 (en) * | 2004-07-02 | 2006-01-12 | The Walter And Eliza Hall Institute Of Medical Research | Alpha-helical mimetics |
| MX2008002014A (es) * | 2005-08-15 | 2008-03-27 | Hoffmann La Roche | Derivados de piperidina y piperazina como antagonistas de p2x3. |
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