CN1030915C - 苯并咪唑衍生物的制备方法 - Google Patents

苯并咪唑衍生物的制备方法 Download PDF

Info

Publication number
CN1030915C
CN1030915C CN91105154A CN91105154A CN1030915C CN 1030915 C CN1030915 C CN 1030915C CN 91105154 A CN91105154 A CN 91105154A CN 91105154 A CN91105154 A CN 91105154A CN 1030915 C CN1030915 C CN 1030915C
Authority
CN
China
Prior art keywords
butyl
ethoxyethyl
benzimidazole
compound
methyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CN91105154A
Other languages
English (en)
Chinese (zh)
Other versions
CN1058404A (zh
Inventor
马里阿·罗萨·库伯利思-阿提森特
约迪·福力高拉-空思坦萨
居安·帕里思-考柔米南
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Esteve Pharmaceuticals SA
Original Assignee
Laboratorios del Dr Esteve SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Laboratorios del Dr Esteve SA filed Critical Laboratorios del Dr Esteve SA
Publication of CN1058404A publication Critical patent/CN1058404A/zh
Application granted granted Critical
Publication of CN1030915C publication Critical patent/CN1030915C/zh
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
CN91105154A 1990-07-26 1991-07-26 苯并咪唑衍生物的制备方法 Expired - Fee Related CN1030915C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9009563 1990-07-26
FR9009563A FR2665161B1 (fr) 1990-07-26 1990-07-26 Nouveaux derives de benzimidazole, leur preparation et leur application en tant que medicaments.

Publications (2)

Publication Number Publication Date
CN1058404A CN1058404A (zh) 1992-02-05
CN1030915C true CN1030915C (zh) 1996-02-07

Family

ID=9399131

Family Applications (1)

Application Number Title Priority Date Filing Date
CN91105154A Expired - Fee Related CN1030915C (zh) 1990-07-26 1991-07-26 苯并咪唑衍生物的制备方法

Country Status (25)

Country Link
US (1) US5182280A (https=)
EP (1) EP0468884B1 (https=)
JP (1) JPH0832703B2 (https=)
KR (1) KR0183028B1 (https=)
CN (1) CN1030915C (https=)
AT (1) ATE131822T1 (https=)
AU (1) AU638857B2 (https=)
CA (1) CA2047880A1 (https=)
CZ (1) CZ280185B6 (https=)
DE (1) DE69115588T2 (https=)
DK (1) DK0468884T5 (https=)
ES (1) ES2038074B1 (https=)
FR (1) FR2665161B1 (https=)
GR (1) GR3019352T3 (https=)
HU (2) HU215109B (https=)
MX (1) MX9100377A (https=)
NO (1) NO178576C (https=)
NZ (1) NZ239104A (https=)
PL (1) PL167222B1 (https=)
PT (1) PT98409B (https=)
RO (1) RO109736B1 (https=)
RU (1) RU2024519C1 (https=)
TW (1) TW314518B (https=)
YU (1) YU48077B (https=)
ZA (1) ZA915839B (https=)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2674856B1 (fr) * 1991-04-05 1993-07-30 Esteve Labor Dr Nouveaux antihistaminiques non sedatifs, derives de benzimidazole, leur procede de preparation et leur utilisation en tant que medicaments.
FR2701260B1 (fr) * 1993-02-05 1995-05-05 Esteve Labor Dr Dérivés de 2-[4-(4-azolylbutyl)-1-pipérazinyl]-5-hydroxypyrimidine, leur préparation et leur application en tant que médicaments.
US5681954A (en) * 1993-05-14 1997-10-28 Daiichi Pharmaceutical Co., Ltd. Piperazine derivatives
JP3338913B2 (ja) * 1993-06-29 2002-10-28 大鵬薬品工業株式会社 テトラゾール誘導体
NZ270985A (en) 1994-04-29 1997-06-24 Lilly Co Eli Substituted benzimidazole derivatives; medicaments and preparation of medicaments
FR2727865B1 (fr) * 1994-12-08 1997-07-18 Esteve Labor Dr Utilisation des derives de 2-(4-(azolybutyl)-piperazinyl- (methyl))-benzimidazole et analogues ainsi que de leurs sels, pour la preparation de medicaments destines au traitement ou a la prophylaxie de l'asthme
FR2731618B1 (fr) * 1995-03-14 1997-08-01 Esteve Labor Dr Composition ophtalmique topique comprenant un derive de 2-(4-(azolylbutyl)-piperazinyl-methyl)-benzimidazole, notamment pour le traitement de la conjonctivite allergique
FR2763950B1 (fr) * 1997-06-02 2002-09-20 Esteve Labor Dr 2- {4- [4-(4,5-dichloro-2-methylimidazol-1-yl)butyl] -1- piperazinyl }-5-fluoropyrimidine, sa preparation et son utilisation therapeutique
CA2362778A1 (en) * 1999-03-03 2000-09-08 Merck & Co., Inc. Inhibitors of prenyl-protein transferase
US7022728B2 (en) 2001-03-09 2006-04-04 Abbott Laboratories Benzimidazoles that are useful in treating male sexual dysfunction
US20020169166A1 (en) * 2001-03-09 2002-11-14 Cowart Marlon D. Benzimidazoles that are useful in treating sexual dysfunction
US6960589B2 (en) 2001-03-09 2005-11-01 Abbott Laboratories Benzimidazoles that are useful in treating sexual dysfunction
WO2003101994A1 (en) * 2002-05-29 2003-12-11 Abbott Laboratories Fused bicyclic aromatic compounds that are useful in treating sexual dysfunction
US7057042B2 (en) 2002-05-29 2006-06-06 Abbott Laboratories Fused bicyclic aromatic compounds that are useful in treating sexual dysfunction
WO2004032861A2 (en) * 2002-10-11 2004-04-22 Bristol-Myers Squibb Company Hexahydro-benzimidazolone compounds useful as anti-inflammatory agents
EA011242B1 (ru) * 2004-03-25 2009-02-27 Янссен Фармацевтика Н.В. Производные имидазола
CN101089000B (zh) 2006-06-16 2011-01-05 北京大学 螺环哌嗪季铵盐类化合物及其制备方法和应用
WO2011136384A1 (en) 2010-04-26 2011-11-03 Dainippon Sumitomo Pharma Co., Ltd. A process of a quaternary ammonium salt using phosphate

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL272996A (https=) * 1960-12-28
US4200641A (en) * 1976-12-21 1980-04-29 Janssen Pharmaceutica, N.V. 1-[(Heterocyclyl)-alkyl]-4-diarylmethoxy piperidine derivatives
US4179505A (en) * 1977-03-30 1979-12-18 Janssen Pharmaceutica N.V. 5-[4-(Diarylmethyl)-1-piperazinylalkyl]benzimidazole derivatives
JPS5879983A (ja) * 1981-11-06 1983-05-13 Kanebo Ltd 新規なベンズイミダゾ−ル誘導体、その製造法およびその医薬組成物
JPS59199679A (ja) * 1983-04-27 1984-11-12 Kanebo Ltd 新規なベンズイミダゾ−ル誘導体、その製造法およびその医薬組成物
DE3336409A1 (de) * 1983-10-06 1985-04-18 Ludwig Heumann & Co GmbH, 8500 Nürnberg Chinazolinderivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
US4684654A (en) * 1985-08-14 1987-08-04 American Cyanamid Company 3-heteroalkyl-2,4-quinzaolinediones
CA1317939C (en) * 1987-07-01 1993-05-18 Janssen Pharmaceutica Naamloze Vennootschap ¬(bicyclic heterocyclyl)methyl and -hetero| substituted hexahydro-1h-azepines and pyrrolidines
IT1226100B (it) * 1988-07-07 1990-12-10 Dompe Farmaceutici Spa Derivati benzimidazolici farmacologicamente attivi.
US4902687A (en) * 1989-03-27 1990-02-20 Eli Lilly And Company Excitatory amino acid receptor antagonists
FR2672052B1 (fr) * 1991-01-28 1995-05-24 Esteve Labor Dr Derives d'aryl (ou heteroaryl)-piperazinyl-alkyl-azoles, leur preparation et leur application en tant que medicaments.
FR2673628B1 (fr) * 1991-03-07 1993-07-09 Esteve Labor Dr Procede de preparation de derives d'aryl (ou heteroaryl)-piperazinyl-butyl-azoles.

Also Published As

Publication number Publication date
NO178576C (no) 1996-04-24
FR2665161B1 (fr) 1992-11-27
NO178576B (no) 1996-01-15
EP0468884B1 (fr) 1995-12-20
HU215109B (hu) 2000-04-28
JPH04234387A (ja) 1992-08-24
RU2024519C1 (ru) 1994-12-15
ATE131822T1 (de) 1996-01-15
YU48077B (sh) 1997-01-08
CN1058404A (zh) 1992-02-05
AU8128091A (en) 1992-01-30
TW314518B (https=) 1997-09-01
HUT58320A (en) 1992-02-28
DK0468884T5 (da) 1996-09-30
YU123691A (sh) 1994-05-10
NO912669D0 (no) 1991-07-08
ZA915839B (en) 1992-04-29
EP0468884A1 (fr) 1992-01-29
CZ280185B6 (cs) 1995-11-15
HU211599A9 (en) 1995-12-28
NZ239104A (en) 1993-12-23
CS235191A3 (en) 1992-04-15
GR3019352T3 (en) 1996-06-30
KR0183028B1 (ko) 1999-05-01
CA2047880A1 (fr) 1992-01-27
DE69115588D1 (de) 1996-02-01
US5182280A (en) 1993-01-26
PT98409A (pt) 1992-06-30
AU638857B2 (en) 1993-07-08
RO109736B1 (ro) 1995-05-30
KR920002587A (ko) 1992-02-28
PL167222B1 (pl) 1995-08-31
FR2665161A1 (fr) 1992-01-31
HU912518D0 (en) 1992-01-28
NO912669L (no) 1992-01-27
PL291247A1 (en) 1992-03-09
PT98409B (pt) 1999-01-29
DE69115588T2 (de) 1996-06-20
MX9100377A (es) 1992-02-28
ES2038074B1 (es) 1994-02-01
JPH0832703B2 (ja) 1996-03-29
ES2038074A1 (es) 1993-07-01

Similar Documents

Publication Publication Date Title
CN1030915C (zh) 苯并咪唑衍生物的制备方法
CN1255406C (zh) 取代的2－芳基－3－(杂芳基)－咪唑并[1，2－a]嘧啶类化合物以及相关的药物组合物和方法
CN1034865C (zh) 2-氨基嘧啶酮的制备方法
CN1028367C (zh) 苯并咪唑衍生物的制备方法
CN100347164C (zh) 苯并呋喃基衍生物及其应用
CN1832927A (zh) 新型γ－分泌酶抑制剂
US5252584A (en) Hydroxyquinolone derivatives
CN1189170C (zh) 噻吩基唑基烷氧基乙胺,它们的制备以及它们作为药物的应用
HUP9901016A2 (hu) 4-Kinolinkarboxamid-származékok, előállításuk, valamint neurokinin-3 (NK-3) és neurokinin-2 (NK-2) receptor antagonistákként történő felhasználásuk
CN1261885A (zh) 2－取代的4,5－二芳基咪唑
CN1582278A (zh) 多晶型rimonabant,其制备方法及含有它的药物组合物
CN1429200A (zh) 邻氨基苯甲酸酰胺及其作为药物的应用
CN1368969A (zh) 作为抗组胺剂和抗过敏剂的吲哚基哌啶衍生物
CN1823062A (zh) 作为5－羟色胺－6配体的磺酰基二氢苯并咪唑酮化合物
CN1177847C (zh) 作为5－ht2a拮抗剂的噁唑烷酮类化合物
CN1162424C (zh) 喹啉-4-基衍生物ⅱ
CN87107723A (zh) 二氢吡啶抗变应性剂和抗炎性剂
CN1015627B (zh) 芳香基呱嗪基-亚烷基苯基-杂环化合物的制备方法
CN1278789A (zh) 作为磷脂酶抑制剂的9,10－二氢－9,10－桥亚乙基蒽衍生物
DE60200089T2 (de) Octahydro-2H-pyrido[1,2-a]pyrazinderivate, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Zubereitungen
CN1058397A (zh) 1-二苯甲基哌嗪的新颖衍生物，其制备方法及其医药用途
HU182070B (en) Process for producing phenyl-piperazine derivatives
EP0378468B1 (fr) Dérivés des bisarylalcènes, leurs procédés de préparation et les compositions pharmaceutiques qui les contiennent
CN1277607A (zh) 2－取代的1,2－苯并异噻唑衍生物及其作为血清素拮抗剂(5－ht1a,5－ht1b和5－ht1d)的应用
US5376748A (en) Nitroquinolone derivatives

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C14 Grant of patent or utility model
GR01 Patent grant
C15 Extension of patent right duration from 15 to 20 years for appl. with date before 31.12.1992 and still valid on 11.12.2001 (patent law change 1993)
OR01 Other related matters
C19 Lapse of patent right due to non-payment of the annual fee
CF01 Termination of patent right due to non-payment of annual fee