CN103080125A - 用于治疗性结合物的短且含d氨基酸的多肽及其使用 - Google Patents

用于治疗性结合物的短且含d氨基酸的多肽及其使用 Download PDF

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Publication number
CN103080125A
CN103080125A CN2011800412044A CN201180041204A CN103080125A CN 103080125 A CN103080125 A CN 103080125A CN 2011800412044 A CN2011800412044 A CN 2011800412044A CN 201180041204 A CN201180041204 A CN 201180041204A CN 103080125 A CN103080125 A CN 103080125A
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arg
gly
lys
tyr
neurotensin
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让-保罗·卡斯泰恩
米歇尔·德默勒
克里斯蒂安·切
卡里纳·蒂奥特
劳伦斯·佩斯尔赫尔布
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Angiochem Inc
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Angiochem Inc
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    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
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    • A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
    • A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
    • A61K47/6811—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug being a protein or peptide, e.g. transferrin or bleomycin
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    • C07K14/81—Protease inhibitors
    • C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
    • C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
    • C07K14/8114—Kunitz type inhibitors
    • C07K14/8117—Bovine/basic pancreatic trypsin inhibitor (BPTI, aprotinin)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
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CN2011800412044A 2010-07-02 2011-07-04 用于治疗性结合物的短且含d氨基酸的多肽及其使用 Pending CN103080125A (zh)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US36130510P 2010-07-02 2010-07-02
US61/361,305 2010-07-02
US201161494368P 2011-06-07 2011-06-07
US201161494277P 2011-06-07 2011-06-07
US61/494,277 2011-06-07
US61/494,368 2011-06-07
PCT/CA2011/050408 WO2012000118A1 (en) 2010-07-02 2011-07-04 Short and d-amino acid-containing polypeptides for therapeutic conjugates and uses thereof

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Publication Number Publication Date
CN103080125A true CN103080125A (zh) 2013-05-01

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CN2011800412044A Pending CN103080125A (zh) 2010-07-02 2011-07-04 用于治疗性结合物的短且含d氨基酸的多肽及其使用

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US (2) US20160263236A1 (enExample)
EP (1) EP2588490B1 (enExample)
JP (1) JP2013530993A (enExample)
CN (1) CN103080125A (enExample)
AU (1) AU2011274229A1 (enExample)
BR (1) BR112012033295A2 (enExample)
CA (1) CA2803646A1 (enExample)
MX (1) MX2013000250A (enExample)
RU (1) RU2013103763A (enExample)
WO (1) WO2012000118A1 (enExample)

Cited By (4)

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Publication number Priority date Publication date Assignee Title
CN106163569A (zh) * 2014-01-20 2016-11-23 维克塔-霍洛斯公司 活化的神经降压素分子及其用途
CN106267231A (zh) * 2016-08-29 2017-01-04 苏州普罗达生物科技有限公司 一种小分子cd19抗体多肽与环磷酰胺偶联的结合物
CN110551203A (zh) * 2019-09-25 2019-12-10 成都奥达生物科技有限公司 一种艾塞那肽类似物
CN114187967A (zh) * 2021-12-28 2022-03-15 大连工业大学 一种面向降血压肽活性的氨基酸序列预测方法

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EP2346906A4 (en) 2008-10-15 2013-04-24 Angiochem Inc CONJUGATES FROM GLP-1 AGONISTS AND THEIR USE
JP5759379B2 (ja) 2008-12-05 2015-08-05 アンジオケム インコーポレーテッド ニューロテンシンまたはニューロテンシンアナログおよびその使用
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EP2885318A4 (en) * 2012-08-14 2016-03-30 Angiochem Inc PEPTIDE DENDRIMER CONJUGATES AND ITS USES
AU2013302273A1 (en) * 2012-08-14 2015-02-19 Angiochem Inc. Conjugates including an antibody moiety, a polypeptide that traverses the blood-brain barrier, and a cytotoxin
MX377795B (es) * 2012-11-12 2025-03-11 Angiochem Inc Conjugados de polipeptido derivado de aprotinina-anticuerpo.
CA2989400A1 (en) 2015-06-15 2016-12-22 Angiochem Inc. Ang1005 for the treatment of leptomeningeal carcinomatosis
PL3393496T3 (pl) 2015-12-23 2024-04-22 The Johns Hopkins University Długo działający agonista glp-1r jako terapia stanów neurologicznych i neurodegeneracyjnych
MA50746A (fr) 2017-10-02 2020-08-12 Denali Therapeutics Inc Protéines de fusion comprenant des enzymes d'enzymothérapie substitutive
CN112079841B (zh) * 2020-09-22 2022-04-26 武汉天马微电子有限公司 一种有机化合物、电致发光材料及其应用
WO2024192242A2 (en) * 2023-03-14 2024-09-19 The Board Of Trustees Of The Leland Stanford Junior University Compositions and methods relating to age-related, neurological, and vascular disease conditions
CN120733009B (zh) * 2025-08-29 2025-11-04 天津尤金生物科技有限公司 一种具有减肥功效的复合活性多肽组合物及其制备方法

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