RU2013103763A - Короткие и содержащие d-аминокислоты полипептиды для терапевтических конъюгатов и их применения - Google Patents
Короткие и содержащие d-аминокислоты полипептиды для терапевтических конъюгатов и их применения Download PDFInfo
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- RU2013103763A RU2013103763A RU2013103763/10A RU2013103763A RU2013103763A RU 2013103763 A RU2013103763 A RU 2013103763A RU 2013103763/10 A RU2013103763/10 A RU 2013103763/10A RU 2013103763 A RU2013103763 A RU 2013103763A RU 2013103763 A RU2013103763 A RU 2013103763A
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- Prior art keywords
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- tyr
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- neurotensin
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- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/81—Protease inhibitors
- C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
- C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
- C07K14/8114—Kunitz type inhibitors
- C07K14/8117—Bovine/basic pancreatic trypsin inhibitor (BPTI, aprotinin)
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
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- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
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| PCT/CA2011/050408 WO2012000118A1 (en) | 2010-07-02 | 2011-07-04 | Short and d-amino acid-containing polypeptides for therapeutic conjugates and uses thereof |
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| US9365634B2 (en) | 2007-05-29 | 2016-06-14 | Angiochem Inc. | Aprotinin-like polypeptides for delivering agents conjugated thereto to tissues |
| WO2010043047A1 (en) | 2008-10-15 | 2010-04-22 | Angiochem Inc. | Conjugates of glp-1 agonists and uses thereof |
| US9914754B2 (en) | 2008-12-05 | 2018-03-13 | Angiochem Inc. | Conjugates of neurotensin or neurotensin analogs and uses thereof |
| AU2009327267A1 (en) | 2008-12-17 | 2011-07-14 | Angiochem, Inc. | Membrane type-1 matrix metalloprotein inhibitors and uses thereof |
| ES2729261T3 (es) | 2009-04-20 | 2019-10-31 | Angiochem Inc | Tratamiento del cáncer de ovario utilizando un agente anticancerígeno conjugado con un análogo de Angiopep-2 |
| WO2011000095A1 (en) | 2009-07-02 | 2011-01-06 | Angiochem Inc. | Multimeric peptide conjugates and uses thereof |
| EP2885321A4 (en) * | 2012-08-14 | 2016-03-30 | Angiochem Inc | CONJUGATES WITH AN ANTIBODY PART, A POLYPEPTIDE THROUGH THE BLOOD BRAIN BARRIER, AND A CYTOTOXIN |
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| CN105026432A (zh) * | 2012-11-12 | 2015-11-04 | 安吉奥开米公司 | 抑肽酶衍生的多肽-抗体缀合物 |
| EP2896402A1 (en) | 2014-01-20 | 2015-07-22 | Vect-Horus | Activated neurotensin molecules and the uses thereof |
| EP3307326B9 (en) | 2015-06-15 | 2021-02-24 | Angiochem Inc. | Methods for the treatment of leptomeningeal carcinomatosis |
| PL3393496T3 (pl) | 2015-12-23 | 2024-04-22 | The Johns Hopkins University | Długo działający agonista glp-1r jako terapia stanów neurologicznych i neurodegeneracyjnych |
| CN106267231A (zh) * | 2016-08-29 | 2017-01-04 | 苏州普罗达生物科技有限公司 | 一种小分子cd19抗体多肽与环磷酰胺偶联的结合物 |
| BR112020005271A2 (pt) | 2017-10-02 | 2020-09-15 | Denali Therapeutics Inc. | proteína, polipeptídeo, polinucleotídeo, vetor, célula hospedeira, método para produção de um polipeptídeo, métodos de tratamento de um distúrbio, de diminuição do acúmulo, de monitoramento, de transporte de um agente e de tratamento de um lsd e composição farmacêutica |
| CN110551203B (zh) * | 2019-09-25 | 2023-02-10 | 成都奥达生物科技有限公司 | 一种艾塞那肽类似物 |
| CN112079841B (zh) * | 2020-09-22 | 2022-04-26 | 武汉天马微电子有限公司 | 一种有机化合物、电致发光材料及其应用 |
| CN114187967B (zh) * | 2021-12-28 | 2024-10-29 | 大连工业大学 | 一种面向降血压肽活性的氨基酸序列预测方法 |
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| CN120733009B (zh) * | 2025-08-29 | 2025-11-04 | 天津尤金生物科技有限公司 | 一种具有减肥功效的复合活性多肽组合物及其制备方法 |
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| JP2006517790A (ja) | 2003-01-09 | 2006-08-03 | インヴィトロジェン コーポレーション | ポリペプチド−核酸複合体の細胞の送達および活性化 |
| KR100512483B1 (ko) | 2003-05-07 | 2005-09-05 | 선바이오(주) | 신규한 폴리에틸렌글리콜-말레이미드 유도체의 합성방법 |
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-
2011
- 2011-07-04 MX MX2013000250A patent/MX2013000250A/es not_active Application Discontinuation
- 2011-07-04 JP JP2013516932A patent/JP2013530993A/ja active Pending
- 2011-07-04 AU AU2011274229A patent/AU2011274229A1/en not_active Abandoned
- 2011-07-04 BR BR112012033295A patent/BR112012033295A2/pt not_active IP Right Cessation
- 2011-07-04 CN CN2011800412044A patent/CN103080125A/zh active Pending
- 2011-07-04 RU RU2013103763/10A patent/RU2013103763A/ru not_active Application Discontinuation
- 2011-07-04 EP EP11800042.1A patent/EP2588490B1/en not_active Not-in-force
- 2011-07-04 CA CA2803646A patent/CA2803646A1/en not_active Abandoned
- 2011-07-04 WO PCT/CA2011/050408 patent/WO2012000118A1/en not_active Ceased
-
2015
- 2015-10-23 US US14/921,584 patent/US20160263236A1/en not_active Abandoned
-
2017
- 2017-02-22 US US15/439,526 patent/US20180015180A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| MX2013000250A (es) | 2013-10-28 |
| BR112012033295A2 (pt) | 2016-10-11 |
| WO2012000118A1 (en) | 2012-01-05 |
| EP2588490B1 (en) | 2017-02-22 |
| US20160263236A1 (en) | 2016-09-15 |
| CN103080125A (zh) | 2013-05-01 |
| CA2803646A1 (en) | 2012-01-05 |
| EP2588490A1 (en) | 2013-05-08 |
| AU2011274229A1 (en) | 2013-01-10 |
| EP2588490A4 (en) | 2013-11-13 |
| US20180015180A1 (en) | 2018-01-18 |
| JP2013530993A (ja) | 2013-08-01 |
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| Date | Code | Title | Description |
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| FA92 | Acknowledgement of application withdrawn (lack of supplementary materials submitted) |
Effective date: 20160401 |