JP2013530993A5 - - Google Patents
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- JP2013530993A5 JP2013530993A5 JP2013516932A JP2013516932A JP2013530993A5 JP 2013530993 A5 JP2013530993 A5 JP 2013530993A5 JP 2013516932 A JP2013516932 A JP 2013516932A JP 2013516932 A JP2013516932 A JP 2013516932A JP 2013530993 A5 JP2013530993 A5 JP 2013530993A5
- Authority
- JP
- Japan
- Prior art keywords
- arg
- gly
- lys
- tyr
- neurotensin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- ODKSFYDXXFIFQN-SCSAIBSYSA-N D-arginine Chemical group OC(=O)[C@H](N)CCCNC(N)=N ODKSFYDXXFIFQN-SCSAIBSYSA-N 0.000 claims 76
- 108090000765 processed proteins & peptides Proteins 0.000 claims 64
- 229920001184 polypeptide Polymers 0.000 claims 50
- 102000004196 processed proteins & peptides Human genes 0.000 claims 50
- 230000001225 therapeutic effect Effects 0.000 claims 38
- QIVBCDIJIAJPQS-SECBINFHSA-N D-tryptophane Chemical compound C1=CC=C2C(C[C@@H](N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-SECBINFHSA-N 0.000 claims 34
- KDXKERNSBIXSRK-RXMQYKEDSA-N D-lysine Chemical group NCCCC[C@@H](N)C(O)=O KDXKERNSBIXSRK-RXMQYKEDSA-N 0.000 claims 22
- 150000001413 amino acids Chemical group 0.000 claims 21
- 239000003795 chemical substances by application Substances 0.000 claims 21
- 238000000034 method Methods 0.000 claims 20
- ONIBWKKTOPOVIA-SCSAIBSYSA-N D-Proline Chemical compound OC(=O)[C@H]1CCCN1 ONIBWKKTOPOVIA-SCSAIBSYSA-N 0.000 claims 15
- 208000002193 Pain Diseases 0.000 claims 15
- OUYCCCASQSFEME-MRVPVSSYSA-N D-tyrosine Chemical compound OC(=O)[C@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-MRVPVSSYSA-N 0.000 claims 14
- 108010025020 Nerve Growth Factor Proteins 0.000 claims 13
- 102000007072 Nerve Growth Factors Human genes 0.000 claims 13
- 239000003900 neurotrophic factor Substances 0.000 claims 13
- COLNVLDHVKWLRT-MRVPVSSYSA-N D-phenylalanine Chemical group OC(=O)[C@H](N)CC1=CC=CC=C1 COLNVLDHVKWLRT-MRVPVSSYSA-N 0.000 claims 11
- 108010069042 neurotensin-like immunoreactivity Proteins 0.000 claims 11
- PCJGZPGTCUMMOT-ISULXFBGSA-N neurotensin Chemical compound C([C@@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(C)C)C(O)=O)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](CCCCN)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CC(C)C)NC(=O)[C@H]1NC(=O)CC1)C1=CC=C(O)C=C1 PCJGZPGTCUMMOT-ISULXFBGSA-N 0.000 claims 10
- DQDBCHHEIKQPJD-ODKJCKIQSA-N (2s)-2-[[(2s,3s)-2-[[(2s)-2-[[(2s)-1-[(2s)-2-[[(2s)-2-amino-5-(diaminomethylideneamino)pentanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]pyrrolidine-2-carbonyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-3-methylpentanoyl]amino]-4-methylpentanoic acid Chemical compound C([C@@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(C)C)C(O)=O)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)CCCN=C(N)N)C1=CC=C(O)C=C1 DQDBCHHEIKQPJD-ODKJCKIQSA-N 0.000 claims 9
- 108010081387 neurotensin (8-13) Proteins 0.000 claims 9
- 239000003814 drug Substances 0.000 claims 8
- 229940124597 therapeutic agent Drugs 0.000 claims 8
- 206010028980 Neoplasm Diseases 0.000 claims 7
- 239000012634 fragment Substances 0.000 claims 7
- 102000034615 Glial cell line-derived neurotrophic factor Human genes 0.000 claims 6
- 108091010837 Glial cell line-derived neurotrophic factor Proteins 0.000 claims 6
- OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical group OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 claims 6
- 201000011510 cancer Diseases 0.000 claims 6
- 206010003571 Astrocytoma Diseases 0.000 claims 5
- 102000004219 Brain-derived neurotrophic factor Human genes 0.000 claims 5
- 108090000715 Brain-derived neurotrophic factor Proteins 0.000 claims 5
- 229940077737 brain-derived neurotrophic factor Drugs 0.000 claims 5
- 239000013598 vector Substances 0.000 claims 5
- 208000003174 Brain Neoplasms Diseases 0.000 claims 4
- 206010018338 Glioma Diseases 0.000 claims 4
- 108060003951 Immunoglobulin Proteins 0.000 claims 4
- 239000002246 antineoplastic agent Substances 0.000 claims 4
- 238000012217 deletion Methods 0.000 claims 4
- 230000037430 deletion Effects 0.000 claims 4
- 102000018358 immunoglobulin Human genes 0.000 claims 4
- NRYBAZVQPHGZNS-ZSOCWYAHSA-N leptin Chemical compound O=C([C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](N)CC(C)C)CCSC)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](CS)C(O)=O NRYBAZVQPHGZNS-ZSOCWYAHSA-N 0.000 claims 4
- 108020004707 nucleic acids Proteins 0.000 claims 4
- 102000039446 nucleic acids Human genes 0.000 claims 4
- 150000007523 nucleic acids Chemical class 0.000 claims 4
- 208000011117 substance-related disease Diseases 0.000 claims 4
- 230000008685 targeting Effects 0.000 claims 4
- 150000008574 D-amino acids Chemical group 0.000 claims 3
- 206010020772 Hypertension Diseases 0.000 claims 3
- 208000012902 Nervous system disease Diseases 0.000 claims 3
- 239000003937 drug carrier Substances 0.000 claims 3
- 239000000203 mixture Substances 0.000 claims 3
- XUUXCWCKKCZEAW-YFKPBYRVSA-N Arg-Gly Chemical compound OC(=O)CNC(=O)[C@@H](N)CCCN=C(N)N XUUXCWCKKCZEAW-YFKPBYRVSA-N 0.000 claims 2
- CEZSLNCYQUFOSL-BQBZGAKWSA-N Cys-Arg-Gly Chemical compound [H]N[C@@H](CS)C(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(O)=O CEZSLNCYQUFOSL-BQBZGAKWSA-N 0.000 claims 2
- DSTWKJOBKSMVCV-UWVGGRQHSA-N Cys-Tyr Chemical compound SC[C@H](N)C(=O)N[C@H](C(O)=O)CC1=CC=C(O)C=C1 DSTWKJOBKSMVCV-UWVGGRQHSA-N 0.000 claims 2
- AOJJSUZBOXZQNB-TZSSRYMLSA-N Doxorubicin Chemical compound O([C@H]1C[C@@](O)(CC=2C(O)=C3C(=O)C=4C=CC=C(C=4C(=O)C3=C(O)C=21)OC)C(=O)CO)[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 AOJJSUZBOXZQNB-TZSSRYMLSA-N 0.000 claims 2
- 206010013654 Drug abuse Diseases 0.000 claims 2
- 206010014967 Ependymoma Diseases 0.000 claims 2
- 208000000527 Germinoma Diseases 0.000 claims 2
- 208000032612 Glial tumor Diseases 0.000 claims 2
- PHONAZGUEGIOEM-GLLZPBPUSA-N Glu-Glu-Thr Chemical compound [H]N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H]([C@@H](C)O)C(O)=O PHONAZGUEGIOEM-GLLZPBPUSA-N 0.000 claims 2
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 claims 2
- XUJNEKJLAYXESH-REOHCLBHSA-N L-Cysteine Chemical compound SC[C@H](N)C(O)=O XUJNEKJLAYXESH-REOHCLBHSA-N 0.000 claims 2
- 125000000415 L-cysteinyl group Chemical group O=C([*])[C@@](N([H])[H])([H])C([H])([H])S[H] 0.000 claims 2
- ZUKPVRWZDMRIEO-VKHMYHEASA-N L-cysteinylglycine Chemical compound SC[C@H]([NH3+])C(=O)NCC([O-])=O ZUKPVRWZDMRIEO-VKHMYHEASA-N 0.000 claims 2
- 102000016267 Leptin Human genes 0.000 claims 2
- 108010092277 Leptin Proteins 0.000 claims 2
- 101800001814 Neurotensin Proteins 0.000 claims 2
- 102400001103 Neurotensin Human genes 0.000 claims 2
- 229940122508 Neurotensin receptor agonist Drugs 0.000 claims 2
- 201000010133 Oligodendroglioma Diseases 0.000 claims 2
- GCFNFKNPCMBHNT-IRXDYDNUSA-N Phe-Tyr-Gly Chemical compound C1=CC=C(C=C1)C[C@@H](C(=O)N[C@@H](CC2=CC=C(C=C2)O)C(=O)NCC(=O)O)N GCFNFKNPCMBHNT-IRXDYDNUSA-N 0.000 claims 2
- 108091030071 RNAI Proteins 0.000 claims 2
- 201000000582 Retinoblastoma Diseases 0.000 claims 2
- JJKSSJVYOVRJMZ-FXQIFTODSA-N Ser-Arg-Cys Chemical compound C(C[C@@H](C(=O)N[C@@H](CS)C(=O)O)NC(=O)[C@H](CO)N)CN=C(N)N JJKSSJVYOVRJMZ-FXQIFTODSA-N 0.000 claims 2
- HQTKVSCNCDLXSX-BQBZGAKWSA-N Ser-Arg-Gly Chemical compound [H]N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(O)=O HQTKVSCNCDLXSX-BQBZGAKWSA-N 0.000 claims 2
- 206010043276 Teratoma Diseases 0.000 claims 2
- WJKJJGXZRHDNTN-UWVGGRQHSA-N Tyr-Cys Chemical compound SC[C@@H](C(O)=O)NC(=O)[C@@H](N)CC1=CC=C(O)C=C1 WJKJJGXZRHDNTN-UWVGGRQHSA-N 0.000 claims 2
- 201000000053 blastoma Diseases 0.000 claims 2
- 230000008499 blood brain barrier function Effects 0.000 claims 2
- 210000001218 blood-brain barrier Anatomy 0.000 claims 2
- 230000036760 body temperature Effects 0.000 claims 2
- 230000001886 ciliary effect Effects 0.000 claims 2
- 108010016616 cysteinylglycine Proteins 0.000 claims 2
- 108010069495 cysteinyltyrosine Proteins 0.000 claims 2
- 206010013663 drug dependence Diseases 0.000 claims 2
- 201000008184 embryoma Diseases 0.000 claims 2
- 108020001507 fusion proteins Proteins 0.000 claims 2
- 102000037865 fusion proteins Human genes 0.000 claims 2
- 230000009368 gene silencing by RNA Effects 0.000 claims 2
- 239000003877 glucagon like peptide 1 receptor agonist Substances 0.000 claims 2
- 229940039781 leptin Drugs 0.000 claims 2
- 208000030159 metabolic disease Diseases 0.000 claims 2
- 201000004058 mixed glioma Diseases 0.000 claims 2
- 208000027831 neuroepithelial neoplasm Diseases 0.000 claims 2
- 208000020016 psychiatric disease Diseases 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- 150000003573 thiols Chemical class 0.000 claims 2
- 206010002383 Angina Pectoris Diseases 0.000 claims 1
- 108010064942 Angiopep-2 Proteins 0.000 claims 1
- 208000006820 Arthralgia Diseases 0.000 claims 1
- 206010006002 Bone pain Diseases 0.000 claims 1
- 201000006474 Brain Ischemia Diseases 0.000 claims 1
- 206010008120 Cerebral ischaemia Diseases 0.000 claims 1
- 206010016059 Facial pain Diseases 0.000 claims 1
- 208000001640 Fibromyalgia Diseases 0.000 claims 1
- 206010017999 Gastrointestinal pain Diseases 0.000 claims 1
- 206010019233 Headaches Diseases 0.000 claims 1
- 206010065390 Inflammatory pain Diseases 0.000 claims 1
- 208000007914 Labor Pain Diseases 0.000 claims 1
- 208000000172 Medulloblastoma Diseases 0.000 claims 1
- 208000019695 Migraine disease Diseases 0.000 claims 1
- 208000000112 Myalgia Diseases 0.000 claims 1
- ZDZOTLJHXYCWBA-VCVYQWHSSA-N N-debenzoyl-N-(tert-butoxycarbonyl)-10-deacetyltaxol Chemical compound O([C@H]1[C@H]2[C@@](C([C@H](O)C3=C(C)[C@@H](OC(=O)[C@H](O)[C@@H](NC(=O)OC(C)(C)C)C=4C=CC=CC=4)C[C@]1(O)C3(C)C)=O)(C)[C@@H](O)C[C@H]1OC[C@]12OC(=O)C)C(=O)C1=CC=CC=C1 ZDZOTLJHXYCWBA-VCVYQWHSSA-N 0.000 claims 1
- 208000028389 Nerve injury Diseases 0.000 claims 1
- 206010029260 Neuroblastoma Diseases 0.000 claims 1
- 229930012538 Paclitaxel Natural products 0.000 claims 1
- 208000000450 Pelvic Pain Diseases 0.000 claims 1
- 206010065016 Post-traumatic pain Diseases 0.000 claims 1
- 208000004550 Postoperative Pain Diseases 0.000 claims 1
- 108020004459 Small interfering RNA Proteins 0.000 claims 1
- 208000006011 Stroke Diseases 0.000 claims 1
- 206010043269 Tension headache Diseases 0.000 claims 1
- 208000008548 Tension-Type Headache Diseases 0.000 claims 1
- 208000005298 acute pain Diseases 0.000 claims 1
- 238000007792 addition Methods 0.000 claims 1
- 150000001412 amines Chemical class 0.000 claims 1
- 230000002917 arthritic effect Effects 0.000 claims 1
- 210000004556 brain Anatomy 0.000 claims 1
- 206010008118 cerebral infarction Diseases 0.000 claims 1
- 238000002512 chemotherapy Methods 0.000 claims 1
- 239000000412 dendrimer Substances 0.000 claims 1
- 229920000736 dendritic polymer Polymers 0.000 claims 1
- 229960003668 docetaxel Drugs 0.000 claims 1
- 229960004679 doxorubicin Drugs 0.000 claims 1
- VJJPUSNTGOMMGY-MRVIYFEKSA-N etoposide Chemical compound COC1=C(O)C(OC)=CC([C@@H]2C3=CC=4OCOC=4C=C3[C@@H](O[C@H]3[C@@H]([C@@H](O)[C@@H]4O[C@H](C)OC[C@H]4O3)O)[C@@H]3[C@@H]2C(OC3)=O)=C1 VJJPUSNTGOMMGY-MRVIYFEKSA-N 0.000 claims 1
- 229960005420 etoposide Drugs 0.000 claims 1
- 201000003115 germ cell cancer Diseases 0.000 claims 1
- 208000005017 glioblastoma Diseases 0.000 claims 1
- 231100000869 headache Toxicity 0.000 claims 1
- 208000002551 irritable bowel syndrome Diseases 0.000 claims 1
- 208000030175 lameness Diseases 0.000 claims 1
- 150000002632 lipids Chemical group 0.000 claims 1
- 206010027599 migraine Diseases 0.000 claims 1
- 208000013465 muscle pain Diseases 0.000 claims 1
- 208000010125 myocardial infarction Diseases 0.000 claims 1
- 208000031225 myocardial ischemia Diseases 0.000 claims 1
- 239000002105 nanoparticle Substances 0.000 claims 1
- 230000008764 nerve damage Effects 0.000 claims 1
- 210000003757 neuroblast Anatomy 0.000 claims 1
- 210000004498 neuroglial cell Anatomy 0.000 claims 1
- 201000001119 neuropathy Diseases 0.000 claims 1
- 230000007823 neuropathy Effects 0.000 claims 1
- 230000004112 neuroprotection Effects 0.000 claims 1
- 210000004248 oligodendroglia Anatomy 0.000 claims 1
- 229960001592 paclitaxel Drugs 0.000 claims 1
- 230000002093 peripheral effect Effects 0.000 claims 1
- 208000033808 peripheral neuropathy Diseases 0.000 claims 1
- -1 polyplexes Substances 0.000 claims 1
- 150000003141 primary amines Chemical class 0.000 claims 1
- 230000035945 sensitivity Effects 0.000 claims 1
- 229940126586 small molecule drug Drugs 0.000 claims 1
- 150000003384 small molecules Chemical class 0.000 claims 1
- 238000006467 substitution reaction Methods 0.000 claims 1
- RCINICONZNJXQF-MZXODVADSA-N taxol Chemical compound O([C@@H]1[C@@]2(C[C@@H](C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)OC(=O)[C@H](O)[C@@H](NC(=O)C=1C=CC=CC=1)C=1C=CC=CC=1)O)C(=O)C1=CC=CC=C1 RCINICONZNJXQF-MZXODVADSA-N 0.000 claims 1
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US36130510P | 2010-07-02 | 2010-07-02 | |
| US61/361,305 | 2010-07-02 | ||
| US201161494368P | 2011-06-07 | 2011-06-07 | |
| US201161494277P | 2011-06-07 | 2011-06-07 | |
| US61/494,368 | 2011-06-07 | ||
| US61/494,277 | 2011-06-07 | ||
| PCT/CA2011/050408 WO2012000118A1 (en) | 2010-07-02 | 2011-07-04 | Short and d-amino acid-containing polypeptides for therapeutic conjugates and uses thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2013530993A JP2013530993A (ja) | 2013-08-01 |
| JP2013530993A5 true JP2013530993A5 (enExample) | 2014-08-21 |
Family
ID=45401275
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013516932A Pending JP2013530993A (ja) | 2010-07-02 | 2011-07-04 | 治療用コンジュゲートのための短く且つｄ−アミノ酸を含有するポリペプチドおよびその使用 |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US20160263236A1 (enExample) |
| EP (1) | EP2588490B1 (enExample) |
| JP (1) | JP2013530993A (enExample) |
| CN (1) | CN103080125A (enExample) |
| AU (1) | AU2011274229A1 (enExample) |
| BR (1) | BR112012033295A2 (enExample) |
| CA (1) | CA2803646A1 (enExample) |
| MX (1) | MX2013000250A (enExample) |
| RU (1) | RU2013103763A (enExample) |
| WO (1) | WO2012000118A1 (enExample) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2004060403A2 (en) | 2003-01-06 | 2004-07-22 | Angiochem Inc. | Aprotinin and anglos as carriers across the blood-brain barrier |
| ES2744225T3 (es) | 2005-07-15 | 2020-02-24 | Angiochem Inc | Uso de polipéptidos de aprotinina como portadores en conjugados farmacéuticos |
| US9365634B2 (en) | 2007-05-29 | 2016-06-14 | Angiochem Inc. | Aprotinin-like polypeptides for delivering agents conjugated thereto to tissues |
| CA2740316A1 (en) | 2008-10-15 | 2010-04-22 | Angiochem Inc. | Conjugates of glp-1 agonists and uses thereof |
| CA2745524C (en) | 2008-12-05 | 2020-06-09 | Angiochem Inc. | Conjugates of neurotensin or neurotensin analogs and uses thereof |
| US8853353B2 (en) | 2008-12-17 | 2014-10-07 | Angiochem, Inc. | Membrane type-1 matrix metalloprotein inhibitors and uses thereof |
| MX2011011023A (es) | 2009-04-20 | 2012-01-20 | Angiochem Inc | Tratamiento de cancer de ovarios usando un agente anti-cancer conjugado con un analogo de angiopep-2. |
| RU2012103240A (ru) | 2009-07-02 | 2013-08-10 | Ангиокем Инк. | Мультимерные пептидные конъюгаты и их применение |
| JP2015526434A (ja) | 2012-08-14 | 2015-09-10 | アンジオケム インコーポレーテッド | ペプチド−デンドリマーコンジュゲート及びその使用 |
| US20160106856A1 (en) * | 2012-08-14 | 2016-04-21 | Angiochem Inc. | Conjugates including an antibody moiety, a polypeptide that traverses the blood-brain barrier, and a cytotoxin |
| JP2015535523A (ja) * | 2012-11-12 | 2015-12-14 | アンジオケム インコーポレーテッド | アプロチニン由来ポリペプチド−抗体コンジュゲート |
| EP2896402A1 (en) | 2014-01-20 | 2015-07-22 | Vect-Horus | Activated neurotensin molecules and the uses thereof |
| EP3307326B9 (en) | 2015-06-15 | 2021-02-24 | Angiochem Inc. | Methods for the treatment of leptomeningeal carcinomatosis |
| CN108697768B (zh) | 2015-12-23 | 2022-07-22 | 约翰霍普金斯大学 | 长效glp-1r激动剂作为神经系统病状和神经退行性病状的治疗方法 |
| CN106267231A (zh) * | 2016-08-29 | 2017-01-04 | 苏州普罗达生物科技有限公司 | 一种小分子cd19抗体多肽与环磷酰胺偶联的结合物 |
| CR20200129A (es) | 2017-10-02 | 2020-08-22 | Denali Therapeutics Inc | Proteínas de fusión que comprenden enzimas de terapia de reemplazo de enzimas |
| CN110551203B (zh) * | 2019-09-25 | 2023-02-10 | 成都奥达生物科技有限公司 | 一种艾塞那肽类似物 |
| CN112079841B (zh) * | 2020-09-22 | 2022-04-26 | 武汉天马微电子有限公司 | 一种有机化合物、电致发光材料及其应用 |
| CN114187967B (zh) * | 2021-12-28 | 2024-10-29 | 大连工业大学 | 一种面向降血压肽活性的氨基酸序列预测方法 |
| WO2024192242A2 (en) * | 2023-03-14 | 2024-09-19 | The Board Of Trustees Of The Leland Stanford Junior University | Compositions and methods relating to age-related, neurological, and vascular disease conditions |
| CN120733009B (zh) * | 2025-08-29 | 2025-11-04 | 天津尤金生物科技有限公司 | 一种具有减肥功效的复合活性多肽组合物及其制备方法 |
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| GB1518390A (en) | 1976-03-30 | 1978-07-19 | Farmaceutici Italia | Doxorubicin thioesters |
| US4301277A (en) | 1980-10-20 | 1981-11-17 | Sri International | 3-Deamino-3-(4-morpholinyl) derivatives of daunorubicin and doxorubicin |
| US4314054A (en) | 1981-03-23 | 1982-02-02 | Sri International | 3'-Deamino-3'-(4-methoxy-1-piperidinyl) derivatives of daunorubicin and doxorubicin |
| US4826964A (en) | 1982-07-20 | 1989-05-02 | Sri International | Bridged oxygen analogs of daunorubcin and doxorubicin |
| US4464529A (en) | 1982-07-20 | 1984-08-07 | Sri International | Analogues of morpholinyl daunorubicin and morpholinyl doxorubicin |
| US4507466A (en) | 1983-01-07 | 1985-03-26 | The Dow Chemical Corporation | Dense star polymers having core, core branches, terminal groups |
| US4585859A (en) | 1983-05-24 | 1986-04-29 | Sri International | Analogues of morpholinyl daunorubicin and morpholinyl doxorubicin |
| US4567253A (en) | 1984-02-03 | 1986-01-28 | Tony Durst | 2-Substituted derivatives of podophyllotoxin and etoposide |
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| GB2172594B (en) | 1985-03-22 | 1988-06-08 | Erba Farmitalia | New morpholino derivatives of daunorubicin and doxorubicin |
| GB8508079D0 (en) | 1985-03-28 | 1985-05-01 | Erba Farmitalia | Antitumor anthracyclines |
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| IL77334A (en) | 1985-12-16 | 1991-04-15 | Univ Bar Ilan | Synthesis of 9-epipodophyllotoxin glucoside derivatives and some novel intermediates therefor |
| FR2601675B1 (fr) | 1986-07-17 | 1988-09-23 | Rhone Poulenc Sante | Derives du taxol, leur preparation et les compositions pharmaceutiques qui les contiennent |
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-
2011
- 2011-07-04 JP JP2013516932A patent/JP2013530993A/ja active Pending
- 2011-07-04 AU AU2011274229A patent/AU2011274229A1/en not_active Abandoned
- 2011-07-04 CN CN2011800412044A patent/CN103080125A/zh active Pending
- 2011-07-04 EP EP11800042.1A patent/EP2588490B1/en not_active Not-in-force
- 2011-07-04 WO PCT/CA2011/050408 patent/WO2012000118A1/en not_active Ceased
- 2011-07-04 MX MX2013000250A patent/MX2013000250A/es not_active Application Discontinuation
- 2011-07-04 CA CA2803646A patent/CA2803646A1/en not_active Abandoned
- 2011-07-04 RU RU2013103763/10A patent/RU2013103763A/ru not_active Application Discontinuation
- 2011-07-04 BR BR112012033295A patent/BR112012033295A2/pt not_active IP Right Cessation
-
2015
- 2015-10-23 US US14/921,584 patent/US20160263236A1/en not_active Abandoned
-
2017
- 2017-02-22 US US15/439,526 patent/US20180015180A1/en not_active Abandoned
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