JP2012529891A5 - - Google Patents
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- Publication number
- JP2012529891A5 JP2012529891A5 JP2012515229A JP2012515229A JP2012529891A5 JP 2012529891 A5 JP2012529891 A5 JP 2012529891A5 JP 2012515229 A JP2012515229 A JP 2012515229A JP 2012515229 A JP2012515229 A JP 2012515229A JP 2012529891 A5 JP2012529891 A5 JP 2012529891A5
- Authority
- JP
- Japan
- Prior art keywords
- antibody
- antigen
- binding fragment
- chimeric polypeptide
- item
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US26873209P | 2009-06-15 | 2009-06-15 | |
| US61/268,732 | 2009-06-15 | ||
| PCT/US2010/038703 WO2010148010A1 (en) | 2009-06-15 | 2010-06-15 | Methods and compositions for treatment of myotubular myopathy using chimeric polypeptides comprising myotubularih 1 (mtm1) polypeptides |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2012529891A JP2012529891A (ja) | 2012-11-29 |
| JP2012529891A5 true JP2012529891A5 (enExample) | 2013-08-01 |
| JP6166041B2 JP6166041B2 (ja) | 2017-07-19 |
Family
ID=43356726
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012515229A Expired - Fee Related JP6166041B2 (ja) | 2009-06-15 | 2010-06-15 | ミオチューブラリン１（ｍｔｍ１）ポリペプチドを含むキメラポリペプチドを使用して筋細管ミオパシーを処置するための方法および組成物 |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US8834866B2 (enExample) |
| EP (1) | EP2443155B1 (enExample) |
| JP (1) | JP6166041B2 (enExample) |
| AU (1) | AU2010260145B2 (enExample) |
| BR (1) | BRPI1011236A2 (enExample) |
| CA (1) | CA2797480A1 (enExample) |
| ES (1) | ES2630057T3 (enExample) |
| WO (1) | WO2010148010A1 (enExample) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2010260145B2 (en) | 2009-06-15 | 2015-08-20 | Valerion Therapeutics, Llc | Methods and compositions for treatment of Myotubular Myopathy using chimeric polypeptides comprising myotubularin 1 (MTM1) polypeptides |
| WO2012135831A1 (en) | 2011-04-01 | 2012-10-04 | Yale University | Cell-penetrating anti-dna antibodies and uses thereof inhibit dna repair |
| WO2013138662A1 (en) * | 2012-03-16 | 2013-09-19 | 4S3 Bioscience, Inc. | Antisense conjugates for decreasing expression of dmpk |
| US9732146B2 (en) * | 2012-03-30 | 2017-08-15 | The United States Of America As Represented By The Department Of Veterans Affairs | Antibody-mediated transduction of heat shock proteins into living cells |
| WO2013177428A1 (en) * | 2012-05-23 | 2013-11-28 | Valerion Therapeutics, Inc. | Methods for increasing muscle contractility |
| US10017581B2 (en) | 2013-02-20 | 2018-07-10 | Valerion Therapeutics, Llc | Methods and compositions for treatment of Pompe disease |
| US8957044B2 (en) | 2013-03-01 | 2015-02-17 | Wake Forest University Health Sciences | Systemic gene replacement therapy for treatment of X-linked myotubular myopathy (XLMTM) |
| FR3004463A1 (fr) | 2013-04-11 | 2014-10-17 | Genethon | Systeme d'expression pour une therapie genique selective |
| AU2015204446A1 (en) | 2014-01-13 | 2016-07-14 | Valerion Therapeutics, Llc | Internalizing moieties |
| CN106459186B (zh) * | 2014-02-28 | 2021-02-02 | 美国卫生和人力服务部 | 针对hiv-1 v1v2 env区域的广谱中和性单克隆抗体 |
| US10202591B2 (en) | 2014-06-13 | 2019-02-12 | Valerion Therapeutics, Llc | Methods and compositions for treatment of glycogen storage diseases and glycogen metabolism disorders |
| EP3186278A4 (en) | 2014-08-27 | 2018-04-04 | Valerion Therapeutics, LLC | Internalizing moieties for treatment of cancer |
| US10383945B2 (en) | 2015-02-18 | 2019-08-20 | The United States of America as Represented by the Department of Verterans Affairs | Methods for DNA-dependent targeting of a cell permeant antibody |
| US12486318B2 (en) | 2016-06-15 | 2025-12-02 | Yale University | Anti-guanosine antibody as a molecular delivery vehicle |
| AU2017286733B2 (en) | 2016-06-15 | 2020-07-02 | Yale University | Antibody-mediated autocatalytic, targeted delivery of nanocarriers to tumors |
| JP2019535645A (ja) | 2016-09-09 | 2019-12-12 | バレリオン セラピューティクス， エルエルシー | ラフォラ病の処置のための方法及び組成物 |
| US20200215168A1 (en) * | 2017-07-03 | 2020-07-09 | Universite De Strasbourg | Mtmr2-s polypeptide for use in the treatment of myopathies |
| AU2020336992A1 (en) * | 2019-08-30 | 2022-04-14 | Yale University | Compositions and methods for delivery of nucleic acids to cells |
| US20240216530A1 (en) * | 2021-03-03 | 2024-07-04 | Yale University | Compositions and Methods for Treating Skeletal Muscle Disease |
| GB202201713D0 (en) * | 2022-02-10 | 2022-03-30 | Univ Dundee | An affinity directed phosphatase system for targeted protein dephosphorylation |
| WO2024238807A2 (en) | 2023-05-16 | 2024-11-21 | Affinia Therapeutics Inc. | Recombinant aavs with improved tropism and specificity |
Family Cites Families (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4179337A (en) | 1973-07-20 | 1979-12-18 | Davis Frank F | Non-immunogenic polypeptides |
| JPS6023084B2 (ja) | 1979-07-11 | 1985-06-05 | 味の素株式会社 | 代用血液 |
| US4640835A (en) | 1981-10-30 | 1987-02-03 | Nippon Chemiphar Company, Ltd. | Plasminogen activator derivatives |
| US4496689A (en) | 1983-12-27 | 1985-01-29 | Miles Laboratories, Inc. | Covalently attached complex of alpha-1-proteinase inhibitor with a water soluble polymer |
| EP0206448B1 (en) | 1985-06-19 | 1990-11-14 | Ajinomoto Co., Inc. | Hemoglobin combined with a poly(alkylene oxide) |
| US4791192A (en) | 1986-06-26 | 1988-12-13 | Takeda Chemical Industries, Ltd. | Chemically modified protein with polyethyleneglycol |
| US5223409A (en) | 1988-09-02 | 1993-06-29 | Protein Engineering Corp. | Directed evolution of novel binding proteins |
| US5198346A (en) | 1989-01-06 | 1993-03-30 | Protein Engineering Corp. | Generation and selection of novel DNA-binding proteins and polypeptides |
| US5096815A (en) | 1989-01-06 | 1992-03-17 | Protein Engineering Corporation | Generation and selection of novel dna-binding proteins and polypeptides |
| US5264618A (en) | 1990-04-19 | 1993-11-23 | Vical, Inc. | Cationic lipids for intracellular delivery of biologically active molecules |
| AU7979491A (en) | 1990-05-03 | 1991-11-27 | Vical, Inc. | Intracellular delivery of biologically active substances by means of self-assembling lipid complexes |
| US5173414A (en) | 1990-10-30 | 1992-12-22 | Applied Immune Sciences, Inc. | Production of recombinant adeno-associated virus vectors |
| US5541087A (en) | 1994-09-14 | 1996-07-30 | Fuji Immunopharmaceuticals Corporation | Expression and export technology of proteins as immunofusins |
| US6068829A (en) | 1995-09-11 | 2000-05-30 | The Burnham Institute | Method of identifying molecules that home to a selected organ in vivo |
| US5622699A (en) | 1995-09-11 | 1997-04-22 | La Jolla Cancer Research Foundation | Method of identifying molecules that home to a selected organ in vivo |
| JP2000507225A (ja) * | 1996-03-08 | 2000-06-13 | ザ リージェンツ オブ ザ ユニバーシティー オブ カリフォルニア | ｍａｂ ３Ｅ１０ ならびにその突然変異体および／または機能性フラグメントを使用する送達システム |
| US6329501B1 (en) | 1997-05-29 | 2001-12-11 | Auburn University | Methods and compositions for targeting compounds to muscle |
| US6180084B1 (en) | 1998-08-25 | 2001-01-30 | The Burnham Institute | NGR receptor and methods of identifying tumor homing molecules that home to angiogenic vasculature using same |
| JPH11151088A (ja) | 1997-11-20 | 1999-06-08 | Univ Tokyo | 脱リン酸化反応を触媒する新規酵素 |
| US6174687B1 (en) | 1999-02-26 | 2001-01-16 | The Burnham Institute | Methods of identifying lung homing molecules using membrane dipeptidase |
| US6232287B1 (en) | 1998-03-13 | 2001-05-15 | The Burnham Institute | Molecules that home to various selected organs or tissues |
| US6303573B1 (en) | 1999-06-07 | 2001-10-16 | The Burnham Institute | Heart homing peptides and methods of using same |
| US6551809B2 (en) | 2001-03-20 | 2003-04-22 | Applera Corporation | Isolated human phosphatase proteins, nucleic acid molecules encoding human phophatase proteins, and uses thereof |
| US6992174B2 (en) | 2001-03-30 | 2006-01-31 | Emd Lexigen Research Center Corp. | Reducing the immunogenicity of fusion proteins |
| US20100183695A1 (en) | 2004-05-27 | 2010-07-22 | John Knopf | Cerberus/coco derivatives and uses thereof |
| US20100143358A1 (en) | 2007-01-22 | 2010-06-10 | The United States Government As Represented By The Department Of Veterans Affairs | Use of Antibody Conjugates |
| CA2688240A1 (en) | 2007-05-24 | 2008-12-04 | The United States Government As Represented By The Department Of Veterans Affairs | Intranuclear protein transduction through a nucleoside salvage pathway |
| US8609615B2 (en) | 2008-10-15 | 2013-12-17 | Valerion Therapeutics, Llc | Methods and compositions for treatment of myotonic dystrophy |
| CA2799608C (en) | 2009-05-28 | 2023-02-28 | Richard H. Weisbart | Amino acid sequences which enhance peptide conjugate solubility |
| AU2010260145B2 (en) | 2009-06-15 | 2015-08-20 | Valerion Therapeutics, Llc | Methods and compositions for treatment of Myotubular Myopathy using chimeric polypeptides comprising myotubularin 1 (MTM1) polypeptides |
| GB2476671B (en) | 2010-01-04 | 2014-11-26 | Plastic Logic Ltd | Touch-sensing systems |
| JP5240316B2 (ja) | 2010-10-26 | 2013-07-17 | 株式会社デンソー | 車両乗員非操作運転システム |
| US8702968B2 (en) | 2011-04-05 | 2014-04-22 | Chevron Oronite Technology B.V. | Low viscosity marine cylinder lubricating oil compositions |
| WO2013177428A1 (en) | 2012-05-23 | 2013-11-28 | Valerion Therapeutics, Inc. | Methods for increasing muscle contractility |
-
2010
- 2010-06-15 AU AU2010260145A patent/AU2010260145B2/en not_active Ceased
- 2010-06-15 ES ES10790070.6T patent/ES2630057T3/es active Active
- 2010-06-15 BR BRPI1011236A patent/BRPI1011236A2/pt not_active Application Discontinuation
- 2010-06-15 US US13/378,283 patent/US8834866B2/en not_active Expired - Fee Related
- 2010-06-15 CA CA2797480A patent/CA2797480A1/en not_active Abandoned
- 2010-06-15 JP JP2012515229A patent/JP6166041B2/ja not_active Expired - Fee Related
- 2010-06-15 EP EP10790070.6A patent/EP2443155B1/en not_active Not-in-force
- 2010-06-15 WO PCT/US2010/038703 patent/WO2010148010A1/en not_active Ceased
-
2014
- 2014-09-12 US US14/485,524 patent/US9447394B2/en not_active Expired - Fee Related
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