JP2019535645A5 - - Google Patents

Info

Publication number

JP2019535645A5

JP2019535645A5 JP2019513898A JP2019513898A JP2019535645A5 JP 2019535645 A5 JP2019535645 A5 JP 2019535645A5 JP 2019513898 A JP2019513898 A JP 2019513898A JP 2019513898 A JP2019513898 A JP 2019513898A JP 2019535645 A5 JP2019535645 A5 JP 2019535645A5

Authority

JP

Japan

Prior art keywords

chimeric polypeptide

cell

polypeptide according

seq

amino acid

Prior art date

2017-09-08

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

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• 108090000765 processed proteins & peptides Proteins 0.000 claims description 188
• 229920001184 polypeptide Polymers 0.000 claims description 187
• 102000004196 processed proteins & peptides Human genes 0.000 claims description 187
• 210000004027 cell Anatomy 0.000 claims description 44
• 125000003275 alpha amino acid group Chemical group 0.000 claims description 32
• 102000004139 alpha-Amylases Human genes 0.000 claims description 30
• 108090000637 alpha-Amylases Proteins 0.000 claims description 30
• 229940024171 alpha-amylase Drugs 0.000 claims description 30
• 238000000034 method Methods 0.000 claims description 18
• 239000000427 antigen Substances 0.000 claims description 16
• 108091007433 antigens Proteins 0.000 claims description 16
• 102000036639 antigens Human genes 0.000 claims description 16
• 239000012634 fragment Substances 0.000 claims description 16
• 102000039446 nucleic acids Human genes 0.000 claims description 16
• 108020004707 nucleic acids Proteins 0.000 claims description 16
• 150000007523 nucleic acids Chemical class 0.000 claims description 16
• 210000000663 muscle cell Anatomy 0.000 claims description 11
• 210000004962 mammalian cell Anatomy 0.000 claims description 10
• 210000002569 neuron Anatomy 0.000 claims description 10
• 239000002773 nucleotide Substances 0.000 claims description 8
• 125000003729 nucleotide group Chemical group 0.000 claims description 8
• 208000005870 Lafora disease Diseases 0.000 claims description 7
• 208000014161 Lafora myoclonic epilepsy Diseases 0.000 claims description 7
• 108020001507 fusion proteins Proteins 0.000 claims description 6
• 102000037865 fusion proteins Human genes 0.000 claims description 6
• 230000003301 hydrolyzing effect Effects 0.000 claims description 6
• 239000013598 vector Substances 0.000 claims description 6
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims description 4
• 150000001413 amino acids Chemical class 0.000 claims description 4
• 210000004958 brain cell Anatomy 0.000 claims description 4
• 210000004978 chinese hamster ovary cell Anatomy 0.000 claims description 4
• 210000003527 eukaryotic cell Anatomy 0.000 claims description 4
• 238000000338 in vitro Methods 0.000 claims description 4
• 210000000107 myocyte Anatomy 0.000 claims description 3
• 241000271566 Aves Species 0.000 claims description 2
• 125000001433 C-terminal amino-acid group Chemical group 0.000 claims description 2
• 108010078791 Carrier Proteins Proteins 0.000 claims description 2
• 102100021468 Equilibrative nucleoside transporter 2 Human genes 0.000 claims description 2
• 241000238631 Hexapoda Species 0.000 claims description 2
• 101000822017 Homo sapiens Equilibrative nucleoside transporter 2 Proteins 0.000 claims description 2
• 125000001429 N-terminal alpha-amino-acid group Chemical group 0.000 claims description 2
• 102000019055 Nucleoside Transport Proteins Human genes 0.000 claims description 2
• 210000004556 brain Anatomy 0.000 claims description 2
• 210000004671 cell-free system Anatomy 0.000 claims description 2
• 230000000694 effects Effects 0.000 claims description 2
• 230000013595 glycosylation Effects 0.000 claims description 2
• 238000006206 glycosylation reaction Methods 0.000 claims description 2
• 108091006527 nucleoside transporters Proteins 0.000 claims description 2
• 210000001236 prokaryotic cell Anatomy 0.000 claims description 2
• 210000005253 yeast cell Anatomy 0.000 claims description 2
• 239000000203 mixture Substances 0.000 claims 15