CN103038232B - 单独的和与PDE5抑制剂相组合的sGC刺激剂、sGC活化剂用于治疗系统性硬化症(SSc)的用途 - Google Patents

单独的和与PDE5抑制剂相组合的sGC刺激剂、sGC活化剂用于治疗系统性硬化症(SSc)的用途 Download PDF

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Publication number
CN103038232B
CN103038232B CN201180036565.XA CN201180036565A CN103038232B CN 103038232 B CN103038232 B CN 103038232B CN 201180036565 A CN201180036565 A CN 201180036565A CN 103038232 B CN103038232 B CN 103038232B
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systemic sclerosis
ssc
compound
fibrosis
treatment
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Expired - Fee Related
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Chinese (zh)
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CN103038232A (zh
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C.希尔特-迪特里希
P.桑德纳
J-P.施塔施
A.克诺尔
G.冯德根费尔德
M.哈恩
M.福尔曼
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Adfolio Pharmaceutical LLC
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Adfolio Pharmaceutical LLC
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    • C07D495/04—Ortho-condensed systems
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    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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CN201180036565.XA 2010-05-26 2011-05-24 单独的和与PDE5抑制剂相组合的sGC刺激剂、sGC活化剂用于治疗系统性硬化症(SSc)的用途 Expired - Fee Related CN103038232B (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
DE102010021637.2 2010-05-26
DE102010021637A DE102010021637A1 (de) 2010-05-26 2010-05-26 Substituierte 5-Fluor-1H-Pyrazolopyridine und ihre Verwendung
EP10170413.8 2010-07-22
EP10170413 2010-07-22
PCT/EP2011/058433 WO2011147810A1 (en) 2010-05-26 2011-05-24 THE USE OF sGC STIMULATORS, sGC ACTIVATORS, ALONE AND COMBINATIONS WITH PDE5 INHIBITORS FOR THE TREATMENT OF SYSTEMIC SCLEROSIS (SSc).

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CN103038232A CN103038232A (zh) 2013-04-10
CN103038232B true CN103038232B (zh) 2016-01-20

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CN201180036565.XA Expired - Fee Related CN103038232B (zh) 2010-05-26 2011-05-24 单独的和与PDE5抑制剂相组合的sGC刺激剂、sGC活化剂用于治疗系统性硬化症(SSc)的用途

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DE102010021637A1 (de) * 2010-05-26 2011-12-01 Bayer Schering Pharma Aktiengesellschaft Substituierte 5-Fluor-1H-Pyrazolopyridine und ihre Verwendung
EP2637659B1 (en) 2010-11-09 2016-05-18 Ironwood Pharmaceuticals, Inc. Sgc stimulators
EP2594270A3 (en) * 2011-11-18 2013-07-31 BIP Patents The use of sGC stimulators, sGC activators, alone and combinations with PDE5 inhibitors for the treatment of systemic sclerosis (SSc)
CN102491974B (zh) * 2011-12-12 2013-08-07 南京药石药物研发有限公司 1-（2-氟苄基）-1H-吡唑并[3，4-b]吡啶-3-甲脒盐酸盐的合成方法
CN106117194A (zh) 2011-12-27 2016-11-16 铁木医药有限公司 可用作sgc刺激剂的2‑苄基、3‑(嘧啶‑2‑基)取代的吡唑类
ES2644781T3 (es) * 2012-03-06 2017-11-30 Bayer Intellectual Property Gmbh Azabiciclos sustituidos y su uso
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CN105102457A (zh) 2013-02-21 2015-11-25 阿德弗里奥药品有限责任公司 {4,6-二氨基-2-[1-(2-氟苄基)-1H-吡唑并[3,4-b]吡啶-3-基]嘧啶-5-基}甲基氨基甲酸甲酯的形式
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EP3024455A1 (en) 2013-07-25 2016-06-01 Bayer Pharma Aktiengesellschaft Sgc stimulators or sgc activators and pde5 inhibitors in combination with additional treatment for the therapy of cystic fibrosis
WO2015056663A1 (ja) * 2013-10-15 2015-04-23 トーアエイヨー株式会社 ４－アミノメチル安息香酸誘導体
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