CN102970978B - 活性药物成分的颗粒加工方法 - Google Patents

活性药物成分的颗粒加工方法 Download PDF

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Publication number
CN102970978B
CN102970978B CN201180024407.2A CN201180024407A CN102970978B CN 102970978 B CN102970978 B CN 102970978B CN 201180024407 A CN201180024407 A CN 201180024407A CN 102970978 B CN102970978 B CN 102970978B
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China
Prior art keywords
active pharmaceutical
ingredient
active
particle size
cavitation
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CN201180024407.2A
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Chinese (zh)
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CN102970978A (zh
Inventor
M·吉尔
C·卡塞拉
R·门东萨
F·加斯帕尔
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Hovione Inter AG
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Hovione Inter AG
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
    • A61J3/02—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of powders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0075—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/46—8-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles

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  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Emergency Medicine (AREA)
  • Pulmonology (AREA)
  • Otolaryngology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CN201180024407.2A 2010-04-21 2011-04-21 活性药物成分的颗粒加工方法 Active CN102970978B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
PT105058A PT105058B (pt) 2010-04-21 2010-04-21 Processo para processamento de partículas de ingredientes activos farmacêuticos
PT105058 2010-04-21
PCT/GB2011/000631 WO2011131947A2 (en) 2010-04-21 2011-04-21 A process for particle processing of active pharmaceutical ingredients

Publications (2)

Publication Number Publication Date
CN102970978A CN102970978A (zh) 2013-03-13
CN102970978B true CN102970978B (zh) 2017-05-10

Family

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CN201180024407.2A Active CN102970978B (zh) 2010-04-21 2011-04-21 活性药物成分的颗粒加工方法

Country Status (13)

Country Link
US (1) US9956144B2 (enExample)
EP (1) EP2560620B1 (enExample)
JP (2) JP6347608B2 (enExample)
CN (1) CN102970978B (enExample)
BR (1) BR112012026941A2 (enExample)
CA (1) CA2796978C (enExample)
IL (1) IL222596B (enExample)
MX (1) MX338594B (enExample)
PL (1) PL2560620T3 (enExample)
PT (1) PT105058B (enExample)
RU (1) RU2597790C2 (enExample)
SG (1) SG185003A1 (enExample)
WO (1) WO2011131947A2 (enExample)

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Also Published As

Publication number Publication date
PL2560620T3 (pl) 2021-04-06
EP2560620B1 (en) 2020-09-16
WO2011131947A3 (en) 2012-01-05
MX2012012215A (es) 2013-05-09
BR112012026941A2 (pt) 2016-07-12
IL222596B (en) 2019-03-31
JP2017019845A (ja) 2017-01-26
PT105058B (pt) 2013-04-17
RU2012149459A (ru) 2014-05-27
US9956144B2 (en) 2018-05-01
WO2011131947A2 (en) 2011-10-27
IL222596A0 (en) 2012-12-31
PT105058A (pt) 2011-10-21
SG185003A1 (en) 2012-11-29
MX338594B (es) 2016-04-25
EP2560620A2 (en) 2013-02-27
RU2597790C2 (ru) 2016-09-20
US20130203717A1 (en) 2013-08-08
JP6347608B2 (ja) 2018-06-27
JP2013525338A (ja) 2013-06-20
JP6857467B2 (ja) 2021-04-14
CA2796978A1 (en) 2011-10-27
CA2796978C (en) 2019-07-02
CN102970978A (zh) 2013-03-13

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