MX2012012215A - Un procedimiento para el procesamiento de partículas de principios farmaceuticos activos. - Google Patents

Un procedimiento para el procesamiento de partículas de principios farmaceuticos activos.

Info

Publication number
MX2012012215A
MX2012012215A MX2012012215A MX2012012215A MX2012012215A MX 2012012215 A MX2012012215 A MX 2012012215A MX 2012012215 A MX2012012215 A MX 2012012215A MX 2012012215 A MX2012012215 A MX 2012012215A MX 2012012215 A MX2012012215 A MX 2012012215A
Authority
MX
Mexico
Prior art keywords
active pharmaceutical
pharmaceutical ingredients
particle processing
pharmaceutical ingredient
processing
Prior art date
Application number
MX2012012215A
Other languages
English (en)
Other versions
MX338594B (es
Inventor
Marco Gil
Constanca Cacela
Ricardo Mendonca
Filipe Gaspar
Original Assignee
Hovione Int Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hovione Int Ltd filed Critical Hovione Int Ltd
Publication of MX2012012215A publication Critical patent/MX2012012215A/es
Publication of MX338594B publication Critical patent/MX338594B/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
    • A61J3/02—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of powders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0075—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/46—8-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles

Landscapes

  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Emergency Medicine (AREA)
  • Pulmonology (AREA)
  • Otolaryngology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Un proceso para reducir el tamaño de partículas de un ingrediente farmacéutico activo (API) mientras se mantiene su forma polimórfica, comprende la etapa de procesar el ingrediente farmacéutico activo por cavitación a presión elevada. El proceso comprende preferiblemente la etapa de aislar el ingrediente activo procesado en forma de polvo, en el que la etapa de aislamiento comprende la filtración o secado por pulverización. Las partículas producidas por el procedimiento de la invención tienen típicamente un valor de intervalo de menos de 2.5.
MX2012012215A 2010-04-21 2011-04-21 Un procedimiento para el procesamiento de partículas de principios farmaceuticos activos. MX338594B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
PT105058A PT105058B (pt) 2010-04-21 2010-04-21 Processo para processamento de partículas de ingredientes activos farmacêuticos
PCT/GB2011/000631 WO2011131947A2 (en) 2010-04-21 2011-04-21 A process for particle processing of active pharmaceutical ingredients

Publications (2)

Publication Number Publication Date
MX2012012215A true MX2012012215A (es) 2013-05-09
MX338594B MX338594B (es) 2016-04-25

Family

ID=44194836

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2012012215A MX338594B (es) 2010-04-21 2011-04-21 Un procedimiento para el procesamiento de partículas de principios farmaceuticos activos.

Country Status (13)

Country Link
US (1) US9956144B2 (es)
EP (1) EP2560620B1 (es)
JP (2) JP6347608B2 (es)
CN (1) CN102970978B (es)
BR (1) BR112012026941A2 (es)
CA (1) CA2796978C (es)
IL (1) IL222596B (es)
MX (1) MX338594B (es)
PL (1) PL2560620T3 (es)
PT (1) PT105058B (es)
RU (1) RU2597790C2 (es)
SG (1) SG185003A1 (es)
WO (1) WO2011131947A2 (es)

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Also Published As

Publication number Publication date
JP6857467B2 (ja) 2021-04-14
WO2011131947A3 (en) 2012-01-05
US9956144B2 (en) 2018-05-01
MX338594B (es) 2016-04-25
BR112012026941A2 (pt) 2016-07-12
CN102970978B (zh) 2017-05-10
CA2796978A1 (en) 2011-10-27
WO2011131947A2 (en) 2011-10-27
IL222596B (en) 2019-03-31
RU2012149459A (ru) 2014-05-27
PT105058B (pt) 2013-04-17
SG185003A1 (en) 2012-11-29
CA2796978C (en) 2019-07-02
US20130203717A1 (en) 2013-08-08
PT105058A (pt) 2011-10-21
EP2560620B1 (en) 2020-09-16
JP6347608B2 (ja) 2018-06-27
JP2017019845A (ja) 2017-01-26
PL2560620T3 (pl) 2021-04-06
RU2597790C2 (ru) 2016-09-20
EP2560620A2 (en) 2013-02-27
IL222596A0 (en) 2012-12-31
CN102970978A (zh) 2013-03-13
JP2013525338A (ja) 2013-06-20

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