CN102858951B - 可从机体组织分离的多能干细胞 - Google Patents
可从机体组织分离的多能干细胞 Download PDFInfo
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- CN102858951B CN102858951B CN201080041908.7A CN201080041908A CN102858951B CN 102858951 B CN102858951 B CN 102858951B CN 201080041908 A CN201080041908 A CN 201080041908A CN 102858951 B CN102858951 B CN 102858951B
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Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201611060144.1A CN107012117B (zh) | 2009-07-15 | 2010-07-15 | 可从机体组织分离的多能干细胞 |
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US21378809P | 2009-07-15 | 2009-07-15 | |
| US61/213788 | 2009-07-15 | ||
| US29015909P | 2009-12-24 | 2009-12-24 | |
| US61/290159 | 2009-12-24 | ||
| PCT/JP2010/062480 WO2011007900A1 (ja) | 2009-07-15 | 2010-07-15 | 生体組織から単離できる多能性幹細胞 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201611060144.1A Division CN107012117B (zh) | 2009-07-15 | 2010-07-15 | 可从机体组织分离的多能干细胞 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN102858951A CN102858951A (zh) | 2013-01-02 |
| CN102858951B true CN102858951B (zh) | 2016-12-07 |
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ID=43449509
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201611060144.1A Active CN107012117B (zh) | 2009-07-15 | 2010-07-15 | 可从机体组织分离的多能干细胞 |
| CN201080041908.7A Active CN102858951B (zh) | 2009-07-15 | 2010-07-15 | 可从机体组织分离的多能干细胞 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201611060144.1A Active CN107012117B (zh) | 2009-07-15 | 2010-07-15 | 可从机体组织分离的多能干细胞 |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US9550975B2 (OSRAM) |
| EP (3) | EP3680323B1 (OSRAM) |
| JP (7) | JP5185443B2 (OSRAM) |
| KR (4) | KR20120069663A (OSRAM) |
| CN (2) | CN107012117B (OSRAM) |
| AU (1) | AU2010271722B8 (OSRAM) |
| CA (1) | CA2768238C (OSRAM) |
| DK (2) | DK3214170T3 (OSRAM) |
| ES (3) | ES3015175T3 (OSRAM) |
| HR (1) | HRP20250245T1 (OSRAM) |
| HU (3) | HUE071170T2 (OSRAM) |
| NO (1) | NO2455452T3 (OSRAM) |
| PL (3) | PL2455452T5 (OSRAM) |
| PT (2) | PT2455452T (OSRAM) |
| SG (1) | SG177705A1 (OSRAM) |
| WO (1) | WO2011007900A1 (OSRAM) |
Families Citing this family (91)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9550975B2 (en) * | 2009-07-15 | 2017-01-24 | Mari Dezawa | SSEA-3 pluripotent stem cell isolated from body tissue |
| JP2014133703A (ja) * | 2011-03-30 | 2014-07-24 | Clio Inc | 生体組織から単離できるssea−3陽性の多能性幹細胞を含む他家移植用細胞治療用組成物 |
| JP2014132830A (ja) * | 2011-03-30 | 2014-07-24 | Clio Inc | 生体の臍帯又は脂肪組織から単離できる多能性幹細胞 |
| US9399758B2 (en) | 2009-07-15 | 2016-07-26 | Mari Dezawa | SSEA3(+) pluripotent stem cell that can be isolated from body tissue |
| MX2012002117A (es) | 2009-08-21 | 2012-06-01 | Univ Leland Stanford Junior | Eficiencia mejorada para la generacion de celulas madre pluripotentes inducidas a partir de las celulas somaticas humanas. |
| US10130736B1 (en) | 2010-05-14 | 2018-11-20 | Musculoskeletal Transplant Foundation | Tissue-derived tissuegenic implants, and methods of fabricating and using same |
| US8883210B1 (en) | 2010-05-14 | 2014-11-11 | Musculoskeletal Transplant Foundation | Tissue-derived tissuegenic implants, and methods of fabricating and using same |
| US9352003B1 (en) | 2010-05-14 | 2016-05-31 | Musculoskeletal Transplant Foundation | Tissue-derived tissuegenic implants, and methods of fabricating and using same |
| CA2837419C (en) * | 2011-06-06 | 2021-07-13 | ReGenesys BVBA | Expansion of stem cells in hollow fiber bioreactors |
| US9453840B2 (en) | 2011-07-27 | 2016-09-27 | Kyoto University | Markers for dopaminergic neuron progenitor cells |
| KR101751355B1 (ko) * | 2011-08-24 | 2017-07-04 | (주)아모레퍼시픽 | 인간 피부 진피 유래 성체 줄기세포 |
| JP6162604B2 (ja) | 2011-10-21 | 2017-07-12 | 国立大学法人京都大学 | 層流による多能性維持単一分散細胞培養法 |
| US20150056170A1 (en) * | 2012-03-06 | 2015-02-26 | Sct&B Inc. | Placental stem cells, methods for isolating same and use thereof |
| US11963977B2 (en) * | 2012-04-24 | 2024-04-23 | Vcell Therapeutics Inc. | Generating pluripotent cells de novo |
| AU2013295793A1 (en) * | 2012-07-27 | 2015-02-19 | Bioquark, Inc. | Extracts isolated from electroporated ambhibian oocytes and use thereof in treating diseases and disorders |
| WO2014027474A1 (ja) | 2012-08-17 | 2014-02-20 | 株式会社Clio | 心筋梗塞の修復再生を誘導する多能性幹細胞 |
| WO2014100806A1 (en) * | 2012-12-21 | 2014-06-26 | Rutgers, The State University Of New Jersey | Muse cells isolation and expansion |
| US9709554B2 (en) | 2013-01-31 | 2017-07-18 | Rutgers, The State University Of New Jersey | In vitro model of macrosteatotic (fatty) liver |
| EP2955223B1 (en) | 2013-02-08 | 2019-12-18 | Kyoto University | Production methods for megakaryocytes and platelets |
| JPWO2014133090A1 (ja) * | 2013-02-28 | 2017-02-02 | 国立大学法人浜松医科大学 | 脳腫瘍治療のための多能性幹細胞 |
| JP6511606B2 (ja) | 2013-03-01 | 2019-05-15 | 株式会社生命科学インスティテュート | 多能性幹細胞を損傷部位に誘導する遊走因子を含む医薬組成物 |
| EP2970892A1 (en) * | 2013-03-15 | 2016-01-20 | The Jackson Laboratory | Isolation of non-embryonic stem cells and uses thereof |
| WO2014148646A1 (ja) | 2013-03-21 | 2014-09-25 | 国立大学法人京都大学 | 神経分化誘導用の多能性幹細胞 |
| EP2980207B1 (en) | 2013-03-25 | 2018-12-05 | Foundation for Biomedical Research and Innovation at Kobe | Cell sorting method |
| EP2985344B1 (en) | 2013-04-12 | 2018-07-18 | Kyoto University | Method for inducing alveolar epithelium progenitor cells |
| US9822342B2 (en) | 2013-05-14 | 2017-11-21 | Kyoto University | Method of efficiently inducing cardiomyocytes |
| EP3613846A1 (en) | 2013-05-22 | 2020-02-26 | The Regents of the University of California | Pluripotent human adipose adult stem cells: isolation, characterization and clinical implications |
| EP3027235A1 (en) | 2013-07-30 | 2016-06-08 | Musculoskeletal Transplant Foundation | Acellular soft tissue-derived matrices and methods for preparing same |
| JP6378183B2 (ja) | 2013-08-07 | 2018-08-22 | 国立大学法人京都大学 | 膵ホルモン産生細胞の製造法 |
| WO2015030149A1 (ja) | 2013-08-29 | 2015-03-05 | 国立大学法人鳥取大学 | 細胞のアンチエイジングに関連する生体分子群 |
| EP3048169B1 (en) | 2013-09-04 | 2019-07-10 | Otsuka Pharmaceutical Factory, Inc. | Method for preparing pluripotent stem cells |
| JP6558580B2 (ja) | 2013-09-05 | 2019-08-14 | 国立大学法人京都大学 | 新規ドーパミン産生神経前駆細胞の誘導方法 |
| JP6635505B2 (ja) | 2013-11-01 | 2020-01-29 | 国立大学法人京都大学 | 新規軟骨細胞誘導方法 |
| WO2015081094A1 (en) * | 2013-11-27 | 2015-06-04 | University Of Louisville Research Foundation, Inc. | Cardiac progenitor cells and methods of use therefor |
| JP6519038B2 (ja) * | 2014-02-26 | 2019-05-29 | 株式会社生命科学インスティテュート | 脳梗塞治療のための多能性幹細胞 |
| JP2015160820A (ja) * | 2014-02-26 | 2015-09-07 | 株式会社Clio | 慢性腎障害治療のための多能性幹細胞 |
| RU2711942C2 (ru) | 2014-03-19 | 2020-01-23 | Виселл Терапеутикс, Инк. | Способы, относящиеся к плюрипотентным клеткам |
| CN106536718B (zh) | 2014-05-21 | 2021-04-27 | 国立大学法人京都大学 | 胰芽细胞的制造方法及含有胰芽细胞的胰疾病治疗剂 |
| KR101592401B1 (ko) * | 2014-06-13 | 2016-02-05 | 주식회사 비비에이치씨 | 지방-유래 중간엽 줄기세포로부터 유도만능 줄기세포를 제조하는 방법 및 그 방법에 의해 제조된 유도만능 줄기세포 |
| JP6391364B2 (ja) * | 2014-08-25 | 2018-09-19 | 国立大学法人 鹿児島大学 | 認知機能障害改善用細胞製剤 |
| JP6452107B2 (ja) * | 2014-09-05 | 2019-01-16 | 国立大学法人 東京大学 | 糖尿病性皮膚潰瘍治療のための多能性幹細胞 |
| KR101700598B1 (ko) * | 2014-11-11 | 2017-01-31 | 한국원자력의학원 | Cd105를 포함하는 줄기세포능을 가진 섬유아세포 분리용 바이오마커 조성물 및 이를 이용한 줄기세포능을 가진 섬유아세포 분리 방법 |
| CA2986702C (en) | 2015-05-21 | 2023-04-04 | David Wang | Modified demineralized cortical bone fibers |
| CN107635570B (zh) * | 2015-05-29 | 2019-03-19 | 日本脏器制药株式会社 | 多能性干细胞迁移促进剂 |
| US10912864B2 (en) | 2015-07-24 | 2021-02-09 | Musculoskeletal Transplant Foundation | Acellular soft tissue-derived matrices and methods for preparing same |
| US11052175B2 (en) | 2015-08-19 | 2021-07-06 | Musculoskeletal Transplant Foundation | Cartilage-derived implants and methods of making and using same |
| JP6627027B2 (ja) * | 2015-09-11 | 2020-01-08 | 福美人株式会社 | 皮膚細胞の活性化作用を呈するフラボノイド誘導体 |
| AU2017207154B2 (en) * | 2016-01-15 | 2020-09-17 | Mari Dezawa | Mobilization of pluripotent stem cells for ischemic cerebral infarction |
| JP6770673B2 (ja) * | 2016-02-26 | 2020-10-21 | 国立大学法人東海国立大学機構 | 急性心筋梗塞の予後マーカー及びその利用 |
| CN115011555B (zh) * | 2016-03-17 | 2024-12-24 | 辛诺瓦生命科学股份有限公司 | 使用冲击波或机械冲击分离、解离和/或裂解细胞的方法 |
| WO2017183736A1 (ja) | 2016-04-22 | 2017-10-26 | 国立大学法人京都大学 | ドーパミン産生神経前駆細胞の製造方法 |
| AU2017267809B2 (en) * | 2016-05-16 | 2020-01-30 | Life Science Institute, Inc. | Amelioration and treatment of perinatal brain damage with pluripotent stem cells |
| CA3029505A1 (en) | 2016-07-01 | 2018-01-04 | Tohoku University | Prophylactic or therapeutic agent for organ fibrosis |
| EP3492091B1 (en) * | 2016-07-29 | 2021-07-14 | Tohoku University | "muse" cells as prophylactic or therapeutic agent for aneurysm |
| JP7045670B2 (ja) | 2016-08-03 | 2022-04-01 | 皓 矢吹 | 多能性幹細胞による虚血再灌流肺障害の軽減及び治療 |
| CN109661461B (zh) * | 2016-08-03 | 2024-05-24 | 株式会社生命科学研究院 | 在体外分化诱导多能性干细胞的方法 |
| SG11201900983TA (en) * | 2016-08-03 | 2019-03-28 | Univ Nagoya Nat Univ Corp | Amelioration and treatment of chronic lung disease using pluripotent stem cells |
| US20200270579A1 (en) | 2017-02-03 | 2020-08-27 | Kyushu University, National University Corporation | Method for preparing dental pulp stem cells from cells derived from dental pulp tissue |
| CN110494559B (zh) * | 2017-03-28 | 2023-10-31 | 味之素株式会社 | 不分化地维持用培养基添加剂 |
| CA3067963A1 (en) * | 2017-06-19 | 2018-12-27 | National University Corporation Hokkaido University | Treatment agent for epidermolysis bullosa |
| CN110869034A (zh) | 2017-06-20 | 2020-03-06 | 国立大学法人名古屋大学 | 利用多能干细胞进行的伴随胎儿生长迟缓的脑损伤的改善和治疗 |
| CN111225676A (zh) | 2017-10-17 | 2020-06-02 | 国立大学法人广岛大学 | 诱导骨软骨修复的多能性干细胞 |
| EP3708662A4 (en) * | 2017-11-10 | 2021-08-25 | Regenesis Science Co., Ltd. | METHOD FOR PRODUCING A CULTIVATED CELL, AND METHOD FOR PRODUCING A THERAPEUTIC AGENT FOR SPINAL CORD INJURY DISEASE |
| EP3719501B1 (en) | 2017-11-28 | 2023-01-04 | Cell2in, Inc. | Method for measuring quality of therapeutic cell through real-time glutathione measurement |
| JP6604492B2 (ja) * | 2018-04-09 | 2019-11-13 | 株式会社生命科学インスティテュート | 脳梗塞治療のための多能性幹細胞 |
| JPWO2019216380A1 (ja) * | 2018-05-09 | 2021-05-13 | 株式会社生命科学インスティテュート | 脊髄損傷の治療剤 |
| JP7072777B2 (ja) * | 2018-07-03 | 2022-05-23 | 株式会社生命科学インスティテュート | 慢性腎障害治療のための多能性幹細胞 |
| JP7285015B2 (ja) | 2018-07-19 | 2023-06-01 | 国立大学法人京都大学 | 多能性幹細胞由来の板状軟骨およびその製造方法 |
| CN113039269A (zh) * | 2018-11-14 | 2021-06-25 | 株式会社片冈制作所 | 胰岛素产生细胞的制造方法和组合物 |
| EP3888751B1 (en) * | 2018-11-30 | 2024-04-17 | Kyoto Prefectural Public University Corporation | Cell product for use in treating a peripheral blood flow disorder |
| EP3900787A4 (en) | 2018-12-21 | 2022-02-23 | Kyoto University | LUBRICIN-LOCALIZED CARTILE-LIKE TISSUE, METHOD OF MANUFACTURE THEREOF AND COMPOSITION THEREOF FOR TREATMENT OF ARTICULATE-CARTILAGE DEFECTS |
| JP2022528965A (ja) * | 2019-04-09 | 2022-06-16 | ラトガース,ザ ステート ユニバーシティ オブ ニュー ジャージー | 細胞集団を濃縮する方法 |
| US20220395536A1 (en) | 2019-08-09 | 2022-12-15 | Tohoku University | Agent for treating or preventing vascular dementia |
| EP4026551A1 (en) * | 2019-09-05 | 2022-07-13 | Tohoku University | Therapeutic agent for myocarditis |
| CN114630898B (zh) | 2019-10-01 | 2024-08-02 | 国立大学法人京都大学 | 输尿管芽顶端部细胞的分离方法 |
| JPWO2021085639A1 (OSRAM) * | 2019-10-31 | 2021-05-06 | ||
| WO2021117886A1 (ja) | 2019-12-12 | 2021-06-17 | 国立大学法人千葉大学 | 巨核球および血小板を含む凍結乾燥製剤 |
| IL296317A (en) | 2020-03-19 | 2022-11-01 | Orizuru Therapeutics Inc | Cardiomyocyte purification method |
| CN115427552A (zh) | 2020-03-19 | 2022-12-02 | 千纸鹤治疗公司 | 心肌细胞的精制方法 |
| WO2021201286A1 (ja) | 2020-04-02 | 2021-10-07 | 国立大学法人東北大学 | ハイポテンシャル多能性幹細胞 |
| JP7429294B2 (ja) | 2020-07-13 | 2024-02-07 | 国立大学法人京都大学 | 骨格筋前駆細胞及びその精製方法、筋原性疾患を治療するための組成物、並びに骨格筋前駆細胞を含む細胞群の製造方法 |
| US20230270790A1 (en) * | 2020-07-15 | 2023-08-31 | National University Corporation Okayama University | Pluripotent stem cells effective for treatment of motor neuron disease (mnd) |
| JP2021073305A (ja) * | 2021-02-09 | 2021-05-13 | 株式会社生命科学インスティテュート | 慢性腎障害治療のための多能性幹細胞 |
| TWI832070B (zh) * | 2021-07-15 | 2024-02-11 | 國璽幹細胞應用技術股份有限公司 | 幹細胞製劑用於治療關節炎的用途及用於製備幹細胞製劑的方法 |
| JP2023041486A (ja) * | 2021-09-13 | 2023-03-24 | 国立大学法人東北大学 | 毛髪損傷の治療剤 |
| EP4477746A1 (en) | 2022-02-09 | 2024-12-18 | Sumitomo Pharma Co., Ltd. | Method for assessing differentiation potential of cells in culture broth in differentiation of pluripotent stem cells into neural cells of midbrain floor plate region |
| JPWO2023228908A1 (OSRAM) | 2022-05-23 | 2023-11-30 | ||
| WO2024210126A1 (ja) | 2023-04-03 | 2024-10-10 | 大塚製薬株式会社 | 巨核球の製造方法 |
| WO2024248017A1 (ja) | 2023-05-29 | 2024-12-05 | 国立研究開発法人理化学研究所 | 心筋細胞を成熟させる方法及び成熟した心筋細胞の製造方法 |
| CN117187174B (zh) * | 2023-11-08 | 2024-02-06 | 广州正源生物技术有限公司 | 一种Muse细胞培养基以及一种脂肪Muse细胞的提取方法 |
| JP2025123077A (ja) * | 2024-02-09 | 2025-08-22 | 国立大学法人東北大学 | 脊髄梗塞治療のための多能性幹細胞 |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PT1226233E (pt) | 1999-08-05 | 2011-10-04 | Abt Holding Co | Células estaminais adultas multipotentes e métodos para isolamento |
| US7575921B2 (en) * | 1999-12-30 | 2009-08-18 | Vbi Technologies, L.L.C. | Spore-like cells and uses thereof |
| WO2002057428A1 (en) * | 2000-10-30 | 2002-07-25 | University Of Massachusetts | Isolation of spore-like cells from tissues exposed to extreme conditions |
| JP4182742B2 (ja) | 2002-12-12 | 2008-11-19 | 日産自動車株式会社 | 自動車の前部車体構造 |
| WO2005017117A2 (en) | 2003-08-14 | 2005-02-24 | Martin Haas | Multipotent amniotic fetal stem cells (mafsc) and banking of same |
| CA2536909A1 (en) * | 2003-08-29 | 2005-03-10 | Regents Of The University Of Minnesota | Kidney derived stem cells and methods for their isolation, differentiation and use |
| US20060216821A1 (en) * | 2004-02-26 | 2006-09-28 | Reliance Life Sciences Pvt. Ltd. | Pluripotent embryonic-like stem cells derived from corneal limbus, methods of isolation and uses thereof |
| CN101180389A (zh) * | 2005-05-17 | 2008-05-14 | 利莱恩斯生命科学有限公司 | 采用哺乳动物细胞确立人胚胎干细胞系 |
| US9388382B2 (en) * | 2005-10-05 | 2016-07-12 | The Board Of Trustees Of The University Of Illinois | Isolation of CD14 negative, CD45 positive and CD117 positive embryonic-like stem cells free of monocytes from human umbilical cord blood mononuclear cells |
| WO2007047581A2 (en) | 2005-10-17 | 2007-04-26 | Academia Sinica | Pulmonary stem cells, related methods and kits |
| WO2009059032A2 (en) * | 2007-10-30 | 2009-05-07 | University Of Louisville Research Foundation, Inc. | Uses and isolation of very small embryonic-like (vsel) stem cells |
| ZA200804673B (en) * | 2005-12-13 | 2009-11-25 | Univ Kyoto | Nuclear reprogramming factor |
| WO2008080200A1 (en) | 2006-12-29 | 2008-07-10 | Irina Kerkis | Process for obtaining stem cells |
| JP2008307007A (ja) | 2007-06-15 | 2008-12-25 | Bayer Schering Pharma Ag | 出生後のヒト組織由来未分化幹細胞から誘導したヒト多能性幹細胞 |
| US20090172832A1 (en) * | 2007-12-28 | 2009-07-02 | Timothy Caspar | Expression of rubisco enzyme from a non-rubisco locus |
| ITRM20080342A1 (it) * | 2008-06-26 | 2009-12-27 | Univ Degli Studi Udine | Cellule di polpa dentale midollo-simili, metodi per isolamento ed uso. |
| US9550975B2 (en) * | 2009-07-15 | 2017-01-24 | Mari Dezawa | SSEA-3 pluripotent stem cell isolated from body tissue |
-
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-
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Non-Patent Citations (3)
| Title |
|---|
| Ear mesenchymal stem cells: An efficient adult multipotent cell population;Sébastien Sart,et al;《Journal of Biotechnology》;20090223;第139卷;291–299 * |
| Isolation of Mesenchymal Stem Cells from Human Placental Decidua Basalis and Resistance to Hypoxia and Serum Deprivation;Yong-Can Huang,et al;《Stem Cell Rev and Rep》;20090523;第5卷;摘要,正文第248页右栏第2段-4段,第253页正文左栏第1段 * |
| 脂肪组织来源的多能干细胞培养和外源基因的表达;刘相名 等;《中华实验外科杂志》;20030228;第20卷(第2期);正文162页右栏第2段-163页左栏第一段 * |
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